CY1105476T1 - Δικυκλικα παραγωγα πυριδινης και πυριμιδινης σαν ανταγωνιστες υποδοχεα νευροπεπτιδιου υ - Google Patents

Δικυκλικα παραγωγα πυριδινης και πυριμιδινης σαν ανταγωνιστες υποδοχεα νευροπεπτιδιου υ

Info

Publication number
CY1105476T1
CY1105476T1 CY20061100932T CY061100932T CY1105476T1 CY 1105476 T1 CY1105476 T1 CY 1105476T1 CY 20061100932 T CY20061100932 T CY 20061100932T CY 061100932 T CY061100932 T CY 061100932T CY 1105476 T1 CY1105476 T1 CY 1105476T1
Authority
CY
Cyprus
Prior art keywords
neuropeptide
receptor antagonists
pyrimidine derivatives
bicyclic pyridine
bicyclic
Prior art date
Application number
CY20061100932T
Other languages
English (en)
Inventor
Mark H. Norman
Ning Chen
Nianhe Han
Longbin Liu
Clarence R. Hurt
Christopher H. Fotsch
Tracy J. Jenkins
Offir A. MORENO
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of CY1105476T1 publication Critical patent/CY1105476T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
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  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Oncology (AREA)
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Abstract

Παρέχονται ενώσεις, συνθέσεις και μέθοδοι χρήσεις αυτών στη ρύθμιση συμπεριφοράς διατροφής, παχυσαρκίας, διαβήτη, καρκίνου (όγκου), φλεγμονωδών διαταραχών, κατάθλιψης, συναφών με στρες διαταραχών, ασθένειας Alzheimer και άλλων καταστάσεων ασθένειας.
CY20061100932T 1998-02-06 2006-07-06 Δικυκλικα παραγωγα πυριδινης και πυριμιδινης σαν ανταγωνιστες υποδοχεα νευροπεπτιδιου υ CY1105476T1 (el)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US7398198P 1998-02-06 1998-02-06
US7392798P 1998-02-06 1998-02-06
US9348298P 1998-07-20 1998-07-20
US9357798P 1998-07-20 1998-07-20
US09/246,775 US6187777B1 (en) 1998-02-06 1999-02-04 Compounds and methods which modulate feeding behavior and related diseases
PCT/US1999/002500 WO1999040091A1 (en) 1998-02-06 1999-02-05 Bicyclic pyridine and pyrimidine derivatives as neuropeptide y receptor antagonists

Publications (1)

Publication Number Publication Date
CY1105476T1 true CY1105476T1 (el) 2010-07-28

Family

ID=27535987

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100932T CY1105476T1 (el) 1998-02-06 2006-07-06 Δικυκλικα παραγωγα πυριδινης και πυριμιδινης σαν ανταγωνιστες υποδοχεα νευροπεπτιδιου υ

Country Status (13)

Country Link
US (2) US6187777B1 (el)
EP (1) EP1054887B1 (el)
JP (1) JP2003502272A (el)
AT (1) ATE323088T1 (el)
AU (1) AU747920B2 (el)
CA (1) CA2319275C (el)
CY (1) CY1105476T1 (el)
DE (1) DE69930835T2 (el)
DK (1) DK1054887T3 (el)
ES (1) ES2257851T3 (el)
PT (1) PT1054887E (el)
SI (1) SI1054887T1 (el)
WO (1) WO1999040091A1 (el)

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