GB822947A - Improvements in and relating to sulphonamides - Google Patents

Improvements in and relating to sulphonamides

Info

Publication number
GB822947A
GB822947A GB268457A GB268457A GB822947A GB 822947 A GB822947 A GB 822947A GB 268457 A GB268457 A GB 268457A GB 268457 A GB268457 A GB 268457A GB 822947 A GB822947 A GB 822947A
Authority
GB
United Kingdom
Prior art keywords
butyl
sulphonamides
thiadiazole
preparation
halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB268457A
Inventor
Florence June Macrae
David John Drain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew PLC
TJ Smith and Nephew Ltd
Original Assignee
Smith and Nephew PLC
TJ Smith and Nephew Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith and Nephew PLC, TJ Smith and Nephew Ltd filed Critical Smith and Nephew PLC
Priority to GB268457A priority Critical patent/GB822947A/en
Publication of GB822947A publication Critical patent/GB822947A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention comprises sulphonamides of the formula <FORM:0822947/IV (a)/1> wherein R is an alkyl group, preferably containing 3-6 carbon atoms, and their preparation by reacting a reactive derivative of benzenesulphonic acid such as an ester or halide with a 2-alkyl-5-amino-thiadiazole. Suitably a benzenesulphonyl halide, such as the chloride is reacted in the presence of an acidbinding agent such as pyridine. In an example, the preparation of 2-n-butyl-5-benzenesulphonamide thiadiazole and the corresponding 2-n-propyl-, isopropyl-, isobutyl-, sec-butyl-, tert-butyl- and amyl-derivatives is described.
GB268457A 1957-01-25 1957-01-25 Improvements in and relating to sulphonamides Expired GB822947A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB268457A GB822947A (en) 1957-01-25 1957-01-25 Improvements in and relating to sulphonamides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB268457A GB822947A (en) 1957-01-25 1957-01-25 Improvements in and relating to sulphonamides

Publications (1)

Publication Number Publication Date
GB822947A true GB822947A (en) 1959-11-04

Family

ID=9743962

Family Applications (1)

Application Number Title Priority Date Filing Date
GB268457A Expired GB822947A (en) 1957-01-25 1957-01-25 Improvements in and relating to sulphonamides

Country Status (1)

Country Link
GB (1) GB822947A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3449499A (en) * 1964-01-27 1969-06-10 Rhone Poulenc Sa Method for the reduction of glycemia
WO2003044000A1 (en) * 2001-11-22 2003-05-30 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
WO2003044009A1 (en) * 2001-11-22 2003-05-30 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
WO2004103980A1 (en) * 2003-05-21 2004-12-02 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type i
WO2005042513A1 (en) * 2003-10-23 2005-05-12 Sterix Limited Phenyl carboxamide and sulfonamide derivatives for use as 11-beta-hydroxysteroid dehydrogenase
US7030135B2 (en) 2000-05-22 2006-04-18 Biovitrum Ab Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
US7074788B2 (en) 2001-11-22 2006-07-11 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US7094792B2 (en) 2001-11-22 2006-08-22 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US7173030B2 (en) 2003-05-21 2007-02-06 Biovitrum Ab Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
US7230020B2 (en) 2003-10-23 2007-06-12 Sterix Limited 11β-hydroxysteroid dehydrogenase inhibitors

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3449499A (en) * 1964-01-27 1969-06-10 Rhone Poulenc Sa Method for the reduction of glycemia
US7618961B2 (en) 2000-05-22 2009-11-17 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US7030135B2 (en) 2000-05-22 2006-04-18 Biovitrum Ab Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
US7132436B2 (en) 2000-05-22 2006-11-07 Biovitrum Ab Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
WO2003044000A1 (en) * 2001-11-22 2003-05-30 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
WO2003044009A1 (en) * 2001-11-22 2003-05-30 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US7671051B2 (en) 2001-11-22 2010-03-02 Biovitrum Ab Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
US7074788B2 (en) 2001-11-22 2006-07-11 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US7094792B2 (en) 2001-11-22 2006-08-22 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
WO2004103980A1 (en) * 2003-05-21 2004-12-02 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type i
US7173030B2 (en) 2003-05-21 2007-02-06 Biovitrum Ab Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
US7230020B2 (en) 2003-10-23 2007-06-12 Sterix Limited 11β-hydroxysteroid dehydrogenase inhibitors
WO2005042513A1 (en) * 2003-10-23 2005-05-12 Sterix Limited Phenyl carboxamide and sulfonamide derivatives for use as 11-beta-hydroxysteroid dehydrogenase

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