JP2016512844A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016512844A5 JP2016512844A5 JP2016501972A JP2016501972A JP2016512844A5 JP 2016512844 A5 JP2016512844 A5 JP 2016512844A5 JP 2016501972 A JP2016501972 A JP 2016501972A JP 2016501972 A JP2016501972 A JP 2016501972A JP 2016512844 A5 JP2016512844 A5 JP 2016512844A5
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- sulfamoyl
- propyl
- pain
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 33
- 208000002193 Pain Diseases 0.000 claims 19
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 12
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- -1 5-methyl-2-oxo-1,3-dioxol-4-yl Chemical group 0.000 claims 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 4
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- 208000001294 Nociceptive Pain Diseases 0.000 claims 2
- CZVXBNJPXXJDGL-UHFFFAOYSA-N S1N=CN=C1NS(=O)(=O)C1=CC(=C(OC2=C(C=C(C=C2)Cl)CCCNCCC)C=C1F)Cl Chemical compound S1N=CN=C1NS(=O)(=O)C1=CC(=C(OC2=C(C=C(C=C2)Cl)CCCNCCC)C=C1F)Cl CZVXBNJPXXJDGL-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 1
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000004516 1,2,4-thiadiazol-5-yl group Chemical group S1N=CN=C1* 0.000 claims 1
- YRBMLUDTYBOAQY-UHFFFAOYSA-N 1-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,2,4-thiadiazol-5-ylsulfamoyl)phenoxy]phenyl]propyl]piperidine-4-carboxylic acid Chemical compound C1CC(C(=O)O)CCN1CCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2SN=CN=2)C=C1Cl YRBMLUDTYBOAQY-UHFFFAOYSA-N 0.000 claims 1
- MGSFVZDDZXCGRW-UHFFFAOYSA-N 1-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]phenyl]propyl]piperidine-3-carboxylic acid Chemical compound C1C(C(=O)O)CCCN1CCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2N=CSC=2)C=C1Cl MGSFVZDDZXCGRW-UHFFFAOYSA-N 0.000 claims 1
- VDNXSICDYYQJEH-UHFFFAOYSA-N 1-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]phenyl]propyl]piperidine-4-carboxylic acid Chemical compound C1CC(C(=O)O)CCN1CCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2N=CSC=2)C=C1Cl VDNXSICDYYQJEH-UHFFFAOYSA-N 0.000 claims 1
- PNNDFMDCGIONSI-UHFFFAOYSA-N 2-[1-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,2,4-thiadiazol-5-ylsulfamoyl)phenoxy]phenyl]propyl]piperidin-4-yl]acetic acid Chemical compound C1CC(CC(=O)O)CCN1CCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2SN=CN=2)C=C1Cl PNNDFMDCGIONSI-UHFFFAOYSA-N 0.000 claims 1
- LNZMKYCMCXMMRE-UHFFFAOYSA-N 2-[3-[2-[2-chloro-5-fluoro-4-(1,2,4-thiadiazol-5-ylsulfamoyl)phenoxy]phenyl]propylamino]acetic acid Chemical compound OC(=O)CNCCCC1=CC=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2SN=CN=2)C=C1Cl LNZMKYCMCXMMRE-UHFFFAOYSA-N 0.000 claims 1
- LEHXCZNUWZNFJL-UHFFFAOYSA-N 2-[3-[5-chloro-2-[2,5-difluoro-4-(1,3-thiazol-2-ylsulfamoyl)phenoxy]phenyl]propylamino]acetic acid Chemical compound OC(=O)CNCCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2SC=CN=2)C=C1F LEHXCZNUWZNFJL-UHFFFAOYSA-N 0.000 claims 1
- MYRXJVGNDDTXEV-UHFFFAOYSA-N 2-[3-[5-chloro-2-[2,5-difluoro-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]phenyl]propylamino]acetic acid Chemical compound OC(=O)CNCCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2N=CSC=2)C=C1F MYRXJVGNDDTXEV-UHFFFAOYSA-N 0.000 claims 1
- AFIYUNZJZBVSBB-UHFFFAOYSA-N 2-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,3-thiazol-2-ylsulfamoyl)phenoxy]phenyl]propylamino]acetic acid Chemical compound OC(=O)CNCCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2SC=CN=2)C=C1Cl AFIYUNZJZBVSBB-UHFFFAOYSA-N 0.000 claims 1
- YXDPLLFMUMFORJ-UHFFFAOYSA-N 2-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]phenyl]propylamino]-n-methylacetamide Chemical compound CNC(=O)CNCCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2N=CSC=2)C=C1Cl YXDPLLFMUMFORJ-UHFFFAOYSA-N 0.000 claims 1
- CCHQXXOVICLEOW-UHFFFAOYSA-N 2-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]phenyl]propylamino]acetic acid Chemical compound OC(=O)CNCCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2N=CSC=2)C=C1Cl CCHQXXOVICLEOW-UHFFFAOYSA-N 0.000 claims 1
- AWOHJRVCJKXEPJ-UHFFFAOYSA-N 2-[acetyl-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]phenyl]propyl]amino]acetic acid Chemical compound OC(=O)CN(C(=O)C)CCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2N=CSC=2)C=C1Cl AWOHJRVCJKXEPJ-UHFFFAOYSA-N 0.000 claims 1
- DRVYUUZVFWRQMZ-UHFFFAOYSA-N 2-amino-4-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]phenyl]propylamino]butanoic acid Chemical compound OC(=O)C(N)CCNCCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2N=CSC=2)C=C1Cl DRVYUUZVFWRQMZ-UHFFFAOYSA-N 0.000 claims 1
- OAPISBIIXJPSAF-UHFFFAOYSA-N 3-[3-[2-[2-chloro-5-fluoro-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]-5-fluorophenyl]propylamino]propanoic acid Chemical compound OC(=O)CCNCCCC1=CC(F)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2N=CSC=2)C=C1Cl OAPISBIIXJPSAF-UHFFFAOYSA-N 0.000 claims 1
- XNJXUSXGUDKONA-UHFFFAOYSA-N 3-[3-[5-chloro-2-[2,5-difluoro-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]phenyl]propylamino]propanoic acid Chemical compound OC(=O)CCNCCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2N=CSC=2)C=C1F XNJXUSXGUDKONA-UHFFFAOYSA-N 0.000 claims 1
- TYNPLTLSAPMWIL-UHFFFAOYSA-N 3-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,3-thiazol-2-ylsulfamoyl)phenoxy]phenyl]propylamino]propanoic acid Chemical compound OC(=O)CCNCCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2SC=CN=2)C=C1Cl TYNPLTLSAPMWIL-UHFFFAOYSA-N 0.000 claims 1
- OPSIRGRDQKKTJS-UHFFFAOYSA-N 3-[3-[5-chloro-2-[2-chloro-5-fluoro-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]phenyl]propylamino]propanoic acid Chemical compound OC(=O)CCNCCCC1=CC(Cl)=CC=C1OC1=CC(F)=C(S(=O)(=O)NC=2N=CSC=2)C=C1Cl OPSIRGRDQKKTJS-UHFFFAOYSA-N 0.000 claims 1
- LQIQUKQNKZJWLP-UHFFFAOYSA-N 3-[3-[5-chloro-2-[2-cyano-4-(1,3-thiazol-4-ylsulfamoyl)phenoxy]phenyl]propylamino]propanoic acid Chemical compound OC(=O)CCNCCCC1=CC(Cl)=CC=C1OC1=CC=C(S(=O)(=O)NC=2N=CSC=2)C=C1C#N LQIQUKQNKZJWLP-UHFFFAOYSA-N 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 claims 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 1
- KJIOILLRHLJKQM-UHFFFAOYSA-N CCCN(CCCc1cc(Cl)ccc1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)CC(O)=O Chemical compound CCCN(CCCc1cc(Cl)ccc1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)CC(O)=O KJIOILLRHLJKQM-UHFFFAOYSA-N 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 239000005973 Carvone Substances 0.000 claims 1
- 208000009043 Chemical Burns Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000013586 Complex regional pain syndrome type 1 Diseases 0.000 claims 1
- 208000034656 Contusions Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000004454 Hyperalgesia Diseases 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- LKJPYSCBVHEWIU-UHFFFAOYSA-N N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide Chemical compound C=1C=C(C#N)C(C(F)(F)F)=CC=1NC(=O)C(O)(C)CS(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-UHFFFAOYSA-N 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 208000000491 Tendinopathy Diseases 0.000 claims 1
- 206010043255 Tendonitis Diseases 0.000 claims 1
- 206010053615 Thermal burn Diseases 0.000 claims 1
- 102000016913 Voltage-Gated Sodium Channels Human genes 0.000 claims 1
- 108010053752 Voltage-Gated Sodium Channels Proteins 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 206010053552 allodynia Diseases 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003195 fascia Anatomy 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000002631 hypothermal effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 230000003040 nociceptive effect Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 208000005877 painful neuropathy Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 230000011514 reflex Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 230000002889 sympathetic effect Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000004415 tendinitis Diseases 0.000 claims 1
- 230000036575 thermal burns Effects 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361787618P | 2013-03-15 | 2013-03-15 | |
| US61/787,618 | 2013-03-15 | ||
| PCT/US2014/025809 WO2014151472A1 (en) | 2013-03-15 | 2014-03-13 | Sodium channel modulators for the treatment of pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512844A JP2016512844A (ja) | 2016-05-09 |
| JP2016512844A5 true JP2016512844A5 (https=) | 2017-09-07 |
| JP6449845B2 JP6449845B2 (ja) | 2019-01-09 |
Family
ID=51580969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501972A Active JP6449845B2 (ja) | 2013-03-15 | 2014-03-13 | 疼痛の処置のためのナトリウムチャネルモジュレーター |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10179781B2 (https=) |
| EP (1) | EP2968234B1 (https=) |
| JP (1) | JP6449845B2 (https=) |
| KR (1) | KR20150131254A (https=) |
| CN (1) | CN105188694B (https=) |
| AU (1) | AU2014234105B2 (https=) |
| BR (1) | BR112015022096A8 (https=) |
| CA (1) | CA2900604A1 (https=) |
| ES (1) | ES2687481T3 (https=) |
| HK (1) | HK1219060A1 (https=) |
| IL (1) | IL242564A0 (https=) |
| MX (1) | MX363680B (https=) |
| MY (1) | MY188139A (https=) |
| PH (1) | PH12015501740A1 (https=) |
| RU (1) | RU2669367C2 (https=) |
| WO (1) | WO2014151472A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2014121984A (ru) | 2011-10-31 | 2015-12-10 | Ксенон Фармасьютикалз Инк. | Бензолсульфонамидные соединения и их применение в качестве терапевтических средств |
| JP6014155B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用 |
| CN104718188B (zh) | 2012-05-22 | 2018-08-21 | 基因泰克公司 | N-取代的苯甲酰胺类及其在治疗疼痛中的用途 |
| KR101663436B1 (ko) | 2012-07-06 | 2016-10-06 | 제넨테크, 인크. | N-치환된 벤즈아미드 및 이의 사용 방법 |
| RU2015143906A (ru) | 2013-03-14 | 2017-04-18 | Дженентек, Инк. | Замещенные триазолопиридины и способы их применения |
| CA2900604A1 (en) | 2013-03-15 | 2014-09-25 | Chromocell Corporation | Sodium channel modulators for the treatment of pain |
| BR112015023397A2 (pt) | 2013-03-15 | 2017-07-18 | Genentech Inc | benzoxazois substituídos e métodos de uso dos mesmos |
| UA120353C2 (uk) * | 2013-09-10 | 2019-11-25 | Хромоселл Корпорейшн | Модулятори натрієвого каналу для лікування болю і діабету |
| WO2015078374A1 (en) | 2013-11-27 | 2015-06-04 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| JP2017525677A (ja) | 2014-07-07 | 2017-09-07 | ジェネンテック， インコーポレイテッド | 治療用化合物及びその使用方法 |
| WO2016040315A1 (en) * | 2014-09-09 | 2016-03-17 | Chromocell Corporation | Selective nav1.7 inhibitors for the treatment of diabetes |
| CN104710379B (zh) * | 2015-03-09 | 2017-01-18 | 华南理工大学 | 一种bms‑191011的合成方法 |
| HK1252567A1 (zh) | 2015-05-22 | 2019-05-31 | 基因泰克公司 | 被取代的苯甲酰胺和其使用方法 |
| JP2018526371A (ja) | 2015-08-27 | 2018-09-13 | ジェネンテック， インコーポレイテッド | 治療化合物及びその使用方法 |
| CA2999769A1 (en) | 2015-09-28 | 2017-04-06 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| EP3359151A4 (en) | 2015-10-07 | 2019-08-14 | Arizona Board of Regents on behalf of the University of Arizona | CRMP2 SUMOYLATION INHIBITORS AND USES THEREOF |
| EP3380466A1 (en) | 2015-11-25 | 2018-10-03 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| AU2016370554B2 (en) | 2015-12-18 | 2018-11-29 | Merck Sharp & Dohme Corp. | Hydroxyalkylamine- and hydroxycycloalkylamine-substituted diamine-arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| EP3436432B1 (en) | 2016-03-30 | 2021-01-27 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| PE20190980A1 (es) | 2016-10-17 | 2019-07-09 | Genentech Inc | Compuestos terapeuticos y metodos para utilizarlos |
| JP2020511511A (ja) | 2017-03-24 | 2020-04-16 | ジェネンテック， インコーポレイテッド | ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体 |
| AR114263A1 (es) | 2018-02-26 | 2020-08-12 | Genentech Inc | Compuestos terapéuticos y métodos para utilizarlos |
| US10947251B2 (en) | 2018-03-30 | 2021-03-16 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| WO2019200369A1 (en) * | 2018-04-13 | 2019-10-17 | Chromocell Corporation | Compounds and methods of using compounds for the prevention or treatment of peripheral nerve damage |
| WO2019217822A1 (en) * | 2018-05-11 | 2019-11-14 | Chromocell Corporation | Compounds and methods of using compounds for the prevention or treatment of inflammatory conditions |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| CN112689636B (zh) | 2018-09-10 | 2024-08-20 | 科研制药株式会社 | 新型杂原子芳香族酰胺衍生物以及含有其的药剂 |
| WO2020161606A1 (en) * | 2019-02-04 | 2020-08-13 | Simon Fraser University | Methods and compounds for inhibition of inactivation of voltage-gated sodium channels |
| CN112759559B (zh) * | 2019-11-06 | 2022-08-12 | 成都康弘药业集团股份有限公司 | 作为钠通道阻滞剂的磺酰胺类化合物及其用途 |
| US12533341B2 (en) | 2019-12-11 | 2026-01-27 | Duke University | Small molecule inhibitors of voltage-gated sodium channel 1.7 and methods of using same |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3905971A (en) * | 1971-03-29 | 1975-09-16 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
| US5356897A (en) | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
| EP1368355B1 (de) * | 2001-03-14 | 2006-06-07 | Grünenthal GmbH | Substituierte pyrazolo- und thiazolopyrimidine als analgetika |
| US7659082B2 (en) | 2002-02-19 | 2010-02-09 | Xenon Pharmaceuticals Inc. | Methods for identifying analgesic agents |
| BR0312023A (pt) | 2002-06-27 | 2005-03-22 | Novo Nordisk As | Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica |
| RU2006107211A (ru) * | 2003-08-08 | 2007-09-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Композиции, полезные в качестве ингибиторов потенциалозависимых натриевых каналов |
| GB0324792D0 (en) | 2003-10-23 | 2003-11-26 | Sterix Ltd | Compound |
| WO2005054202A1 (en) | 2003-11-25 | 2005-06-16 | Eli Lilly And Company | 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b) |
| EP1751136B1 (en) | 2004-05-07 | 2014-07-02 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
| AU2005266090A1 (en) * | 2004-07-23 | 2006-02-02 | Pfizer Inc. | Pyridine derivatives |
| EP1807391A4 (en) | 2004-10-29 | 2010-01-06 | Astrazeneca Ab | NOVEL SULFONAMIDE DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR AND FOR THE TREATMENT OF INFLAMMATORY DISEASES |
| AR054394A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de 2- (1h-indolilsulfanil)-aril amina |
| UA96283C2 (uk) | 2005-12-23 | 2011-10-25 | Зіланд Фарма А/С | Модифіковані міметики лізину |
| CA2693588C (en) * | 2007-07-13 | 2015-11-17 | Icagen, Inc. | Sodium channel inhibitors |
| US8853250B2 (en) | 2007-07-13 | 2014-10-07 | Icagen, Inc. | Sodium channel inhibitors |
| HUE025013T2 (hu) | 2009-01-12 | 2016-04-28 | Pfizer Ltd | Szulfonamid-származékok |
| EP2435407B1 (en) | 2009-05-29 | 2019-12-25 | RaQualia Pharma Inc. | Aryl substituted carboxamide derivatives as calcium or sodium channel blockers |
| US8895608B2 (en) | 2010-04-23 | 2014-11-25 | Kineta, Inc. | Sulfonamide anti-viral compounds |
| JP5872552B2 (ja) | 2010-07-09 | 2016-03-01 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | 化学化合物 |
| WO2012004714A2 (en) * | 2010-07-09 | 2012-01-12 | Pfizer Limited | Chemical compounds |
| WO2012004743A1 (en) * | 2010-07-09 | 2012-01-12 | Pfizer Limited | Benzenesulfonamides useful as sodium channel inhibitors |
| ES2532357T3 (es) * | 2010-07-12 | 2015-03-26 | Pfizer Limited | Derivados de sulfonamida como inhibidores de Nav1.7 para el tratamiento del dolor |
| CA2823707A1 (en) | 2011-01-18 | 2012-07-26 | Amgen Inc. | Nav1.7 knockout mice and uses thereof |
| MX2014001851A (es) | 2011-08-17 | 2014-10-24 | Amgen Inc | Inhibidores del canal de heteroarilo sodio. |
| CA2849505A1 (en) | 2011-09-21 | 2013-03-28 | Gilead Sciences, Inc. | Sodium channel blockers reduce glucagon secretion |
| JP6014155B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用 |
| US9757379B2 (en) | 2012-11-14 | 2017-09-12 | The Board Of Regents Of The University Of Texas System | Inhibition of HIF-2α heterodimerization with HIF1β (ARNT) |
| CA2900604A1 (en) | 2013-03-15 | 2014-09-25 | Chromocell Corporation | Sodium channel modulators for the treatment of pain |
| WO2015035223A1 (en) | 2013-09-09 | 2015-03-12 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
| UA120353C2 (uk) * | 2013-09-10 | 2019-11-25 | Хромоселл Корпорейшн | Модулятори натрієвого каналу для лікування болю і діабету |
-
2014
- 2014-03-13 CA CA2900604A patent/CA2900604A1/en active Pending
- 2014-03-13 WO PCT/US2014/025809 patent/WO2014151472A1/en not_active Ceased
- 2014-03-13 MX MX2015011907A patent/MX363680B/es unknown
- 2014-03-13 RU RU2015133310A patent/RU2669367C2/ru not_active IP Right Cessation
- 2014-03-13 HK HK16107214.7A patent/HK1219060A1/zh unknown
- 2014-03-13 MY MYPI2015702635A patent/MY188139A/en unknown
- 2014-03-13 AU AU2014234105A patent/AU2014234105B2/en not_active Ceased
- 2014-03-13 EP EP14767550.8A patent/EP2968234B1/en not_active Not-in-force
- 2014-03-13 JP JP2016501972A patent/JP6449845B2/ja active Active
- 2014-03-13 US US14/776,016 patent/US10179781B2/en active Active
- 2014-03-13 KR KR1020157029193A patent/KR20150131254A/ko not_active Abandoned
- 2014-03-13 CN CN201480014410.XA patent/CN105188694B/zh not_active Expired - Fee Related
- 2014-03-13 ES ES14767550.8T patent/ES2687481T3/es active Active
- 2014-03-13 BR BR112015022096A patent/BR112015022096A8/pt not_active IP Right Cessation
-
2015
- 2015-08-07 PH PH12015501740A patent/PH12015501740A1/en unknown
- 2015-11-12 IL IL242564A patent/IL242564A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016512844A5 (https=) | ||
| RU2015133310A (ru) | Модуляторы натриевого канала для лечения боли | |
| JP2010506825A5 (https=) | ||
| RU2454411C2 (ru) | Производные хинолина | |
| JP2017517508A5 (https=) | ||
| RU2009118602A (ru) | Производное индола | |
| JP2010534647A5 (https=) | ||
| JP2016505619A5 (https=) | ||
| JP2016536363A5 (https=) | ||
| JP2016532716A5 (https=) | ||
| JP2016517417A5 (https=) | ||
| CA2662305A1 (en) | Heterocyclic gpr40 modulators | |
| JP2007504160A5 (https=) | ||
| JP2010524932A5 (https=) | ||
| AU2007265454A1 (en) | Human protein tyrosine phosphatase inhibitors and methods of use | |
| JP2017526636A5 (https=) | ||
| JP2016506960A5 (https=) | ||
| CA2558585A1 (en) | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders | |
| JP2007536224A5 (https=) | ||
| JP2011515341A5 (https=) | ||
| RU2014122035A (ru) | Соединения с нематоцидной активностью | |
| CA2553705A1 (en) | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them | |
| RU2018120242A (ru) | Хинолиновые соединения, способы их получения и их применения в качестве лекарственного средства, ингибирующего транспортер уратов | |
| JP2014528450A5 (https=) | ||
| JP2010540462A5 (https=) |