CN115463077A - Firming and repairing essence and preparation method thereof - Google Patents

Firming and repairing essence and preparation method thereof Download PDF

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CN115463077A
CN115463077A CN202211324537.4A CN202211324537A CN115463077A CN 115463077 A CN115463077 A CN 115463077A CN 202211324537 A CN202211324537 A CN 202211324537A CN 115463077 A CN115463077 A CN 115463077A
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extract
skin
tightening
firming
repairing
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杜锡萍
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
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    • A61K2800/59Mixtures
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    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

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Abstract

The application relates to the field of skin care products, and particularly discloses a firming and repairing essence which comprises the following components: 1,2-hexanediol; p-hydroxyacetophenone; xanthan gum; triethanolamine; a softening agent; a soothing agent; a tightening and repairing agent; water; the firming and repairing agent comprises a dioscorea root extract, a honeysuckle flower extract, a porphyridium extract and a rosemary leaf extract, wherein the dioscorea root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract respectively account for the skin conditioner in percentage by mass: 1-2%, 3-5%, 4-6%, 2-4% and the balance of solvent. This application has the transdermal osmosis who improves the repair essence of tightening, promotes elastin, collagen synthesis, promotes skin and tightens and elasticity, simultaneously, alleviates the treatment through symptoms such as red swelling, hot pain, skinning, pruritus that medical and beauty postoperative skin caused, promotes wound repair's effect.

Description

Firming and repairing essence and preparation method thereof
Technical Field
The application relates to the field of skin care products, in particular to a firming and repairing essence and a preparation method thereof.
Background
With the improvement of living standard, people have more and more demand on beauty, people have deeper and deeper understanding on beauty, and the requirement on the long-term beauty value is gradually increased, so that medical beauty is gradually a consumption hot spot of the public.
At present, when people are subjected to environment or improper nursing, and cause skin itch, sensitive skin, pathological skin such as hormone dermatitis and problem skin, the selection of taking medical and beauty operations such as micro-needle, hydro-acupuncture, laser and the like to help reduce wrinkles and restore tender and white facial skin for the skin problem is favored.
However, because the skin barrier is damaged and the skin is inflamed and pruritus and other facial wounds are easy to occur after minimally invasive surgery, the existing skin care products only act on the wounded skin part, cannot penetrate into the inner layer of the skin more deeply, cannot enable the skin to be absorbed more quickly, and further cannot repair the damaged skin quickly, so that the tender and elastic skin cannot be restored quickly, and the postoperative recovery effect of people is influenced. Thus, there is still room for improvement.
Disclosure of Invention
In order to improve the transdermal osmosis effect of the tightening repair essence, promote the synthesis of elastin and collagen, promote the skin tightening and elasticity, relieve the symptoms of red swelling, hot pain, skin peeling, pruritus and the like caused by skin after medical and beauty operations and promote wound repair, the application provides the tightening repair essence and the preparation method thereof.
The application provides a firming and repairing essence, which adopts the following technical scheme:
the tightening and repairing essence comprises the following components in percentage by mass:
1,2 hexanediol 1-2%;
0.03-0.08% of p-hydroxyacetophenone;
0.4 to 0.9 percent of xanthan gum;
0.03-0.05% of triethanolamine;
0.88 to 1.72 percent of softening agent;
4.22 to 6.58 percent of soothing agent;
10-14% of a firming and repairing agent;
the balance of water;
the firming and repairing agent comprises a dioscorea root extract, a honeysuckle flower extract, a porphyridium extract and a rosemary leaf extract, wherein the dioscorea root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract respectively account for the skin conditioner in percentage by mass: 1-2%, 3-5%, 4-6%, 2-4% and the balance of solvent.
By adopting the technical scheme, the yam root extract contains various amino acids, and active ingredients such as diosgenin, dopamine, polyphenol oxidase, allantoin, various sterols and the like, and has the effects of moisturizing, moistening and inhibiting bacteria.
The honeysuckle flower extract contains caffeic acid, luteolin and other components, has good antibacterial and anti-inflammatory effects, has strong permeability to skin, can reach deep skin, can inhibit hyaluronidase activity, prolong the activity of the product, eliminate free radicals, and absorb ultraviolet ray.
Porphyridium extract is capable of producing many bioactive substances such as phycobiliprotein, polyunsaturated fatty acids and exopolysaccharide substances; also has the functions of brightening skin, moisturizing, locking water, keeping skin flexible and tight.
The rosemary leaf extract has the inhibition effect on elastase and collagenase, and has the effects of activating skin, resisting aging, resisting inflammation and astringing.
The research personnel find that the dioscorea root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract are matched with one another, so that the synthesis of elastin and collagen is facilitated, the skin firmness and elasticity are improved, the transdermal permeation effect of the tightening and repairing essence is improved, the effect and the effect of active substances are better exerted, the active substances penetrate into the inner layer of the skin deeply, and the skin can recover to be tender and tight more quickly.
Meanwhile, certain active ingredients in the dioscorea root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract have a synergistic effect mutually, so that the skin-care product is favorable for relieving symptoms such as redness, swelling, hot pain, skin fading, pruritus and the like caused by skin after medical and beauty operations, the damaged skin is repaired, the wound repair is promoted, the skin-care product is suitable for medical and beauty postoperative repair of micro needles, hydro-optic needles, lasers and the like, the skin resistance can be improved after the operation, the skin healing is accelerated, and the postoperative recovery effect is improved.
Therefore, the application adopts the mutual matching of the dioscorea root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract, so that the transdermal permeation effect of the tightening and repairing essence is improved, the synthesis of elastin and collagen is promoted, the skin tightness and elasticity are improved, and the maintenance effect of the goose egg face is improved; meanwhile, the traditional Chinese medicine composition is also beneficial to relieving and treating symptoms such as red swelling, hot pain, skin fading, pruritus and the like caused by skin after medical and aesthetic operations, and promoting the rapid repair of wounds.
Preferably, the mass ratio of the dioscorea root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract is 1:2:2: (1-2).
By adopting the technical scheme, the yam root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract in a specific ratio are matched with one another, so that the skin permeation effect of the tightening repair essence can be further improved, the production of elastic fibers and basement membrane proteins can be promoted, the collagen synthesis capacity can be improved, broken subcutaneous collagen tissues can be quickly repaired, the collagen density can be improved, and the skin can quickly recover elasticity.
Preferably, the firming and repairing agent further comprises aloe vera extract and lithospermum erythrorhizon extract, wherein the aloe vera extract and the lithospermum erythrorhizon extract respectively account for 1-2% and 3-5% of the firming and repairing agent by mass percent.
By adopting the technical scheme, the aloe vera extract has the functions of increasing fibrin, removing free radicals, resisting bacteria, diminishing inflammation and preserving moisture; the radix Arnebiae extract has effects of promoting cathepsin activity, promoting metabolism of skin cells, and resisting aging. Therefore, the aloe vera extract and the lithospermum extract are matched with each other, so that the synthesis of elastin and collagen is facilitated, the skin firmness and elasticity are improved, the retaining effect of the goose egg face is improved, the symptoms of redness, swelling, hot pain, skin fading, pruritus and the like caused by skin after medical and aesthetic operations are eliminated, and the effect of quick recovery is achieved.
Preferably, the emollient comprises one or more of soluble collagen, tripeptide-1 copper, hydrolyzed vegetable protein.
Preferably, the softening agent comprises the following components in percentage by mass:
0.5-1% of soluble collagen;
tripeptide-1 copper 0.3-0.6%;
0.08-0.12% of hydrolyzed vegetable protein.
By adopting the technical scheme, the soluble collagen can effectively supplement collagen of the skin, delay skin aging, keep skin moisture and elasticity and promote the skin to be smooth and tender; tripeptide-1 copper can remove collagen, elastin and scar tissue damaged by skin, and has anti-wrinkle and anti-inflammatory effects; the hydrolyzed vegetable protein is a substance obtained by hydrolyzing vegetable protein, and is easily absorbed by skin. Therefore, the soluble collagen, the tripeptide-1 copper and the hydrolyzed vegetable protein are matched with each other, so that the elasticity of the skin is improved, the tightening effect of the tightening and repairing essence is further improved, the retaining effect of the goose egg-shaped face is further improved, and the repairing effect after the operation is improved.
Preferably, the soothing agent comprises one or more of centella asiatica extract, fibronectin, sodium hyaluronate.
Preferably, the soothing agent comprises the following components in percentage by mass:
2.8 to 4.3 percent of centella asiatica extract;
0.02-0.08% fibronectin;
1.4 to 2.2 percent of sodium hyaluronate.
By adopting the technical scheme, the effective components in the centella extract are mainly asiaticoside and madecassoside, so that the centella extract has the effects of promoting the growth of skin fibers, promoting the synthesis of skin collagen and inhibiting the activity of matrix metalloproteinase, and also has the effects of repairing damaged skin, slowing down skin ulceration, accelerating wound healing and promoting the growth of skin; fibronectin has the effects of decomposing abnormally secreted melanin, removing color spots, increasing cell activity and accelerating cell renewal; the sodium hyaluronate can repair skin injury, promote proliferation and differentiation of epidermal cells, remove oxygen free radicals, and delay skin aging. Therefore, the asiatic centella extract, the fibronectin and the sodium hyaluronate are mutually matched, so that the asiatic centella extract, the fibronectin and the sodium hyaluronate are favorable for relieving and treating symptoms such as red swelling, hot pain, skin fading and pruritus caused by skin after medical and aesthetic operations, and promoting the rapid repair of wounds.
In a second aspect, the application provides a preparation method of a firming and repairing essence, which adopts the following technical scheme:
a preparation method of a firming and repairing essence comprises the following steps:
respectively adding 1,2-hexanediol, p-hydroxyacetophenone, xanthan gum, triethanolamine, a softening agent, a soothing agent, a tightening repairing agent and water into a stirring kettle, and uniformly stirring to obtain the tightening repairing essence.
By adopting the technical scheme, the preparation method is simple and convenient and is suitable for industrial production.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the application adopts the mutual matching of the dioscorea root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract, so that the transdermal permeation effect of the tightening and repairing essence is improved, the synthesis of elastin and collagen is promoted, the skin tightness and elasticity are improved, and the maintenance effect of the goose egg face is improved; meanwhile, the ointment is also beneficial to relieving and treating symptoms such as red swelling, hot pain, skin fading, pruritus and the like caused by the skin after medical and aesthetic operations, and promoting the rapid repair of wounds.
2. By adopting the aloe vera extract and the lithospermum extract to be matched with each other, the synthesis of elastin and collagen is facilitated, the skin firmness and elasticity are improved, the retaining effect of the goose egg face is further improved, the symptoms of redness, swelling, hot pain, skin fading, pruritus and the like caused by skin after medical and aesthetic operations are eliminated, and the effect of quick recovery is achieved.
3. Through adopting soluble collagen, tripeptide-1 copper and the vegetable protein of hydrolysising to mutually support, be favorable to improving the elasticity of skin, further promote the effect of compacting of the repair essence of compacting to further promote the maintenance effect of "goose egg face", improve the restoration effect of postoperative.
Detailed Description
The present application will be described in further detail with reference to examples.
Preparation examples 1 to 2
A preparation method of a firming and repairing agent comprises respectively adding rhizoma Dioscoreae extract, flos Lonicerae extract, porphyridium extract, herba Rosmarini officinalis extract and water into a stirring kettle at normal temperature, and stirring at a rotation speed of 45r/min to obtain the firming and repairing agent.
Preparation example 3
The difference from preparation example 2 is that: the mass ratio of the dioscorea root extract to the honeysuckle flower extract to the porphyridium extract to the rosemary leaf extract is 1:2:2:1.
preparation example 4
The difference from preparation example 2 is that: the mass ratio of the dioscorea root extract to the honeysuckle flower extract to the porphyridium extract to the rosemary leaf extract is 1:2:2:2.
preparation example 5
The difference from preparation example 4 is that: equal amount of water was used in place of the yam root extract.
Preparation example 6
The difference from preparation example 4 is that: equal amount of water was used instead of the honeysuckle flower extract.
Preparation example 7
The difference from preparation example 4 is that: equal amount of water was substituted for porphyridium extract.
Preparation example 8
The difference from preparation example 4 is that: the rosemary leaf extract was replaced with an equal amount of water.
The components and the amounts used in preparation examples 1 to 8 are shown in Table 1, and the units of the amounts used in Table 1 are kg.
TABLE 1
Figure 422772DEST_PATH_IMAGE002
Preparation examples 9 to 10
The difference from preparation example 4 is that: the firming and repairing agent further comprises Aloe Barbadensis Miller extract and radix Arnebiae extract.
Preparation example 11
The difference from preparation example 10 is that: equal amount of water was substituted for the aloe vera extract.
Preparation example 12
The difference from preparation example 10 is that: equal amount of water was used instead of the lithospermum extract.
The components and the amounts used in preparation examples 9 to 12 are shown in Table 2, and the units of the amounts used in Table 2 are kg.
TABLE 2
Figure 402229DEST_PATH_IMAGE004
Examples 1 to 4
The embodiment discloses a tightening and repairing essence which comprises the following components:
1,2-hexanediol; p-hydroxyacetophenone; xanthan gum; triethanolamine; a softening agent; a soothing agent; a tightening and repairing agent; water;
wherein the firming and repairing agent is prepared by the firming and repairing agents prepared in preparation examples 1-4 respectively; the emollient comprises soluble collagen, tripeptide-1 copper, and hydrolyzed vegetable protein; the soothing agent comprises centella asiatica extract, fibronectin, and sodium hyaluronate.
The embodiment also provides a preparation method of the tightening and repairing essence, which comprises the following steps:
respectively adding 1,2-hexanediol, p-hydroxyacetophenone, xanthan gum, triethanolamine, emollient, soothing agent, tightening repairing agent and water into a stirring kettle, and uniformly stirring at a rotating speed of 50r/min to obtain the tightening repairing essence.
The components and amounts used in examples 1-4 are shown in Table 3, and the units for the amounts used in Table 3 are in kg.
TABLE 3
Figure 978704DEST_PATH_IMAGE006
Example 5
The difference from example 4 is that: the firming and repairing agent is the firming and repairing agent prepared in the preparation example 9, namely the firming and repairing agent also comprises aloe vera extract and lithospermum erythrorhizon extract.
Example 6
The difference from example 4 is that: the firming and repairing agent prepared in the preparation example 10 is adopted, namely the firming and repairing agent further comprises aloe vera extract and lithospermum erythrorhizon extract.
Example 7
The difference from example 4 is that: the firming and repairing agent is prepared by the firming and repairing agent prepared in the preparation example 11, namely the firming and repairing agent also comprises lithospermum extract.
Example 8
The difference from example 4 is that: the firming and repairing agent is the firming and repairing agent prepared in the preparation example 12, namely the firming and repairing agent also comprises aloe vera extract.
Comparative example 1
The differences from example 4 are: the firming and repairing agent prepared in the preparation example 5 is adopted, namely, the yam root extract is not added into the firming and repairing agent.
Comparative example 2
The difference from example 4 is that: the firming and repairing agent prepared in the preparation example 6 is adopted, namely the honeysuckle flower extract is not added into the firming and repairing agent.
Comparative example 3
The difference from example 4 is that: the firming and repairing agent is the firming and repairing agent prepared in the preparation example 7, namely the porphyridium extract is not added in the firming and repairing agent.
Comparative example 4
The difference from example 4 is that: the firming and repairing agent prepared in the preparation example 8 is adopted, namely rosemary leaf extract is not added into the firming and repairing agent.
Comparative example 5
The differences from example 4 are:
the tightening and repairing essence comprises the following components in parts by mass:
1,2-hexanediol, 3kg; 0.01kg of p-hydroxyacetophenone; 0.3kg of xanthan gum; 0.02kg of triethanolamine; 0.5kg of softening agent; 7.2kg of soothing agent; 16kg of firming and repairing agent; water 72.97kg.
Comparative example 6
The difference from example 4 is that:
the tightening and repairing essence comprises the following components in parts by mass:
1,2-hexanediol 0.8kg; 1.0kg of p-hydroxyacetophenone; 1.3kg of xanthan gum; 0.09kg of triethanolamine; 1.9kg of softening agent; 3.7kg of a soothing agent; 8kg of firming and repairing agent; water 83.21kg.
Experiment 1
In the experiment, in-vitro pigskin is used as an experimental material, the back skin of a non-traumatic pig is selected, a subcutaneous fat layer is removed, hair on the surface of the pigskin is cut to be below 2mm by an electric hair clipper, then a circular sheet with the diameter of 4cm is drilled by a circular puncher, and the thickness of the sheet is trimmed to be not more than 1mm. The knocked-down pigskin sample was cleaned and mounted on a Franz diffusion transdermal cell with its dermal layer facing the receiving cell containing PBS and the stratum corneum exposed in the dosing chamber and mounted with iron clips. 100 mul of the tightening and repairing essence prepared in examples 1-8 and comparative examples 1-6 was added to the administration pool, and then massaged for 2min with the aid of a massager, and transdermal application was performed for 24h. Accurately collecting 3mL of receiving solution at regular time (and supplementing 3mL of receiving solution), accurately adding 1mL of ethyl acetate, extracting on shaking table, adding quantitative anhydrous ethanol, measuring absorbance at 274nm, and calculating the cumulative permeation amount (μ g/cm) after transdermal for 24h 3 ). The larger the cumulative penetration amount is, the better the skin penetration effect of the firming and repairing essence is.
Experiment 2 skin elasticity
The firming and repairing essence prepared in the above examples 1 to 8 and comparative examples 1 to 6 is subjected to a human skin elasticity test, the test instrument is a skin elasticity tester (skin elasticity tester dual MPA 580), and the test method is as follows: and selecting 30 healthy women for each group of compact repair essence diluted samples, wherein the age is 30 +/-2 years old, the samples are smeared at the cheeks, the skin elasticity test is carried out on the samples by using an instrument before smearing and after using the samples for four weeks, the parallel test is carried out for 3 times, the average value is taken, and the R2 value is recorded.
Wherein, the change rate is relative to the change rate before use, and the calculation formula is as follows:
skin elasticity change rate (%) after four weeks of use relative to before use
Figure DEST_PATH_IMAGE007
(ii) a In the formula, T 0 -the pre-sample R2 value is used in the test area; t is 4 R2 values after four weeks of sample use in the test area; n-number of subjects.
The closer the skin elasticity R2 value is to 1, the better the skin elasticity is; the higher the change rate of the R2 value is, the better the effect of the firming and repairing essence on improving the skin elasticity is.
Experiment 3 inhibition ratio of Elastase
The inhibition rate of elastase was determined by spectrophotometry. Congo red-elastin is used as a substrate, after the elastin is decomposed by enzyme, the Congo red falls off, and the content of the Congo red in the solution is measured to characterize the enzyme activity. Respectively dissolving the tightening repair essence prepared in the examples 1-8 and the comparative examples 1-6 in water to prepare test solutions with the concentration of 6 mg/mL; congo red-elastin and boric acid buffer solution were added to the Erlenmeyer flask, preheated in a 37 ℃ water bath for 10min, and then the above test solution and 0.2mg/mL elastase solution were added, as shown in Table 4.
TABLE 4
Figure DEST_PATH_IMAGE009
The reaction system is placed in a constant temperature water bath oscillator at 37 ℃ and shaken for 20min, 5.0ml of phosphate buffer solution with pH6.0 is immediately added for mixing and stopping the reaction, and the mixture is centrifuged for 15min at 5000 r/min. Accurately sucking 2.0mL of supernatant, adding 2.0mL of mixed solution of pH8.8 boric acid buffer solution and pH6.0 phosphate buffer solution, fully shaking and measuring the absorbance at 495nm, wherein the inhibition rate of the elastase is calculated as follows: the inhibition rate of elastase = (1- (A1-A2)/(B1-B2)) × 100%.
The higher the inhibition rate of the elastase is, the better the anti-wrinkle effect of the firming and repairing essence is.
The results of experiments 1-3 are shown in Table 5.
TABLE 5
Figure DEST_PATH_IMAGE011
According to the data of comparative examples 1 to 4 in table 5, which are respectively compared with the data of example 4, the dioscorea root extract is not added in comparative example 1, the honeysuckle flower extract is not added in comparative example 2, the porphyridium officinale extract is not added in comparative example 3, the rosemary leaf extract is not added in comparative example 4, the dioscorea root extract, the honeysuckle flower extract, the porphyridium algae extract and the rosemary leaf extract are simultaneously added in example 4, the cumulative penetration amount of the firming and repairing essence in example 4 is higher than that of comparative examples 1 to 4, and the change rate of the R2 value in the firming and repairing essence is higher than that of comparative examples 1 to 4.
According to the comparison of the data of the comparative examples 5 to 6 in the table 5 with the data of the example 4, the amounts of the components in the comparative examples 5 to 6 are not within the range protected by the present application, and compared with the example 4, the cumulative penetration of the tightening repair essence in the comparative examples 5 to 6 is not as good as the cumulative penetration of the example 4, and the change rate of the R2 value is not as good as the change rate of the R2 value in the example 4, which indicates that the amounts of the components in the tightening repair essence are within the range protected by the present application, so that the effect of improving the transdermal effect of the tightening repair essence is achieved, and the technical effect of the present application cannot be achieved at any ratio.
According to the comparison of the data of the examples 5-8 in the table 5 with the data of the example 4, the tightening and repairing agents in the examples 5-6 are simultaneously added with the aloe vera extract and the lithospermum extract, the cumulative transmittance of the tightening and repairing essence is higher than that of the example 4, the change rate of the R2 value is higher than that of the example 4, and the situation that the aloe vera extract and the lithospermum extract are simultaneously added to be matched with each other is proved to be beneficial to promoting the synthesis of elastin and collagen, improving the skin tightening and elasticity and further improving the keeping effect of the goose egg faces.
Experiment 4
Selecting skin after minimally invasive operations such as facial laser, fruit acid skin changing, micro plastic and the like of people in beauty medical institutions such as hospitals and the like, and damaged skin caused by reasons such as sensitive skin, dermatitis and the like. Of the 280 patients in the clinic, 89 women and 71 men aged 18-60 were randomized into 14 groups of 20 patients each.
The using method comprises the following steps: (1) basic treatment: the skin lesion was cleaned with water. (2) packet usage: after basic treatment, subjects respectively apply the tightening repair essence prepared in the above examples and comparative examples for 2 times a day, once in the morning and evening and 2mL once, and continuously use for 15 days.
The curative effect index is as follows: symptom scores were made with reference to the facial sensitization dermatitis criteria, as shown in table 6.
TABLE 6
Figure DEST_PATH_IMAGE013
And (3) evaluating the curative effect:
and (3) healing: the integral reduction of symptoms and signs is more than or equal to 95 percent.
The effect is shown: the pain symptom and sign integral is reduced by more than or equal to 70 percent and less than 95 percent.
The method has the following advantages: the integral reduction of symptoms and signs is more than or equal to 30 percent and less than 70 percent.
And (4) invalidation: the reduction of symptoms and signs is less than 30%.
Cure + significant effect + effective number of cases to calculate the total effective rate.
The calculation formula is as follows: [ (pre-treatment score-post-treatment score)/pre-treatment score ] x 100%.
TABLE 7
Figure DEST_PATH_IMAGE015
According to the data of comparative examples 1 to 4 in table 7, which can be obtained from comparative example 4, the total effective rates of comparative examples 1 to 4 are all lower than the total effective rate of example 4, which shows that the adoption of the dioscorea root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract in cooperation with each other is beneficial to relieving and treating symptoms such as red swelling, hot pain, skin fading and pruritus caused by the medical and beauty operations of the skin, promoting wound repair, accelerating skin healing and improving the postoperative recovery effect.
According to the comparison of the data of the examples 5 to 8 in the table 7 with the data of the example 4, the examples 5 to 6 are based on the example 4, the aloe vera extract and the lithospermum extract are simultaneously added, the total effective rate of the examples 5 to 6 is higher than that of the example 4, the lithospermum extract is independently added in the example 7 based on the example 4, the aloe vera extract is independently added in the example 8 based on the example 4, the total effective rate of the examples 7 to 8 is not the same as that of the examples 5 to 6, and the results show that the synthesis of elastin and collagen can be better promoted, the skin firmness and elasticity can be improved, the retention effect of the goose egg face can be improved, the symptoms of red swelling, hot pain, skin fading, pruritus and the like caused by the skin after medical and beauty operations can be eliminated, and the effect of quick recovery can be achieved.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.

Claims (8)

1. The tightening repair essence is characterized in that: the composite material comprises the following components in percentage by mass:
1,2 hexanediol 1-2%;
0.03-0.08% of p-hydroxyacetophenone;
0.4-0.9% of xanthan gum;
0.03-0.05% of triethanolamine;
0.88 to 1.72 percent of softening agent;
4.22 to 6.58 percent of soothing agent;
10-14% of a firming and repairing agent;
the balance of water;
the firming and repairing agent comprises a dioscorea root extract, a honeysuckle flower extract, a porphyridium extract and a rosemary leaf extract, wherein the dioscorea root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract respectively account for the skin conditioner in percentage by mass: 1-2%, 3-5%, 4-6%, 2-4% and the balance of solvent.
2. The tightening repair essence according to claim 1, wherein: the mass ratio of the dioscorea root extract, the honeysuckle flower extract, the porphyridium extract and the rosemary leaf extract is 1:2:2: (1-2).
3. The tightening repair essence according to claim 1, wherein: the firming and repairing agent also comprises an aloe vera extract and a lithospermum extract, wherein the aloe vera extract and the lithospermum extract respectively account for 1-2% and 3-5% of the firming and repairing agent by mass.
4. The tightening repair essence according to claim 1, wherein: the emollient comprises one or more of soluble collagen, tripeptide-1 copper, and hydrolyzed vegetable protein.
5. The tightening repair essence according to claim 4, wherein: the softening agent comprises the following components in percentage by mass:
0.5-1% of soluble collagen;
tripeptide-1 copper 0.3-0.6%;
0.08-0.12% of hydrolyzed vegetable protein.
6. The tightening repair essence according to claim 1, wherein: the soothing agent comprises one or more of centella asiatica extract, fibronectin, and sodium hyaluronate.
7. The tightening repair essence according to claim 6, wherein: the soothing agent comprises the following components in percentage by mass:
2.8 to 4.3 percent of centella asiatica extract;
0.02-0.08% fibronectin;
1.4-2.2% of sodium hyaluronate.
8. A method for preparing the tightening repair essence according to any one of claims 1 to 7, wherein: the method comprises the following steps:
respectively adding 1,2-hexanediol, p-hydroxyacetophenone, xanthan gum, triethanolamine, a softening agent, a soothing agent, a tightening repairing agent and water into a stirring kettle, and uniformly stirring to obtain the tightening repairing essence.
CN202211324537.4A 2022-10-27 2022-10-27 Firming and repairing essence and preparation method thereof Withdrawn CN115463077A (en)

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Application publication date: 20221213