|
US4911920A
(en)
*
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
*
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
US4801575A
(en)
*
|
1986-07-30 |
1989-01-31 |
The Regents Of The University Of California |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US4902505A
(en)
|
1986-07-30 |
1990-02-20 |
Alkermes |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US5624898A
(en)
*
|
1989-12-05 |
1997-04-29 |
Ramsey Foundation |
Method for administering neurologic agents to the brain
|
|
US6407061B1
(en)
*
|
1989-12-05 |
2002-06-18 |
Chiron Corporation |
Method for administering insulin-like growth factor to the brain
|
|
ATE141502T1
(de)
*
|
1991-01-15 |
1996-09-15 |
Alcon Lab Inc |
Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
|
|
US5212162A
(en)
*
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
US6287792B1
(en)
*
|
1991-06-17 |
2001-09-11 |
The Regents Of The University Of California |
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
|
|
TW282460B
(https=)
|
1993-12-28 |
1996-08-01 |
Yamanouchi Pharma Co Ltd |
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
US5728718A
(en)
*
|
1994-12-20 |
1998-03-17 |
The United States Of America As Represented By The Department Of Health And Human Services |
2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
|
|
EP1196609A2
(en)
*
|
1999-06-28 |
2002-04-17 |
Oklahoma Medical Research Foundation |
Catalytically active recombinant memapsin and methods of use thereof
|
|
ES2298168T3
(es)
*
|
1999-12-16 |
2008-05-16 |
Emisphere Technologies, Inc. |
Compuestos y composiciones para suministrar agentes activos.
|
|
US20040110928A1
(en)
*
|
2000-04-12 |
2004-06-10 |
Andrea Crisanti |
Peptide conjugates for drug delivery
|
|
US6372250B1
(en)
*
|
2000-04-25 |
2002-04-16 |
The Regents Of The University Of California |
Non-invasive gene targeting to the brain
|
|
PE20020276A1
(es)
*
|
2000-06-30 |
2002-04-06 |
Elan Pharm Inc |
COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
|
|
EP1299352B1
(en)
|
2000-06-30 |
2005-12-28 |
Elan Pharmaceuticals, Inc. |
Compounds to treat alzheimer's disease
|
|
US6846813B2
(en)
|
2000-06-30 |
2005-01-25 |
Pharmacia & Upjohn Company |
Compounds to treat alzheimer's disease
|
|
US20040121947A1
(en)
*
|
2000-12-28 |
2004-06-24 |
Oklahoma Medical Research Foundation |
Compounds which inhibit beta-secretase activity and methods of use thereof
|
|
AU2002239727C1
(en)
|
2000-12-28 |
2005-12-22 |
Oklahoma Medical Research Foundation |
Inhibitors of memapsin 2 and use thereof
|
|
AU2002248432A1
(en)
|
2001-02-14 |
2002-08-28 |
Sankyo Company, Limited |
Oxazole derivatives, their preparation and their use as cytokine inhibitors
|
|
CA2464736A1
(en)
|
2001-10-23 |
2003-05-15 |
Oklahoma Medical Research Foundation |
Beta-secretase inhibitors and methods of use
|
|
US20060234944A1
(en)
*
|
2001-10-23 |
2006-10-19 |
Oklahoma Medical Reseach Foundation |
Beta-secretase inhibitors and methods of use
|
|
NZ533107A
(en)
|
2001-11-08 |
2007-04-27 |
Upjohn Co |
N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives
|
|
BR0214736A
(pt)
|
2001-12-06 |
2004-11-23 |
Elan Pharm Inc |
Composto e seus sais farmaceuticamente aceitáveis, composição farmacêutica e método de tratar seres humanos ou animais que sofrem de doenças ou condições
|
|
IL163652A0
(en)
|
2002-02-27 |
2005-12-18 |
Upjohn Co |
Substituted hydroxyethylamines
|
|
AU2003220115A1
(en)
*
|
2002-05-20 |
2003-12-12 |
Board Of Regents, The University Of Texas System |
Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone, and other tissues
|
|
CN1732161A
(zh)
|
2002-09-06 |
2006-02-08 |
艾伦药物公司 |
1,3-二氨基-2-羟基丙烷前体药物衍生物
|
|
CA2505098A1
(en)
|
2002-11-12 |
2004-05-27 |
Merck & Co., Inc. |
Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US20040102369A1
(en)
*
|
2002-11-27 |
2004-05-27 |
The Regents Of The University Of California |
Transport of basic fibroblast growth factor across the blood brain barrier
|
|
US7388079B2
(en)
*
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
GB0228410D0
(en)
|
2002-12-05 |
2003-01-08 |
Glaxo Group Ltd |
Novel Compounds
|
|
GB0305918D0
(en)
|
2003-03-14 |
2003-04-23 |
Glaxo Group Ltd |
Novel compounds
|
|
ES2323068T3
(es)
*
|
2003-08-08 |
2009-07-06 |
Schering Corporation |
Inhibidores de bace-1 de aminas ciclicas con un sustituyente de benzamida.
|
|
KR100793095B1
(ko)
|
2003-10-01 |
2008-01-10 |
주식회사 프로메디텍 |
Bace 저해효능을 가진 신규한 술폰 아미드 유도체
|
|
CA2548849A1
(en)
|
2003-12-19 |
2005-07-21 |
Merck & Co., Inc. |
Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US7585885B2
(en)
*
|
2004-04-22 |
2009-09-08 |
Eli Lilly And Company |
Pyrrolidine derivatives useful as BACE inhibitors
|
|
WO2005108358A2
(en)
|
2004-04-22 |
2005-11-17 |
Eli Lilly And Company |
Pyrrolidine derivatives useful as bace inhibitors
|
|
CA2570995A1
(en)
|
2004-06-15 |
2006-01-05 |
Merck & Co., Inc. |
Pyrrolidin-3-yl compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US8436006B2
(en)
*
|
2004-08-06 |
2013-05-07 |
Jansssen Pharmaceutica N.V. |
2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
|
|
JP2008513495A
(ja)
*
|
2004-09-17 |
2008-05-01 |
コメンティス,インコーポレーテッド |
ベータ−セクレターゼ活性を阻害する二環式化合物およびその使用方法
|
|
EP1799660A2
(en)
*
|
2004-09-17 |
2007-06-27 |
Comentis, Inc. |
Amino-containing compounds which inhibit memapsin 2 beta-secretase activity and methods of use thereof
|
|
CN100475786C
(zh)
*
|
2005-02-18 |
2009-04-08 |
中国科学院上海药物研究所 |
一类4-羟基戊酰胺类化合物及其制备方法和用途
|
|
WO2006099352A1
(en)
|
2005-03-10 |
2006-09-21 |
Bristol-Myers Squibb Company |
Novel isophthalates as beta-secretase inhibitors
|
|
KR20080015079A
(ko)
|
2005-04-08 |
2008-02-18 |
코멘티스, 인코포레이티드 |
베타 세크레타제 활성을 억제하는 화합물 및 이것의 사용방법
|
|
MY144968A
(en)
|
2005-04-11 |
2011-11-30 |
Xenon Pharmaceuticals Inc |
Spiro-oxindole compounds and their uses as therapeutic agents
|
|
AR054044A1
(es)
|
2005-05-23 |
2007-05-30 |
Astrazeneca Ab |
Derivados de cromano y tetrahidronaftaleno como moduladores del receptor 5 - ht6; intermediarios en su preparacion; composiciones farmaceuticas que los contienen y su empelo en la fabricacion de medicamentos para el tratamiento de enfermedades del snc y de la obesidad.
|
|
AR054363A1
(es)
|
2005-05-23 |
2007-06-20 |
Astrazeneca Ab |
Compuestos que exhiben actividad moduladora en el receptor 5-hidroxi-triptamina 6
|
|
GB0513886D0
(en)
|
2005-07-06 |
2005-08-10 |
Glaxo Group Ltd |
Novel compounds
|
|
US7476764B2
(en)
*
|
2005-08-04 |
2009-01-13 |
Bristol-Myers Squibb Company |
Phenylcarboxyamides as beta-secretase inhibitors
|
|
US7790745B2
(en)
|
2005-10-21 |
2010-09-07 |
Bristol-Myers Squibb Company |
Tetrahydroisoquinoline LXR Modulators
|
|
TW200804290A
(en)
|
2005-11-15 |
2008-01-16 |
Astrazeneca Ab |
Compounds and uses thereof
|
|
EP2077719B1
(en)
|
2006-09-21 |
2011-12-28 |
Merck Sharp & Dohme Corp. |
Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US20100286145A1
(en)
|
2007-07-26 |
2010-11-11 |
Comentis, Inc. |
Isophthalamide derivatives inhibiting beta-secretase activity
|
|
KR20100059919A
(ko)
|
2007-09-24 |
2010-06-04 |
코멘티스, 인코포레이티드 |
치료를 위한 베타-세크레타제 억제제로서 (3-히드록시-4-아미노-부탄-2일)-3-(2-티아졸-2-일-피롤리딘-1-카르보닐) 벤즈아미드 유도체 및 관련 화합물
|
|
US8791135B2
(en)
|
2008-07-01 |
2014-07-29 |
Purdue Research Foundation |
Nonpeptide HIV-1 protease inhibitors
|
|
CA2739875A1
(en)
|
2008-10-10 |
2010-04-15 |
Comentis, Inc. |
Pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof
|
|
WO2010042796A1
(en)
|
2008-10-10 |
2010-04-15 |
Purdue Research Foundation |
Compounds for treatment of alzheimer's disease
|
|
US8394807B2
(en)
|
2008-11-20 |
2013-03-12 |
Purdue Research Foundation |
Quinazoline inhibitors of BACE 1 and methods of using
|
|
WO2010065861A2
(en)
|
2008-12-05 |
2010-06-10 |
Purdue Research Foundation |
Inhibitors of bace 1 and methods for treating alzheimer's disease
|
|
US20120214802A1
(en)
|
2009-03-25 |
2012-08-23 |
Bilcer Geoffrey M |
Pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof
|
|
US20130059840A1
(en)
|
2009-10-05 |
2013-03-07 |
Comentis, Inc. |
Sulfonamido pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof
|