JP2010506825A5 - - Google Patents
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- Publication number
- JP2010506825A5 JP2010506825A5 JP2009515658A JP2009515658A JP2010506825A5 JP 2010506825 A5 JP2010506825 A5 JP 2010506825A5 JP 2009515658 A JP2009515658 A JP 2009515658A JP 2009515658 A JP2009515658 A JP 2009515658A JP 2010506825 A5 JP2010506825 A5 JP 2010506825A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- methyl
- indol
- group
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 19
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 7
- -1 2-thienylsulfonyl Chemical group 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- CBOSBNKSXLFSCD-UHFFFAOYSA-N 2-[2-[7-[methyl(pyridin-2-ylsulfonyl)amino]-1h-indol-2-yl]-4,5-dihydro-1,3-thiazol-5-yl]acetamide Chemical compound C=1C=CC=NC=1S(=O)(=O)N(C)C(C=1N2)=CC=CC=1C=C2C1=NCC(CC(N)=O)S1 CBOSBNKSXLFSCD-UHFFFAOYSA-N 0.000 claims 2
- OAXSUSZGLQWOOI-UHFFFAOYSA-N 2-[2-[7-[methyl(thiophen-2-ylsulfonyl)amino]-1h-indol-2-yl]-1-thia-3,8-diazaspiro[4.5]dec-2-en-8-yl]acetamide Chemical compound C=1C=CSC=1S(=O)(=O)N(C)C(C=1N2)=CC=CC=1C=C2C(S1)=NCC21CCN(CC(N)=O)CC2 OAXSUSZGLQWOOI-UHFFFAOYSA-N 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 2
- 229940124828 glucokinase activator Drugs 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 125000001064 morpholinomethyl group Chemical group [H]C([H])(*)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 claims 2
- BEYYLQOWGYFPAA-UHFFFAOYSA-N n-[2-[4-(hydroxymethyl)-4,5-dihydro-1,3-thiazol-2-yl]-5-(2-methoxyethoxy)-1h-indol-7-yl]-n-methylpyridine-2-sulfonamide Chemical compound C=12NC(C=3SCC(CO)N=3)=CC2=CC(OCCOC)=CC=1N(C)S(=O)(=O)C1=CC=CC=N1 BEYYLQOWGYFPAA-UHFFFAOYSA-N 0.000 claims 2
- LKZWRIUWVWHYKZ-UHFFFAOYSA-N n-methyl-n-[2-(8-oxa-1-thia-3-azaspiro[4.5]dec-2-en-2-yl)-1h-indol-7-yl]thiophene-2-sulfonamide Chemical compound C=1C=CSC=1S(=O)(=O)N(C)C(C=1N2)=CC=CC=1C=C2C(S1)=NCC21CCOCC2 LKZWRIUWVWHYKZ-UHFFFAOYSA-N 0.000 claims 2
- HYMJWLBAIUGXBW-UHFFFAOYSA-N n-methyl-n-[2-[5-(morpholin-4-ylmethyl)-4,5-dihydro-1,3-thiazol-2-yl]-1h-indol-7-yl]thiophene-2-sulfonamide Chemical compound C=1C=CSC=1S(=O)(=O)N(C)C(C=1N2)=CC=CC=1C=C2C(S1)=NCC1CN1CCOCC1 HYMJWLBAIUGXBW-UHFFFAOYSA-N 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009515658A JP5260507B2 (ja) | 2006-10-19 | 2007-10-18 | インドール化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006285551 | 2006-10-19 | ||
| JP2006285551 | 2006-10-19 | ||
| JP2009515658A JP5260507B2 (ja) | 2006-10-19 | 2007-10-18 | インドール化合物 |
| PCT/JP2007/070772 WO2008050821A1 (en) | 2006-10-19 | 2007-10-18 | Indole compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010506825A JP2010506825A (ja) | 2010-03-04 |
| JP2010506825A5 true JP2010506825A5 (https=) | 2010-10-28 |
| JP5260507B2 JP5260507B2 (ja) | 2013-08-14 |
Family
ID=39010108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009515658A Expired - Fee Related JP5260507B2 (ja) | 2006-10-19 | 2007-10-18 | インドール化合物 |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US7652133B2 (https=) |
| EP (2) | EP2508524A3 (https=) |
| JP (1) | JP5260507B2 (https=) |
| KR (1) | KR101444486B1 (https=) |
| CN (1) | CN101573357B (https=) |
| AU (1) | AU2007310064B2 (https=) |
| BR (1) | BRPI0717722A2 (https=) |
| CA (1) | CA2666973C (https=) |
| CL (1) | CL2008001017A1 (https=) |
| CR (1) | CR10748A (https=) |
| EC (1) | ECSP099330A (https=) |
| GE (1) | GEP20115241B (https=) |
| IL (1) | IL198154A (https=) |
| MA (1) | MA30890B1 (https=) |
| ME (1) | ME00681B (https=) |
| MX (1) | MX2009003972A (https=) |
| MY (1) | MY158052A (https=) |
| NO (1) | NO20091948L (https=) |
| NZ (1) | NZ576570A (https=) |
| PE (1) | PE20090884A1 (https=) |
| RU (1) | RU2454415C9 (https=) |
| TN (1) | TN2009000129A1 (https=) |
| TW (1) | TWI460176B (https=) |
| UA (1) | UA97257C2 (https=) |
| WO (1) | WO2008050821A1 (https=) |
| ZA (1) | ZA200902585B (https=) |
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| JPWO2008136428A1 (ja) | 2007-04-27 | 2010-07-29 | 武田薬品工業株式会社 | 含窒素５員複素環化合物 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CN101801965B (zh) * | 2007-08-17 | 2014-07-30 | 株式会社Lg生命科学 | 作为细胞坏死抑制剂的吲哚化合物 |
| RU2450001C2 (ru) * | 2007-12-20 | 2012-05-10 | Эл Джи Лайф Сайенсиз Лтд. | Активаторы глюкокиназы и фармацевтические композиции, содержащие их в качестве активного ингредиента |
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| EP1632491A1 (en) * | 2004-08-30 | 2006-03-08 | Laboratorios Del Dr. Esteve, S.A. | Substituted indole compounds and their use as 5-HT6 receptor modulators |
| EP2308839B1 (en) * | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| WO2007037543A1 (ja) | 2005-09-29 | 2007-04-05 | Banyu Pharmaceutical Co., Ltd. | ビアリールアミド誘導体 |
| AU2006295645B2 (en) | 2005-09-30 | 2011-09-29 | Msd K.K. | 2-heteroaryl-substituted indole derivative |
| UY31292A1 (es) | 2007-08-14 | 2009-03-31 | Imidazoles biciclicos fusionados | |
| PT2188291E (pt) | 2007-08-14 | 2012-12-20 | Bayer Ip Gmbh | Pirimidinas bicíclicas fundidas |
| JP2011500625A (ja) | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリ置換された１，２，４−トリアゾール |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
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2007
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- 2007-10-18 AU AU2007310064A patent/AU2007310064B2/en not_active Ceased
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- 2007-10-18 TW TW096138971A patent/TWI460176B/zh not_active IP Right Cessation
- 2007-10-18 NZ NZ576570A patent/NZ576570A/en not_active IP Right Cessation
- 2007-10-18 EP EP12170280A patent/EP2508524A3/en not_active Withdrawn
- 2007-10-18 KR KR1020097010151A patent/KR101444486B1/ko not_active Expired - Fee Related
- 2007-10-18 ZA ZA200902585A patent/ZA200902585B/xx unknown
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- 2007-10-18 RU RU2009118602/04A patent/RU2454415C9/ru not_active IP Right Cessation
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- 2007-10-18 GE GEAP200711259A patent/GEP20115241B/en unknown
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