JP2003502272A - 神経ペプチドｙ受容体拮抗薬としての二環式ピリジンおよびピリミジン誘導体 - Google Patents

神経ペプチドｙ受容体拮抗薬としての二環式ピリジンおよびピリミジン誘導体

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Publication number
JP2003502272A
JP2003502272A JP2000530520A JP2000530520A JP2003502272A JP 2003502272 A JP2003502272 A JP 2003502272A JP 2000530520 A JP2000530520 A JP 2000530520A JP 2000530520 A JP2000530520 A JP 2000530520A JP 2003502272 A JP2003502272 A JP 2003502272A
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alkyl
cycloalkyl
alkoxy
aryl
group
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JP2003502272A5 (https=
Inventor
ノーマン，マーク・エイチ
チエン，ニン
ハン，ニアンホー
リウ，ロンビン
ハート，クラレンス・アール
フオツチ，クリストフアー・エイチ
ジエンキンズ，トレイシー・ジエイ
モレノ，オフアー・エイ
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アムジエン・インコーポレーテツド
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Publication of JP2003502272A publication Critical patent/JP2003502272A/ja
Publication of JP2003502272A5 publication Critical patent/JP2003502272A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
JP2000530520A 1998-02-06 1999-02-05 神経ペプチドｙ受容体拮抗薬としての二環式ピリジンおよびピリミジン誘導体 Withdrawn JP2003502272A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US7392798P 1998-02-06 1998-02-06
US7398198P 1998-02-06 1998-02-06
US60/073,981 1998-02-06
US60/073,927 1998-02-06
US9357798P 1998-07-20 1998-07-20
US9348298P 1998-07-20 1998-07-20
US60/093,577 1998-07-20
US60/093,482 1998-07-20
US09/246,775 1999-02-04
US09/246,775 US6187777B1 (en) 1998-02-06 1999-02-04 Compounds and methods which modulate feeding behavior and related diseases
PCT/US1999/002500 WO1999040091A1 (en) 1998-02-06 1999-02-05 Bicyclic pyridine and pyrimidine derivatives as neuropeptide y receptor antagonists

Publications (2)

Publication Number Publication Date
JP2003502272A true JP2003502272A (ja) 2003-01-21
JP2003502272A5 JP2003502272A5 (https=) 2006-01-19

Family

ID=27535987

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JP2000530520A Withdrawn JP2003502272A (ja) 1998-02-06 1999-02-05 神経ペプチドｙ受容体拮抗薬としての二環式ピリジンおよびピリミジン誘導体

Country Status (13)

Country Link
US (2) US6187777B1 (https=)
EP (1) EP1054887B1 (https=)
JP (1) JP2003502272A (https=)
AT (1) ATE323088T1 (https=)
AU (1) AU747920B2 (https=)
CA (1) CA2319275C (https=)
CY (1) CY1105476T1 (https=)
DE (1) DE69930835T2 (https=)
DK (1) DK1054887T3 (https=)
ES (1) ES2257851T3 (https=)
PT (1) PT1054887E (https=)
SI (1) SI1054887T1 (https=)
WO (1) WO1999040091A1 (https=)

Cited By (11)

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WO2005118588A1 (ja) * 2004-06-02 2005-12-15 Takeda Pharmaceutical Company Limited 縮合複素環化合物
JP2006519251A (ja) * 2003-03-04 2006-08-24 アデックス ファーマシューティカルズ ソシエテ アノニム ｍＧｌｕＲ５アンタゴニストとしての新規アミノピリジン誘導体
JP2008517893A (ja) * 2004-10-25 2008-05-29 パイレームド リミテッド 医薬化合物
JP2011503115A (ja) * 2007-11-15 2011-01-27 ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド Ｎ含有複素環式化合物
JP2011513272A (ja) * 2008-02-27 2011-04-28 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング ピロロピリミジンカルボキサミド
JP2013503131A (ja) * 2009-08-26 2013-01-31 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング メチルピロロピリミジンカルボキサミド
JP2013536208A (ja) * 2010-08-27 2013-09-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング フロピリジン誘導体
JP2015508085A (ja) * 2012-02-21 2015-03-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ フロピリジン誘導体
JP2016526550A (ja) * 2013-06-27 2016-09-05 ヤンセン・サイエンシズ・アイルランド・ユーシー ウイルス感染症および他の疾病の処置のためのピロロ［３，２−ｄ］ピリミジン誘導体
JP2017513915A (ja) * 2014-04-30 2017-06-01 マサリコヴァ ユニヴェルジタ プロテインキナーゼのインヒビターとしてのフロピリジン
JP2017519023A (ja) * 2014-06-25 2017-07-13 武田薬品工業株式会社 ３−置換２−アミノ−インドール誘導体

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DE122007000044I2 (de) * 1997-01-07 2011-05-05 Amylin Pharmaceuticals Inc Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme
EP1028964A1 (en) 1997-11-11 2000-08-23 Pfizer Products Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
ATE314371T1 (de) * 1998-11-10 2006-01-15 Merck & Co Inc Spiro-indole als y5-rezeptor antagonisten
ES2180338T3 (es) 1998-11-12 2003-02-01 Neurocrine Biosciences Inc Antagonistas del receptor de crf y metodos relacionados.
US6531475B1 (en) 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
SI1165564T1 (sl) * 1999-04-08 2009-08-31 Ind Res Ltd Postopek priprave inhibitorjev metabolizma nukleozidov
GB9915437D0 (en) 1999-07-01 1999-09-01 Cerebrus Ltd Chemical compounds III
JP4815083B2 (ja) * 1999-08-31 2011-11-16 メルク・シャープ・エンド・ドーム・コーポレイション 複素環化合物およびそれの使用方法
ES2277855T3 (es) * 1999-09-30 2007-08-01 Neurogen Corporation Pirazolo-(1,5-a)-1,5-pirimidinas y pirazolo-(1,5-a)-1,3,5-triazinas amino sustituidas.
CA2379585C (en) * 1999-09-30 2006-06-20 James W. Darrow Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines
PL354784A1 (en) 1999-09-30 2004-02-23 Neurogen Corporation Certain alkylene diamine-substituted heterocycles
US6440960B1 (en) 2000-05-18 2002-08-27 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
US7276492B2 (en) * 2000-06-01 2007-10-02 Kevorkian Robert C Use of ACE inhibitors for treatment of patients suffering from behavioral disorders
CA2424622A1 (en) * 2000-10-03 2002-04-11 Clyde W. Hodge Use of neuropeptide-y antagonists in treatment of alcoholism
US8564661B2 (en) 2000-10-24 2013-10-22 Objectvideo, Inc. Video analytic rule detection system and method
GB0100620D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical cokpounds V
US20050226918A1 (en) * 2001-08-13 2005-10-13 Macdonald Stuart G Delivery system for insulin and other therapeutic agents
US6770652B2 (en) * 2001-10-18 2004-08-03 Duquesne University Of The Holy Ghost Multiple acting anti-angiogenic and cytotoxic compounds and methods for using the same
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JP2015508085A (ja) * 2012-02-21 2015-03-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ フロピリジン誘導体
JP2016526550A (ja) * 2013-06-27 2016-09-05 ヤンセン・サイエンシズ・アイルランド・ユーシー ウイルス感染症および他の疾病の処置のためのピロロ［３，２−ｄ］ピリミジン誘導体
JP2020203929A (ja) * 2013-06-27 2020-12-24 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ウイルス感染症および他の疾病の処置のためのピロロ［３，２−ｄ］ピリミジン誘導体
JP2017513915A (ja) * 2014-04-30 2017-06-01 マサリコヴァ ユニヴェルジタ プロテインキナーゼのインヒビターとしてのフロピリジン
JP2017519023A (ja) * 2014-06-25 2017-07-13 武田薬品工業株式会社 ３−置換２−アミノ−インドール誘導体

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US6583154B1 (en) 2003-06-24
AU2659099A (en) 1999-08-23
DK1054887T3 (da) 2006-05-08
ATE323088T1 (de) 2006-04-15
CY1105476T1 (el) 2010-07-28
WO1999040091A1 (en) 1999-08-12
DE69930835D1 (de) 2006-05-24
DE69930835T2 (de) 2006-10-19
PT1054887E (pt) 2006-06-30
CA2319275C (en) 2007-10-16
CA2319275A1 (en) 1999-08-12
SI1054887T1 (sl) 2006-08-31
US6187777B1 (en) 2001-02-13
ES2257851T3 (es) 2006-08-01

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