JP3436544B2 - Skin treatment - Google Patents

Description

Detailed Description of the Invention

[0001]

INDUSTRIAL APPLICABILITY The present invention uses a water extract or an organic solvent extract of rice to have a skin tissue regeneration function-promoting effect, and also has an antibacterial action, and further has a moisturizing and cleaning effect. The present invention also relates to a skin treatment agent having both.

[0002]

2. Description of the Related Art Currently, more and more people are suffering from various skin diseases in their daily lives. One is caused by a primary external physical cause, one is caused by a secondary virus, bacterium, fungus, etc., and the other is eczema, etc., which is an instinct.

Therefore, for these diseases, disinfection, tissue protection is currently performed as the first treatment, and analgesics, anti-inflammatory agents, bactericides, antihistamines, vitamins and the like are administered as the second treatment. ing. In severe cases, antibiotics, corticosteroids, etc. are administered.

[0004] However, these drugs have problems of side effects due to administration and restrictions on the amount and period of use. Also,
Most of these are due to the mixture of single substances, so not only from the side effect of a single substance, but also the safety problem caused by combining them,
Furthermore, it is also a problem in terms of safety caused by long-term continuous use. That is, a safe therapeutic agent that is effective against various skin diseases, has no side effects, and is safe has not yet been developed.

On the other hand, rice has been used as a staple food, as well as sake, shochu, amazake, mirin, vinegar, koji, etc., and has been indispensable for life since ancient times. In addition to this, bran bags are known for cosmetic purposes. It is believed that these were due to the fact that rice was viewed as merely a staple food, or at best as a source of starch. In addition, even if the rice bran bag is said to be good for the skin, it has been customarily used as it is, and there was no concept of an active ingredient and no idea of extraction.

[0006]

At present, there is a problem of side effects of drugs on the human body, and there is a demand for a skin treatment agent that has no side effects and is sufficiently safe even when used as a prophylactic or therapeutic agent. There is. The present invention is safe and inexpensive, has a skin tissue regeneration function promoting effect and an antibacterial effect necessary for the treatment of skin diseases, and further has a moisturizing and cleaning effect,
Moreover, it is an object of the present invention to provide a therapeutic agent for various skin diseases derived from rice, which is completely safe even if it is regularly used as a preventive or therapeutic agent.

[0007]

[Means for Solving the Problems] From the viewpoint of animal and plant harmony, the present inventors have conducted research on various plant components centering on rice, which is a staple food. In the process, it has become clear that rice has many unpredictable possibilities and effects. Therefore, we have been studying rice as a staple food, which has been proven to have the highest safety for thousands of years, as the theme, and have conducted comprehensive studies on the comprehensive utilization of rice. As a result, when the rice extract was applied to various skin diseases, it was found that it has an excellent dermal tissue regeneration promoting effect, has an antibacterial effect, and has a moisturizing and cleaning effect. The present invention has been completed.

That is, the present invention (1) is a skin treatment characterized by containing a water extract or an organic solvent extract of white rice or an alcoholic fermentation product thereof as an active ingredient,
It relates to an improving or preventive agent. The present invention (2) also relates to the skin treatment, improving or preventing agent (1) having a moisturizing effect. Further, the present invention (3) includes cuts, scratches and other scratches and scratches, burns, burns, diaper rash, heat rash, hand rash, frostbite, hemorrhoids, hemorrhoids, athlete's foot, ringworm, pork,
Snail, skippy, acne, atopic dermatitis, eczema, rash, butterbur, xerosis, wisteria, cracks, cracks, stomatitis, helminths, dandruff prevention, the above skin treatment used for healing insect bites, It relates to an improving or preventing agent (1) or (2). Further, the present invention (4) relates to a skin tissue regeneration function-promoting agent comprising a white rice water extract or organic solvent extract or an alcoholic fermentation product thereof as an active ingredient. Furthermore, the present invention (5) relates to an antibacterial agent characterized by containing a water extract or an organic solvent extract of white rice or an alcoholic fermentation product thereof as an active ingredient. Further, the present invention (6) relates to a detergent comprising a water extract or an organic solvent extract of white rice or an alcoholic fermentation product thereof as an active ingredient. ADVANTAGE OF THE INVENTION According to this invention, the skin treatment or improving agent which shows very excellent prevention of various skin diseases, and also the therapeutic effect is obtained simply, cheaply, and completely safe.

The term "skin treatment agent" as used herein means an effect of promoting skin tissue regeneration function, an antibacterial effect, a moisturizing effect, and a cleaning effect (effect of removing old keratin and dirt of pores).
Alternatively, it refers to all that prevent and cure skin diseases by combining these effects.

[0010] Cuts, scratches and other scratches and scratches, burns, burns, diaper rash, bruise, hand rubbing, shiitake burn,
Hemorrhoids, anal fistula, etc. are healed and improved by the effect of promoting skin tissue regeneration function that promotes the activation of cells, and athlete's foot, ringworm, pox
Skin diseases caused by fungi such as snails, jumps, and herpes, bacteria, viruses, etc. are cured by antibacterial action. In addition, acne, atopic dermatitis, eczema, rashes, wipes,
Moisturizing such as xerosis, sprouts, cracks, cracks, stomatitis, vesicles, dandruff prevention, insect bites, etc. can be achieved by a moisturizing effect, or by having a moisturizing effect, a cleaning effect and a skin tissue regeneration function promoting effect, and an antibacterial effect. Heal.

In the present invention, when the extraction operation is carried out, crushing or pulverizing the rice increases the surface area, so that the extraction efficiency is improved. This method may be a general method using a crusher or a rice mill. Although it is not necessary to grind, in this case, it takes a long time to decompose and extract the rice tissue.

In the water extraction, rice is hydrated as it is, preferably ground or pulverized. The rice may be brown rice or white rice. About the amount of water, 2 to rice
It is efficiently extracted in a 5-fold amount, but may be appropriately selected depending on the yield, workability, purpose of final use and the like. Then, the mixture is heated and the extraction is completed at the time of boiling. After completing the extraction, if you squeeze and filter according to the purpose of use,
A clear extract is obtained. Note that hot water may be added from the beginning to perform extraction.

Although the active ingredient in the extract has not been clarified, it has been confirmed that this unknown active ingredient is stable to heat. Therefore, the extraction temperature at the time of water extraction is efficiently high. If it is left at a low temperature for a long time, it can be sufficiently extracted. However, at a low temperature of 40 ° C. or lower, it is necessary to make the pH acidic or alkaline or to add a preservative. The extraction time may be a few minutes in the case of boiling extraction, but if the temperature is lower than that, several hours to one day is required. When the temperature is low, it depends on the crushed state of rice,
It takes a few days to a month. However, even in this case, it is more effective to heat at the end as much as possible.

In the case of water extraction, the most problematic is the gelatinization phenomenon. If it becomes pasty, not only the extraction efficiency will deteriorate, but it will be extremely difficult in actual work. In order to prevent this, the reaction may be carried out by adding amylase or by acidifying with hydrochloric acid or the like to decompose the starch. By using this method, it can be sufficiently solved and there is no problem in practice.

Since the active ingredient in the extract is stable to acids and alkalis, acid extraction or alkali extraction is also effective. Further, in the case of water extraction, a method of pre-treating with an acid or alkali or reacting with an enzyme (for example, amylase) that acts on the tissue of rice to perform pre-treatment and extracting is effective. This is probably because the pretreatment makes it easier for the active ingredient to be extracted.

Furthermore, it has been found that an extract having this effect can be extracted even by extraction with an organic solvent. This is extremely effective in advancing the elucidation of the active ingredient, and also in the usage such as extracting the active ingredient into a concrete or blending with an insoluble substance. In this case, it is preferable to pulverize or pulverize as much as possible. The organic solvent used here is preferably alcohol, such as alcohol, which is safe to administer to the human body.

Extraction of the product of the present invention from rice is more effective if it is subjected to organic solvent extraction or water extraction as described above, and the active ingredient in the extract is further subjected to solvent extraction. But,
This seems to be because the concentrated state is obtained, and the same effect can be obtained by concentrating. In addition, depending on the application, the presence of sugar may cause stickiness or hinder the effect. In that case, the sugar may be removed by feeding the sugar to yeast, fractionating the active ingredient with an adsorbent, or extracting with an organic solvent. In any case, the effect can be obtained by performing extraction, so that unnecessary components may be removed by various methods depending on the application.
Furthermore, even if the extract was subjected to fermentation treatment such as alcohol fermentation and lactic acid fermentation, the same effect was obtained.

Since rice is eaten as a staple food every day, it was so close to us that there was no concept of using it as a therapeutic agent for various skin diseases, and it was unexpected. Also, it has been used for sake, shochu, vinegar, etc. other than eating, but the idea and method of extracting rice have not been taken.
This may be due to the fact that when rice is extracted by heating, it becomes pasty as a characteristic of rice, which is very difficult in the conventional way of thinking. Therefore, in the present invention, the purpose can be achieved by using organic solvent extraction, acid or alkali extraction, and in the case of water extraction, by making amylase etc. act to facilitate extraction.

As described above, the active ingredient as a very excellent therapeutic agent for various skin diseases can be extracted only after sufficient extraction operation. The effects of the product of the present invention as a skin treatment agent are shown below.

First, the panelists of various skin diseases were allowed to continuously use the product of the present invention twice daily in the affected area twice a day, and the progress of one month was diagnosed to judge the effectiveness of the product of the present invention. The results are shown in Table 1. As the product of the present invention, the product obtained in Example 1 was used, and the number of panelists was 35 men and 40 women, a total of 75, and the average age was 30.5 years (age 1 to 87 years).

[0021]

[Table 1]

As for the usefulness against scratches (7 incisions and 6 abrasions), a useful rate of 84.6% was obtained as shown in Table 1. Especially in severe cases, suppuration will inevitably occur, and it will take time to completely recover.
None of the panelists coated with the product of the present invention had suppuration. In general, not only did it take less time to recover completely than usual, but many people also found that their wounds were not noticeable or remained.

As for the usefulness against burns, 9
A remarkable useful rate of 2.9% was obtained. In the case of burns as well, it was said that the inflammation subsided as quickly as the wounds, and the number of days required for complete healing was early. Also, most of the useful panelists
The pain immediately after the burn was alleviated by applying.
Furthermore, he said that it is less likely to cause water swelling and that there is no residual burn. Moreover, an excellent usefulness rate against diaper rash and insect bite was obtained.

It has been found that the product of the present invention has very excellent utility against the skin diseases that occur in the above-mentioned daily routine. These diseases are mainly cured by the effect of promoting the function of regenerating the skin tissue, which proves that the product of the present invention has the effect of promoting the function of regenerating the skin tissue.

The therapeutic effect of the product of the present invention against athlete's foot is shown in Table 1.
It was found that the usefulness rate was 100% for the panelists of this subject, and it was extremely effective, and all had some improvement effect.

[0026] A detailed sensory result on athlete's foot was reported. As a control, vesicle-type athlete's foot of the vesicle was completely itchless on the affected part to which water was applied, but on the affected part to which the product of the present invention was applied. It was said that the itch did not feel itch in 4.4 days on average. Regarding the tingling sensation, the affected area to which the product of the present invention was applied was considered to have lost the tingling sensation after 6.8 days on average. Furthermore, 2
After continuous use for a week, two people felt a slight reddishness in the affected area and the others said that they had normal skin conditions. In addition, it was considered that these two persons did not feel any itchiness or jerky feeling on the skin at all, and were considered to be quite effective. From these results, it was found that the application of the product of the present invention is clearly effective against vesicular athlete's foot.

Next, I asked a keratinized athlete's foot panelist who had an itch and hardened the keratin. As a control, water was applied instead of the product of the present invention. As a result, regarding the affected part to which the product of the present invention was applied, the skin of the foot was cleaned every time it was applied, and it was considered that 4 out of 5 people had healed in a week. Further, even for one person who did not have a remarkable effect in one week, it was considered that the skin was cleaned and the hard parts of the keratin were reduced in about two weeks by further applying the product of the present invention.

The product of the present invention was also effective against tinea pedis, fungus and beetle, which are skin diseases caused by Trichophyton, like athlete's foot. In addition, the product of the present invention has a useful rate of 87.0% even with a dried product and a blowout product, which proves to be extremely effective.

As described above, the product of the present invention is considered to be cured by the skin tissue regeneration function promoting effect and antibacterial effect. Since it is also effective against athlete's foot, boll, and pimples, the product of the present invention can be said to be a skin treatment agent having both a skin tissue regeneration function promoting effect and an antibacterial effect.

Further, the product of the present invention was extremely effective as shown in Table 1 even when it was used on a cracked part or a part where the skin was bulky. From this, it was revealed that the product of the present invention is effective against diseases requiring a moisturizing effect.

As shown in Table 1, with respect to diseases such as itching of the skin, eczema, atopic dermatitis, etc., the useful rate for itching of the skin was 92.3%, and the useful rate for eczema was 88.
2%, useful rate against atopic dermatitis 79.2%,
It was extremely effective.

In addition, when used for diseases such as heat rash, morbidity, hemorrhoids, anal fistula, stomatitis, tongue, acne, herpes, moisturizing, cleansing, antibacterial action and activation of cells, which are used for healing and improvement, all of these diseases Proved to be effective against. Furthermore, when the product of the present invention was applied to a person with dandruff, it was effective in preventing dandruff.

No one panelist was aggravated by the product of the present invention, which also proves to be a very safe skin treatment agent. Therefore, we asked 19 panelists who were particularly effective for xeroderma, which is said to have a particularly effective moisturizing effect, to give their impressions. From the 3rd day, "Itching is lighter""Dryness is improved"
It was said that the improvement effect was obtained, such as "soft feeling of tightness" and "decrease of desquamation". And 92% in the second week
Some improvement effect was obtained for this person. This tendency was more remarkable in younger people (up to about 30 years old) and in severely ill people. In other words, the effects appeared on the 2nd day for young people and severely ill people.

The present inventors examined this moisturizing effect as data. First, in order to exemplify the strength of the moisturizing effect of the product of the present invention, a single coating test was conducted using a moisture meter (SKICON200). An environment in which the room temperature was 20 ° C. and the relative humidity was 65% was set as a measurement condition, and the panelists were allowed to rest in the above environment for about 10 minutes before the measurement. The test site (both sides) was selected on the flexion side of the forearm where no rash was observed. The panelists were five people who were suffering from xeroderma.

Main test (using the product of the present invention obtained in Example 1) read from a moisture meter and control test (using water)
The average values of changes in the water content of the stratum corneum are shown in FIG. 1
The measurement method of the repeated application test is as follows.

Measurement method 1) A test site and a control site of 5 × 5 cm are set on the forearm flexion side of the panel. 2) Measure the water content of the stratum corneum at each site. 3) Measure the water content of the stratum corneum immediately after coating the sample and after 30, 60, 90 and 120 minutes.

From FIG. 1, it was confirmed that the water content of the stratum corneum of the product of the present invention increased about 10 times as much as that of the control, immediately after coating. In addition, regarding the period from 30 minutes to 120 minutes after the application, at the application site of the present invention, from the control 2 to 120 minutes.
It can be seen that the water content is tripled. From this, it can be said that the product of the present invention is rich in moisturizing property.

Next, in order to numerically prove the therapeutic effect of the product of the present invention on xeroderma, a water load test was carried out before and after the use of the product of the present invention for 2 weeks using a moisture meter (SKICON200). . The panelists were the 5 persons used in FIG. 1, and the measurement conditions were the same as the one-time application test. It should be noted that a control (measurement at a site not coated with the product of the present invention) was always set so that the effect determination is not affected by the seasonal change in the water content of the living horny layer. The water content of the stratum corneum was shown as the average value of 5 panelists. The result is shown in FIG.

As the product of the present invention, the product obtained in Example 1 was used. The measuring method of the water load test is as follows. Measurement method 1) The water content of the stratum corneum of the test site is measured. 2) Place one drop of distilled water on the test site, and after 10 seconds, completely wipe off the water drop with dry gauze. 3) Immediately after wiping, the water content of the stratum corneum is measured after 30, 60, 90 and 120 seconds.

As shown in the graph of FIG. 2, by applying the product of the present invention, the water absorption capacity of the skin (the water content in the stratum corneum after 0 seconds of water loading minus the water content in the stratum corneum before loading) ),
It can be seen that both the water retention capacity (the curve drawn by the water content of the stratum corneum from 0 to 120 seconds after water loading) is simultaneously improved.

In other words, the skin before use of the product of the present invention has a very low water content in the stratum corneum before water loading (4.2 on average), and the water absorption capacity (40.8 on average) is considerably reduced. In addition, the stratum corneum of the skin of a normal person also has a water-retaining ability, and the water content absorbed by the corneal layer gradually returns to the value before the water load 30 seconds after the water load. These results show that the water absorption capacity, the water retention capacity, and the barrier function were all decreased in the measured morbid stratum corneum. On the other hand, the skin after use of the product of the present invention has a two- to three-fold increase in the water content and water absorption capacity of the stratum corneum before water loading, and the water retention capacity is considerably improved to the same level as that of a normal person. I understood.

From the above, it can be said that the product of the present invention has an excellent effect on the water content of the pathological stratum corneum and the improvement of the barrier function. Further, when the present invention product is evaluated in combination with the moisturizing effect obtained from the one-time application test, the present invention product increases the water absorption capacity and water retention capacity of the stratum corneum and absorbs a large amount of water from the external environment.
Further, it can be said that there is a moisturizing effect that gives the stratum corneum a property of not releasing the once absorbed water.

Further, the effect on acne was examined. Before the test, the symptom of acne of the panelist is objectively judged, and the progress of 8 weeks of application of the present invention is observed statistically based on factors such as age, sex, and degree of acne. evaluated.

Using 10 panelists (3 males and 7 females) with acne skin, the product of the present invention was applied daily after washing the face in the morning and evening twice a day, before starting the test and during the test (after 2 weeks, After 4 weeks), after the completion (8 weeks), a total of 4 determinations were made. The results are shown in Table 2. The skin symptoms of the panelists before application of the present invention in this clinical test were moderate to mild acne with an average comed number of 28.1, an average papule number of 14.5, and an average pustule number of 11.3.

[0045]

[Table 2]

As can be seen from Table 2, there are some fluctuations depending on the panelists, but from the first week of application of the product of the present invention,
It was found that a clear therapeutic effect on acne was obtained. Also, at the 4th week, a clear acne treatment effect was obtained for all 10 panelists. This tendency was more pronounced in people with more pustules. That is, the reduction of comedones and papules was not so significant at 2 weeks as compared with before application, but pustules were significantly reduced as compared to before application. Generally, it is said that papules and pustules will heal naturally within 14 days without treatment, and comedones will usually heal naturally within 4 weeks. However, when the product of the present invention is applied, regardless of age or sex, Since the number of acne is reduced over 8 weeks, it can be said that it is effective not only for the treatment of existing acne but also for the prevention of new acne.

Also, when 10 panelists with acne-skin applied with the product of the present invention were asked about their sensory findings, "the skin was transparent" and "dullness was not noticeable".
It was also found that a relatively large number of people answered that "it became difficult to lose makeup,""pores became inconspicuous," and "fat removal was significantly improved." From this, it can be said that there is a cleaning effect that effectively removes not only old dead skin cells and sebum, but also pore dirt.

Further, in order to experimentally demonstrate the secretion inhibiting effect of the sebum amount of the product of the present invention, changes in the sebum amount after washing the face were measured. As panelists, five persons randomly selected from those used in Table 2 were used, and the average value of the change in the amount of sebum between the main test (after washing the face and applying the product of the present invention) and the control test (only the face washing) is shown in FIG. It was shown to. As the product of the present invention, the product obtained in Example 1 was used.

As shown in the graph of FIG. 3, it was found that the application of the product of the present invention significantly suppressed the increase in the amount of sebum. The inhibitory effect on the amount of sebum secretion of the product of the present invention also confirmed the preventive and therapeutic effect on acne.

As described above, the product of the present invention has the effects of promoting skin tissue regeneration function, antibacterial action, moisturizing and cleaning effects, etc., and therefore is effective in the prevention and treatment of all skin diseases and extracts rice. It has been found that it can be widely used as a skin treatment drug because it is a completely safe thing.

[0051]

EFFECTS OF THE INVENTION As is clear from the above data, by extracting rice with water or organic solvent, it is easy and completely safe, and the effect of promoting skin tissue regeneration function is
An excellent skin treatment agent having an antibacterial action, a moisturizing effect and a cleansing effect can be obtained.

Since rice has been the staple food until now, almost no development has been made on its production method or application in a new field other than food. Furthermore, rice has been the staple food until now, and its safety has been well demonstrated. That is, the present invention has not only found a skin therapeutic agent having a very excellent therapeutic effect on various skin diseases, but has also found a new application for use, which is said to be overproduction of rice.
And it is extremely meaningful to be able to increase consumption by improving the image of rice.

[0053]

EXAMPLES Next, examples of the present invention will be described. Example 1 15 kg of white rice was crushed well, 45 liters of warm water at 60 ° C and 50 g of liquefied enzyme were added thereto, and the mixture was stirred well. afterwards,
Gradually raise the temperature, boil and extract for 5 minutes, then 30
Cooled to ° C. After that, the product of the present invention 41
1 liter and 16 kg of residue were obtained.

Example 2 1 kg of white rice was crushed well, 5 liters of 0.1% hydrochloric acid water was added, well stirred, and allowed to stand for 6 hours. Then, it was squeezed with a squeezing machine to separate 4.6 liters of squeezed liquid and 1.2 kg of residue. This compressed liquid was neutralized with 1N NaOH to obtain 4.7 liters of the product of the present invention.

Example 3 1 kg of white rice was well crushed, 3 liters of 95% alcohol was added, and the mixture was stirred well and left to stand. Four days later, it was squeezed with a squeezing machine to obtain 2.5 liters of squeezed liquid and 1.2 kg of residue. One part of this squeezed liquid was added with 500 ml of water, and alcohol was completely removed by a rotary evaporator to obtain 480 ml of the product of the present invention.

Example 4 7 kg of white rice was well crushed, and 21 liters of warm water at 60 ° C. and 20 g of liquefying enzyme were added to this and well stirred. After that, gradually raise the temperature, boil and extract for 5 minutes, then 30 ℃
Cooled down. Then, the extract was cultured yeast (Association No. 7)
100 ml of the liquid was added, and alcohol fermentation was carried out at 25 ° C for 10 days. Then, the product was squeezed with a squeezing machine to obtain 21 liters of the present invention and 3 kg of residue.

[Brief description of drawings]

FIG. 1 shows a moisture meter (SK
It is a graph which shows the result of having performed the coating test once using ICON200).

FIG. 2 is a graph showing the results of a water load test before use of the product of the present invention and after use for 2 weeks.

FIG. 3 is a graph showing the results of testing changes in the amount of sebum when the product of the present invention was applied after washing the face and when the face was washed only.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ identification code FI A61P 17/00 A61P 17/00 37/08 37/08 (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K 35 / 78 A01K 65/00 A61K 7/00

Claims (6)

(57) [Claims] 1. An agent for treating, improving or preventing skin, which comprises a water extract or an organic solvent extract of white rice or an alcoholic fermentation product thereof as an active ingredient. 2. The skin treatment, improving or preventing agent according to claim 1, which has a moisturizing effect. 3. A scratch or scratch such as a cut or abrasion, a burn,
After burns, diaper rash, bruise, hand damage, shyness,
Hemorrhoids, hemorrhoids, athlete's foot, tinea, ringworm, bugs, jumps,
The skin according to claim 1 or 2, which is used for acne, atopic dermatitis, eczema, rash, wiping, xeroderma, wisteria burns, cracks, cracks, stomatitis, helminthia, dandruff prevention and healing of insect bites. Treatment, improvement or prevention agent. 4. A skin tissue regeneration function-promoting agent comprising a water extract or an organic solvent extract of white rice or an alcoholic fermentation product thereof as an active ingredient. 5. An antibacterial agent comprising a water extract or an organic solvent extract of white rice or an alcoholic fermentation product thereof as an active ingredient. 6. A detergent comprising a water extract or an organic solvent extract of white rice or an alcoholic fermentation product thereof as an active ingredient.