JP2010506825A5 - - Google Patents
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- Publication number
- JP2010506825A5 JP2010506825A5 JP2009515658A JP2009515658A JP2010506825A5 JP 2010506825 A5 JP2010506825 A5 JP 2010506825A5 JP 2009515658 A JP2009515658 A JP 2009515658A JP 2009515658 A JP2009515658 A JP 2009515658A JP 2010506825 A5 JP2010506825 A5 JP 2010506825A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- methyl
- indol
- group
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 19
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 7
- -1 2-thienylsulfonyl Chemical group 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- CBOSBNKSXLFSCD-UHFFFAOYSA-N 2-[2-[7-[methyl(pyridin-2-ylsulfonyl)amino]-1h-indol-2-yl]-4,5-dihydro-1,3-thiazol-5-yl]acetamide Chemical compound C=1C=CC=NC=1S(=O)(=O)N(C)C(C=1N2)=CC=CC=1C=C2C1=NCC(CC(N)=O)S1 CBOSBNKSXLFSCD-UHFFFAOYSA-N 0.000 claims 2
- OAXSUSZGLQWOOI-UHFFFAOYSA-N 2-[2-[7-[methyl(thiophen-2-ylsulfonyl)amino]-1h-indol-2-yl]-1-thia-3,8-diazaspiro[4.5]dec-2-en-8-yl]acetamide Chemical compound C=1C=CSC=1S(=O)(=O)N(C)C(C=1N2)=CC=CC=1C=C2C(S1)=NCC21CCN(CC(N)=O)CC2 OAXSUSZGLQWOOI-UHFFFAOYSA-N 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 2
- 229940124828 glucokinase activator Drugs 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 125000001064 morpholinomethyl group Chemical group [H]C([H])(*)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 claims 2
- BEYYLQOWGYFPAA-UHFFFAOYSA-N n-[2-[4-(hydroxymethyl)-4,5-dihydro-1,3-thiazol-2-yl]-5-(2-methoxyethoxy)-1h-indol-7-yl]-n-methylpyridine-2-sulfonamide Chemical compound C=12NC(C=3SCC(CO)N=3)=CC2=CC(OCCOC)=CC=1N(C)S(=O)(=O)C1=CC=CC=N1 BEYYLQOWGYFPAA-UHFFFAOYSA-N 0.000 claims 2
- LKZWRIUWVWHYKZ-UHFFFAOYSA-N n-methyl-n-[2-(8-oxa-1-thia-3-azaspiro[4.5]dec-2-en-2-yl)-1h-indol-7-yl]thiophene-2-sulfonamide Chemical compound C=1C=CSC=1S(=O)(=O)N(C)C(C=1N2)=CC=CC=1C=C2C(S1)=NCC21CCOCC2 LKZWRIUWVWHYKZ-UHFFFAOYSA-N 0.000 claims 2
- HYMJWLBAIUGXBW-UHFFFAOYSA-N n-methyl-n-[2-[5-(morpholin-4-ylmethyl)-4,5-dihydro-1,3-thiazol-2-yl]-1h-indol-7-yl]thiophene-2-sulfonamide Chemical compound C=1C=CSC=1S(=O)(=O)N(C)C(C=1N2)=CC=CC=1C=C2C(S1)=NCC1CN1CCOCC1 HYMJWLBAIUGXBW-UHFFFAOYSA-N 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009515658A JP5260507B2 (ja) | 2006-10-19 | 2007-10-18 | インドール化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006285551 | 2006-10-19 | ||
| JP2006285551 | 2006-10-19 | ||
| JP2009515658A JP5260507B2 (ja) | 2006-10-19 | 2007-10-18 | インドール化合物 |
| PCT/JP2007/070772 WO2008050821A1 (en) | 2006-10-19 | 2007-10-18 | Indole compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010506825A JP2010506825A (ja) | 2010-03-04 |
| JP2010506825A5 true JP2010506825A5 (https=) | 2010-10-28 |
| JP5260507B2 JP5260507B2 (ja) | 2013-08-14 |
Family
ID=39010108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009515658A Expired - Fee Related JP5260507B2 (ja) | 2006-10-19 | 2007-10-18 | インドール化合物 |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US8410087B2 (https=) |
| EP (2) | EP2508524A3 (https=) |
| JP (1) | JP5260507B2 (https=) |
| KR (1) | KR101444486B1 (https=) |
| CN (1) | CN101573357B (https=) |
| AU (1) | AU2007310064B2 (https=) |
| BR (1) | BRPI0717722A2 (https=) |
| CA (1) | CA2666973C (https=) |
| CL (1) | CL2008001017A1 (https=) |
| CR (1) | CR10748A (https=) |
| EC (1) | ECSP099330A (https=) |
| GE (1) | GEP20115241B (https=) |
| IL (1) | IL198154A (https=) |
| MA (1) | MA30890B1 (https=) |
| ME (1) | MEP11809A (https=) |
| MX (1) | MX2009003972A (https=) |
| MY (1) | MY158052A (https=) |
| NO (1) | NO20091948L (https=) |
| NZ (1) | NZ576570A (https=) |
| PE (1) | PE20090884A1 (https=) |
| RU (1) | RU2454415C9 (https=) |
| TN (1) | TN2009000129A1 (https=) |
| TW (1) | TWI460176B (https=) |
| UA (1) | UA97257C2 (https=) |
| WO (1) | WO2008050821A1 (https=) |
| ZA (1) | ZA200902585B (https=) |
Families Citing this family (87)
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|---|---|---|---|---|
| MY162157A (en) * | 2007-04-16 | 2017-05-31 | Abbott Lab | Substituted indole mcl-1 inhibitors |
| JPWO2008136428A1 (ja) | 2007-04-27 | 2010-07-29 | 武田薬品工業株式会社 | 含窒素５員複素環化合物 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DK2178870T3 (en) * | 2007-08-17 | 2018-10-22 | Lg Chemical Ltd | INDOLE AND INDAZOLIC COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSE |
| KR101133772B1 (ko) * | 2007-12-20 | 2012-04-24 | 주식회사 엘지생명과학 | 글루코키나아제 활성화제 및 이를 활성성분으로 함유하는 약제학적 조성물 |
| US20100291533A1 (en) * | 2008-01-04 | 2010-11-18 | Soon Ha Kim | Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect |
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| US7229986B2 (en) | 2000-05-16 | 2007-06-12 | Takeda Pharmaceutical Company Ltd. | Melanin-concentrating hormone antagonist |
| PL375149A1 (en) * | 2002-10-03 | 2005-11-28 | F.Hoffmann-La Roche Ag | Indole-3-carboxamides as glucokinase (gk) activators |
| EP1532980A1 (en) * | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
| US7498445B2 (en) * | 2004-05-05 | 2009-03-03 | Renopharm Ltd. | Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof |
| EP1632491A1 (en) * | 2004-08-30 | 2006-03-08 | Laboratorios Del Dr. Esteve, S.A. | Substituted indole compounds and their use as 5-HT6 receptor modulators |
| US8957070B2 (en) | 2005-04-20 | 2015-02-17 | Takeda Pharmaceutical Company Limited | Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity |
| WO2007037543A1 (ja) | 2005-09-29 | 2007-04-05 | Banyu Pharmaceutical Co., Ltd. | ビアリールアミド誘導体 |
| WO2007037534A1 (ja) | 2005-09-30 | 2007-04-05 | Banyu Pharmaceutical Co., Ltd. | ２－へテロアリール置換インドール誘導体 |
| NZ583267A (en) | 2007-08-14 | 2012-03-30 | Bayer Schering Pharma Ag | Fused bicyclic pyrimidines |
| WO2009021990A1 (en) | 2007-08-14 | 2009-02-19 | Bayer Schering Pharma Aktiengesellschaft | Fused imidazoles for cancer treatment |
| CA2697974C (en) | 2007-10-18 | 2015-06-30 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4-triazoles |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
-
2007
- 2007-10-18 RU RU2009118602/04A patent/RU2454415C9/ru not_active IP Right Cessation
- 2007-10-18 GE GEAP200711259A patent/GEP20115241B/en unknown
- 2007-10-18 CN CN2007800470664A patent/CN101573357B/zh not_active Expired - Fee Related
- 2007-10-18 MY MYPI20091549A patent/MY158052A/en unknown
- 2007-10-18 BR BRPI0717722-4A patent/BRPI0717722A2/pt not_active IP Right Cessation
- 2007-10-18 CA CA2666973A patent/CA2666973C/en not_active Expired - Fee Related
- 2007-10-18 ME MEP-118/09A patent/MEP11809A/xx unknown
- 2007-10-18 UA UAA200904957A patent/UA97257C2/ru unknown
- 2007-10-18 TW TW096138971A patent/TWI460176B/zh not_active IP Right Cessation
- 2007-10-18 NZ NZ576570A patent/NZ576570A/en not_active IP Right Cessation
- 2007-10-18 US US12/311,893 patent/US8410087B2/en not_active Expired - Fee Related
- 2007-10-18 ZA ZA200902585A patent/ZA200902585B/xx unknown
- 2007-10-18 MX MX2009003972A patent/MX2009003972A/es active IP Right Grant
- 2007-10-18 US US11/907,929 patent/US7652133B2/en not_active Expired - Fee Related
- 2007-10-18 EP EP12170280A patent/EP2508524A3/en not_active Withdrawn
- 2007-10-18 AU AU2007310064A patent/AU2007310064B2/en not_active Ceased
- 2007-10-18 WO PCT/JP2007/070772 patent/WO2008050821A1/en not_active Ceased
- 2007-10-18 EP EP07830506A patent/EP2074119A1/en not_active Withdrawn
- 2007-10-18 KR KR1020097010151A patent/KR101444486B1/ko not_active Expired - Fee Related
- 2007-10-18 JP JP2009515658A patent/JP5260507B2/ja not_active Expired - Fee Related
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- 2008-04-10 CL CL2008001017A patent/CL2008001017A1/es unknown
- 2008-04-16 PE PE2008000659A patent/PE20090884A1/es not_active Application Discontinuation
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2009
- 2009-03-19 US US12/382,623 patent/US7718798B2/en not_active Expired - Fee Related
- 2009-03-19 US US12/382,622 patent/US7777047B2/en not_active Expired - Fee Related
- 2009-04-08 TN TNP2009000129A patent/TN2009000129A1/fr unknown
- 2009-04-16 IL IL198154A patent/IL198154A/en not_active IP Right Cessation
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- 2009-05-19 NO NO20091948A patent/NO20091948L/no not_active Application Discontinuation
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