JP2003534337A5 - - Google Patents
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- Publication number
- JP2003534337A5 JP2003534337A5 JP2001586279A JP2001586279A JP2003534337A5 JP 2003534337 A5 JP2003534337 A5 JP 2003534337A5 JP 2001586279 A JP2001586279 A JP 2001586279A JP 2001586279 A JP2001586279 A JP 2001586279A JP 2003534337 A5 JP2003534337 A5 JP 2003534337A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- thiazol
- chloro
- acetyl
- methylbenzenesulfonamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 14
- 150000002431 hydrogen Chemical group 0.000 description 14
- 239000001257 hydrogen Substances 0.000 description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 7
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 description 5
- -1 4-bromo-5-chloro-2-thienyl Chemical group 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
- 229910052736 halogen Inorganic materials 0.000 description 5
- 150000002367 halogens Chemical group 0.000 description 5
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 5
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 4
- 125000004104 aryloxy group Chemical group 0.000 description 4
- PPXUHEORWJQRHJ-UHFFFAOYSA-N ethyl isovalerate Chemical compound CCOC(=O)CC(C)C PPXUHEORWJQRHJ-UHFFFAOYSA-N 0.000 description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 4
- 229920002554 vinyl polymer Polymers 0.000 description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 3
- UMGDCJDMYOKAJW-UHFFFAOYSA-N aminothiocarboxamide Natural products NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 description 2
- RAIPHJJURHTUIC-UHFFFAOYSA-N 1,3-thiazol-2-amine Chemical compound NC1=NC=CS1 RAIPHJJURHTUIC-UHFFFAOYSA-N 0.000 description 2
- AQRONHMIKZUPDV-UHFFFAOYSA-N 2,4-dichloro-6-methyl-n-(4-pentyl-1,3-thiazol-2-yl)benzenesulfonamide Chemical compound CCCCCC1=CSC(NS(=O)(=O)C=2C(=CC(Cl)=CC=2C)Cl)=N1 AQRONHMIKZUPDV-UHFFFAOYSA-N 0.000 description 2
- YONLSQQDISIPRX-UHFFFAOYSA-N 3-chloro-2-methyl-n-(4-methyl-1,3-thiazol-2-yl)benzenesulfonamide Chemical compound CC1=CSC(NS(=O)(=O)C=2C(=C(Cl)C=CC=2)C)=N1 YONLSQQDISIPRX-UHFFFAOYSA-N 0.000 description 2
- LLKPYCDTFPVDSU-UHFFFAOYSA-N 3-chloro-2-methyl-n-(4-methyl-5-propyl-1,3-thiazol-2-yl)benzenesulfonamide Chemical compound CC1=C(CCC)SC(NS(=O)(=O)C=2C(=C(Cl)C=CC=2)C)=N1 LLKPYCDTFPVDSU-UHFFFAOYSA-N 0.000 description 2
- ZMOURMHOEOISKY-UHFFFAOYSA-N 3-chloro-2-methyl-n-(4-propan-2-yl-1,3-thiazol-2-yl)benzenesulfonamide Chemical compound CC(C)C1=CSC(NS(=O)(=O)C=2C(=C(Cl)C=CC=2)C)=N1 ZMOURMHOEOISKY-UHFFFAOYSA-N 0.000 description 2
- MQKRAYBWXSMTEC-UHFFFAOYSA-N 3-chloro-2-methyl-n-(4-propyl-1,3-thiazol-2-yl)benzenesulfonamide Chemical compound CCCC1=CSC(NS(=O)(=O)C=2C(=C(Cl)C=CC=2)C)=N1 MQKRAYBWXSMTEC-UHFFFAOYSA-N 0.000 description 2
- FKBBDKZYXDJBGC-UHFFFAOYSA-N 3-chloro-n-(4-ethenyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)NC1=NC(C=C)=CS1 FKBBDKZYXDJBGC-UHFFFAOYSA-N 0.000 description 2
- ZLIJGGLRZJYQFO-UHFFFAOYSA-N 3-chloro-n-(4-ethyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide Chemical compound CCC1=CSC(NS(=O)(=O)C=2C(=C(Cl)C=CC=2)C)=N1 ZLIJGGLRZJYQFO-UHFFFAOYSA-N 0.000 description 2
- OREQNKNJTKBWIJ-UHFFFAOYSA-N 3-chloro-n-(4-ethyl-5-methyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide Chemical compound S1C(C)=C(CC)N=C1NS(=O)(=O)C1=CC=CC(Cl)=C1C OREQNKNJTKBWIJ-UHFFFAOYSA-N 0.000 description 2
- MNSJVJKRADQCFU-UHFFFAOYSA-N 3-chloro-n-(5-ethyl-4-methyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide Chemical compound CC1=C(CC)SC(NS(=O)(=O)C=2C(=C(Cl)C=CC=2)C)=N1 MNSJVJKRADQCFU-UHFFFAOYSA-N 0.000 description 2
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 2
- KNKUKOSDOPKXJS-UHFFFAOYSA-N ethyl 2-[(2,4-dichloro-6-methylphenyl)sulfonylamino]-4-methyl-1,3-thiazole-5-carboxylate Chemical compound CC1=C(C(=O)OCC)SC(NS(=O)(=O)C=2C(=CC(Cl)=CC=2C)Cl)=N1 KNKUKOSDOPKXJS-UHFFFAOYSA-N 0.000 description 2
- HJDYIOHXQBXMQA-UHFFFAOYSA-N ethyl 2-[(3-chloro-2-methylphenyl)sulfonylamino]-4-methyl-1,3-thiazole-5-carboxylate Chemical compound CC1=C(C(=O)OCC)SC(NS(=O)(=O)C=2C(=C(Cl)C=CC=2)C)=N1 HJDYIOHXQBXMQA-UHFFFAOYSA-N 0.000 description 2
- IUOAAYAMNDKEHN-UHFFFAOYSA-N ethyl 3-[2-[(2,4-dichloro-6-methylphenyl)sulfonylamino]-1,3-thiazol-4-yl]-3-methylbutanoate Chemical compound CCOC(=O)CC(C)(C)C1=CSC(NS(=O)(=O)C=2C(=CC(Cl)=CC=2C)Cl)=N1 IUOAAYAMNDKEHN-UHFFFAOYSA-N 0.000 description 2
- KZNGELWLMODZPT-UHFFFAOYSA-N ethyl 4-methyl-2-[(2,4,6-trichlorophenyl)sulfonylamino]-1,3-thiazole-5-carboxylate Chemical compound CC1=C(C(=O)OCC)SC(NS(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)=N1 KZNGELWLMODZPT-UHFFFAOYSA-N 0.000 description 2
- VVBJTZJDNHUXFS-UHFFFAOYSA-N ethyl 4-methyl-2-[(4-phenylphenyl)sulfonylamino]-1,3-thiazole-5-carboxylate Chemical compound CC1=C(C(=O)OCC)SC(NS(=O)(=O)C=2C=CC(=CC=2)C=2C=CC=CC=2)=N1 VVBJTZJDNHUXFS-UHFFFAOYSA-N 0.000 description 2
- QQEZVIJOZCZTID-UHFFFAOYSA-N ethyl 4-methyl-2-[(4-propylphenyl)sulfonylamino]-1,3-thiazole-5-carboxylate Chemical compound C1=CC(CCC)=CC=C1S(=O)(=O)NC1=NC(C)=C(C(=O)OCC)S1 QQEZVIJOZCZTID-UHFFFAOYSA-N 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 2
- RBZGUHWMMJOALQ-UHFFFAOYSA-N n-(4-butyl-1,3-thiazol-2-yl)-3-chloro-2-methylbenzenesulfonamide Chemical compound CCCCC1=CSC(NS(=O)(=O)C=2C(=C(Cl)C=CC=2)C)=N1 RBZGUHWMMJOALQ-UHFFFAOYSA-N 0.000 description 2
- BPTHAAUNEWLQSY-UHFFFAOYSA-N n-(4-tert-butyl-1,3-thiazol-2-yl)-3-chloro-2-methylbenzenesulfonamide Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)NC1=NC(C(C)(C)C)=CS1 BPTHAAUNEWLQSY-UHFFFAOYSA-N 0.000 description 2
- CFQCDGGNFHOXTH-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2,4,5-trichlorobenzenesulfonamide Chemical compound CC1=C(C(=O)C)SC(NS(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)=N1 CFQCDGGNFHOXTH-UHFFFAOYSA-N 0.000 description 2
- KHQBTIINCMGCHV-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2,4,6-trichlorobenzenesulfonamide Chemical compound CC1=C(C(=O)C)SC(NS(=O)(=O)C=2C(=CC(Cl)=CC=2Cl)Cl)=N1 KHQBTIINCMGCHV-UHFFFAOYSA-N 0.000 description 2
- UHHBLIGTCQFIQL-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2,4-dichloro-6-methylbenzenesulfonamide Chemical compound CC1=C(C(=O)C)SC(NS(=O)(=O)C=2C(=CC(Cl)=CC=2C)Cl)=N1 UHHBLIGTCQFIQL-UHFFFAOYSA-N 0.000 description 2
- XBFJEUAGXOUBKK-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2,6-dichlorobenzenesulfonamide Chemical compound CC1=C(C(=O)C)SC(NS(=O)(=O)C=2C(=CC=CC=2Cl)Cl)=N1 XBFJEUAGXOUBKK-UHFFFAOYSA-N 0.000 description 2
- HAUBHWUSJGRODE-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-bromo-1,4-difluorocyclohexa-2,4-diene-1-sulfonamide Chemical compound CC1=C(C(=O)C)SC(NS(=O)(=O)C2(F)C=C(Br)C(F)=CC2)=N1 HAUBHWUSJGRODE-UHFFFAOYSA-N 0.000 description 2
- UJTUJQVBTGZREF-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-chloro-2-methylbenzenesulfonamide Chemical compound CC1=C(C(=O)C)SC(NS(=O)(=O)C=2C(=C(Cl)C=CC=2)C)=N1 UJTUJQVBTGZREF-UHFFFAOYSA-N 0.000 description 2
- QTAPTYOHUUDPKW-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-(3-chloro-2-cyanophenoxy)benzenesulfonamide Chemical compound CC1=C(C(=O)C)SC(NS(=O)(=O)C=2C=CC(OC=3C(=C(Cl)C=CC=3)C#N)=CC=2)=N1 QTAPTYOHUUDPKW-UHFFFAOYSA-N 0.000 description 2
- ACRDEWAKELMRBD-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-chlorobenzenesulfonamide Chemical compound CC1=C(C(=O)C)SC(NS(=O)(=O)C=2C=CC(Cl)=CC=2)=N1 ACRDEWAKELMRBD-UHFFFAOYSA-N 0.000 description 2
- YMROFWINSIVBQO-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-phenylbenzenesulfonamide Chemical compound CC1=C(C(=O)C)SC(NS(=O)(=O)C=2C=CC(=CC=2)C=2C=CC=CC=2)=N1 YMROFWINSIVBQO-UHFFFAOYSA-N 0.000 description 2
- SIYKFXOWZBEVSI-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-propylbenzenesulfonamide Chemical compound C1=CC(CCC)=CC=C1S(=O)(=O)NC1=NC(C)=C(C(C)=O)S1 SIYKFXOWZBEVSI-UHFFFAOYSA-N 0.000 description 2
- GFWICMHJJWBKDL-UHFFFAOYSA-N n-(5-butyl-4-methyl-1,3-thiazol-2-yl)-2,4-dichloro-6-methylbenzenesulfonamide Chemical compound CC1=C(CCCC)SC(NS(=O)(=O)C=2C(=CC(Cl)=CC=2C)Cl)=N1 GFWICMHJJWBKDL-UHFFFAOYSA-N 0.000 description 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- 229940124530 sulfonamide Drugs 0.000 description 2
- 150000003456 sulfonamides Chemical class 0.000 description 2
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- HJUGFYREWKUQJT-UHFFFAOYSA-N tetrabromomethane Chemical compound BrC(Br)(Br)Br HJUGFYREWKUQJT-UHFFFAOYSA-N 0.000 description 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 2
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- ILVQJNYBERWUIJ-UHFFFAOYSA-N 3-chloro-2-methyl-n-[4-methyl-5-(2,2,2-trichloroethyl)-1,3-thiazol-2-yl]benzenesulfonamide Chemical compound S1C(CC(Cl)(Cl)Cl)=C(C)N=C1NS(=O)(=O)C1=CC=CC(Cl)=C1C ILVQJNYBERWUIJ-UHFFFAOYSA-N 0.000 description 1
- XXOYUNQCBYNWNL-UHFFFAOYSA-N 4-chloro-n-(4-methyl-1,3-thiazol-2-yl)benzenesulfonamide Chemical compound CC1=CSC(NS(=O)(=O)C=2C=CC(Cl)=CC=2)=N1 XXOYUNQCBYNWNL-UHFFFAOYSA-N 0.000 description 1
- KBQQNRQRLQSXMB-UHFFFAOYSA-N 4-chloro-n-[4-methyl-5-(2,2,2-trichloroethyl)-1,3-thiazol-2-yl]benzenesulfonamide Chemical compound S1C(CC(Cl)(Cl)Cl)=C(C)N=C1NS(=O)(=O)C1=CC=C(Cl)C=C1 KBQQNRQRLQSXMB-UHFFFAOYSA-N 0.000 description 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 description 1
- 201000008980 hyperinsulinism Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- VOVYJLUBJANLEN-UHFFFAOYSA-N n-(4-methyl-1,3-thiazol-2-yl)benzenesulfonamide Chemical compound CC1=CSC(NS(=O)(=O)C=2C=CC=CC=2)=N1 VOVYJLUBJANLEN-UHFFFAOYSA-N 0.000 description 1
- KWYMIRMCLAOGGL-UHFFFAOYSA-N n-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-bromo-5-chlorothiophene-2-sulfonamide Chemical compound CC1=C(C(=O)C)SC(NS(=O)(=O)C=2SC(Cl)=C(Br)C=2)=N1 KWYMIRMCLAOGGL-UHFFFAOYSA-N 0.000 description 1
- LHALODNUSDEBTM-UHFFFAOYSA-N n-(5-bromo-4-tert-butyl-1,3-thiazol-2-yl)-4-chlorobenzenesulfonamide Chemical compound S1C(Br)=C(C(C)(C)C)N=C1NS(=O)(=O)C1=CC=C(Cl)C=C1 LHALODNUSDEBTM-UHFFFAOYSA-N 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 150000003585 thioureas Chemical class 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0001899A SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | New compounds |
| SE0001899-4 | 2000-05-22 | ||
| PCT/SE2001/001156 WO2001090091A1 (en) | 2000-05-22 | 2001-05-22 | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003534337A JP2003534337A (ja) | 2003-11-18 |
| JP2003534337A5 true JP2003534337A5 (https=) | 2008-05-15 |
Family
ID=20279781
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001586278A Abandoned JP2003534336A (ja) | 2000-05-22 | 2001-05-22 | １１−ベータ−ヒドロキシステロイド・デヒドロゲナーゼタイプ１の阻害因子 |
| JP2001586282A Abandoned JP2003534339A (ja) | 2000-05-22 | 2001-05-22 | １１−ベータヒドロキシステロイドデヒドロゲナーゼタイプ１の阻害剤 |
| JP2001586280A Abandoned JP2003534338A (ja) | 2000-05-22 | 2001-05-22 | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 |
| JP2001586279A Abandoned JP2003534337A (ja) | 2000-05-22 | 2001-05-22 | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001586278A Abandoned JP2003534336A (ja) | 2000-05-22 | 2001-05-22 | １１−ベータ−ヒドロキシステロイド・デヒドロゲナーゼタイプ１の阻害因子 |
| JP2001586282A Abandoned JP2003534339A (ja) | 2000-05-22 | 2001-05-22 | １１−ベータヒドロキシステロイドデヒドロゲナーゼタイプ１の阻害剤 |
| JP2001586280A Abandoned JP2003534338A (ja) | 2000-05-22 | 2001-05-22 | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US7618961B2 (https=) |
| EP (4) | EP1283832B1 (https=) |
| JP (4) | JP2003534336A (https=) |
| KR (4) | KR20030016269A (https=) |
| CN (4) | CN1437588A (https=) |
| AR (1) | AR033534A1 (https=) |
| AT (2) | ATE443055T1 (https=) |
| AU (6) | AU6093201A (https=) |
| BR (1) | BR0111099A (https=) |
| CA (4) | CA2408783A1 (https=) |
| DE (3) | DE60139931D1 (https=) |
| EA (1) | EA005274B1 (https=) |
| ES (1) | ES2333846T3 (https=) |
| HU (1) | HUP0302435A3 (https=) |
| IL (4) | IL152790A0 (https=) |
| MX (1) | MXPA02011632A (https=) |
| NO (4) | NO323831B1 (https=) |
| NZ (4) | NZ522507A (https=) |
| PE (1) | PE20020100A1 (https=) |
| PL (1) | PL360137A1 (https=) |
| SE (1) | SE0001899D0 (https=) |
| WO (5) | WO2001090094A1 (https=) |
| ZA (4) | ZA200209364B (https=) |
Families Citing this family (192)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| AU2001276378A1 (en) * | 2000-07-05 | 2002-01-14 | Bayer Aktiengesellschaft | Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme |
| GB0107383D0 (en) * | 2001-03-23 | 2001-05-16 | Univ Edinburgh | Lipid profile modulation |
| AU2007205749B2 (en) * | 2001-11-22 | 2009-04-23 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| RS44204A (sr) * | 2001-11-22 | 2007-06-04 | Biovitrum Ab., | Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1 |
| WO2003044000A1 (en) * | 2001-11-22 | 2003-05-30 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| AU2002353718B2 (en) | 2001-11-22 | 2007-05-10 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| US20030130279A1 (en) * | 2001-11-22 | 2003-07-10 | Guido Kurz | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| RS44304A (sr) * | 2001-11-22 | 2007-06-04 | Biovitrum Ab., | Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1 |
| JP2005529846A (ja) | 2002-01-16 | 2005-10-06 | ユニバーシティ オブ バージニア パテント ファウンデーション | Ａ１アデノシン受容体の２−アミノチアゾールアロステリックエンハンサ |
| WO2003065983A2 (en) * | 2002-02-01 | 2003-08-14 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
| US7338969B2 (en) * | 2002-03-08 | 2008-03-04 | Quonova, Llc | Modulation of pathogenicity |
| EP2141143A3 (en) * | 2002-03-29 | 2010-05-05 | Schering Corporation | Stereoselective alkylation of chiral 2-methyl-4 protected piperazines |
| SE0201194D0 (sv) * | 2002-04-19 | 2002-04-19 | Astrazeneca Ab | New compounds |
| US20030198965A1 (en) | 2002-04-19 | 2003-10-23 | Isis Pharmaceuticals Inc. | Antisense modulation of hydroxysteroid 11-beta dehydrogenase 1 expression |
| AR040241A1 (es) * | 2002-06-10 | 2005-03-23 | Merck & Co Inc | Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| WO2004027047A2 (en) * | 2002-09-18 | 2004-04-01 | Hanauske-Abel Hartmut M | INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE AND USES THEREFOR |
| CA2501611A1 (en) * | 2002-10-11 | 2004-04-22 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors |
| GB0224830D0 (en) | 2002-10-24 | 2002-12-04 | Sterix Ltd | Compound |
| EP1556040A1 (en) * | 2002-10-24 | 2005-07-27 | Sterix Limited | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 and type 2 |
| JP2006514102A (ja) * | 2002-11-07 | 2006-04-27 | アストラゼネカ アクチボラグ | ２−オキソ−エタンスルホンアミド誘導体 |
| GB0226602D0 (en) * | 2002-11-14 | 2002-12-24 | Novartis Ag | Organic compounds |
| AR041952A1 (es) * | 2002-11-14 | 2005-06-01 | Novartis Ag | N-sulfonilaminotiazol |
| JO2397B1 (en) * | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| FR2849598B1 (fr) * | 2003-01-07 | 2006-09-22 | Merck Sante Sas | Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans |
| FR2849599B1 (fr) * | 2003-01-07 | 2006-12-29 | Merck Sante Sas | Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete |
| TW200503994A (en) * | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| DE10314610A1 (de) | 2003-04-01 | 2004-11-04 | Aventis Pharma Deutschland Gmbh | Neues Diphenylazetidinon mit verbesserten physiologischen Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindungen enthaltende Arzneimittel und dessen Verwendung |
| ATE467616T1 (de) * | 2003-04-11 | 2010-05-15 | High Point Pharmaceuticals Llc | Verbindungen mit aktivität an der 11beta- hydroxasteroiddehydrogenase |
| US7700583B2 (en) | 2003-04-11 | 2010-04-20 | High Point Pharmaceuticals, Llc | 11β-hydroxysteroid dehydrogenase type 1 active compounds |
| US7501405B2 (en) | 2003-04-11 | 2009-03-10 | High Point Pharmaceuticals, Llc | Combination therapy using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders |
| DE602004025220D1 (de) | 2003-04-11 | 2010-03-11 | High Point Pharmaceuticals Llc | Pharmazeutische verwendungen von kondensierten 1,2,4-triazolen |
| EP1785424A3 (en) * | 2003-04-11 | 2009-12-23 | High Point Pharmaceuticals, LLC | Fused 1,2,4-triazoles and pharmaceutical uses thereof |
| WO2004103980A1 (en) * | 2003-05-21 | 2004-12-02 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type i |
| US7173030B2 (en) | 2003-05-21 | 2007-02-06 | Biovitrum Ab | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 |
| US8026264B2 (en) | 2003-05-29 | 2011-09-27 | Merck Sharp And Dohme Corp. | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 |
| WO2004113310A1 (en) * | 2003-06-25 | 2004-12-29 | Biovitrum Ab | Use of an inhibitor of 11-b-hydroxysteroid dehydrogenase type 1 compounds for promoting wound healing |
| SE0301883D0 (sv) * | 2003-06-25 | 2003-06-25 | Biovitrum Ab | New use II |
| SE0301885D0 (sv) * | 2003-06-25 | 2003-06-25 | Biovitrum Ab | New use IV |
| SE0301882D0 (sv) * | 2003-06-25 | 2003-06-25 | Biovitrum Ab | New use I |
| SE0301884D0 (sv) * | 2003-06-25 | 2003-06-25 | Biovitrum Ab | New use III |
| AU2004274309B2 (en) | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
| GB0324792D0 (en) | 2003-10-23 | 2003-11-26 | Sterix Ltd | Compound |
| GB0325745D0 (en) * | 2003-11-05 | 2003-12-10 | Astrazeneca Ab | Chemical compounds |
| AP2006003633A0 (en) * | 2003-12-19 | 2006-06-30 | Pfizer | Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-BETA-hydroxysteroid dehydrogenase type 1 (11-BETA-HSD-1) for the treatment of diabetes and obesity |
| JP2007515490A (ja) | 2003-12-22 | 2007-06-14 | アムジェン インコーポレーティッド | アリールスルホンアミド化合物およびそれに関連する使用法 |
| US7875642B2 (en) | 2004-01-26 | 2011-01-25 | Merck Sharp & Dohme Corp. | Crystalline forms of an inhibitor of 11-β-hydroxysteroid dehydrogenase type 1 |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| JP2007261945A (ja) * | 2004-04-07 | 2007-10-11 | Taisho Pharmaceut Co Ltd | チアゾール誘導体 |
| US7402704B2 (en) | 2004-04-14 | 2008-07-22 | Amgen Inc. | Arylsulfones and uses related thereto |
| GB0408771D0 (en) * | 2004-04-20 | 2004-05-26 | Sterix Ltd | Compound |
| JP2007533749A (ja) * | 2004-04-20 | 2007-11-22 | アムゲン インコーポレイティッド | アリールスルホンアミドおよびそれに関連する使用方法 |
| NZ551077A (en) | 2004-05-07 | 2009-05-31 | Janssen Pharmaceutica Nv | Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| CN1964956B (zh) | 2004-05-24 | 2013-03-27 | 安美基公司 | 11-β-羟基类固醇脱氢酶1型的抑制剂 |
| US8686011B2 (en) | 2004-05-24 | 2014-04-01 | Amgen Inc. | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 |
| DK1763517T3 (da) * | 2004-06-28 | 2011-06-06 | Hoffmann La Roche | Pyrimidinderivater som 11beta-HSD1-inhibitorer |
| CA2575339A1 (en) * | 2004-08-05 | 2006-02-09 | F. Hoffmann-La Roche Ag | Substituted n-acyl-2-aminothiazoles |
| DE602005017159D1 (de) | 2004-08-30 | 2009-11-26 | Janssen Pharmaceutica Nv | Oxysteroid-dehydrogenase-inhibitoren |
| BRPI0515121A (pt) | 2004-08-30 | 2008-07-08 | Janssen Pharmaceutica Nv | derivados da n-2 adamantil-2-fenóxi acetamida como inibidores da 11-beta hidroxiesteróide desidrogenase |
| MY141198A (en) | 2004-08-30 | 2010-03-31 | Janssen Pharmaceutica Nv | Tricyclic adamantylamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| WO2006034804A1 (en) | 2004-09-29 | 2006-04-06 | F.Hoffmann-La Roche Ag | Indozolone derivatives as 11b-hsd1 inhibitors |
| EP1799647A1 (en) * | 2004-10-04 | 2007-06-27 | F.Hoffmann-La Roche Ag | Alkil-pyridines as 11-beta inhibitors for diabetes |
| KR101325519B1 (ko) * | 2004-10-14 | 2013-11-08 | 애보트 게엠베하 운트 콤파니 카게 | 도파민 ｄ3 수용체의 조절에 반응하는 장애를 치료하기에적합한 아릴설포닐메틸 또는 아릴설폰아미드 치환된 방향족화합물 |
| WO2006047302A1 (en) | 2004-10-21 | 2006-05-04 | Transtech Pharma, Inc. | Bissulfonamide compounds as agonists of galr1, compositions, and methods of use |
| EP1666467A1 (en) * | 2004-11-08 | 2006-06-07 | Evotec AG | 11Beta-HSD1 Inhibitors |
| EP1659113A1 (en) * | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| WO2006051662A1 (ja) * | 2004-11-09 | 2006-05-18 | Taisho Pharmaceutical Co., Ltd. | チアゾール誘導体 |
| WO2006059507A1 (ja) * | 2004-11-30 | 2006-06-08 | Sankyo Company, Limited | 11β-HSD1アンチセンス化合物 |
| JP2008524244A (ja) * | 2004-12-17 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | 水酸化ステロイド脱水素酵素阻害剤 |
| GB0506133D0 (en) * | 2005-03-24 | 2005-05-04 | Sterix Ltd | Compound |
| EP1866298A2 (en) | 2005-03-31 | 2007-12-19 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| DK1928840T3 (da) | 2005-04-05 | 2011-09-12 | Hoffmann La Roche | 1H-pyrazol-4-carboxamider, deres fremstilling og deres anvendelse som 11-beta-hydroxysteroid-dehydrogenaseinhibitorer |
| CA2609388C (en) | 2005-05-30 | 2013-08-06 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
| AU2006257646A1 (en) * | 2005-06-16 | 2006-12-21 | Pfizer Inc. | N-(pyridin-2-YL)-sulfonamide derivatives |
| WO2006134481A1 (en) * | 2005-06-16 | 2006-12-21 | Pfizer Inc. | Inhibitors of 11-beta hydroxysteroid dehydrogenase type 1 |
| JPWO2007018248A1 (ja) | 2005-08-10 | 2009-02-19 | 萬有製薬株式会社 | ピリドン化合物 |
| EP1921065B1 (en) | 2005-08-24 | 2010-10-20 | Banyu Pharmaceutical Co., Ltd. | Phenylpyridone derivative |
| US7622492B2 (en) | 2005-08-31 | 2009-11-24 | Hoffmann-La Roche Inc. | Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase |
| WO2007029847A1 (ja) | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | 二環性芳香族置換ピリドン誘導体 |
| BRPI0616463A2 (pt) | 2005-09-29 | 2011-06-21 | Merck & Co Inc | composto, composição farmacêutica, e, uso de um composto |
| JP2007099659A (ja) * | 2005-10-03 | 2007-04-19 | Toray Fine Chemicals Co Ltd | ピペラジンカルボン酸エステルの製造法 |
| RU2008118350A (ru) * | 2005-10-12 | 2009-11-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бифенильные производные в качестве модуляторов потенциалзависимых ионных каналов |
| WO2007048027A2 (en) | 2005-10-21 | 2007-04-26 | Novartis Ag | Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent |
| AU2006307046A1 (en) | 2005-10-27 | 2007-05-03 | Msd K.K. | Novel benzoxathiin derivative |
| US8158791B2 (en) | 2005-11-10 | 2012-04-17 | Msd K.K. | Aza-substituted spiro derivatives |
| US20070110802A1 (en) * | 2005-11-15 | 2007-05-17 | Janan Jona | Wet granulation process |
| CA2630718A1 (en) | 2005-11-22 | 2007-05-31 | Amgen Inc. | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| NZ593074A (en) | 2005-12-21 | 2012-04-27 | Vertex Pharma | sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels |
| WO2007076875A2 (en) * | 2006-01-06 | 2007-07-12 | Aarhus Universitet | Compounds acting on the serotonin transporter |
| BRPI0710479A2 (pt) | 2006-01-18 | 2012-08-14 | Hoffmann La Roche | composto, processo para sua preparaÇço, composiÇço farmacÊutica, uso de um composto e mÉtodo de tratamento de doenÇa ou desosrdem metabàlica. |
| EA016959B1 (ru) * | 2006-04-24 | 2012-08-30 | Эли Лилли Энд Компани | Замещенные пирролидиноны в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 типа |
| EP2049475B1 (en) * | 2006-04-24 | 2012-02-01 | Eli Lilly & Company | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| CN101096363B (zh) * | 2006-06-27 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途 |
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| JP5489333B2 (ja) | 2006-09-22 | 2014-05-14 | メルク・シャープ・アンド・ドーム・コーポレーション | 脂肪酸合成阻害剤を用いた治療の方法 |
| AU2007301126A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
| DE102007005045B4 (de) | 2007-01-26 | 2008-12-18 | Sanofi-Aventis | Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CN101668524B (zh) * | 2007-02-12 | 2012-10-24 | 阿斯利康(瑞典)有限公司 | 作为11-β-HSD1抑制剂的吡唑衍生物 |
| JP2010519239A (ja) | 2007-02-23 | 2010-06-03 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | １１−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害因子としてのｎ−アドマンチルベンザミド |
| EP2125704A1 (en) | 2007-02-23 | 2009-12-02 | High Point Pharmaceuticals, LLC | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| ZA200904916B (en) | 2007-02-23 | 2010-09-29 | High Point Pharmaceuticals Llc | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| JP5361857B2 (ja) | 2007-03-23 | 2013-12-04 | ファイザー・リミテッド | イオンチャネルの阻害剤 |
| CA2682727C (en) | 2007-04-02 | 2016-03-22 | Banyu Pharmaceutical Co., Ltd. | Indoledione derivative |
| CN101677562A (zh) * | 2007-04-11 | 2010-03-24 | 高点制药有限责任公司 | 新化合物 |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2527360B1 (en) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| JP5223864B2 (ja) | 2007-06-27 | 2013-06-26 | 大正製薬株式会社 | １１β−ＨＳＤ１阻害活性を有する化合物 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| US20110015181A1 (en) | 2008-03-06 | 2011-01-20 | Makoto Ando | Alkylaminopyridine derivative |
| EP2272841A1 (en) | 2008-03-28 | 2011-01-12 | Banyu Pharmaceutical Co., Ltd. | Diarylmethylamide derivative having antagonistic activity on melanin-concentrating hormone receptor |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AU2009261248A1 (en) | 2008-06-19 | 2009-12-23 | Banyu Pharmaceutical Co., Ltd. | Spirodiamine-diarylketoxime derivative |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| WO2010013595A1 (ja) | 2008-07-30 | 2010-02-04 | 萬有製薬株式会社 | ５員－５員又は５員－６員縮環シクロアルキルアミン誘導体 |
| WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| JP5635991B2 (ja) | 2008-10-30 | 2014-12-03 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | イソニコチンアミドオレキシン受容体アンタゴニスト |
| JP5557845B2 (ja) | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| KR200452117Y1 (ko) * | 2008-11-10 | 2011-02-08 | 대성공업주식회사 | 휠체어용 브레이크 와이어 케이블 지지 브래킷 |
| JP2012509879A (ja) * | 2008-11-21 | 2012-04-26 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | アダマンチルベンズアミド化合物 |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| MX2012001729A (es) | 2009-08-26 | 2012-06-13 | Sanofi Sa | Nuevos hidratos cristalinos de fluoroglicosido heteroaromatico, productos farmaceuticos que comprenden estos compuestos, y su empleo. |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| US8513430B2 (en) | 2010-07-27 | 2013-08-20 | High Point Pharmaceuticals, Llc | Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| BR112013021236B1 (pt) | 2011-02-25 | 2021-05-25 | Merck Sharp & Dohme Corp | composto derivado de benzimidazol, e, composição |
| ES2664873T3 (es) | 2011-03-01 | 2018-04-23 | Synergy Pharmaceuticals Inc. | Proceso de preparación de agonistas de guanilato ciclasa C |
| US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| CN103204824B (zh) * | 2012-01-12 | 2015-04-08 | 清华大学深圳研究生院 | 2-氨基噻唑-4-酰胺类衍生物及其制备方法与应用 |
| US9527875B2 (en) | 2012-08-02 | 2016-12-27 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
| SI3004138T1 (sl) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Limited | Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| KR102431436B1 (ko) | 2014-08-29 | 2022-08-10 | 테스 파마 에스.알.엘. | α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제 |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| CN105001152A (zh) * | 2015-07-19 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 一类二甲胺基二吡啶叔醇结构的11β-HSD1抑制剂及其用途 |
| CN105017135A (zh) * | 2015-07-19 | 2015-11-04 | 佛山市赛维斯医药科技有限公司 | 一类二吡啶叔醇结构的11β-HSD1抑制剂、制备方法及其用途 |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| AR109950A1 (es) | 2016-10-14 | 2019-02-06 | Tes Pharma S R L | INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA |
| CN107663204A (zh) * | 2016-10-19 | 2018-02-06 | 首都医科大学附属北京世纪坛医院 | 一种化合物的抗结核应用 |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| EP3717459B1 (en) | 2017-11-30 | 2026-01-21 | Step Pharma S.A.S. | Compounds |
| WO2019106146A1 (en) | 2017-11-30 | 2019-06-06 | Step Pharma S.A.S. | Compounds |
| JP7214743B2 (ja) | 2018-02-15 | 2023-01-30 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターとしての大環状分子、それらの医薬組成物、嚢胞性線維症の治療におけるそれらの使用、及びそれらの製造方法 |
| CN108358869B (zh) * | 2018-03-27 | 2019-09-10 | 河北师范大学 | 一种n-苯并噻唑基苯磺酰胺类衍生物、制备方法及用途 |
| CN108659219B (zh) * | 2018-06-08 | 2021-02-09 | 扬州大学 | 一种聚苯胺的制备方法 |
| KR102919209B1 (ko) | 2018-08-10 | 2026-01-28 | 다이아핀 테라퓨틱스, 엘엘씨 | 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료 |
| AR117122A1 (es) | 2018-11-20 | 2021-07-14 | Tes Pharma S R L | INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA |
| CN109748831A (zh) * | 2018-12-17 | 2019-05-14 | 南通正达农化有限公司 | 一种三氟甲磺酸三氟乙酯的制备方法 |
| WO2020167701A1 (en) | 2019-02-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | Pyrrolidine orexin receptor agonists |
| US11098029B2 (en) | 2019-02-13 | 2021-08-24 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
| UY38630A (es) | 2019-04-03 | 2020-10-30 | Vertex Pharma | Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| US12312332B2 (en) | 2019-08-08 | 2025-05-27 | Merck Sharp & Dohme Llc | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
| TWI867024B (zh) | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| TWI899097B (zh) | 2019-08-14 | 2025-10-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
| WO2021030552A1 (en) | 2019-08-14 | 2021-02-18 | Vertex Pharmaceuticals Incorporated | Crystalline forms of cftr modulators |
| WO2021101927A1 (en) | 2019-11-18 | 2021-05-27 | Vanderbilt University | Wdr5-myc inhibitors |
| CN111620837B (zh) * | 2020-06-29 | 2022-02-15 | 郑州大学 | 香柏酮噻唑酰胺类化合物、及其制备方法和应用 |
| BR112023002957A2 (pt) | 2020-08-18 | 2023-04-04 | Merck Sharp & Dohme Llc | Composto, composição farmacêutica, e, métodos para tratar narcolepsia e para tratar hipersonia em um sujeito mamífero |
| US20230373974A1 (en) * | 2020-10-07 | 2023-11-23 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| CN112451514A (zh) * | 2020-11-26 | 2021-03-09 | 江西农业大学 | 二氢杨梅素纳米硒及其制备方法和应用 |
| KR20230118123A (ko) | 2020-12-10 | 2023-08-10 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 치료 방법 |
| CN113461635A (zh) * | 2021-07-07 | 2021-10-01 | 上海毕得医药科技股份有限公司 | 4-（2-氯乙基）噻唑-2-羧酸乙酯及其制备方法和应用 |
| CN118103038A (zh) * | 2021-08-20 | 2024-05-28 | 英安塔制药有限公司 | 17β-羟基类固醇脱氢酶13型抑制剂及其使用方法 |
| CN117105824A (zh) * | 2023-08-26 | 2023-11-24 | 衢州市九洲化工有限公司 | 一种三氟甲磺酸三氟乙酯的制备方法 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB517272A (en) | 1938-06-03 | 1940-01-25 | May & Baker Ltd | The preparation of new therapeutically useful heterocyclic compounds |
| GB620654A (en) * | 1939-10-03 | 1949-03-29 | Chinoin Gyogyszer Es Vegyeszet | A process for the preparation of sulphonamide derivatives of 2-amino-thiazole |
| US2611770A (en) * | 1949-04-16 | 1952-09-23 | American Cyanamid Co | N-(2-thiazolyl)-2-hydroxypyridine-5-sulfonamides |
| GB822947A (en) | 1957-01-25 | 1959-11-04 | Smith & Nephew | Improvements in and relating to sulphonamides |
| DE1620508A1 (de) * | 1965-07-23 | 1969-09-18 | Thomae Gmbh Dr K | Verfahren zur Herstellung neuer 4,5,6,7-Tetrahydrothiazolo-[5,4-c]-pyridine |
| CA1088049A (en) | 1975-06-03 | 1980-10-21 | Takashi Masugi | 3-substituted-7-substituted alkanamido-3-cephem-4- carboxylic acid compounds and processes for preparation thereof |
| FR2384498A1 (fr) | 1975-11-26 | 1978-10-20 | Parcor | Nouveaux derives sulfonylamino thiazoliques et leurs applications en medecine humaine et veterinaire |
| EP0246749A3 (en) * | 1986-05-17 | 1988-08-31 | AgrEvo UK Limited | Triazole herbicides |
| US5591761A (en) | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5594021A (en) | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| JPH021483A (ja) | 1988-03-10 | 1990-01-05 | Nippon Tokushu Noyaku Seizo Kk | 農業用殺菌剤 |
| JPH078863B2 (ja) | 1989-09-21 | 1995-02-01 | 久光製薬株式会社 | 新規なジフェニルチアゾール誘導体 |
| DE69206725T2 (de) * | 1991-09-10 | 1996-05-02 | Zeneca Ltd | Benzolsulfonamidderivate als 5-Lipoxygenasehemmer |
| JPH0670024B2 (ja) | 1993-04-13 | 1994-09-07 | 塩野義製薬株式会社 | グルタコン酸エステル誘導体の製法 |
| US6030991A (en) | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| JPH07149745A (ja) * | 1993-11-30 | 1995-06-13 | Hisamitsu Pharmaceut Co Inc | 新規な２−アミノチアゾール誘導体 |
| JPH07149746A (ja) * | 1993-11-30 | 1995-06-13 | Hisamitsu Pharmaceut Co Inc | 新規な２−置換アミノチアゾール誘導体 |
| JPH07309757A (ja) * | 1994-05-18 | 1995-11-28 | Asahi Chem Ind Co Ltd | βアミロイド蛋白神経細胞毒性低減剤 |
| SI0779810T1 (en) | 1994-08-09 | 2003-12-31 | Cortendo Ab | Use of ketoconazole and related substances in medicaments for treatment of type ii diabetes |
| AU689972B2 (en) * | 1994-11-29 | 1998-04-09 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof |
| SE505391C2 (sv) | 1995-05-30 | 1997-08-18 | Cortendo Ab | Användning av kortisol-agonister för framställning av ett system för diagnostisering av det metabola syndromet |
| GB9512697D0 (en) | 1995-06-22 | 1995-08-23 | Zeneca Ltd | Heterocyclic compounds |
| GB9517622D0 (en) * | 1995-08-29 | 1995-11-01 | Univ Edinburgh | Regulation of intracellular glucocorticoid concentrations |
| WO1997047299A1 (en) * | 1996-06-12 | 1997-12-18 | 3-Dimensional Pharmaceuticals, Inc. | Amidino and guanidino heterocyclic protease inhibitors |
| US5877193A (en) | 1996-07-19 | 1999-03-02 | Hoffmann-La Roche Inc. | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides |
| WO1998016520A1 (en) | 1996-10-16 | 1998-04-23 | American Cyanamid Company | The preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| SE9700642D0 (sv) | 1997-02-24 | 1997-02-24 | Kronvall Stefan Med Ab | Medel och sätt för förebyggande och behandling av det metabola syndromet |
| US5783597A (en) | 1997-03-04 | 1998-07-21 | Ortho Pharmaceutical Corporation | 2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and inducible cyclooxygenase (COX-2) enzymes, composition and use |
| AU736256B2 (en) | 1997-07-11 | 2001-07-26 | Smithkline Beecham Plc | Novel compounds |
| GB9725141D0 (en) | 1997-11-27 | 1998-01-28 | Pharmacia & Upjohn Spa | Benzenesulfonamide compounds |
| CA2332325A1 (en) | 1998-06-18 | 1999-12-23 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
| CN1332943C (zh) | 1998-07-08 | 2007-08-22 | 萨诺费－阿文蒂斯德国有限公司 | 硫取代的磺酰基氨基羧酸n－芳基酰胺,其制备方法、用途以及含有该化合物的药物制剂 |
| GB9915625D0 (en) | 1999-07-02 | 1999-09-01 | Cortendo Ab | Method |
| GB0001449D0 (en) | 2000-01-21 | 2000-03-08 | Cortendo Ab | Compositions |
| IT1317735B1 (it) | 2000-01-26 | 2003-07-15 | Nicox Sa | Sali di agenti antimicrobici. |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| AU2002213048A1 (en) | 2000-10-05 | 2002-04-15 | Smith Kline Beecham Corporation | Phosphate transport inhibitors |
| GB0118300D0 (en) | 2001-07-26 | 2001-09-19 | Cortendo Ab | Formulations |
| RS44304A (sr) | 2001-11-22 | 2007-06-04 | Biovitrum Ab., | Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1 |
| AU2002353718B2 (en) | 2001-11-22 | 2007-05-10 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| US20030130279A1 (en) | 2001-11-22 | 2003-07-10 | Guido Kurz | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| RS44204A (sr) | 2001-11-22 | 2007-06-04 | Biovitrum Ab., | Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1 |
-
2000
- 2000-05-22 SE SE0001899A patent/SE0001899D0/xx unknown
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- 2001-05-18 PE PE2001000450A patent/PE20020100A1/es not_active Application Discontinuation
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