GB824978A - Improvements in sulphonamides - Google Patents
Improvements in sulphonamidesInfo
- Publication number
- GB824978A GB824978A GB386857A GB386857A GB824978A GB 824978 A GB824978 A GB 824978A GB 386857 A GB386857 A GB 386857A GB 386857 A GB386857 A GB 386857A GB 824978 A GB824978 A GB 824978A
- Authority
- GB
- United Kingdom
- Prior art keywords
- butyl
- thiadiazole
- sulphonamides
- chlorobenzenesulphonamido
- hexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
Abstract
The invention comprises sulphonamides of the general formula <FORM:0824978/IV (b)/1> wherein X is a halogen atom and R is an alkyl group preferably containing 3-6 carbon atoms, and their preparation by treating a 2-alkyl-5-amino - 1:3:4 - thiadiazole with a reactive derivative of a p-halogenobenzenesulphonic acid such as a halide or ester. Suitably a phalogenobenzene sulphonyl halide such as the chloride is used in the presence of an acid-binding agent such as pyridine. In an example, the preparation of 2-n-butyl-5-p-chlorobenzenesulphonamido-thiadiazole and the corresponding 2-n-propyl-, isopropyl-, sec.-butyl-, tert.butyl- and n-hexyl-derivatives is described. Specification 811,522 is referred to.ALSO:Sulphonamides of the formula <FORM:0824978/VI/1> where X is a halogen atom and R is an alkyl group (see Group IV (b)) are stated to have a hypoglycaemic action. For test purposes the drugs, for example 5-p-chlorobenzenesulphonamido - 2 - n - butyl - 1 : 3 : 4 - thiadiazole and its 2-tert-butyl and 2-n-hexyl analogues are administered orally to rabbits in suspension in gum acacia. Specification 811,522 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB386857A GB824978A (en) | 1957-02-05 | 1957-02-05 | Improvements in sulphonamides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB386857A GB824978A (en) | 1957-02-05 | 1957-02-05 | Improvements in sulphonamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB824978A true GB824978A (en) | 1959-12-09 |
Family
ID=9766405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB386857A Expired GB824978A (en) | 1957-02-05 | 1957-02-05 | Improvements in sulphonamides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB824978A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3449499A (en) * | 1964-01-27 | 1969-06-10 | Rhone Poulenc Sa | Method for the reduction of glycemia |
-
1957
- 1957-02-05 GB GB386857A patent/GB824978A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3449499A (en) * | 1964-01-27 | 1969-06-10 | Rhone Poulenc Sa | Method for the reduction of glycemia |
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