GB811522A - Improvements in sulphonamides - Google Patents

Improvements in sulphonamides

Info

Publication number
GB811522A
GB811522A GB2268356A GB2268356A GB811522A GB 811522 A GB811522 A GB 811522A GB 2268356 A GB2268356 A GB 2268356A GB 2268356 A GB2268356 A GB 2268356A GB 811522 A GB811522 A GB 811522A
Authority
GB
United Kingdom
Prior art keywords
group
butyl
alkyl
compounds
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2268356A
Inventor
Florence June Macrae
David John Drain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew PLC
TJ Smith and Nephew Ltd
Original Assignee
Smith and Nephew PLC
TJ Smith and Nephew Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith and Nephew PLC, TJ Smith and Nephew Ltd filed Critical Smith and Nephew PLC
Priority to GB2268356A priority Critical patent/GB811522A/en
Publication of GB811522A publication Critical patent/GB811522A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0811522/IV (b)/1> wherein R is an alkyl or cycloalkyl group, preferably an alkyl group of 3-5 carbon atoms, for example a branched chain alkyl group or an n-butyl group. The compounds are made by condensing a reactive derivative of p-toluene sulphonic acid such as a halide or ester with a 2-alkyl - 5 - amino - 1:3:4 - thiadiazole preferably in the presence of an acid-binding agent such as pyridine. In an example the method for the preparation of 2-substituted-5-p-toluenesulphonyl amino-thiadiazoles in which R is a methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec. - butyl, tert. - butyl, n - amyl, n-hexyl, cyclohexyl and n-heptyl group is described in detail.ALSO:Sulphonamides having hypoglycaemic action comprise compounds of the formula <FORM:0811522/VI/1> wherein R is an alkyl or cycloalkyl radical (see Group IV (b)). For test purposes the drugs are administered to rabbits orally in suspension in gum acacia.
GB2268356A 1956-07-23 1956-07-23 Improvements in sulphonamides Expired GB811522A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2268356A GB811522A (en) 1956-07-23 1956-07-23 Improvements in sulphonamides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2268356A GB811522A (en) 1956-07-23 1956-07-23 Improvements in sulphonamides

Publications (1)

Publication Number Publication Date
GB811522A true GB811522A (en) 1959-04-08

Family

ID=10183422

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2268356A Expired GB811522A (en) 1956-07-23 1956-07-23 Improvements in sulphonamides

Country Status (1)

Country Link
GB (1) GB811522A (en)

Similar Documents

Publication Publication Date Title
KR890005086A (en) 1-[(2-pyrimidinyl) aminoalkyl] piperidine, for use in its preparation and treatment
GB989013A (en) New guanidines and process for their manufacture
GB822947A (en) Improvements in and relating to sulphonamides
GB811522A (en) Improvements in sulphonamides
YU35148B (en) Process for obtaining pregnane acid derivatives
GB963373A (en) Improvements in or relating to substituted cobamides
GB981192A (en) Improvements in or relating to 4 hydroxytryptamine esters
GB1110792A (en) Novel 5(10)-dehydro-steroids
GB869007A (en) New heterocyclically substituted steroids
GB824978A (en) Improvements in sulphonamides
GB830012A (en) Phenothiazine derivatives
GB1112909A (en) Ergoline derivatives
SE8703494D0 (en) INTERMEDIATES USEFUL IN THE PREPARATION OF 2-THIOFENEETIC ACETIC ACID DERIVATIVES
GB917944A (en) í~-androstenes and method of preparing the same
GB866838A (en) New sulphonamides and method for preparing same
GB1114166A (en) Anthraquinone dyestuffs
GB975357A (en) 1 substituted isatin-ª‰-thiosemicarbazones,their preparation and pharmaceutical preparations containing them
GB782909A (en) Ethyl esters of substituted thiolbenzoic acids
GB940534A (en) Process for the preparation of new piperidine derivatives
GB884414A (en) Thiopivalic acid esters, and process for the preparation thereof
GB778951A (en) Ethyl esters of thiolcarboxylic acids
GB884883A (en) Diamino-5,8-quinoline-quinone derivatives
GB562314A (en) Process for the manufacture of substituted derivatives of 3-ketotetrahydrothiophene
GB975812A (en) New sulphonamide derivatives
GB924539A (en) Thiamine derivatives