TW201210632A - Use of plant or like for improving pores, method for improving pores and oral preparation for improving pores - Google Patents

Abstract

To make the bucket-shaped structure of pores inconspicuous by preventing parakeratosis caused by stimulatory components in the sebum around the pores and maintaining the skin around the pores in the normal state.An oral preparation for improving pores which comprises one or more plants selected from the plants belonging to the genus of the Psophocarpus in the family of Leguminosae or an extract of the same

Description

201210632 VI. Description of the Invention: [Technical Field] The present invention relates to a method for suppressing keratinization caused by a stimulating component in sebum around a hair follicle, keeping the skin around the pores normal, and inhibiting the research of Mao Ba A large pore-shaped hairmelt improver. [Prior Art] In recent years, tS is centered on young women, and the trouble associated with the thickening of the hairy pores has increased, and it has been required to have an external preparation for improving the skin of the hairy pores. However, there are cases where the mechanism for making the hairs thick and severe is not sufficiently clear, and it is usually dealt with by the elimination of astringent lotion or angle plugs. Or, there are many cases in which the foundation is used to improve the appearance. However, for example, the purpose of astringent lotion and tightening of the skin is to temporarily lower the surface temperature of the skin by alcohol alone: or to solidify the protein by an organic acid or the like. Therefore, although the load on the skin is large, the pores are not fundamentally solved, and the effect is not sufficient. In the patent text m, the mechanism of the hairy hole is studied as follows. The epidermal keratinocytes proliferate in the basal layer and transfer to the upper layer, mature and become the horn layer, and intracellularly transform into the horn layer. The nucleus disappears and the cells are flattened. However, there are cases where epidermal keratinocytes are present in the horn layer in a state in which the nucleus has a nucleus in the cell. Calling it keratosis, causing parakeratosis causes multi-layer peeling of the corner layer and thus enlarges the hair. 々 , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛 毛Poor, and 157764.doc 201210632 caused parakeratosis, thus expanding the pores. In short, the reason for the gross hole mechanism is that the keratinization caused by sebum is incomplete, and the substance that inhibits parakeratosis is effective for reducing the pores. In other words, if the keratosis is suppressed, the pores can be narrowed and the pores can be enlarged. According to this point of view, it has been found in the patent document that oleic acid, which is a stimulating component in sebum and causes parakeratosis, has an effect of exciting cells such as epidermal keratinocytes (increasing calcium concentration), and excitatory cells are also affected. The agonist of the body and the antagonist of the inhibitory cell receptor have an effect of aggravating the parakeratosis. Specific examples of the compound include gamma-aminobutyric acid (GABA), and Patent Document 2 Among them, β-alaninyl-L-histidine is exemplified as a substance having a keratinization inhibitory effect and a hair-shrinking effect. However, the applicant has proposed an external preparation for skin containing an extract of Wounded Bean (scientific name: Psophocarpus tetragonolobus) which increases the production of laminin 5 in epidermal cells and has an anti-aging and anti-aging effect (Patent Document) 3). It has also been found that the extract of Winged Bean has cell thinning promotion, TGF-P (Transforming Growth Factor-β) production promotion, collagen gel contraction promotion, integrin production promotion, collagen production promotion, hyaluronic acid Various effects such as promotion and inhibition of protein saccharification, and various promoters and inhibitors containing extracts of Winged Beans have been proposed (Patent Documents 4, 5, and 6). [PRIOR ART DOCUMENT] [Patent Document 1] Patent Document 1 Japanese Patent Laid-Open No. 2003-342195 No. 157764.doc 201210632 [Patent Document 2] Japanese Patent Laid-Open Publication No. 2005-281197 [Patent Document 3] Japanese Patent No. 3687747 [Patent Document 4] Japanese Laid-Open Patent Publication No. 2010-24211 (Patent Document 5) Japanese Patent Laid-Open Publication No. 2010-132632 [Problems to be Solved by the Invention] Although the extract of Winged Bean has the effects disclosed in Patent Documents 3 to 6, the effect in the case of orally ingesting the extract of Winged Bean is not known. The present inventors have conducted research on the present invention, and as a result, it has been found that the extract of the seed and the pod of the Winged Bean has the effect of keratinization and the effect of reducing the pores by the mouth, thereby completing the present invention. The object of the present invention is to provide a transoral hairmelt improving agent which can suppress the parakeratosis caused by the stimulating component in the sebum around the hair shaft, keep the skin around the hair shaft normal, and suppress the coarse structure of the hairy point. [Technical means for solving the problem] The oral cavity improving agent of the present invention comprises one or more plants selected from the group consisting of plants belonging to the genus Psophocarpus or a cultivator thereof. The above-mentioned plant or its extract is preferably a seed or a pod of a plant belonging to the genus Psophocarpus, and the above-mentioned plant belonging to the genus Ps〇ph〇carpus is more preferably a quadrangular bean (ps0ph0carpus). Tetrag〇n〇〗 〇 bus). The above-mentioned oral hair shaft improving agent is preferably an oral hair shaft thickening inhibitor which inhibits the roughening of the hair by repairing keratosis. 157764.doc 201210632 [Effect of the invention] The oral cavity improving agent of the present invention comprises one or more than one plant or an extract thereof selected from plants belonging to the genus Psophocarpus. Inhibition of keratosis caused by stimulating components in sebum around the pores (so-called stimulating components in sebum refers to unsaturated fatty acids such as oleic acid causing parakeratosis), thus greatly reducing epidermal keratinocytes in cells In the case where the core is in an unripe state, it exists in the horn layer, and it is possible to prevent the skin from being roughened. In addition, since the skin is roughened, the skin around the pores can be kept normal. Further, by normalizing the skin around the hair points, it is possible to suppress the coarseness of the mortar-like structure of the hairs, so that the hair points can be reduced, and the improvement of the hair points can be achieved. [Embodiment] Hereinafter, the oral hair shaft improving agent of the present invention will be described in detail. The herbaceous herb of the genus Leguminosae of the genus Pseudophyllum (PS〇Ph〇CarpuS) of the present invention is used in the oral cavity improving agent of the present invention. In the present invention, the plant belonging to the genus Winged Bean is not particularly limited and can be used arbitrarily. Among them, tetragonal beans (Ps〇ph〇carpus tetrag〇n〇l〇buS) can be preferably used. P. 〇 〇 ( (Ps〇ph〇carpus tetrag〇n〇i〇bus) was also introduced into sputum and cultivated. As an improved variety, "udzun" and the like are known. Needless to say, these improved varieties are also included in the present invention. Commercial products can be purchased from Sakata seed, etc. The Winged Bean can be used directly as a raw material or a dried one, but it is preferably used as a dry powder or a solvent extract in terms of usability, formulation, and the like. As a part of the use of ton of beans, seeds can be used 157,764.doc 201210632 pods, leaves, flowers, roots, whole grass, and the like. Among them, seeds or pods can be preferably used. The extract of the Winged Bean can be obtained by a conventional method. For example, the Winged Bean can be dried as needed, and then immersed in an extraction solvent for a certain period of time or brought into contact with an extraction solvent heated under reflux, followed by filtration and concentration. . The extraction solvent may be any solvent as long as it is usually used for extraction, and for example, water, f-alcohol, ethanol, propylene glycol, 1,3-butylene glycol, glycerol-polyol, gas-mound, and sulphur-burning may be used. Organic solvents such as carbon tetrachloride, acetone, and ethyl acetate are used singly or in combination as appropriate. The extract obtained by extracting with the above solvent may be used as it is, or the concentrated extract may be used, or the extract may be removed by an adsorption method such as an ion exchange resin, or a porous polymer may be used. The column of (for example, Ambedhe XAD_2) is adsorbed and then precipitated and concentrated by using methanol or ethanol. Further, an extract obtained by extraction using a distribution method such as water/ethyl acetate or the like can also be used. The Winged Bean Extract obtained in the above manner is safer and has an excellent hair hole improving effect. The case where the Winged Bean and its extract have a hair-melting effect by oral administration has not been known so far, and the present inventors have confirmed for the first time that they have such effects. The oral preparation of the present invention is formulated into a diet. In the case of a feed or the like, the blending amount (dry mass) of the Winged Bean Extract can be appropriately determined depending on the type, purpose, form, usage, etc., for example, it can be set to 0_0001 to 50 in the total amount of foods and drinks. About % by mass. In particular, in the case of use as a food or drink for health care, it is preferred that the active ingredient of the present invention is 157764.doc 201210632 in an amount sufficient to exert a specific effect. The form of the food or drink or the feed may be, for example, granulated, drawn, pasty, gelatinous, solid or liquid. It is intended to contain various substances known to be included in the diet, such as binders, disintegrants, tackifiers, dispersants, resorption enhancers, flavoring agents, buffers, surfactants. An excipient such as a dissolution aid, a preservative, an emulsifier, an isotonic agent, a stabilizer or a rhomodulin. When the oral cavity improving agent of the present invention is used as a pharmaceutical preparation, the 'dosage form is arbitrary' can be suitably prepared into a solid preparation such as a tablet, a granule, a powder, a capsule, or the like by a known method, or Any form such as an oral liquid preparation such as an oral liquid preparation or a syrup preparation. For such pharmaceutical preparations t, the commonly used binders, disintegrating agents, tackifiers, dispersing agents, resorption enhancers, flavoring agents, buffering agents, surfactants, dissolution aids, and preservatives may also be suitably used. Excipients such as emulsifiers, emulsifiers, isotonic agents, stabilizers or pH adjusters. When the oral cavity acupoint improving agent of the present invention is used as a food or drink, a feed, a medical preparation, or the like, it is possible to suppress the parakeratosis caused by the stimulating component of the sebum around the hair shaft, thereby preventing and improving the skin roughening. The normalization of the skin around the pores, the reduction of the pores, etc. are useful. In addition, the physiological functions such as the treatment, prevention, and improvement of the above-mentioned symptoms can be applied to the following functional ingredients such as functional foods, foods for diseases, foods for specific health care, and the like, and the examples are described in more detail by way of examples. The oral cavity improvement of the present invention is described. 157764.doc 201210632 [Examples] (Preparation of extract of Winged Bean Seed and Bean Pod) 50 g of seed portion of Psophocarpus tetragonolobus at room temperature in 90% ethanol The mixture was immersed for 1 week, and the extract was concentrated to obtain 290 g of a 90% ethanol extract (dried product). The Winged Beans pods were treated in the same manner to obtain an ethanol extract (dry matter) of 2.5 g. (Preparation of Winged Bean Seed Extract and Pod Extract Preparation Test Article) The Winged Bean Seed Extract Preparation Test Sample, Pod Extract Preparation Test Sample and Placebo (all tablets) were prepared according to the following Table 1. ). [Table 1] Test Name Name Raw Material Seed Extract Test (mg/table) Pod Extract Test (mg/tablet) Placebo (mg/table) Winged Bean Seed Extract Powder 50 0 0 Winged Bean Pod Extract powder 0 50 0 Powder reduction maltose 60 60 60 Dextrin 60 60 60 Crystalline cellulose 60 60 60 Lactose 56.5 56.5 106.5 Particulate ceria 4.5 4.5 4.5 Sucrose fatty acid ester 9 9 9 Total 300 300 300 (test article Ingestion) Women aged 40 to 49 years old are divided into three groups: the four-legged bean seed extract test product ingestion group, the four-corner bean pod extract test product ingestion group, and the placebo ingestion group (n=30 in each group). The test article was ingested by 157764.doc 201210632 once every 2 months to 3 months. (Evaluation method) It is known that the ratio of transepidermal water evapotranspiration or sebum to the large part of the hair follicle is higher than that of the unsaturated fatty acid. In addition, the skin color is red in the large part of the hair follicle, which causes symptoms such as sensitive musculature, dry state, inflammatory state, and liposuction dermatitis. Therefore, the improvement of red color is an improvement indicator for these symptoms. Therefore, the evaluation was carried out in the following manner from the viewpoints of the amount of transdermal water evapotranspiration, sebum inhibition, the amount of unsaturated fatty acids in sebum, and skin color. (Transdermal water evapotranspiration) Before ingestion (〇M), after 1 month of ingestion (1 M), after ingestion for 2 months (2 M) Using a water evapotranspiration meter (VapoMeter) for Winged Bean Seed Extract The skin of the cheeks of the tester of each of the test article ingestion group and the quadrangular bean pod extract test product ingestion group was measured. The results are shown in Table 2 (the values in Table 2 are the average values of the testers in each group). The lower the measured value, the lower the amount of water evapotranspiration (=the skin condition is good), and it can be confirmed from Table 2 that the ingestion is the present invention. The test group of the Winged Bean Seed Extract of the Oral Cavity Improver and the test article of the Wing Bean Bean Extract were all reduced in transepidermal water evapotranspiration and the skin condition was improved. [Table 2] Group 0M 1 Μ 2Μ Seed extract 16.61 16.52 13.90 Bean extract 15.99 15.63 15.01 157764.doc -10- 201210632 (Serum inhibition) Before ingestion (0M), 1 month after ingestion (1M), intake 2 After the month (2M), the skin of the forehead of the tester of each of the test group of the testis product and the placebo ingestion group was measured by a Sebumeter. The results are shown in Table 3 (the values in Table 3 are expressed as relative values of the amount of sebum of the average of the testers at 0 设为 being set to 100). As is clear from Table 3, the amount of sebum ingested as a group of the testosterone of the quadrangular bean pod extract as the oral pore improving agent of the present invention was suppressed with respect to the increase in the amount of sebum in the placebo ingestion group. [Table 3] Group 0M 1 Μ 2M Pod Extract 100 111 101 Placebo 100 121 114 (Unsaturated Fatty Acid in Sebum) After ingesting the test of the ridged bean pod extract and placebo for 3 months, in each test The filter paper containing the hammer is placed on the skin of the forehead of the face for a minute, and then the filter paper is extracted with acetone, and the amount of sebum and unsaturated fatty acid are quantified by gas chromatography. The measurement results are shown in Table 4 (Table The value of 4 is the average value of the tester, and is calculated based on the amount of unsaturated fatty acid/serum amount X 100 (%). As is clear from Table 4, the amount of the unsaturated fatty acid in the sebum was decreased as compared with the placebo ingestion group as the test group of the tetrad pea pod extract as the oral cavity improving agent of the present invention. 157764.doc 201210632 [Table 4] Group 3M pod extract 3.54 Placebo 3.99 (skin color - red improvement;)

Before ingestion (〇M), after 1 month of ingestion (1 M), and after 2 months of ingestion (2 M), the test of the extract of the test mixture of the four-leaf bean seed extract and the ridged bean pod using a colorimeter The skin of the cheeks of the tester of each of the product intake group and the placebo ingestion group was measured. The results are shown in Table 5 (() Μ-1 M, 〇M 2 M system, and the change values before and after ingestion, before ingestion, and after ingestion for 2 months are calculated as the average value of the test subjects. If the value is positive, the state is improved, and the higher the value, the more improved). According to Table 5, it was clarified that the group of the test article of the Winged Bean Seed Extract and the test article of the Winged Bean Peanut Extract as the oral cavity improving agent of the present invention were continuously used as compared with the placebo ingestion group. Make red better. [Table 5] Group 0M-1 Μ 0Μ-2Μ Seed extract 0.01 0.87 Pod extract 0.37 0.83 Placebo-0.03 0.41 As described above, the ingestion of the Winged Bean Seed Extract as the Oral Cavity Improver of the present invention Test article, test product of Winged Bean Pod Extract, and the amount of transdermal water evapotranspiration decreased compared with that before ingestion, and, compared with placebo intake group, 157764.doc •12· 201210632 Than the stalk of the bean pea pod extract test substance The sebum of the group has decreased and the proportion of unsaturated fatty acids has also decreased. Therefore, it is suggested that the parakeratosis caused by the stimulating component in the sebum around the hair shaft is suppressed, and the skin roughening prevention and improvement can be achieved. Furthermore, by ingesting the test article of the Winged Bean Seed Extract and the test article of the Winged Bean Peanut Extract, the red color of the skin is also improved, and the inflammatory state is cured, suggesting that the skin around the hair point is normalized, and the research of the hair cavity can be suppressed. The shape is coarse, so it can be considered that the pores are reduced. In order to prove the above evaluation, a questionnaire survey using the hearing was conducted on the subjects according to the opening of the pores, the dark spots, and the rough viewpoint. Each of the three evaluation items will be very clearly set to 0, and is not significantly set to i 〇〇. The tester uses the VAS method (visual analogue scale method, visual analog scale method) to answer. (Opening of the pores) [Table 6] Group 0M 1 Μ 2Μ Seed extract 32.29 44.93 49.46 Pod extract 22.29 35.57 40.46 (black spot on the pores) [Table 7] Group 0Μ 1 Μ 2 Μ Seed extract 41.29 51.67 53.96 Pod extract 32.77 42.83 46.21 (rough of the hairy hole) 157764.doc •13- 201210632 [Table 8] Group 0M 1 Μ 2Μ Seed extract 50.65 58.97 60.93 Pod extract 46.68 52.07 61.86 According to the above table 6~8 delicious, dark spots, rough change Not obvious. According to the above results, it is clear that the oral pore improving agent of the present invention suppresses the keratinization caused by the stimulating component in the sebum around the pores, and can prevent the skin from being rough and dry, and can be used to make the skin around the pores The skin is normalized and the grind-like structure of the pores is suppressed, and it is effective as a hair-melting agent such as a reduction in the pores. (Prescription Example) The mouthpiece does not contain a prescription such as a supplement of a mouth-acupoint improving agent of the present invention or a food drink in the following table. Further, the blending amount is shown in parts by mass or mass. (tablet) (1,500 mg / day) (mixed ingredients) (mg) 70 74 36 25 sucrose ester crystals of vegan methyl cellulose glycerol: this car is a kind of electricity, improver: four edges Bean pod extract (dry residue 157764.doc 475 201210632 servings) N-acetamidine glucosamine 1 〇〇 hyaluronic acid 50 vitamin E 30 mildew vitamin B6 20 • Vitamin B2 1〇α-lipoic acid 20 Coenzyme Qig 40 Ceramide (konjac Extract) 50 L-Proline 1 〇〇 Collagen 400 (soft capsule) (1,500 mg / day) (mixed ingredients) (mg) Edible Soybean Oil 530 Eucommia Extract 50 Human 蔘 Extract 50 This is improved by mouth Agent: Winged Bean Seed Extract (dry residue 1〇〇* part), Royal Jelly 50 Maca 30 Aminobutyric acid (GABA) 30 Beeswax 60 Gelatin 375 157764.doc -15· 201210632 Glycerin 120 Glycerol fatty acid ester 105 (Pellet) (Materials) (mg) Benzo Hair Improver: Winged Bean Pod Extract (400 parts dry) Vitamin C 100 Soy Isoflavones 250 Reduced Lactose 300 Soy Oligosaccharide 36 Erythritol 36 Dextrin 30 spices 24 citric acid 24 (beverage) (tune) Ingredients) (50 ml medium quality ° / 〇) Eucommia extract 1.6 human extracts 1.6 Oral hair improver: Winged bean pod extract (dry residue) 1.6 Reducing maltose sugar 28 Erythritol 8 Citric acid 2 Spice 157764.doc •16- 3 201210632 N-acetamidine Glucosamine Hyaluronic Acid Vitamin E Vitamin B6 Vitamin B2 Alpha-lipoic acid ceramide (konjac extract) L-proline collagen peptide purified water (cookie) ( Blending Ingredients) Low-gluten flour cream granulated sugar Oral hair point improver: Winged Beans mandarin extract Egg lemon spice 0.5 0.3 0.2 0.1 0.2 0.4 2 10 Residual (% by mass) 45.0 17.5 20.0 Sub-pulverized product 4.0 Appropriate amount 12.5 157764.doc 17

Claims (1)

201210632 VII. Patent application scope: 1. An oral hair shaft improving agent comprising one or more plants or extracts thereof selected from the group consisting of plants belonging to the genus Psophocarpus. 2. The oral hair shaft improving agent according to claim 1, wherein the plant or the extract thereof is a seed or a bean pod of a plant belonging to the genus Ps〇ph〇carpus. Oral hairmelt improving agent, wherein the above-mentioned oral insufficiency inhibits the enlargement of the pores. The oral cavity improving agent of claim 1, 2 or 3 is used to repair the keratinized hair thickening inhibitor. 157764.doc 201210632 IV. Designated representative map: (1) The representative representative of the case is: (none) (2) The symbol of the symbol of the representative figure is simple: 5. If there is a chemical formula in this case, please reveal the best indication of the characteristics of the invention. Chemical formula: (none) 157764.doc