JP2003520248A5 - - Google Patents
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- JP2003520248A5 JP2003520248A5 JP2001552932A JP2001552932A JP2003520248A5 JP 2003520248 A5 JP2003520248 A5 JP 2003520248A5 JP 2001552932 A JP2001552932 A JP 2001552932A JP 2001552932 A JP2001552932 A JP 2001552932A JP 2003520248 A5 JP2003520248 A5 JP 2003520248A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- neisseria meningitidis
- seq
- composition according
- protective antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000623 proteins and genes Proteins 0.000 description 17
- 102000004169 proteins and genes Human genes 0.000 description 17
- 101710194807 Protective antigen Proteins 0.000 description 12
- 241000588650 Neisseria meningitidis Species 0.000 description 11
- 239000012528 membrane Substances 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 230000002163 immunogen Effects 0.000 description 6
- 239000012634 fragment Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241000588653 Neisseria Species 0.000 description 4
- 101150075249 ORF40 gene Proteins 0.000 description 4
- 101100156835 Paenarthrobacter nicotinovorans xdh gene Proteins 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 241000588807 Bordetella Species 0.000 description 1
- 101000874355 Escherichia coli (strain K12) Outer membrane protein assembly factor BamA Proteins 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 241000588654 Neisseria cinerea Species 0.000 description 1
- 241000588649 Neisseria lactamica Species 0.000 description 1
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 description 1
- 241000947238 Neisseria meningitidis serogroup C Species 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- -1 PilC Proteins 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 108010031133 Transferrin-Binding Protein A Proteins 0.000 description 1
- 108010031127 Transferrin-Binding Protein B Proteins 0.000 description 1
- 241000607734 Yersinia <bacteria> Species 0.000 description 1
- 229940009976 deoxycholate Drugs 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0001067.8 | 2000-01-17 | ||
| GB0001067A GB0001067D0 (en) | 2000-01-17 | 2000-01-17 | Supplemented norwegian vaccine |
| GBGB0005699.4A GB0005699D0 (en) | 2000-03-09 | 2000-03-09 | Supplemented OMV vaccines |
| GB0005699.4 | 2000-03-09 | ||
| PCT/IB2001/000166 WO2001052885A1 (en) | 2000-01-17 | 2001-01-17 | Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011061748A Division JP2011116793A (ja) | 2000-01-17 | 2011-03-18 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003520248A JP2003520248A (ja) | 2003-07-02 |
| JP2003520248A5 true JP2003520248A5 (https=) | 2008-02-28 |
Family
ID=26243421
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001552932A Withdrawn JP2003520248A (ja) | 2000-01-17 | 2001-01-17 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2011061748A Pending JP2011116793A (ja) | 2000-01-17 | 2011-03-18 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2013124554A Expired - Fee Related JP5823446B2 (ja) | 2000-01-17 | 2013-06-13 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2013124555A Pending JP2013181036A (ja) | 2000-01-17 | 2013-06-13 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2013124556A Pending JP2013181037A (ja) | 2000-01-17 | 2013-06-13 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2015145631A Pending JP2015193652A (ja) | 2000-01-17 | 2015-07-23 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011061748A Pending JP2011116793A (ja) | 2000-01-17 | 2011-03-18 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2013124554A Expired - Fee Related JP5823446B2 (ja) | 2000-01-17 | 2013-06-13 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2013124555A Pending JP2013181036A (ja) | 2000-01-17 | 2013-06-13 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2013124556A Pending JP2013181037A (ja) | 2000-01-17 | 2013-06-13 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
| JP2015145631A Pending JP2015193652A (ja) | 2000-01-17 | 2015-07-23 | Ｎ．ｍｅｎｉｎｇｉｔｉｄｉｓ血清型ｂ外膜タンパク質を含む外膜小胞（ｏｍｖ）ワクチン |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US8273360B2 (https=) |
| EP (6) | EP1248647B1 (https=) |
| JP (6) | JP2003520248A (https=) |
| CN (2) | CN1416352B (https=) |
| AT (1) | ATE476988T1 (https=) |
| AU (2) | AU784518B2 (https=) |
| BR (2) | BRPI0107679B8 (https=) |
| CA (2) | CA2397508C (https=) |
| CY (3) | CY1111056T1 (https=) |
| DE (1) | DE60142772D1 (https=) |
| DK (3) | DK1248647T3 (https=) |
| ES (2) | ES2588917T3 (https=) |
| MX (1) | MXPA02006962A (https=) |
| NZ (1) | NZ520466A (https=) |
| PT (3) | PT2289545T (https=) |
| RU (1) | RU2279889C2 (https=) |
| WO (1) | WO2001052885A1 (https=) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2324093A (en) | 1996-01-04 | 1998-10-14 | Rican Limited | Helicobacter pylori bacterioferritin |
| EP2298900A1 (en) | 1996-09-17 | 2011-03-23 | Novartis Vaccines and Diagnostics, Inc. | Compositions and methods for treating intracellular diseases |
| US20070026021A1 (en) * | 1998-05-01 | 2007-02-01 | Chiron S.R.I. | Neisseria meningitidis antigens and compositions |
| EP2261338A3 (en) | 1998-05-01 | 2012-01-04 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
| GB9823978D0 (en) * | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| US10967045B2 (en) * | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
| CA2371994C (en) * | 1999-02-26 | 2010-09-28 | Guido Grandi | Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs |
| WO2000066741A2 (en) | 1999-04-30 | 2000-11-09 | Chiron S.P.A. | Conserved neisserial antigens |
| NZ515935A (en) | 1999-05-19 | 2004-01-30 | Chiron S | Combination Neisserial compositions and vaccines for the prevention of infections due to Neisseria bacteria such as meningococcal meningitis |
| JP2004508801A (ja) | 1999-10-29 | 2004-03-25 | カイロン ソチエタ ア レスポンサビリタ リミタータ | ナイセリア抗原性ペプチド |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| PT2289545T (pt) * | 2000-01-17 | 2016-09-06 | Glaxosmithkline Biologicals Sa | Vacina de omv suplementada contra meningococos |
| NZ521531A (en) | 2000-02-28 | 2005-12-23 | Chiron S | Heterologous expression of neisserial proteins |
| ES2519440T3 (es) | 2000-07-27 | 2014-11-07 | Children's Hospital & Research Center At Oakland | Vacunas para la protección de amplio espectro contra enfermedades causadas por Neisseria meningitidis |
| GB0103170D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| CA2881568C (en) | 2000-10-27 | 2019-09-24 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from streptococcus groups a & b |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| ATE469915T1 (de) * | 2001-07-27 | 2010-06-15 | Novartis Vaccines & Diagnostic | Antikörper gegen das meningokokken adhäsin app |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| RU2331435C2 (ru) | 2001-12-12 | 2008-08-20 | Чирон Срл. | Иммунизация против chlamydia trachomatis |
| GB0130123D0 (en) | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| US20060057160A1 (en) * | 2002-08-02 | 2006-03-16 | Ralph Biemans | Vaccine composition |
| RU2364418C2 (ru) * | 2002-08-02 | 2009-08-20 | ГлаксоСмитКлайн Байолоджикалз с.а. | ВАКЦИННЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ЛИПОПОЛИСАХАРИДЫ ИММУНОТИПА L2 И/ИЛИ L3, ПРОИСХОДЯЩИЕ ИЗ ШТАММА NEISSERIA MENINGITIDIS IgtB- |
| GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| HUE031886T2 (en) | 2002-10-11 | 2017-08-28 | Glaxosmithkline Biologicals Sa | Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines |
| CA2503946C (en) | 2002-11-01 | 2016-08-16 | Glaxosmithkline Biologicals S.A. | Drying process |
| EP1562982B1 (en) * | 2002-11-15 | 2010-05-05 | Novartis Vaccines and Diagnostics S.r.l. | Unexpected surface proteins in neisseria meningitidis |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| EP2263687B1 (en) | 2002-12-27 | 2015-03-25 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic compositions containing phospholipid |
| EP2172213B1 (en) | 2003-01-30 | 2013-04-03 | Novartis AG | Injectable vaccines against multiple meningococcal serogroups |
| WO2004087153A2 (en) | 2003-03-28 | 2004-10-14 | Chiron Corporation | Use of organic compounds for immunopotentiation |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| JP5557415B2 (ja) | 2003-06-02 | 2014-07-23 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物 |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| NZ550533A (en) * | 2004-04-30 | 2010-02-26 | Novartis Vaccines & Diagnostic | Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| WO2006002422A2 (en) | 2004-06-24 | 2006-01-05 | Novartis Vaccines And Diagnostics Inc. | Compounds for immunopotentiation |
| JP2008508320A (ja) | 2004-07-29 | 2008-03-21 | カイロン コーポレイション | Ｓｔｒｅｐｔｏｃｏｃｃｕｓａｇａｌａｃｔｉａｅのようなグラム陽性細菌に対する免疫原性組成物 |
| GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| WO2006081259A2 (en) | 2005-01-27 | 2006-08-03 | Children's Hospital & Research Center At Oakland | Gna1870-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| GB0502096D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
| GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| CA2626253A1 (en) | 2005-10-18 | 2007-04-26 | Novartis Vaccines And Diagnostics, Inc. | Mucosal and systemic immunizations with alphavirus replicon particles |
| ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| ES2536426T3 (es) | 2006-03-23 | 2015-05-25 | Novartis Ag | Compuestos de imidazoquinoxalina como inmunomoduladores |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| CA2695467A1 (en) * | 2007-08-02 | 2009-03-26 | Children's Hospital & Research Center At Oakland | Fhbp- and lpxl1-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| KR101621837B1 (ko) | 2007-09-12 | 2016-05-17 | 노파르티스 아게 | Ｇａｓ57 돌연변이 항원 및 ｇａｓ57 항체 |
| BR122016015627A2 (pt) | 2007-10-19 | 2018-10-30 | Novartis Ag | kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica |
| EP2537857B1 (en) | 2007-12-21 | 2017-01-18 | GlaxoSmithKline Biologicals SA | Mutant forms of streptolysin O |
| CN102356089B (zh) | 2008-02-21 | 2014-02-19 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽 |
| CN102015651B (zh) | 2008-03-03 | 2014-12-31 | Irm责任有限公司 | 作为tlr活性调节剂的化合物和组合物 |
| UA99659C2 (uk) * | 2008-05-30 | 2012-09-10 | Дзе Ю.Ес.Ей., Ес Репрезентед Бай Дзе Секретарі Оф Дзе Армі, Он Бехаф Оф Уолтер Рід Армі | Мультивалентна вакцина з нативних везикул зовнішньої мембрани менінгококів, способи її застосування |
| WO2010027499A2 (en) * | 2008-09-05 | 2010-03-11 | University Of Massachusetts Medical School | Methods, compositions and vaccines relating to neisseria meningitidis antibodies |
| CA2777837C (en) | 2008-10-27 | 2017-07-11 | Novartis Ag | Purification method |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| WO2010070453A2 (en) | 2008-12-17 | 2010-06-24 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
| US8425922B2 (en) | 2009-01-05 | 2013-04-23 | EpitoGenesis, Inc. | Adjuvant compositions and methods of use |
| CN103897045A (zh) | 2009-01-12 | 2014-07-02 | 诺华股份有限公司 | 抗革兰氏阳性细菌疫苗中的Cna_B结构域 |
| EP2411048B1 (en) | 2009-03-24 | 2020-05-06 | GlaxoSmithKline Biologicals SA | Adjuvanting meningococcal factor h binding protein |
| CN102596240B (zh) | 2009-08-27 | 2015-02-04 | 诺华股份有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
| EP2470205A1 (en) | 2009-08-27 | 2012-07-04 | Novartis AG | Adjuvant comprising aluminium, oligonucleotide and polycation |
| WO2011027222A2 (en) | 2009-09-02 | 2011-03-10 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| BR112012009014B8 (pt) | 2009-09-30 | 2022-10-04 | Novartis Ag | Processo para preparar conjugado de polissacarídeo capsular de s. aureus tipo 5 ou tipo 8 e molécula de transporte crm197, conjugado e composição imunogênica |
| CN102724988B (zh) | 2009-09-30 | 2014-09-10 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽的表达 |
| CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| HUE034251T2 (en) | 2009-10-30 | 2018-02-28 | Glaxosmithkline Biologicals Sa | Purification of staphylococcus aureus type 5 and type 8 capsular saccharides |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| BR112012014624A8 (pt) | 2009-12-15 | 2017-12-26 | Novartis Ag | suspensão homogênea de compostos de imunopotenciação e usos dos destes |
| AU2011288203A1 (en) | 2010-03-18 | 2012-08-23 | Novartis Ag | Adjuvanted vaccines for serogroup B meningococcus |
| EA031379B1 (ru) | 2010-03-23 | 2018-12-28 | Новартис Аг | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний |
| TR201802933T4 (tr) | 2010-03-30 | 2018-03-21 | Childrens Hospital & Res Center At Oakland | Özellikleri değiştirilmiş faktör h bağlama proteinleri (fhbp) ve bunların kullanım yöntemi. |
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-
2001
- 2001-01-17 PT PT101785954T patent/PT2289545T/pt unknown
- 2001-01-17 DK DK01942562.8T patent/DK1248647T3/da active
- 2001-01-17 ES ES10178595.4T patent/ES2588917T3/es not_active Expired - Lifetime
- 2001-01-17 US US10/181,600 patent/US8273360B2/en active Active
- 2001-01-17 BR BRPI0107679A patent/BRPI0107679B8/pt unknown
- 2001-01-17 RU RU2002122111/15A patent/RU2279889C2/ru not_active IP Right Cessation
- 2001-01-17 EP EP01942562A patent/EP1248647B1/en not_active Expired - Lifetime
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- 2001-01-17 JP JP2001552932A patent/JP2003520248A/ja not_active Withdrawn
- 2001-01-17 AU AU28754/01A patent/AU784518B2/en not_active Ceased
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- 2001-01-17 EP EP10178595.4A patent/EP2289545B1/en not_active Expired - Lifetime
- 2001-01-17 CN CN018059201A patent/CN1416352B/zh not_active Expired - Fee Related
- 2001-01-17 PT PT70134531T patent/PT1897555E/pt unknown
- 2001-01-17 AT AT01942562T patent/ATE476988T1/de active
- 2001-01-17 DK DK07013453.1T patent/DK1897555T3/da active
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- 2001-01-17 PT PT01942562T patent/PT1248647E/pt unknown
- 2001-01-17 DK DK10178595.4T patent/DK2289545T3/en active
- 2001-01-17 EP EP10179793A patent/EP2281571A3/en not_active Withdrawn
- 2001-01-17 CN CN201110099744XA patent/CN102172398A/zh active Pending
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- 2001-01-17 EP EP07013453.1A patent/EP1897555B1/en not_active Expired - Lifetime
- 2001-01-17 WO PCT/IB2001/000166 patent/WO2001052885A1/en not_active Ceased
- 2001-01-17 EP EP10179761A patent/EP2281570A3/en not_active Withdrawn
- 2001-01-17 DE DE60142772T patent/DE60142772D1/de not_active Expired - Lifetime
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