US20080021418A1 - Lipolysis stimulator - Google Patents

Lipolysis stimulator Download PDF

Info

Publication number
US20080021418A1
US20080021418A1 US11/782,160 US78216007A US2008021418A1 US 20080021418 A1 US20080021418 A1 US 20080021418A1 US 78216007 A US78216007 A US 78216007A US 2008021418 A1 US2008021418 A1 US 2008021418A1
Authority
US
United States
Prior art keywords
slimming
extract
lipolysis
aqueous ethanol
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/782,160
Inventor
Shinobu Mori
Hiroshi Kusuoku
Mayumi Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kao Corp
Original Assignee
Kao Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2003-203095 priority Critical
Priority to JP2003203095 priority
Priority to JP2004156535A priority patent/JP4373280B2/en
Priority to JP2004-156535 priority
Priority to US10/900,102 priority patent/US7300675B2/en
Application filed by Kao Corp filed Critical Kao Corp
Priority to US11/782,160 priority patent/US20080021418A1/en
Publication of US20080021418A1 publication Critical patent/US20080021418A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/06Preparations for care of the skin for countering cellulitis
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/14Cupressaceae (Cypress family), e.g. juniper or cypress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/52Juglandaceae (Walnut family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/69Polygalaceae (Milkwort family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738Rosa (rose)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/744Gardenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755Gymnosperms [Coniferophyta]
    • A61K8/9761Cupressaceae [Cypress family], e.g. juniper or cypress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/909Obesity

Abstract

The present invention is directed to a lipolysis stimulator and a slimming agent which stimulate or facilitate lipolysis of accumulated adipose tissue, to thereby exert the body slimming effect. The lipolysis stimulator or the slimming agent of the present invention contains as an active ingredient any form of a plant or an extract thereof, the plant being selected from among common juniper, togenashi, rosehip, areca, polygala root, plantago herb, calumba, zuikorodoku, garden nasturtium, kidachiumanosuzukusa, bayberry, cogon grass, kohon, shoyokanzo, Japanese white birch, tanjin, kikubafuro, white mustard, common sunflower, ground ivy, Chinese wolfberry, Japanese pagota tree, sennenken, common fig, kankatto, Chinese hibiscus, usubaakaza, fenugreek, English walnut, sozuku, koniwa-zakura, gardenia, shima-kan-giku, akamino-akane, futaba-mugura, karoou, schizonepeta spike, purslane, karabyakushi, and prostrate knotweed.

Description

    FIELD OF THE INVENTION
  • The present invention relates to a lipolysis stimulator and a slimming agent.
  • BACKGROUND OF THE INVENTION
  • Obesity arises as a result of accumulation of neutral fat in white adipocytes, due to excessive energy intake over energy expenditure. As has been pointed out, a type of obesity accompanying significant accumulation of visceral fat has some relation with certain pathological conditions such as insulin resistance and arteriosclerosis, and another type of obesity accompanying significant accumulation of subcutaneous fat has become a concern to both men and women from the aesthetic point of view.
  • Hitherto, it has been widely accepted that obesity can be well suppressed, prevented, or reversed by habitual drinking of oolong tea or eucommia leaf tea. Moreover, for suppressing calorie intake, a variety of means have been implemented; e.g., limiting meals, consuming low-energy foods, and taking appetite suppressors or digestion/absorption suppressors. However, habitual drinking of oolong tea or eucommia leaf tea, or suppression of calorie intake, is not necessarily sufficient for preventing or reversing obesity. In addition, such means is difficult for people to accept as a habit. Furthermore, these means are not a radical solution, as they do not stimulate lipolysis of accumulated fat.
  • Incidentally, noradrenaline, adrenaline, and similar hormones in the body have conventionally been known as stimulating lipolysis. For example, compounds such as caffeine and theophylline have been reported to stimulate the lipolysis activity of the hormone (see, for example, Japanese Patent Application Laid-Open (kokai) No. 53-59038). However, long-term administration of such hormones for slimming purposes should be avoided, from the viewpoint of safety.
  • SUMMARY OF THE INVENTION
  • The present invention provides a lipolysis stimulator and a slimming agent, containing as an active ingredient any form of a plant or an extract thereof, the plant being selected from among common juniper, togenashi, rosehip, areca, polygala root, plantago herb, calumba, zuikorodoku, garden nasturtium, kidachiumanosuzukusa, bayberry, cogon grass, kohon, shoyokanzo, Japanese white birch, tanjin, kikubafuro, white mustard, common sunflower, ground ivy, Chinese wolfberry, Japanese pagota tree, sennenken, common fig, kankatto, Chinese hibiscus, usubaakaza, fenugreek, English walnut, sozuku, koniwa-zakura, gardenia, shima-kan-giku, akamino-akane, futaba-mugura, karoou, schizonepeta spike, purslane, karabyakushi, and prostrate knotweed.
  • The present invention also provides a slimming method including applying the plant or an extract thereof to the skin.
  • The present invention also provides use of the plant or an extract thereof in manufacture of a lipolysis stimulator or a slimming agent.
  • DETAILED DESCRIPTION OF THE INVENTION
  • The present invention contemplates provision of a lipolysis stimulator and a slimming agent which stimulate lipolysis of accumulated adipose tissue, in particular, subcutaneous fat, to thereby exert slimming effect with high safety. The present inventors searched for a natural substance which stimulates lipolysis and is safe to human body, and found that a certain plant (such as common juniper) or its extract stimulates lipolysis of neutral fat accumulated in adipose tissue, and is therefore useful as a drug, food, or a cosmetic composition which is capable of providing a slimming effect through suppression, prevention, or reversal of obesity.
  • With the lipolysis stimulator or the slimming agent of the present invention, slimming of the body can be realized through suppression, prevention, or reversal of obesity.
  • In the plants of the present invention, common juniper refers, in its narrow sense, to Juniperus communis which belongs to family Cupressaceae. However, analogous plants belonging to family Juniperus may also be used in the present invention. Similarly, togenashi refers to Rosa normalis belonging to family Rosaceae; rosehip refers to Rosa canina belonging to family Rosaceae; areca refers to Areca catechu belonging to family Palmae; polygala root refers to Polygala tenuifolia belonging to family Polygalaceael; plantago herb refers to Plantago asiatica belonging to family Plantaginaceae; calumba refers to Jaterorhiza columba belonging to family Menispermaceae; zuikorodoku refers to Stellera chamaejasme L. belonging to family Thymelaeaceae; garden nasturtium refers to Trollius chinensis Bge. belonging to family Ranunculaceae; kidachiumanosuzukusa refers to Aristolochia manshuriensis Kom. belonging to family Aristolochiales; bayberry refers to Myrica rubra Sieb. et Zucc. belonging to family Myricaceae; cogon grass refers to Imperata cylindrica belonging to family Imperata cylindrica (L.) P. Beauvois var. koenigii (Retz.) Durand et Schinz. (I. cylindrica), kohon refers to Ligusticum sinense Oliv. belonging to family Apiaceae (Umbelliferae); shoyokanzo refers to Hemerocallis plicata Stapf belonging to family Liliaceae, Japanese white birch refers to Betula platyphylla Suk. Var. japonica (Sieb.) Hara belonging to family Betulaceae; tanjin refers to Saivia miltiorrhiza Bge. belonging to family Lamiacea (Labiatae); kikubafuro refers to Erodium stephanianum Willd. belonging to family Geraniaceae; white mustard refers to Brassica hirta Moench (=B. alba (L.) Boiss.) belonging to family Brassicaceae (Crusiferae); common sunflower refers to Helianthus annuus L. belonging to family Asteraceae; ground ivy refers to Glechoma hederacea L. var. grandis (A. Gary) Kudo (Glechoma hederacea L.) belonging to family Lamiaceae; Chinese wolfberry refers to Lycium chinense Mill., L, barbarum L. belonging to family Solanaceae; Japabese pagota tree refers to Sophora japonica L. belonging to family Fabaceae (Leguminosae); sennenken refers to Homalornena occulta (Lour.) Schott belonging to family Araceae; common fig refers to Ficus carie L. belonging to family Moraceae; kankatto refers to Pueraria thomsonii Benth. belonging to family Fabaceae (Leguminosae); Chinese hibiscus refers to Hibiscus rosa-sinensis L. belonging to familv Malvaceae; usubaakaza refers to Chenopodiumn hybridum L. belonging to family Chenopodiaceae; fenugreek refers to Trigonella foenungraecum L. belonging to family Fabaceae (Leguminosae); English walnut refers to Juglans regia L. belonging to family Juglandaceae; sozuku refers to Alpinia katsumadai Hayata belonging to family Zingiberaceae; koniwa-zakura refers to Prunus humilis Bge. P. japonica Thunb., P. tomentosa thunb. belonging to family Rosaceae; gardenia refers to Gardenia jasminoides Ellis, G. jasminoides Ellis var. grandiflora Nakai belonging to family Chenopodiaceae; shima-kan-giku refers to Chrysanthemum indcum L. belonging to family Asteraceae; akamino-akane refers to Rubia cordifolia L. belonging to family Chenopodiaceae; futaba-mugura refers to Hedyotis diffusa Willd. (=Oldenlandia diffusa (Willd.) Roxb. belonging to family Chenopodiaceae; karoou refers to Lysimachia christinae Hance belonging to family Primulaceae; schizonepeta spike refers to Schizonepeta tenuifolia Briq. belonging to family Lamiaceae (Labiatae); purslane refers to Portulaca oleracea L. belonging to family purslane (Portulaca oleracea); karabyakushi refers to Angelica dahurica Benth. et Hook. var. pai-chi Kimura, Hata et Yen belonging to family Apiaceae (Umbelliferae); and prostrate knotweed refers to Polygonum aviculare L. belonging to family Polygonaceae. Analogous plants belonging to the genera of the above-listed plants may also be employed for the purposes of the present invention.
  • In the present invention, any part of the above-listed plants may be employed as appropriate. For example, the whole plant, leaves, bark, branches, fruits, or roots may be used in their original forms or after processing (milled or pulverized). Preferred portions of plants are as follows: fruit of common juniper; fruit of togenashi; fruit of rosehip; the whole plant of plantago herb; seeds of areca; roots of polygala root; roots of calumba; roots of zuikorodoku; flowers of garden nasturtium; stems of kidachiumanosuzukusa; barks of bayberry; rhizomes of cogon grass; rhizomes of kohon; flowers of shoyokanzo; barks of Japanese white birch; roots of tanjin; the whole plant of kikubafuro; seeds of white mustard; seeds of common sunflower; the whole plant of ground ivy; fruit of Vhinese wolfberry; flowers of Japanese pagota tree; rhizomes of sennenken; fruit of common fig; roots of kankatto; flowers of Chinese hibiscus; the whole plant of usubaakaza; seeds of fenugreek; seeds of English walnut; seeds of sozuku; seeds of koniwa-zakura; fruit of gardenia; flowers of shima-kan-giku; roots of akamino-akane; the whole plant of futaba-mugura; the whole plant of karoou; the whole plant of schizonepeta spike; the whole plant of purslane; roots of karabyakushi; and the whole plant of prostrate knotweed.
  • In the context of the present invention, the word “extract” of any of the above-mentioned plants refers to an extract obtained by subjecting any part of the plant to an extraction procedure at ambient temperature or under heat with an appropriate solvent without use of any special extraction device or through use of a specific extractor such as a Soxhlet's extractor; a diluted solution of an extract; a concentrate of an extract; or a dry powder of an extract.
  • The extraction solvent to be used for obtaining the plant extract of the present invention may be either polar or non-polar solvent. A mixture of a polar and a non-polar solvent may also be employed. Examples of the solvent include water; alcohols such as methanol, ethanol, propanol, and butanol; polyhydric alcohols such as propylene glycol and butylene glycol; ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; linear or cyclic ethers such as tetrahydrofuran and diethyl ether; polyethers such as polyethylene glycol; hydrocarbons such as hexane, cyclohexane, and petroleum ether; aromatic hydrocarbons such as benzene and toluene; pyridines; super critical carbon dioxide; fats and oils; waxes; and other types of oils. Of these materials, water, alcohols, and water-alcohol mixtures are preferred, with water-ethanol mixtures, inter alia, a water-ethanol mixture which contains 20 to 80% (vol/vol) ethanol being particularly preferred.
  • Extraction conditions may differ depending on the solvent employed. When the solvent is water, ethanol, or a water-ethanol mixture, preferably, 1 to 100 parts by weight of solvent is used for 1 part by weight of plant, and extraction is carried out at 5 to 70° C., preferably 10 to 60° C., for 1 hour to 30 days, preferably for 7 days to 14 days.
  • The resultant extract may be used as is, but may also be used after being processed. For example, the extract may be diluted, concentrated, or freeze-dried. Optionally, they may further be processed into a powder or a paste.
  • Alternatively, the extract may be used after subjecting to a liquid-liquid partition or a similar technique, to thereby remove inert contaminants. In the context of the present invention, use of an extract which has undergone such a process is preferred. If desired, the thus-obtained contaminant-free extract may be further subjected to a conventionally known deodorizing or decoloring procedure before use.
  • In the present invention, a plant or an extract thereof may be used as a mixture of two or more species.
  • As described hereinbelow in the Examples section, in rat abdominal subcutaneous adipose tissue, a plant or an extract thereof according to the present invention synergistically potentiates the lipolysis activity of norepinephrine. Therefore, through administration of such a plant or extract to a subject of interest, the body of the subject can be slimmed. Moreover, since the above activity is also exerted in the visceral adipose tissue, a composition which contains an effective amount of the plant or plant extract can serve as a lipolysis stimulator or a slimming agent which exerts suppressing, preventive or reversal effect against obesity; or in other words, the slimming effect. In short, the lipolysis stimulator and the slimming agent of the present invention stimulate lipolysis of neutral fat stored in adipose tissue, in particular, subcutaneous fat, to thereby exhibit suppressing, preventive or reversal effect against obesity; or in other words, the slimming effect. Therefore, the lipolysis stimulator and the slimming agent of the present invention can be used as a cosmetic product, a quasi-drug, a drug, or a food, for body slimming purposes.
  • Although the amount of the active ingredient of the lipolysis stimulator or the slimming agent may differ depending on, for example, the form of that ingredient and the manner of administration, it may be selected from broad ranges. For example, in the case where a product of external use is the target product, the active ingredient is incorporated therein in an amount of 0.005 wt. % or more, preferably 0.01 to 30 wt. %, more preferably 0.2 to 25 wt. %, even more preferably 2 to 20 wt. % (all calculated on a dry basis after extracted with a solvent), with respect to the entirety of the composition, whereas in the case where an orally administered product is the target product, the product preferably contains, in a daily dose for an adult, the active ingredient in an amount of 0.01 to 10 g, preferably 0.1 to 5 g, more preferably 1.0 to 5 g (all calculated on a dry basis after extracted with a solvent).
  • The lipolysis stimulator or the slimming agent of the present invention may optionally contain, according to needs, any suitable combinations of various additives which are used in cosmetics, quasi-drugs, drugs, foods, or the like fields; or various pharmaceutically active ingredients. Examples of the additives include powders such as chalk, talc, fuller's earth, kaolin, starch, rubber, and colloidal silica sodium polyacrylate; oils or oily substances such as mineral oil, vegetable oil, and silicone oil; emulsifiers such as sorbitan trioleate, sorbitan tristearate, glycerol monooleate, and silicone polymer surfactants; preservatives such as p-hydroxybenzoate ester; antioxidants such as butyl hydroxytoluene; wetting agents such as glycerol, sorbitol, 2-pyrrolidone-5-carboxylate, dibutylphthalate, gelatin, and polyethylene glycol; buffers such as lactic acid-base (triethanolamine or sodium hydroxide); surfactants such as glycerol ether, and synthesized, animal, or vegetable ceramides; waxes such as beeswax, ozokerite wax, and paraffin wax; thickening agents; activators; colorants; and perfumes. Examples of the pharmaceutically active ingredients include UV absorbers, anti-inflammatory agents, germicides, antioxidants, vitamins, and pharmaceuticals or natural products with fat metabolism promoting effect or uncoupling protein expression promoting effect (e.g. xanthine derivatives, β-adrenergic stimulants, α-adrenergic inhibitors, bipyridine derivatives, isoflavonic acid, rosisterol, octacosanol, hydroxytyrosol, grapefruit oil, raspberry ketone, zingerone, thistle (Cirsium), family Piperaceae, family Rutaceae, family Menispermaceae, Kigelia plants, Gynostemma pentaphyllum, Atractylodis lanceae Rhizoma, benzoin (Styrax benzoin), Coix lacryma-jobi, azuki bean (Vigna angularis (Willd)), fennel (Foeniculum vulgare), Tabebuia, Geranium thunbergii, Scutellaria baicalensis, peach, garden thyme (Thymus vulgaris), Chinese peony (Paeonia lactiflora), tea leaves, Cola acuminata, Swertia Japonica, Cinnamomi Cortex, Sanguisorba officinalis, sage (Salvia officinalis), loquat (Eriobotrya Japonica (Thunb.) Lindl.), bladderwrack (fucus evanescens), carrot, shuitake mashroom, beefsteak geranium (Saxifraga stolonifera), ginkgo (Ginkgo Biloba), and other vegetable extracts).
  • The lipolysis stimulator and the slimming agent of the present invention may be formulated into external-use products, or alternatively, into internal products, injection products, or any other product forms. Example forms include tablets, capsules, liquids, powders, granules, creams, milky lotions, jells, pastes, cataplasms, plasters, sticks, sheets, and tea bags, and they may be appropriately used for oral administration or for the preparation of foods, external medicines, bath-additives, or body detergents, or may be used during taking a shower.
  • The slimming method according to the present invention is characterized by applying to the body the plant or an extract thereof of the present invention. In the context of the present invention, the expression “slimming method” means an esthetic method performed for achieving a slender body with a favorable look.
  • EXAMPLES
  • The present invention will next be described in more detail by way of examples.
  • Production Example 1
  • Production of a Common Juniper Extract
  • A common juniper extract W (1 mL; product of Maruzen Pharmaceuticals Co., Ltd.), which is an extract of the fruit of common juniper with water as a solvent, was thermally processed at 105° C. for 8 hours, whereby a dry matter of the extract (21 mg) was obtained (Invention product 1).
  • Production Example 2
  • Production of a Togenashi Extract
  • A togenashi extract G (1 mL; product of Maruzen Pharmaceuticals Co., Ltd.), which is an extract of the fruit of togenashi with 50% aqueous 1,3-butylene glycol solution as a solvent, was thermally processed at 105° C. for 8 hours, whereby a dry matter of the extract (9 mg) was obtained (Invention product 2).
  • Production Example 3
  • Production of a Rosehip Extract
  • A Pharcolex Rosa canina E (1 mL; product of Ichimaru Pharcos Co., Ltd.), which is an extract of the fruit of Rosa canina with 50% aqueous ethanol solution as a solvent, was thermally processed at 105° C. for 8 hours, whereby a dry matter of the extract (25 mg) was obtained (Invention product 3).
  • Production Example 4
  • Production of an areca Extract
  • An extract (1 mL) obtained by extracting seeds of areca (10 g) with 50% aqueous ethanol solution as a solvent was thermally processed at 105° C. for 8 hours, whereby a dry matter of the extract (26 mg) was obtained (Invention product 4).
  • Production Example 5
  • Production of a polygala Root Extract
  • An extract (1 mL) obtained by extracting roots of polygala root (10 g) with 50% aqueous ethanol solution as a solvent was thermally processed at 105° C. for 8 hours, whereby a dry matter of the extract (126 mg) was obtained (Invention product 5).
  • Production Example 6
  • Production of a plantago Herb Extract
  • An extract (1 mL) obtained by extracting the whole plant of plantago herb (5 g) with 50% aqueous ethanol solution as a solvent was thermally processed at 105° C. for 8 hours, whereby a dry matter of the extract (34 mg) was obtained (Invention product 6).
  • Production Example 7
  • Production of a Calumba Extract
  • An extract (1 mL) obtained by extracting roots of calumba (10 g) with 50% aqueous ethanol solution as a solvent was thermally processed at 105° C. for 8 hours, whereby a dry matter of the extract (54 mg) was obtained (Invention product 7).
  • Production Example 8
  • Production of a Zuikorodoku Extract
  • To one g of roots of zuikorodoku, 10 mL of 50% aqueous ethanol solution was added, followed by an extraction step at room temperature for 7 days. The resultant extract was found to contain an extract of Invention product 8, which is obtained through thermal treatment at 105° C. for 8 hours, in an amount of 1.24 w/v %.
  • Through a similar procedure, respective extracts as shown in Table 1 (Invention products 9 to 42 and Comparative products 1 to 3) were obtained. In Table 1, “hot water” means that extraction was performed with hot water for one hour. TABLE 1 Evaporation residue Sample Plant Extraction solvent (w/v %) Example garden 50% aqueous ethanol 3.25 product 9 nasturtium Example kidachiumano- 50% aqueous ethanol 1.50 product 10 suzukusa Example bayberry 50% aqueous ethanol 1.80 product 11 Example cogon grass 50% aqueous ethanol 2.74 product 12 Example kohon 50% aqueous ethanol 2.07 product 13 Example shoyokanzo 50% aqueous ethanol 5.36 product 14 Example Japanese white 50% aqueous ethanol 1.45 product 15 birch Example tanjin 50% aqueous ethanol 4.71 product 16 Example kikubafuro 50% aqueous ethanol 1.46 product 17 Example white mustard 50% aqueous ethanol 1.47 product 18 Example common 50% aqueous ethanol 0.82 product 19 sunflower Example ground ivy 50% aqueous ethanol 3.60 product 20 Example Chinese 50% aqueous ethanol 6.05 product 21 wolfberry Example Japanese pagota 50% aqueous ethanol 3.61 product 22 tree Example sennenken 50% aqueous ethanol 1.55 product 23 Example common fig 50% aqueous ethanol 3.05 product 24 Example kankatto 50% aqueous ethanol 1.34 product 25 Example Chinese 50% aqueous ethanol 2.97 product 26 hibiscus Example usubaakaza 50% aqueous ethanol 1.73 product 27 Example fenugreek 50% aqueous ethanol 1.40 product 28 Example English walnut 50% aqueous ethanol 0.72 product 29 Example sozuku 50% aqueous ethanol 0.91 product 30 Example koniwa-zakura 50% aqueous ethanol 0.96 product 31 Example gardenia 50% aqueous ethanol 1.91 product 32 Example shima-kan-giku 50% aqueous ethanol 2.93 product 33 Example akamino-akane 50% aqueous ethanol 1.50 product 34 Example futaba-mugura 50% aqueous ethanol 1.44 product 35 Example karoou 50% aqueous ethanol 1.13 product 36 Example schizonepeta 50% aqueous ethanol 1.02 product 37 Example purslane 50% aqueous ethanol 2.16 product 38 Example karabyakushi 50% aqueous ethanol 1.53 product 39 Example prostrate 50% aqueous ethanol 1.50 product 40 knotweed Example cogon grass hot water 2.98 product 41 Example cogon grass ethanol 1.88 product 42 Comparative oolong tea hot water 12.8 product 1 Comparative oolong tea 30% aqueous ethanol 11.9 product 2 Comparative Eucommia leaf hot water 13.1 product 3 tea
  • Example 1
  • The above-described Example products 1 to 42 and Comparative products 1 to 3 were tested as described below for their lipolysis stimulating activity. The results are shown in Table 2 (Tables 2-1 and 2-2).
  • [Test Method]
  • The Rodbell's method was used (Rodbell, M., J. Biol. Chem., 239, 375 (1964)) Specifically, from the abdominal subcutaneous adipose tissue of each of one to three male Wistar rats (each weighing 150 to 200 g), isolated adipocytes were prepared by use of a collagenase solution. The test material was a dried extract or an extract (liquid form). The prepared cells were incubated at 37° C. for 2 hours in a Hanks buffer solution containing bovine serum albumin to which the test material and norepinephrine were added at a concentration of 10 μg/mL on a dry matter basis and 0.3 μM respectively. The resultant free glycerol was assayed by the enzyme method. As a control, incubation was carried out in the presence of norepinephrine alone (without the test material). Lipolysis stimulation activity was calculated by the following equation. The results obtained from a double run of test are shown.
    Lipolysis stimulation activity (%)=(Released glycerol value in each group)÷(Released glycerol value in control group)×100 TABLE 2 Lipolysis stimulation Sample activity (%) 1) Control 100 Example product 1 221 Example product 2 221 Example product 3 199 Example product 4 186 Example product 5 159 Example product 6 157 Example product 7 150 Example product 8 283 Example product 9 268 Example product 10 341 Example product 11 215 Example product 12 2278 Example product 13 2057 Example product 14 3081 Example product 15 198 Example product 16 192 Example product 17 228 Example product 18 275 Example product 19 256 Example product 20 233 Example product 21 326 Example product 22 238 Example product 23 269 Example product 24 335 Example product 25 256 Example product 26 267 Example product 27 259 Example product 28 669 Example product 29 1577 Example product 30 1363 Example product 31 1835 Example product 32 1166 Example product 33 1424 Example product 34 659 Example product 35 793 Example product 36 431 Example product 37 1271 Example product 38 720 Example product 39 1768 Example product 40 1165 Example product 41 1516 Example product 42 1887 Comparative product 1 105 Comparative product 2 98 Comparative product 3 104
    1) unit = %, The same test was repeated 2-4 times. In the Table, average values are shown (n = 2 to 3).
  • As is apparent from Table 2, when 10 μg/mL of a test material is applied to dissociated adipocytes, clear lipolysis stimulating effect was observed in relation to Example products 1 to 42, whereas when any of Comparative products 1 to 3 was used, no such effect was obtained. Therefore, it has been substantiated that the Example products exhibit lipolysis stimulating effect on adipocytes.

Claims (7)

1-4. (canceled)
5. A slimming method comprising applying a lipolysis stimulator comprising as an active ingredient an aqueous or aqueous ethanol plant extract, the plant being at least one selected from the group consisting of togenashi, rosehip, areca, plantago herb, calumba, zuikorodoku, garden nasturtium, kidachiumanosuzukusa, bayberry, kohon, Japanese white birch, kikubafuro, ground ivy, Japanese pagota tree, sennenken, common fig, kankatto, Chinese hibiscus, usubaakaza, English walnut, sozuku, koniwa-zakura, shima-kan-giku, akamino-akane, futaba-mugura, karoou, schizonepeta spike, purslane, karabyakushi, and prostrate knotweed to the skin of a subject.
6. (canceled)
7. The slimming method of claim 5, wherein said lipolysis stimulator comprises as an active ingredient 0.005 weight (wt.) % or more, calculated on a dry basis of said aqueous or aqueous ethanol plant extract based on the entirety of said composition.
8. The slimming method of claim 5, wherein said lipolysis stimulator comprises as an active ingredient 0.01 to 30 wt. %, calculated on a dry basis of said aqueous or aqueous ethanol plant extract based on the entirety of said composition.
9. The slimming method of claim 5, wherein said lipolysis stimulator comprises as an active ingredient 0.02 to 25 wt. %, calculated on a dry basis of said aqueous or aqueous ethanol plant extract based on the entirety of said composition.
10. The slimming method of claim 5, wherein said lipolysis stimulator comprises as an active ingredient 2 to 20 wt. %, calculated on a dry basis of said aqueous or aqueous ethanol plant extract based on the entirety of said composition.
US11/782,160 2003-07-29 2007-07-24 Lipolysis stimulator Abandoned US20080021418A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2003-203095 2003-07-29
JP2003203095 2003-07-29
JP2004156535A JP4373280B2 (en) 2003-07-29 2004-05-26 Lipolysis accelerator
JP2004-156535 2004-05-26
US10/900,102 US7300675B2 (en) 2003-07-29 2004-07-28 Lipolysis stimulator
US11/782,160 US20080021418A1 (en) 2003-07-29 2007-07-24 Lipolysis stimulator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/782,160 US20080021418A1 (en) 2003-07-29 2007-07-24 Lipolysis stimulator

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/900,102 Division US7300675B2 (en) 2003-07-29 2004-07-28 Lipolysis stimulator

Publications (1)

Publication Number Publication Date
US20080021418A1 true US20080021418A1 (en) 2008-01-24

Family

ID=33543566

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/900,102 Expired - Fee Related US7300675B2 (en) 2003-07-29 2004-07-28 Lipolysis stimulator
US11/782,160 Abandoned US20080021418A1 (en) 2003-07-29 2007-07-24 Lipolysis stimulator

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10/900,102 Expired - Fee Related US7300675B2 (en) 2003-07-29 2004-07-28 Lipolysis stimulator

Country Status (3)

Country Link
US (2) US7300675B2 (en)
EP (1) EP1502598B1 (en)
JP (1) JP4373280B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100285153A1 (en) * 2006-04-07 2010-11-11 Kao Corporation Lipolysis Stimulator
CN107411062A (en) * 2017-05-17 2017-12-01 苟春虎 Matrimony vine weight reducing ferment

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2552311C (en) * 2003-12-30 2013-04-23 Md Bioalpha Co., Ltd. Obesity and metabolic syndrome treatment with tanshinone derivatives which increase metabolic activity
WO2005082391A1 (en) * 2004-03-01 2005-09-09 Kaneka Corporation AGONIST TO HUMAN β3 ADRENALINE RECEPTOR
JP3790767B2 (en) 2004-06-30 2006-06-28 森下仁丹株式会社 Fat metabolism improving composition
JP4672304B2 (en) * 2004-08-04 2011-04-20 丸善製薬株式会社 Lipolysis accelerator
US20060210653A1 (en) * 2005-03-18 2006-09-21 Gardiner Paul T Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition
US7943183B2 (en) 2005-03-18 2011-05-17 Gardiner Paul T Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition
JP5118292B2 (en) * 2005-06-16 2013-01-16 株式会社ロッテ Lipolysis accelerator
JP5285213B2 (en) * 2006-03-16 2013-09-11 株式会社ロッテ Lipolysis accelerator
JP5222482B2 (en) * 2006-04-07 2013-06-26 花王株式会社 Lipolysis accelerator
WO2007133721A2 (en) * 2006-05-12 2007-11-22 Interleukin Genetics, Inc. Food compositions and methods of treating periodontal disease
JP2010503644A (en) * 2006-09-18 2010-02-04 ソシエテ・デクスプロワタシオン・デ・プロデュイ・プール・レ・アンデュストリー・シミック・セピックSociete D’Exploitation De Produits Pour Les Industries Chimiques Seppic Use of quinoa extract as a cosmetic and slimming agent and / or to prevent the formation of new fat in the human body
JP2008081440A (en) * 2006-09-27 2008-04-10 Noevir Co Ltd Aromatase activity promoter
JP4995543B2 (en) * 2006-11-13 2012-08-08 花王株式会社 Emulsified cosmetics
JP2008120730A (en) * 2006-11-13 2008-05-29 Kao Corp Gel-shaped cosmetic
JP2008137957A (en) * 2006-12-04 2008-06-19 Kao Corp Bathing agent
JP2008143842A (en) * 2006-12-11 2008-06-26 Kao Corp Massaging cosmetic
JP5201832B2 (en) * 2006-12-25 2013-06-05 花王株式会社 Skin external preparation for promoting lipolysis
JP2007197440A (en) * 2007-01-16 2007-08-09 Kao Corp Method of cosmetic slimming
JP5383001B2 (en) * 2007-03-20 2014-01-08 株式会社ノエビア Skin preparations, moisturizers, anti-aging agents, antioxidants, anti-inflammatory agents, whitening agents, and slimming agents
JP5171097B2 (en) * 2007-04-17 2013-03-27 花王株式会社 Heparin-binding epidermal growth factor-like growth factor gene expression promoter containing plant extract
KR100813222B1 (en) * 2007-06-08 2008-03-13 주식회사 뉴젝스 Medicinal herbal extract having anti-obesity effect
JP2009046465A (en) * 2007-07-23 2009-03-05 Maruzen Pharmaceut Co Ltd Skin cosmetic and food/drink
EP2194995A1 (en) * 2007-08-27 2010-06-16 DSM IP Assets B.V. Tryptase inhibiting mustard extract
FR2921270B1 (en) * 2007-09-25 2012-08-10 Limousine D Applic Biolog Ditesilab Soc Ind USE OF ACTIVE INGREDIENTS ON ATGL AND / OR CGI-58 PROTEINS.
JP2009091317A (en) * 2007-10-10 2009-04-30 Kao Corp Sheet-like cosmetic
KR100941800B1 (en) * 2007-10-19 2010-02-10 배지현 Formulation of antimicrobial film, coatings and/or sprays containing Portulaca oleracea extract
US8613960B2 (en) * 2008-01-30 2013-12-24 Harunobu Amagase Formulations and methods for reducing waist circumference
JP2010150207A (en) * 2008-12-26 2010-07-08 Noevir Co Ltd Moisturizer, anti-aging agent, antioxidant, neutral fat-accumulation inhibitor, skin whitening agent, anti-inflammatory agent, immunostimulator, skin care preparation, oral medication
WO2011043212A1 (en) * 2009-10-05 2011-04-14 花王株式会社 Ceramide production enhancer and moisturizing agent
JP2012012385A (en) * 2010-05-31 2012-01-19 Shiseido Co Ltd Sympathetic nerve activator, and cosmetic, food and sundries containing the same
FR2966700B1 (en) 2010-10-29 2013-01-11 Bernard Mompon PROCESS FOR THE PRODUCTION OF PLANT-ORIGIN ARTICLES IMPREGNATED WITH PLANT LIQUID SUBSTANCE
JP5999957B2 (en) * 2012-03-30 2016-09-28 株式会社 資生堂 APJ activator
KR101505901B1 (en) 2012-04-26 2015-03-31 한국생명공학연구원 Pharmaceutical composition containing Alpinia katsumadai extract, fractions thereof or isolated triterpenoid compounds for prevention or treatment of metabolic disease
KR101406126B1 (en) * 2012-08-20 2014-06-12 도종묵 Composition containing Hedyotis diffusa extract for treating or preventing obesity
CN102960503A (en) * 2012-11-08 2013-03-13 慕知君 Ten-treasure health care covered-bowl tea and preparation method thereof
US10293009B2 (en) 2012-12-26 2019-05-21 Korea Food Research Institute Pharmaceutical or food composition comprising Oldenlandia brachypoda, Spergularia marina, Disporum smilacinum, Persicaria posumbu, or Geum aleppicum
ES2633187T3 (en) 2013-06-24 2017-09-19 Mottainai Biomass Research Corporation Natural binder derived from lipophilic spinal fibers (internal fibers of stems or crushed peduncles) separated from stalks or peduncles of sunflowers for processed foods and processed foods containing it
TWI507390B (en) * 2013-08-01 2015-11-11 Lee Ching Kuo Melanogenesis-inhibitory constituents of ligusticum sinense
WO2015014497A1 (en) * 2013-08-02 2015-02-05 Schweitzer-Mauduit International, Inc. Edible product comprising reconstituted plant material
CN106456680A (en) * 2013-08-20 2017-02-22 施韦特-莫迪国际公司 Product comprising a plant for medicinal, cosmetic, coloring or dermatologic use
JP2015086168A (en) * 2013-10-30 2015-05-07 株式会社ブルーム・クラシック Lipase inhibitor, and skin cosmetic for sebum control
CN103621504A (en) * 2013-11-26 2014-03-12 内蒙古自治区农牧业科学院 Stellera chamaejasme microemulsion and preparation method thereof
JP2014133749A (en) * 2014-04-03 2014-07-24 Pola Chem Ind Inc Autonomic nerve activator
JP6047545B2 (en) * 2014-12-09 2016-12-21 コリア インスティテュート オブ オリエンタル メディシン A pharmaceutical composition for preventing or treating obesity, comprising a combined extract of Sangpaxo, Kyo-Oh and Onji

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863804A (en) * 1956-09-11 1958-12-09 Alex M Fuqua Method of treating mange with extract of cedar leaf
US4288433A (en) * 1976-11-08 1981-09-08 L'oreal Cosmetic compositions having a slimming action
JPS6490131A (en) * 1987-09-30 1989-04-06 Shiseido Co Ltd Lipase inhibitor
US5376371A (en) * 1989-10-27 1994-12-27 Indena S.P.A. Compositions for treating fat deposits in humans
US5436230A (en) * 1991-01-14 1995-07-25 L'oreal Use of a growth factor in a slimming composition
US5667793A (en) * 1996-08-02 1997-09-16 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Skin care compositions for treating cellulite
JPH09286734A (en) * 1996-04-23 1997-11-04 Nippon Flour Mills Co Ltd Glycerophosphate dehydrogenase inhibitor
JPH09286737A (en) * 1996-04-23 1997-11-04 Nippon Flour Mills Co Ltd Glycerophosphate dehydrogenase inhibitor
US5705170A (en) * 1995-10-24 1998-01-06 Plantech International, Inc. Herbal cellulite treatments
US5728393A (en) * 1993-11-26 1998-03-17 L'oreal Process for combating adiposity and compositions which may be used for this purpose
US5945107A (en) * 1997-12-08 1999-08-31 Natural Medio Tech A/S Compositions and methods for weight reduction
US5972340A (en) * 1996-05-31 1999-10-26 Dos Santos; Georgina Slimming cream based on plants
CN1314142A (en) * 2000-03-20 2001-09-26 李哲 Natural plant defat bath lotion
JP2002087974A (en) * 2000-09-12 2002-03-27 Maruzen Pharmaceut Co Ltd Prophylactic and therapeutic agent for inflammatory disease
US20020197338A1 (en) * 2000-06-06 2002-12-26 Tseng Albert Peng Sheng Botanical composition and methods for the treatment or prevention of obesity
JP2003192605A (en) * 2001-12-27 2003-07-09 Fancl Corp Lipase inhibitant
US6956058B2 (en) * 2001-04-26 2005-10-18 Kao Corporation Method for improving insulin resistance
US20090082285A1 (en) * 2003-03-03 2009-03-26 San-Ei Gen F.F.I., Inc. Adiponectin expression promoter

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE236446C (en)
DE277061C (en)
FR4582M (en) 1900-01-01
GB689533A (en) 1948-10-01 1953-04-01 Erich Scharps Process for the preparation of a medicament
DE3414743C2 (en) * 1984-04-18 1987-01-08 Hans-Guenther 8000 Muenchen De Stadelmayr
FR2576212B1 (en) * 1985-01-21 1988-09-23 Simard Jean Pierre Method and product for loss, containing essential oils
ES2049661B1 (en) 1992-10-09 1994-11-01 Imbeal S A Lab Anti-cellulite compound and procedure for obtaining the same.
FR2716374B1 (en) 1994-02-18 1996-04-19 Sederma Sa New cosmetic or dermopharmaceutical compositions containing plant extracts.
BE1009545A6 (en) 1995-08-17 1997-05-06 Schorpion Eric Weight reduction nutritional supplement
JP3768626B2 (en) * 1996-12-02 2006-04-19 株式会社カネボウ化粧品 Lipolysis promoter and slimming skin cosmetics
CN1059826C (en) * 1997-11-14 2000-12-27 河南省科学院生物研究所 Liquor for slimming abdomen
FR2781231B1 (en) * 1998-07-17 2002-01-25 Sederma Sa SLIMMING COSMETIC COMPOSITIONS
JP2000063227A (en) * 1998-08-20 2000-02-29 Shiseido Co Ltd Agent for stimulating degradation of lipid and skin preparation for external use and for slimming body
JP3604123B2 (en) * 1998-08-20 2004-12-22 株式会社資生堂 Lipid degradation promoter and skin external preparation for slimming
JP2982872B1 (en) * 1998-09-10 1999-11-29 有限会社松川化学 External preparation for slimming skin
CN1434717A (en) * 2000-02-29 2003-08-06 M.H.F.国际株式会社 Medicine for treating obesity and method of producing and use thereof
CN1339309A (en) * 2000-08-24 2002-03-13 徐超 Preparing process for haw and ginkgo leaf capsule
JP2002138045A (en) * 2000-10-30 2002-05-14 Ichimaru Pharcos Co Ltd Inhibitor for inhibiting differentiation induction of pre- adipocyte
CN1116062C (en) * 2000-12-22 2003-07-30 张志祥 Exterior-applied ointment for lossing weight and its preparing process
JP3615510B2 (en) * 2001-03-27 2005-02-02 日華化学株式会社 Lipase activity enhancer, slimming skin external preparation and slimming bath preparation

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863804A (en) * 1956-09-11 1958-12-09 Alex M Fuqua Method of treating mange with extract of cedar leaf
US4288433A (en) * 1976-11-08 1981-09-08 L'oreal Cosmetic compositions having a slimming action
JPS6490131A (en) * 1987-09-30 1989-04-06 Shiseido Co Ltd Lipase inhibitor
US5376371A (en) * 1989-10-27 1994-12-27 Indena S.P.A. Compositions for treating fat deposits in humans
US5436230A (en) * 1991-01-14 1995-07-25 L'oreal Use of a growth factor in a slimming composition
US5728393A (en) * 1993-11-26 1998-03-17 L'oreal Process for combating adiposity and compositions which may be used for this purpose
US5705170A (en) * 1995-10-24 1998-01-06 Plantech International, Inc. Herbal cellulite treatments
JPH09286734A (en) * 1996-04-23 1997-11-04 Nippon Flour Mills Co Ltd Glycerophosphate dehydrogenase inhibitor
JPH09286737A (en) * 1996-04-23 1997-11-04 Nippon Flour Mills Co Ltd Glycerophosphate dehydrogenase inhibitor
US5972340A (en) * 1996-05-31 1999-10-26 Dos Santos; Georgina Slimming cream based on plants
US5667793A (en) * 1996-08-02 1997-09-16 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Skin care compositions for treating cellulite
US5945107A (en) * 1997-12-08 1999-08-31 Natural Medio Tech A/S Compositions and methods for weight reduction
CN1314142A (en) * 2000-03-20 2001-09-26 李哲 Natural plant defat bath lotion
US20020197338A1 (en) * 2000-06-06 2002-12-26 Tseng Albert Peng Sheng Botanical composition and methods for the treatment or prevention of obesity
JP2002087974A (en) * 2000-09-12 2002-03-27 Maruzen Pharmaceut Co Ltd Prophylactic and therapeutic agent for inflammatory disease
US6956058B2 (en) * 2001-04-26 2005-10-18 Kao Corporation Method for improving insulin resistance
JP2003192605A (en) * 2001-12-27 2003-07-09 Fancl Corp Lipase inhibitant
US20090082285A1 (en) * 2003-03-03 2009-03-26 San-Ei Gen F.F.I., Inc. Adiponectin expression promoter

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Hasegawa, N et al. Phytother Res.2002 Mar;16 Suppl 1 :$91-2. Vitamin C is one of the lipolytic substances in green tea. *
Hasegawa, N et al. Phytother Res.2002 Mar;16 Suppl 1:S91-2. Vitamin C is one of the lipolytic substances in green tea. *
http://www.b-and-t-world-seeds.com/carth.asp?species=Betula%20platyphylla&sref=412. B & T World Seeds: "Betula platyphylla". Downloaded from the world wide web on 5/29/2010. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100285153A1 (en) * 2006-04-07 2010-11-11 Kao Corporation Lipolysis Stimulator
US8197859B2 (en) 2006-04-07 2012-06-12 Kao Corporation Lipolysis stimulator
CN107411062A (en) * 2017-05-17 2017-12-01 苟春虎 Matrimony vine weight reducing ferment

Also Published As

Publication number Publication date
JP4373280B2 (en) 2009-11-25
EP1502598A2 (en) 2005-02-02
US7300675B2 (en) 2007-11-27
EP1502598B1 (en) 2016-11-02
EP1502598A3 (en) 2005-03-30
US20050064049A1 (en) 2005-03-24
JP2005060366A (en) 2005-03-10

Similar Documents

Publication Publication Date Title
KR101728449B1 (en) Combination of active components inducing synergy effects of multi-targeting
CN103906526B (en) Using medicinal flower parcel fermentation process and utilize its Dermatologic preparation composition
CN101277713B (en) Composition for acceleration of type I collagen production
US7198804B2 (en) Crude drug composition for preventing and treating gastrointestinal dyskinetic diseases
CN103432043B (en) Face mask containing plant material residues
Umadevi et al. Traditional and medicinal uses of Withania somnifera
KR100586813B1 (en) Extract of herbal mixture and health food for prevention or treatment of osteoporosis
KR20080032127A (en) Agent for hair growth
CN101698028B (en) Fat-reducing and weight-losing composite and preparation method thereof
KR20030020908A (en) Cosmetic composition using fermentation of natural herb medicine
KR100998225B1 (en) Composition for immune enhancement comprising the extract of Young antler, Cornus officinalis, Ligusticum acutilobum, Chinese matrimony vine, Yam, Aurantii nobilis pericarpium, Gastrodia elata blume, Agastache rugosa, Cinnamomum loureirii, Ginseng steamed red and Schizandra chinensis, as an active ingredient
KR101310970B1 (en) Oriental medicine extract for prevention of alopecia and hair article composition
KR101279598B1 (en) Composition for immune enhancement comprising the extract of Young antler, Cornus officinalis, Ligusticum acutilobum, Aurantii nobilis pericarpium, Chinese matrimony vine, lotus root, Yam, Curcuma aromatica Salisb, Gastrodia elata blume, Agastache rugosa, Cinnamomum loureirii, Ginseng steamed red and Schizandra chinensis, as active ingredient
JPWO2007004390A1 (en) Cachexia improving preparation and cachexia improving food
CN101444273A (en) Health product oral fast-release preparation and production method thereof
JP4647991B2 (en) SCF expression inhibitor
WO2009133998A1 (en) Medicinal plants extract using processing of herbal medicine and composition of skin external application comprising the same
FR2673840A1 (en) Cosmetic or pharmaceutical composition, particularly dermatological, containing oxyacanthin, particularly for stimulating the push of hair or for delaying their fall.
CN103918830B (en) A kind of warm tea beverage
CA2105073A1 (en) Pharmaceutical compositions for the treatment of skin disorders
CN101703221B (en) Food supplement for incretion regulation, blood enrichment, skin maintenance, hairdressing and speckle removal and preparation method thereof
JP2006111560A (en) Ceramide synthesis promoter
KR101758998B1 (en) Composition for preventing hair loss and improving hair growth comprising plant extract
KR101221417B1 (en)