JP7007788B2 - Pore conspicuous prevention / improvement agent - Google Patents

Description

The present invention relates to a pore conspicuous preventive / ameliorating agent.

Skin care is of great interest to men and women of all ages. Conspicuous pores, which are openings to the epidermis of hair follicles, occupy the top ranks as skin problems that should be improved during this skin care. Conspicuous pores are one of the major cosmetic problems on the face, especially on the cheeks and nose.

The pores commonly recognized as "prominent pores" on the cheek are sebaceous hair follicles. The sebaceous hair follicles are characterized by a wide and deep lumen of a funnel-shaped hair follicle that is an opening to the surface of the skin. When the hair funnel portion is widened or the periphery thereof is depressed in a mortar shape, the dents formed on the skin surface are visually recognized as pores, and it is considered that the pores are conspicuous. That is, it becomes "pores with conspicuous opening". From the skin surface morphological analysis around the pores by the replica method, it is known that the pores become conspicuous with aging, and that the cheeks are stretched by sagging and the shape changes to an ellipse.

In order to make the pores inconspicuous, various pores such as naturally occurring polysaccharides such as Hibamata (see, for example, Patent Document 1) and phosphorylated glyceryl ether derivatives having an alkyl group having 8 to 32 carbon atoms (see, for example, Patent Document 2). Conspicuous prevention or improving agents have been proposed. However, it is not always sufficient from the viewpoint of the effect, and it is desired to search for a pore conspicuous prevention or improving agent for fundamentally improving the pore conspicuity.

Another cause that is recognized as conspicuous pores is the occurrence of darkening of the pores. Blackheads in the pores are a mixture of sebum, keratin, etc. called keratin plugs that accumulate in the pores, stain the keratin plugs, oxidize and darken, or darken due to pigmentation derived from melanin in the skin around the pores. It is known that "pores with conspicuous darkening" occur.

Japanese Unexamined Patent Publication No. 2000-169322 Japanese Unexamined Patent Publication No. 2002-187817

An object of the present invention is to provide a novel agent for preventing or improving the appearance of pores.

The technical features of the present invention for solving the above problems are as follows.
1. 1. An agent for preventing and improving the appearance of pores, which contains an extract of the genus Dianthus of the family Dianthus as an active ingredient.
2. 2. The above-mentioned conspicuous pores are caused by the pores in which the opening is conspicuous. A preventive / ameliorating agent for conspicuous pores described in.
3. 3. The conspicuous pores are caused by the pores in which darkening is conspicuous. A preventive / ameliorating agent for conspicuous pores described in.

Hereinafter, the present invention will be described in detail.
The pore conspicuous preventive / ameliorating agent of the present invention is characterized by containing Dianthus (Dianthus) of the family Caryophyllaceae and / or an extract thereof as an active ingredient.

The above-mentioned dianthus family Dianthus is not particularly limited as long as it belongs to this, for example, dianthus dianthus (D. superbus L. var. Longicalycinus), dianthus dianthus (D. superbus L. var. Superbus), dianthus dianthus (D. superbus L. var. Superbus). (D. superbus L. var. Speciosus Reichb.), Himehamanadeshiko (D. kiusianus Makino), Hamanadeshiko (D. japonicus Thunb.), Shinanonadeshiko (D. shinanensis (Yatabe) Makino), Dianthus alpinus, Dianthus amurensis Jacques, Dianthus anatolicus Boiss., Dianthus arenarius L., Dianthus armeria L. (Nohara Nadesico Deptford Pink), Dianthus banaticus (Heuffel) Borbas, Dianthus barbatus L. (American Nadesico) or Sweet William
Dianthus biflorus Sm., Dianthus brevicaulis Fenzl, Dianthus callizonus Schott et Kotschy, Dianthus campestris M. Bieb, Dianthus capitatus Balb. Ex DC., Dianthus carthusianorum L. Dianthus chinensis L., Dianthus collinus W. et K., Dianthus cruentus Griseb., Dianthus deltoides L. --Maiden Pink
Dianthus erinaceus Boiss., Dianthus freynii Vandas, Dianthus fruticosus L.
Dianthus furcatus Balb., Dianthus gallicus Pers. --French Pink or Jersey Pink
Dianthus giganteus d'Urv, Dianthus glacialis Haenke, Dianthus gracilis Sm.
Dianthus graniticus Jord., Dianthus gratianopolitanus Vill. --Cheddar Pink
Dianthus haematocalyx Boiss. Et Heldr., Dianthus hungaricus Pers., Dianthus imereticus (Rupr.) Schischk., Dianthus integer Vis., Dianthus knappii Asch. Et Kanitz ex Borbas, Dianthus lumnitzeri Wiesb.,
Dianthus lusitanus Brot., Dianthus microlepsis Boiss., Dianthus monspessulanus L.
Dianthus myrtinervius Griseb., Dianthus nardiformis Janka, Dianthus nitidus Waldst. Et Kit., Dianthus pavonius Tausch, Dianthus petraeus Waldst. Et Kit., Dianthus superbus, Dianthus pinifolius Sm., Dianthus plumarius L. --Wild Pink, Dianthus p Dianthus pyrenaicus Pourr., Dianthus repens Willd. --Boreal Carnation
Dianthus scardicus Wettst., Dianthus seguieri Vill., Dianthus serotinus Waldst. Et Kit.
Dianthus simulans Stoj. Et Stef., Dianthus spiculifolius Schur., Dianthus squarrosus Bieb., Dianthus subacaulis Vill., Dianthus superbus L. (Large Pink), Dianthus sylvestris Wulfen, Dianthus viscidus Bory et Chaub., Dianthus waldsteinii
Examples include, but are not limited to, Dianthus zonatus Fenzl. It should be noted that these may be used alone or in combination of two or more.

Further, the dianthus genus Dianthus of the family Dianthus can obtain a higher concentration of the active ingredient, which is particularly preferred by D. superbus L. var. Longicalycinus.

In the present invention, the site is not particularly limited, and for example, fruits, seeds, leaves and the like can be used, but it is preferable to use seeds.

The method for obtaining the extract from the above-mentioned Kawaranadeshiko (D. superbus L. var. Longicalycinus) is not particularly limited, and examples thereof include polar solvent extraction and supercritical extraction. In addition, only one of these may be performed, or both of them may be performed. Further, this extraction may be performed only once for each method, or may be performed twice or more.

Here, in the case of extraction by polar solvent extraction, the polar solvent used is not particularly limited, but for example, water, methanol, ethanol, isopropanol, acetone, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin and the like. Alcohol, acetic acid, ethyl acetate, ether and the like can be mentioned. Of these, water and alcohol are preferable. At this time, the alcohol is preferably methanol, ethanol, 1,3-butylenegril or propylene glycol. This is because the active ingredient can be efficiently extracted. It should be noted that these may be used alone or in combination of two or more.

When water is used as the polar solvent, the extraction temperature is preferably 20 to 100 ° C, preferably 40 to 70 ° C. This is because if the extraction temperature is too low, it is difficult to extract the active ingredient. The type of water for extraction is not particularly limited, and tap water, distilled water, mineral water, alkaline ionized water and the like can be used.

When hydrous alcohol is used as the polar solvent, the alcohol concentration is preferably 10 wt% or more, preferably 30 wt% or more. This is so that a high extraction amount of the active ingredient can be obtained. The extraction temperature is preferably 0 to 95 ° C, preferably 20 to 80 ° C. The water-containing alcohol extraction may be repeated at various concentrations in order to improve the content of the active ingredient.

Further, when extracting with a polar solvent, the extraction method is not particularly limited, and for example, any method such as continuous extraction, immersion extraction, countercurrent extraction can be adopted, and any device can be used at room temperature or under reflux heating. Can be used. When the extraction is performed by the above-mentioned method, only one of these methods may be performed, or these methods may be combined. Moreover, these extractions may be performed only once, or may be performed twice or more.

As a specific method, an extraction raw material (seed of Kawaranadeshiko) is put into a treatment tank filled with an extraction solvent, and the active ingredient is eluted while stirring. For example, when water or a hydrous alcohol is used as the extraction solvent, a polar solvent in an amount (weight ratio) of about 5 to 100 times that of the extraction raw material is used, and extraction is performed for about 1 minute to 150 hours. An extract is obtained by eluting the active ingredient in a solvent and then filtering to remove the extraction residue. Then, the extract is subjected to treatments such as dilution, concentration, drying and purification according to a conventional method to obtain an extract containing an active ingredient such as a high concentration polyphenol.
Examples of the purification method include methods such as activated carbon treatment, resin adsorption treatment, ion exchange resin, liquid-liquid countercurrent distribution, and membrane separation.

Further, when the extraction is performed by supercritical extraction, the supercritical fluid used at this time is not particularly limited, and examples thereof include carbon dioxide and nitrogen. It should be noted that these may be used alone or in combination of two or more. Of these, carbon dioxide is particularly preferable.
This is because the active ingredient can be extracted more easily. Further, the extraction method at this time may be a known method. Then, the extract is subjected to treatments such as dilution, concentration, drying and purification according to a conventional method to obtain an extract containing an active ingredient such as a high concentration polyphenol.

The present invention provides a food containing the agent for preventing / improving the conspicuous pores. The food may contain the extract as an active ingredient in an amount of 100-1,000 mg, preferably 250-500 mg per dose, eg, for an adult. In the pore conspicuous prevention / improving agent of the present invention, the content of the active ingredient may change depending on age and the like.

The pore conspicuous prevention / improving agent of the present invention can be used as a material for various foods and drinks. Food and beverages include, for example, edible oil (salad oil), confectionery (gum, candy, caramel, chocolate, cookies, snacks, jelly, gummy, tablet confectionery, etc.), noodles (soba, udon, ramen, etc.), dairy products (soba, udon, ramen, etc.) Milk, ice cream, yogurt, etc.), boiled foods (konbu boiled, paste boiled, small fish boiled, etc.), seasonings (miso, soy sauce, etc.), soups, beverages (juice, coffee, tea, tea, carbonated beverages, sports Examples include general foods such as beverages), health foods (tablets, capsules, etc.), and nutritional supplements (nutrition drinks, etc.). It is advisable to appropriately add the pore conspicuous prevention / improving agent of the present invention to these foods and drinks.

Various ingredients can be added to these foods and drinks depending on the type, for example, glucose, fructose, sucrose, maltose, sorbitol, stebioside, corn syrup, lactose, citric acid, tartrate acid, malic acid, and succinic acid. Acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbicate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, Arabic gum, Food materials such as carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amides, calcium pantothenate, amino acids, calcium salts, pigments, fragrances and preservatives can be used. Furthermore, as a preventive / ameliorating agent for the main pores having a health maintenance function, distribution of other antioxidants and health food materials (for example, antioxidants, reduced ascorbic acid (vitamin C), vitamin E, etc. Reduced glutatin, tocotrienol, vitamin A derivative, lycopene, β-cryptoxanthin, astaxanthin, zeaxanthin, fucoxanthin, uric acid, ubiquinone, coenzyme Q10, folic acid, garlic extract, alicin, sezamine, lignans, catechin, isoflavone, calcon, tannin , Flavonoids, coumarin, isocoumarin, blueberry extract, arbutin, tannin, anthocyanin, apple polyphenol, grape seed extract, eladic acid, koji acid, surge extract health food material, V. (vitamin) A, V.B1, V.B2, V.B6, V.B12, VC, VD, VE, VP, choline, niacin, pantothenic acid, calcium folic acid, EPA, oligosaccharides, dietary fiber, squalene, soybean lecithin, taurine, donariera, protein, octacosanol , DHA, egg yolk lecithin, linoleic acid, lactoferrin, magnesium, zinc, chromium, selenium, potassium, hem iron, oyster extract, chitosan, chitin oligosaccharide, collagen, chondroitin, corn, kanzo, kukoshi, keihi, sanzashi, ginger, Reishi, Shijimi extract, Suppon, Obako, Chamomile, Chamomile, Seiyodanpopo, Hibiscus, Honey, Bohlen, Royal jelly, Lime, Lavender, Rosehip, Rosemary, Sage, Bifizus, Faecalis, Lacris, Wheat germ oil, Sesame oil, Perilla oil, soybean oil, medium chain fatty acid, agarix, ginkgo biloba extract, turmeric, chondroitin, brown rice germ extract, reishi, onion, DHA, EPA, DPA, vitamin tea, winter worm summer grass, garlic, bee cub, papaya, puer, propolis, Megusuri tree, Yabushitake, Royal jelly, Nokogiri palm, Hyaluronic acid, Collagen, GABA, Harpseal oil, Shark cartilage, Glucosamine, Recitin, Phosphatidylserine, Tanana carrot, Mulberry leaf, Soybean extract, Echinacea, Ezokogi, Barley extract , Olive leaf, olive fruit, gymnema, banaba, salasia, garsina, chitosan, St. Jones wort, nuts, carrots, passion flower, broccoli, placenta, honeybee, grape seeds, peanut seed coat, bilve Lee, black kohosh, maria thistle, laurel, sage, rosemary, rafma, black vinegar, bitter gourd, maca, red flower, flax, oolong tea, flower spine, caffeine, capsaicin, xylooligosaccharide, glucosamine, buckwheat, citrus, dietary fiber, protein , Prune, spirulina, barley young leaves, nucleic acid, yeast, shiitake mushroom, plum meat, amino acid, deep sea shark extract, noni, oyster meat, suppon, champignon, obaco, acerola, pineapple, banana, peach, apricot, melon, strawberry, raspberry , Orange, fucoidan, mesimacob, cranberry, chondroitin sulfate, zinc, iron, ceramide, silk peptide, glycine, niacin, chest tree, ceramide, L-cysteine, L-carnitine, red wine leaf, millet, horsetail, biotin, centera Asian Tika, Hascup, Pycnogenol, Fuki, Rubarb, Clove, Rosemary, Catechin, Poor, Citric Acid, Beer Yeast, Merilot, Black Zinger, Ginger, Gajutsu, Natto Kinase, Benikouji, Tocotrienol, Lactoferrin, Cinnamon, Crab Soba, Cocoa, Yuzu seed extract, perilla seed extract, lychee seed extract, evening primrose extract, black rice extract, α-lipoic acid, gaba, raw coffee bean extract, fuki extract, kiwi seed extract, Wenzhou orange extract, red ginger extract, astaxanthin, walnut extract, Canca extract, white jellyfish polysaccharide, lingon berry extract, fucoxanthin, resveratrol, strawberry seed extract, cherry blossom extract, swallow nest extract, black ginger extract, maki berry extract, junsai extract, purple tea extract, chrysanthemum flower extract) Etc. can also be blended.

As a specific manufacturing method, the agent for preventing / improving the conspicuous pores of the present invention can be easily spray-dried or freeze-dried with powdered dextrin in the case of an extract, and this can be easily made into powder, granules, tableting or solution. It can be contained in foods (instant foods, etc.). It is also possible to mix it with a binder such as gum arabic to make it into powder or granules, and add it to solid foods, if necessary. Further, in the case of an extract, it can be added as it is or, for example, dispersed and dissolved in water, ethanol, glycerin or a mixture thereof and added to a beverage.

The pore conspicuous preventive / improving agent of the present invention may be used as a material for drugs (including pharmaceuticals and quasi-drugs). It can be produced by appropriately blending the raw material for a pharmaceutical preparation with the pore conspicuous preventing / improving agent of the present invention. The above chemicals may be used for humans or mammals other than humans. Excipients (dextrose, lactose, sucrose, sodium chloride, starch, calcium carbonate, kaolin, crystalline cellulose, cacao butter, hardened vegetable oil, kaolin, etc. , Tarku, etc.), binder (distilled water, physiological saline, ethanol water, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethyl cellulose, potassium phosphate, polyvinylpyrrolidone, etc.), disintegrant (sodium alginate, canten, etc.) Sodium hydrogen carbonate, calcium carbonate, sodium lauryl sulfate, stearic acid monoglyceride, starch, lactose, gum arabic powder, gelatin, ethanol, etc.), disintegration inhibitor (white sugar, stear, cacao butter, hydrogenated oil, etc.), absorption enhancer ( Examples include quaternary ammonium bases (sodium lauryl sulfate, etc.), excipients (glycerin, starch, lactose, kaolin, bentonite, silica acid, etc.), lubricants (purified talc, stearate, polyethylene glycol, etc.).

The method for administering the pore conspicuous preventing / improving agent according to the present invention can generally be orally administered in the form of tablets, pills, soft / hard capsules, fine granules, powders, granules and the like. In addition, the water-soluble preparation can be orally administered as a liquid preparation. Further, it may be administered parenterally. When administered as a parenteral agent, the pore conspicuous preventive / improving agent of the present invention is dispersed in an appropriate solubilizer such as ethanol or water, and then a poultice, lotion, ointment, tincture, cream, etc. It can be applied in dosage form. In addition, the water-soluble preparation of the main pore conspicuous preventive / improving agent can be used as it is, or with a dispersant, a suspending agent, a stabilizer, etc. added, such as a poultice, a lotion, an ointment, a tincture, and a cream. It can be applied in dosage form.

The dose may vary depending on the administration method, medical condition, age of the patient, etc., but for adults, usually 5 to 200 mg of the active ingredient per day can be administered, and for children, usually about 0.5 to 100 mg can be administered.

The compounding ratio when the pore conspicuous preventing / improving agent of the present invention is used as a drug can be appropriately changed depending on the dosage form, but is usually about 0.0001 to about 0.0001 when administered orally or by mucosal absorption. It should be about 30 wt%, and in the case of parenteral administration, it should be about 0.0001 to 30 wt%.
Since the dose varies depending on various conditions, a dose smaller than the above dose may be sufficient, or it may be necessary to administer beyond the range. In addition to the pore conspicuous preventive / ameliorating agent, the pharmaceutical composition may contain other known compounds commonly used in the pharmaceutical field and compounds necessary for molding into a form suitable for oral administration. Examples of such compounds include lactose, starch, hydroxypropyl cellulose, kaolin, talc, calcium carbonate and the like.

The pore conspicuous preventive / ameliorating agent of the present invention can be expected to have a pore conspicuous preventive / ameliorating effect even when used as a skin external preparation (including cosmetics, pharmaceuticals and quasi-drugs).
Examples of the form of the external skin preparation that can contain the pore conspicuous preventive / improving agent of the present invention include milky lotion, soap, wash pigment, bathing agent, cream, milky lotion, lotion, odecolon, shaving cream, and shaving. Lotion, cosmetic oil, sunscreen / sunscreen lotion, white powder, foundation, perfume, pack, nail cream, enamel, enamel remover, eyebrow, blush, eye cream, eye shadow, mascara, eyeliner, lip balm, lip balm, shampoo , Rinsing, hair dye, dispersion, cleaning agent and the like. In addition, examples of the pharmaceutical products or quasi-drugs to which the agent for preventing / improving the conspicuous pores of the present invention can be added include ointments, creams, and external liquids.

In addition to the pore conspicuous prevention / improving agent according to the present invention, the above-mentioned form of the skin external preparation is a component to be added to skin external preparations such as cosmetics and quasi-drugs as long as the pore conspicuous prevention / improving action is not impaired. , Oils, higher alcohols, fatty acids, UV absorbers, powders, pigments, surfactants, polyhydric alcohols / sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, etc. can.
Examples are listed below, but the invention is not limited to these examples.

(1) Examples of oil content Ester-based oil phase components: glyceryl tri2-ethylhexanate, cetyl 2-ethylhexanate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearic acid Isocetyl, butyl stearate, butyl myristate, ethyl linate, isopropyl linoleate, ethyl oleate, isosetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isosetyl isostearate, diethyl sevacinate, adipine Diisopropyl acid, isoaraquil neopentanoate, glyceryl tri (capril capric acid), trimethylolpropane tri2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra2-ethylhexanoate, cetyl caprylate, decyl laurate, Hexyl laurate, decyl myristate, myristyl myristyl, cetyl myristate, stearyl stearate, decyl oleate, cetyl lysinoreate, isostearyl laurate, isotorideyl myristate, isosetyl myristate, isosteyl myristate, isosetyl palmitate, Isostearyl palmitate, octyl stearate, isosetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexarate, hexyl isostearate, Ethylene glycol dioctarate, ethylene glycol diolaneate, propylene glycol dicaprate, propylene glycol di (capril capric acid), propylene glycol dicaprylate, neopentyl glycol dicaprate, neopentyl glycol dioctarate, glyceryl tricaprylate, glyceryl triundecyl, Glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentaate, isostearyl octanoate, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isosetyl isostearate, isostearyl isostearate, octyldecyl isostearate, poly Glycerin oleic acid ester, polyglycerin isostearic acid ester, charcoal Dipropyl acid, dialkyl carbonate (C12-18), triisocetyl citrate, triisoaraquil citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyl decyl lactate, triethyl citrate, acetyltriethyl citrate, citrate Acetyltributyl acid, trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sevacinate, cholesteryl stearate, cholesteryl isostearite, hydroxysteer Examples thereof include cholesteryl acid, cholesteryl oleate, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, isocetyl 12-stearoyl hydroxystearate, stearyl 12-stearoyl hydroxystearate, and isostearyl 12-stearoyl hydroxystearate.
Hydrocarbon-based oil phase components: squalane, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, petrolatum and the like can be mentioned.
Animal and vegetable oils and their hardened oils, and naturally occurring waxes: beef oils, hardened beef fats, pork fats, hardened pork fats, horse oils, hardened horse oils, mink oils, orange raffy oils, fish oils, hardened fish oils, egg yolk oils and other animal oils. Its hardened oil, avocado oil, almond oil, olive oil, cacao butter, kiwi seed oil, apricot oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil , Perilla oil, brown seed oil, camellia oil, corn oil, rapeseed oil, hardened rapeseed oil, palm kernel oil, hardened palm kernel oil, palm oil, hardened palm oil, peanut oil, hardened peanut oil, castor oil, hardened castor oil , Sunflower oil, grape seed oil, jojoba oil, hardened jojoba oil, macadamia nut oil, medhome oil, cottonseed oil, hardened cottonseed oil, palm oil, hardened palm oil and other vegetable oils and their hardened oils, beeswax, high acidity beeswax, lanolin, reduction. Examples thereof include waxes such as lanorin, hardened lanorin, liquid lanorin, carnauba wax and montan wax.
Silicone-based oil phase components: dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, polyether-modified organopolysiloxane, dimethyl Siloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstealoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic Examples thereof include silicone, trimethylsiloxysilicic acid, and silicone RTV rubber.
Fluorine-based oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluoride pitch, fluorocarbon, fluoroalcohol, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, and the like can be mentioned.

(2) Examples of higher alcohols Examples of higher alcohols include lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, and octyldodecanol.

(3) Examples of fatty acids Caprylic acid, capric acid, undecylic acid, lauric acid, myristic acid, palmitoleic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, araquinic acid, arachidonic acid, behenic acid , Elcaic acid, 2-ethylhexanoic acid and the like.

(4) Examples of UV absorbers Paraaminobenzoic acid, amyl paraaminobenzoate, ethyldihydroxypropyl paraaminobenzoate, glyceryl paraaminobenzoate, ethyl paraaminobenzoate, octyl paraaminobenzoate, octyldimethyl paraaminobenzoate, ethylene glycol salicylate, salicylate Octyl, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomentyl salicylate, benzyl silicate, octyl paramethoxycinerate, 2-ethylhexyl paramethoxycinerate, mono 2-ethylhexyl benzoate Glyceryl ethylhexanate, isopropyl paramethoxycinerate, diethanolamine paramethoxyhydrosilicate diethanolamine salt, diisopropyl diisopropyl silicate ester mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, Dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, butylmethoxydibenzoylmethane, 2,4,6-trianilinino-p- (carbo-2-ethylhexyl-) 1-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole, methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3, 3-diphenylacrylate, Phenylbenzoimidazole sulfate, 3- (4-methylbenziliden) camphor, isopropyldibenzoylmethane, 4- (3,4-dimethoxyphenylmethylene) -2, 5-dioxo-1-imidazolidinepropionate 2-ethylhexyl, etc., and Examples thereof include these polymer derivatives and silane derivatives.

(5) Examples of powders and pigments Red No. 104, Red No. 201, Yellow No. 4, Blue No. 1, Black No. 401, etc., Yellow No. 4 AL Lake, Yellow No. 203 BA Lake, etc., Nylon powder , Silk powder, Urethane powder, Teflon (registered trademark) powder, Silicone powder, Polymethylmethacrylate powder, Cellulose powder, Steel, Silicone elastomer spherical powder, Polymers such as polyethylene powder, Yellow iron oxide, Red iron oxide, Black Colored pigments such as iron oxide, chromium oxide, carbon black, ultramarine and dark blue, white pigments such as zinc oxide, titanium oxide and cerium oxide, constitutional pigments such as talc, mica, sericite, kaolin and barium plate sulfate, mica titanium Pearl pigments such as barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, metal salts such as magnesium silicate, inorganic powders such as silica and alumina, aluminum stearate, magnesium stearate, zinc palmitate, zinc myristine, myristin. Examples thereof include metal powders such as magnesium acid, zinc laurate, zinc undesylene and the like, bentonite, smectite, boron nitride and the like. There are no particular restrictions on the shape (spherical, rod-shaped, needle-shaped, plate-shaped, indefinite-shaped, flaky, spindle-shaped, etc.) and particle size of these powders. These powders are treated with conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, and the like. It may or may not be surface-treated in advance by polyacrylic acid treatment, metal silane treatment, amino acid treatment, lecithin treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, or the like.

(6) Examples of surfactants Anionic surfactants: fatty acid salts, α-acyl sulfonates, alkyl sulfonates, alkylallyl sulfonates, alkylnaphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates , Alkylamide Sulfate, Alkyl Phosphate, POE Alkylphosphate, Alkylamide Phosphate, Alkyylalkyl Taurine Salt, N-Acyl Amino Acid Salt, POE Alkyl Aether carboxylate, Alkyl Sulfonuccinate, Alkyl Sulfo Acetate Examples thereof include sodium, an acylated hydrolyzed collagen peptide salt, and a perfluoroalkyl phosphate ester.
Cationic surfactants: alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, disstearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, benzalconium chloride , Behenic chloride amidopropyldimethylhydroxypropylammonium, diethylaminoethylamide stearate, dimethylaminopropylamide stearate, quaternary ammonium salt of lanolin derivative and the like.
Amphoteric surfactants: carboxybetaine type, amide betaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidoamine type and the like.
Nonionic surfactants: propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbit fatty acid ester, POE glycerin fatty acid ester, POE akill ether, POE fatty acid ester, POE cured sunflower Examples thereof include oil, POE castor oil, POE / POP copolymer, POE / POP alkyl ether, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid and the like.
Natural surfactants: lecithin, saponin, sugar-based surfactants and the like can be mentioned.

(7) Examples of polyhydric alcohols and sugars Ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, 3 -Butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, martitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, purulan and the like. Further, these chemically modified products and the like can also be used.

(8) Examples of polymers Acrylic acid ester / methacrylic acid ester copolymer (plus size, manufactured by Reciprocal Chemical Co., Ltd.), vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC), vinyl acetate / croton Acid / vinyl neodecaneate copolymer (28-2930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP), T-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (rubimer) , BASF), Vinylpyrrolidone / Vinylacetate / Vinylpropionate copolymer (Rubiscol VAP, BASF), Vinylacetate / Crotonic acid copolymer (Rubiset CA, BASF), Vinylacetate / Croton Acid / vinylpyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinylpyrrolidone / acrylate copolymer (Rubiflex, manufactured by BASF), acrylate / acrylamide copolymer (Ultrahold, manufactured by BASF), vinyl acetate / Butylmaleate / isobornylacryllate copolymer (Advantage, manufactured by ISP), carboxyvinyl polymer (Carbopol, manufactured by BFGoodrich), acrylic acid / alkyl methacrylate copolymer (Pemulene, manufactured by BF Goodrich), etc. Anionic polymer compound, dialkylaminoethyl methacrylate polymer acetic acid amphoteric (Yukaformer, manufactured by Mitsubishi Chemical Corporation), octylacrylamide acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, NSC) ) And other amphoteric polymer compounds, vinylpyrrolidone / dimethylaminoethylmethacrylate quaternary products (GAFQUAT, manufactured by ISP), methylvinylimidazolium chloride / vinylpyrrolidone copolymer (rubicote, manufactured by BASF), etc. Polymer compound, polyvinylpyrrolidone (Rubiscol K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (rubiscol VA, manufactured by BASF), vinylpyrrolidone / dimethylaminoethyl methacrylate polymer (copolymer 937, manufactured by ISP) ), Nonionic polymer compounds such as vinyl caprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer VC713, manufactured by ISP). In addition, cellulose or its derivatives, keratin and collagen or its derivatives, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, arabic rubber, crystalline cellulose, arabino. Naturally-derived high molecular compounds such as galactan, carrageenan, tragacanth gum, alginic acid, albumin, casein, curdlan, gellan gum, and dextran can also be preferably used.

(9) Examples of bioactive ingredients Examples of the bioactive ingredients include substances that give some bioactivity to the skin when applied to the skin. For example, whitening ingredients, immunostimulators, anti-aging agents, UV protection agents, slimming agents, tightening agents, antioxidants, hair growth agents, hair growth agents, moisturizers, blood circulation promoters, antibacterial agents, bactericidal agents, desiccants, Examples thereof include cooling sensitizers, warming sensitizers, vitamins, amino acids, wound healing promoters, stimulant relievers, painkillers, cell activators, enzyme components and the like. Examples of these suitable compounding ingredients include, for example, Ashitaba extract, Avocado extract, Amacha extract, Artea extract, Arnica extract, Aloe extract, Anzu extract, Anzu kernel extract, Ginkgo extract, Wikyo extract, Ukon extract, Oolong tea extract, Agetsu. Extract, Echinashi leaf extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otogirisou extract, Odorikosou extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk , Camomila extract, carrot extract, kawarayomogi extract, licorice extract, karukade extract, kakyoku extract, kina extract, cucumber extract, guanosine, kuchinashi extract, kumazasa extract, clara extract, walnut extract, grapefruit extract, clematis extract, chlorella extract, quail extract, Gentiana extract, tea extract, yeast extract, gobo extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, moss peach extract, saishin extract, psycho extract, saitai extract, salvia extract, sabonsou extract, sasa extract, sanzashi extract , Sansho extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Shakuyaku extract, Shobu root extract, Shirakaba extract, Sugina extract, Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogirisou extract Hakka extract, sage extract, zegna oyster extract, senkyu extract, senburi extract, soybean extract, taiso extract, thyme extract, tea extract, chowji extract, chigaya extract, chimpi extract, touki extract, tokinsenka extract, tounin extract, towhi extract, dokudami extract, tomato Extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Parsley extract, Honey, Hamamelis extract, Parietaria extract, Hikiokoshi extract, Visabolol, Biwa extract, Fukitanpopo extract, Fukinoto extract, Bukuryo extract, Butcher Bloom extract, grape extract, propolis, hechima extract, benibana extract, peppermint extract, bodaiju extract, button extract, hop extract, pine extract, malonie extract, mizubasho Cucumber extract, Mukuroji extract, Melissa extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yokuinin extract, Yomogi extract, Lavender extract, Apple extract, Lettuce extract, Lemon extract, Rengesou extract, Rose extract, Rosemary extract, Roman chamomile extract , Royal jelly extract and the like.
In addition, biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membrane, amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidone carboxylate. , Moisturizing ingredients such as betaine, whey, trimethylglycine, oily ingredients such as sphingolipids, ceramides, phytosphingosin, cholesterol, cholesterol derivatives, phospholipids, ε-aminocaproic acid, glycyrrhizinic acid, β-glycyrrhetinic acid, lysoteam chloride, guaiazulene, Immunostimulators such as hydrocortisone, vitamins such as vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinic acid amide, vitamin C ester, allantin, diisopropylamine dichloro Active ingredients such as acetate, 4-aminomethylcyclohexanecarboxylic acid, antioxidants such as tocopherol, carotenoid, flavonoid, tannin, lignan, saponin, cell activators such as α-hydroxy acid and β-hydroxy acid, γ-orizanol, Blood circulation promoters such as vitamin E derivatives, wound healing agents such as retinol and retinol derivatives, whitening agents such as arbutine, kodiic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid and glutathione, cepharanthin, canzo extract, Togarashi tincture, hinokithiol, garlic iodide extract, pyridoxin hydrochloride, DL-α-tocopherol, DL-α-tocopherol acetate, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-pantothenyl alcohol, acetylpantothenyl ethyl ether, biotin , Allantin, isopropylmethylphenol, estradiol, ethynyl estradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, takanal, camphor, salicylic acid, nonyl acid vanillylamide, nonanoic acid vanillylamide, pyrocton olamine, glyceryl pentadecanoate, L-menthol, Mononitroguayacole, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiletin hydrochloride, auxin, female hormone, cantalist tincture, cyclosporin, zincpyrythion, hydrocortisone, minoxidyl, polyoxyethylene sorbitan monostearate, peppermint oil, sasani Hair growth agents such as shiki extract can be mentioned.

(10) Examples of Antioxidants Sodium Sulfite, Sodium Sulfite, Elysorbic Acid, Sodium Elysorbate, Dilauryl Thiodipropionate, Tocopherol, Trirubiguanide, Nordihydroguayaletic Acid, Parahydroxyanisole, Butylatedhydroxyanisole, Dibutylhydroxy Examples thereof include plant extracts having an antioxidant effect such as toluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotenoid, flavonoid, tannin, lignan, saponin, apple extract and chowdi extract.

(11) Examples of solvents Purified water, ethanol, lower alcohols, ethers, LPG, fluorocarbons, N-methylpyrrolidone, fluoroalcohols, volatile linear silicones, next-generation freons and the like can be mentioned.

〔Example〕
Example 1: Preparation of extract of Kawaranadeshiko Kawaranadeshiko seeds were soaked and extracted with 4 times the amount of water for 2 days or more. Then, after rough filtration using the extract, the filtrate was suction-filtered using diatomaceous earth and filter paper to obtain a filtrate. This filtrate was concentrated under reduced pressure, and a solid content was obtained by drying. This solid content was dissolved in a 30% aqueous solution of 1,3-propanediol and then aseptically filtered to obtain a Kawaranadeshiko extract.

Test Example 1: Evaluation of the effect of improving conspicuous pores in the extract of Kawaranadeshiko
The subjects were 14 males and females (9 males and 5 females) aged 23 to 61 years. The subject applied a lotion containing 5% of the above dianthus extract twice daily in the morning and evening to the entire face, and the number of conspicuous pores before application and 8 weeks after the start of application was measured by RoboSkin Analyzer CS50 (Inforward Co., Ltd.). ). The measurement conditions were acclimation for 15 minutes in a room adjusted to room temperature 21 ± 3 ° C and humidity 43 ± 3%, and application was performed for 8 weeks. Here, "conspicuous pores" were defined and detected as follows. That is, in the image created using the BLUE signal of the RoboSkin Analyzer CS50, among the objects whose edges can be detected as "slightly dark parts" and "dark parts" compared to the peripheral parts, they are rounded. A continuous area with a size of 0.1 to 0.6 mm ² was defined as "conspicuous pores" and detected. The results are shown in Table 1.

Results and Effects of Examples in Test Example 1 According to Table 1 above, it can be seen that improvement was observed in 13 of 14 subjects (93%) in the conspicuous pores. From this, it was confirmed that the Kawaranadeshiko extract is very useful as a preventive / ameliorating agent for conspicuous pores.

Test Example 2: Evaluation of the effect of improving pores with conspicuous openings in the extract of Kawaranadeshiko Under the same conditions as above, the effect of improving pores with conspicuous openings was evaluated. The results are shown in Table 2. Here, "pores with conspicuous openings" were defined and detected as follows. That is, in a monochrome image created using the BLUE signal of the RoboSkin Analyzer CS50, among the objects whose edges can be detected as "slightly dark parts" and "dark parts" compared to the peripheral parts, they are rounded. A continuous area with a size of 0.3 to 0.6 mm ² was defined as "pores with conspicuous openings" and detected.

Results and Effects of Examples in Test Example 2 As shown in Table 2, the improving effect was confirmed in 10 out of 14 subjects (71%) in all subjects. Furthermore, a decrease rate of about 24% was observed in middle-aged and older (33 years and older). Based on the above, Kawaranadeshiko extract is useful as a preventive / ameliorating agent for pores with conspicuous openings, and has a particularly excellent effect on the middle age layer in pores with conspicuous openings. It was confirmed that it is particularly useful as an improving agent.

Test Example 3: Evaluation of the effect of improving pores with conspicuous darkening in the extract of Kawaranadeshiko Under the same conditions as above, the effect of improving pores with conspicuous darkening was evaluated. The results are shown in Table 3. Here, "pores with conspicuous darkening" were defined and detected as follows. That is, among the objects that can detect the edge as a "dark part" compared to the peripheral part in the monochrome image created using the BLUE signal of the RoboSkin Analyzer CS50, the object is rounded and has a size of 0.1 to. A continuous area of 0.6 mm ² was defined as "pores with conspicuous darkening" and detected.

Results and effects of Examples in Test Example 3 According to Table 3 above, an improving effect was confirmed in 12 of 14 subjects (86%). From this, it was confirmed that the Kawaranadeshiko extract is useful as a preventive / ameliorating agent for pores in which darkening is conspicuous.

Effect of Examples As described above, according to Test Examples 1 to 3, the Kawaranadeshiko extract is useful as a pore conspicuous improving agent because it can improve the conspicuousness of pores in both pores with conspicuous opening and pores with conspicuous darkening. be.

[Combination example]
The following are examples of formulation of the pore conspicuous prevention / improving agent of the present invention, but the following formulation examples are not limited to the present invention.

Formulation example 10: Cosmetic cream squalane 20.0 wt%
Beeswax 5.0
Refined jojoba oil 5.0
Glycerin 5.0
Glycerin monostearate 2.0
Polyoxyethylene (20) Sorbitan-
Monostearate 2.0
Pore conspicuous prevention / improvement agent 2.0
Preservatives Appropriate amount Fragrance Appropriate amount
Purified water residue
100.0 wt%

Formulation example 11: Toner ethanol 5.0 wt%
Glycerin 2.0
1,3-butylene glycol 2.0
Polyethylene oleyl ether 0.5
Sodium citrate 0.1
Citric acid 0.1
Pore conspicuous prevention / improvement agent 5.0
Purified water residue
100.0 wt%

Formulation example 12: Body gel macadamia nut oil 2.0 wt%
Octyldodecyl myristate 10.0
Methyl Phenyl Polysiloxane 5.0
Behenyl alcohol 3.0
Stearic acid 3.0
Bacil alcohol 1.0
Glyceryl monostearate 1.0
Polyoxyethylene sorbitol 2.0 with tetraoleate
Hydrogenated soybean phospholipid 1.0
Ceramide 0.1
Retinyl palmitate 0.1
Preservatives Appropriate amount of Centella asiatica extract 1.0
Pore conspicuous prevention / improvement agent 1.0
1,3-butylene glycol 5.0
Purified water residue
100.0 wt%

Formulation example 13: Emulsion squalane 4.0 wt%
Vaseline 2.5
Cetanol 2.0
Glycerin 2.0
Oil-based glycerin monostearate 1.0
Stearic acid 1.0
L-Arginine 1.0
Pore conspicuous prevention / improvement agent 0.5
Potassium hydroxide 0.1
Fragrance trace amount
Purified water residue
100.0wt%

As described above, the present invention provides a safe pore conspicuous preventive / improving agent containing a novel ingredient as an active ingredient.

Claims (1)

Kawaranadeshiko ( D. superbus L. var. Longicalycinus ) A pore-conspicuous preventive / improver containing a water extract of seeds as an active ingredient.
The above-mentioned conspicuous pores are caused by pores with conspicuous openings. An external skin preparation for preventing / improving conspicuous pores.