DE69821132D1 - 1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetes - Google Patents
1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetesInfo
- Publication number
- DE69821132D1 DE69821132D1 DE69821132T DE69821132T DE69821132D1 DE 69821132 D1 DE69821132 D1 DE 69821132D1 DE 69821132 T DE69821132 T DE 69821132T DE 69821132 T DE69821132 T DE 69821132T DE 69821132 D1 DE69821132 D1 DE 69821132D1
- Authority
- DE
- Germany
- Prior art keywords
- adenosine
- allergies
- thiazole
- diabetes
- receptor antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP29448597 | 1997-10-27 | ||
PCT/JP1998/004837 WO1999021555A2 (en) | 1997-10-27 | 1998-10-26 | Adenosine a3 receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69821132D1 true DE69821132D1 (de) | 2004-02-19 |
DE69821132T2 DE69821132T2 (de) | 2004-10-21 |
Family
ID=17808383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69821132T Expired - Lifetime DE69821132T2 (de) | 1997-10-27 | 1998-10-26 | 1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetes |
Country Status (8)
Country | Link |
---|---|
US (2) | US6436966B1 (de) |
EP (1) | EP1027050B1 (de) |
JP (1) | JPH11193281A (de) |
AT (1) | ATE257703T1 (de) |
AU (1) | AU9648098A (de) |
CA (1) | CA2302417A1 (de) |
DE (1) | DE69821132T2 (de) |
WO (1) | WO1999021555A2 (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11193281A (ja) * | 1997-10-27 | 1999-07-21 | Takeda Chem Ind Ltd | アデノシンa3受容体拮抗剤およびチアゾール化合物 |
AU4506399A (en) * | 1998-06-05 | 1999-12-30 | Novartis Ag | Aryl pyridinyl thiazoles |
AU765473B2 (en) | 1999-04-23 | 2003-09-18 | Takeda Pharmaceutical Company Limited | 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof |
EP1205478A4 (de) | 1999-08-06 | 2004-06-30 | Takeda Chemical Industries Ltd | INHIBITOREN DER p38MAP-KINASE |
WO2001027094A1 (fr) * | 1999-10-12 | 2001-04-19 | Japan Tobacco Inc. | Remede anti-hypertriglyceridemie et anti-obesite |
AU7922900A (en) | 1999-10-27 | 2001-05-08 | Novartis Ag | Thiazole and imidazo (4,5-b) pyridine compounds and their pharmaceutical use |
MXPA02005106A (es) * | 1999-11-22 | 2002-11-07 | Smithkline Beecham Plc | Compuestos novedosos. |
AU2001237401B2 (en) | 2000-03-01 | 2006-11-09 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
GB0005357D0 (en) | 2000-03-06 | 2000-04-26 | Smithkline Beecham Plc | Compounds |
AU2001244618A1 (en) | 2000-03-30 | 2001-10-15 | Takeda Chemical Industries Ltd. | Substituted 1,3-thiazole compounds, their production and use |
MXPA03001136A (es) * | 2000-08-11 | 2003-06-24 | Eisai Co Ltd | Compuesto de 2-aminopiridina y uso medico del mismo. |
US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
MXPA03002449A (es) | 2000-09-21 | 2003-06-19 | Smithkline Beecham Plc | Derivados de imidazol como inhibidores de cinasa raf. |
GB0028383D0 (en) | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
CA2431171A1 (en) | 2000-12-08 | 2002-06-13 | Takeda Chemical Industries, Ltd. | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
WO2002062792A1 (fr) | 2001-02-02 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Inhibiteur de jnk |
GB0102668D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
WO2002094317A1 (en) * | 2001-05-18 | 2002-11-28 | Endacea Inc. | Methods and formulations of using a1 adenosine and p2x purinoreceptor antagonists |
GB0112348D0 (en) * | 2001-05-19 | 2001-07-11 | Smithkline Beecham Plc | Compounds |
WO2003022837A1 (en) * | 2001-09-05 | 2003-03-20 | Smithkline Beecham P.L.C. | Heterocycle-carboxamide derivatives as raf kinase inhibitors |
WO2003048140A1 (fr) | 2001-12-03 | 2003-06-12 | Japan Tobacco Inc. | Compose azole et utilisation medicinale de celui-ci |
AR038966A1 (es) * | 2002-03-18 | 2005-02-02 | Solvay Pharm Bv | Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial de cb1 |
JP4518956B2 (ja) | 2002-09-18 | 2010-08-04 | ファイザー・プロダクツ・インク | トランスフォーミング成長因子(tgf)阻害剤としての新規トリアゾールおよびオキサゾール化合物 |
OA12927A (en) * | 2002-09-18 | 2006-10-13 | Pfizer Prod Inc | Novel triazole and oxazole compounds as transforming growth factor (TGF) inhibitors. |
TW200505447A (en) * | 2003-02-07 | 2005-02-16 | Daiichi Seiyaku Co | Pyrazole derivative |
AR044519A1 (es) | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
GB0326601D0 (en) * | 2003-11-14 | 2003-12-17 | Novartis Ag | Organic compounds |
EP1700856B1 (de) * | 2003-12-26 | 2015-11-11 | Kyowa Hakko Kirin Co., Ltd. | Thiazolderivat |
US20050227989A1 (en) * | 2004-04-13 | 2005-10-13 | Icagen, Inc. | Polycyclic thiazoles as potassium ion channel modulators |
BRPI0515519A (pt) * | 2004-09-22 | 2008-07-29 | H. Lundbeck & Co A/S | composto, e, uso do mesmo |
EP1894930A4 (de) | 2005-06-23 | 2010-06-23 | Kyowa Hakko Kirin Co Ltd | Thiazolderivat |
PT1921077T (pt) | 2005-08-02 | 2017-10-26 | Kyowa Hakko Kirin Co Ltd | Agente para tratar e/ou prevenir distúrbio do sono |
AU2006290814B2 (en) | 2005-09-13 | 2012-06-07 | Janssen Pharmaceutica N.V. | 2-aniline-4-aryl substituted thiazole derivatives |
MY153263A (en) | 2006-08-15 | 2015-01-29 | Novartis Ag | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid levels |
TW200815428A (en) * | 2006-08-15 | 2008-04-01 | Wyeth Corp | Oxazolidone derivatives as PR modulators |
WO2008021338A2 (en) * | 2006-08-15 | 2008-02-21 | Wyeth | Tricyclic oxazolidone derivatives useful as pr modulators |
US8440701B2 (en) | 2007-10-18 | 2013-05-14 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4 triazoles |
JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
AU2008340053A1 (en) | 2007-12-20 | 2009-07-02 | Novartis Ag | Thiazole derivatives used as PI 3 kinase inhibitors |
NZ587350A (en) | 2008-02-20 | 2012-07-27 | Novartis Ag | Thiazole derivatives featuring an imidazolidine or triazole derivative as inhibitors of stearoyl-CoA desaturase |
KR101564303B1 (ko) | 2008-03-19 | 2015-11-06 | 얀센 파마슈티카 엔.브이. | 니코틴성 아세틸콜린 수용체 조절제로서의 삼치환된 1,2,4-트리아졸 |
US8779158B2 (en) | 2008-05-09 | 2014-07-15 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
US20110190324A1 (en) * | 2008-07-16 | 2011-08-04 | Edward Leung | Methods of treating atherosclerosis |
UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
TWI435874B (zh) * | 2008-10-31 | 2014-05-01 | Toray Industries | 環己烷衍生物及其醫藥用途 |
EP2198710A1 (de) | 2008-12-19 | 2010-06-23 | Bayer CropScience AG | Verwendung von 5-Pyridin-4yl-(1,3)Thiazole zur Bekämpfung phytopathogener Pilze |
US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
ES2536534T3 (es) | 2010-07-30 | 2015-05-26 | Toray Industries, Inc. | Agente terapéutico o agente profiláctico para el dolor neuropático |
DE102011083259A1 (de) * | 2011-09-23 | 2013-03-28 | Beiersdorf Ag | Alkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Alkylamidothiazolen |
US9663529B2 (en) | 2013-07-02 | 2017-05-30 | Bristol-Myers Squibb Company | Tricyclic pyrido-carboxamide derivatives as rock inhibitors |
TW201506024A (zh) | 2013-07-02 | 2015-02-16 | 必治妥美雅史谷比公司 | 作為有效rock抑制劑的三環甲醯胺衍生物 |
US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
ES2578363B1 (es) | 2015-01-22 | 2017-01-31 | Palobiofarma, S.L. | Moduladores de los receptores A3 de adenosina |
CN108495852B (zh) * | 2016-09-08 | 2021-06-15 | 四川科伦博泰生物医药股份有限公司 | 2-酰氨基噻唑类衍生物及其制备方法与用途 |
ES2676535B1 (es) | 2017-01-20 | 2019-04-29 | Palobiofarma Sl | Moduladores de los receptores a3 de adenosina |
CN109293652B (zh) * | 2017-07-24 | 2021-10-22 | 四川科伦博泰生物医药股份有限公司 | 一种取代的噻唑衍生物及其用途 |
CN107400124A (zh) * | 2017-09-14 | 2017-11-28 | 刘双伟 | 一种烟酰胺类化合物、合成路线及其在制备抗过敏药物中的应用 |
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DE2828091A1 (de) * | 1978-06-27 | 1980-01-10 | Boehringer Sohn Ingelheim | 4-substituierte thiazoloxamsaeuren sowie ihre salze und ester |
US4199592A (en) * | 1978-08-29 | 1980-04-22 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-nitroimidazoles |
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GB9201692D0 (en) * | 1992-01-27 | 1992-03-11 | Smithkline Beecham Intercredit | Compounds |
WO1993020061A1 (en) * | 1992-04-01 | 1993-10-14 | The University Of Toledo | 4-[4'-piperidinyl or 3'-pirrolidinyl] substituted imidazoles as h3-receptor antagonists and therapeutic uses thereof |
US5486526A (en) * | 1992-04-01 | 1996-01-23 | The University Of Toledo | Histamine H3 -receptor antagonists and therapeutic uses thereof |
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US5739143A (en) * | 1995-06-07 | 1998-04-14 | Smithkline Beecham Corporation | Imidazole compounds and compositions |
WO1997012613A1 (en) * | 1995-10-05 | 1997-04-10 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
US5972980A (en) * | 1995-10-05 | 1999-10-26 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
US6001866A (en) * | 1995-10-05 | 1999-12-14 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
US6083949A (en) * | 1995-10-06 | 2000-07-04 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
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ES2205167T3 (es) * | 1996-01-11 | 2004-05-01 | Smithkline Beecham Corporation | Nuevos compuestos de imidazol sustituidos. |
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WO1997035856A1 (en) * | 1996-03-25 | 1997-10-02 | Smithkline Beecham Corporation | Novel treatment for cns injuries |
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WO1998007425A1 (en) * | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
JPH1087490A (ja) * | 1996-09-10 | 1998-04-07 | Sagami Chem Res Center | インターロイキン6生産抑制剤、骨吸収抑制剤、抗骨粗鬆症剤、及びチアゾール化合物 |
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JPH11193281A (ja) * | 1997-10-27 | 1999-07-21 | Takeda Chem Ind Ltd | アデノシンa3受容体拮抗剤およびチアゾール化合物 |
JPH11145279A (ja) * | 1997-10-27 | 1999-05-28 | Shijie Xianjin Jiti Electric Co Ltd | 窒化シリコン保護膜のピンホール除去方法 |
-
1998
- 1998-10-26 JP JP10303623A patent/JPH11193281A/ja active Pending
- 1998-10-26 AT AT98950388T patent/ATE257703T1/de not_active IP Right Cessation
- 1998-10-26 WO PCT/JP1998/004837 patent/WO1999021555A2/en active IP Right Grant
- 1998-10-26 CA CA002302417A patent/CA2302417A1/en not_active Abandoned
- 1998-10-26 DE DE69821132T patent/DE69821132T2/de not_active Expired - Lifetime
- 1998-10-26 EP EP98950388A patent/EP1027050B1/de not_active Expired - Lifetime
- 1998-10-26 US US09/463,639 patent/US6436966B1/en not_active Expired - Fee Related
- 1998-10-26 AU AU96480/98A patent/AU9648098A/en not_active Abandoned
-
2002
- 2002-06-03 US US10/161,181 patent/US6620825B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU9648098A (en) | 1999-05-17 |
DE69821132T2 (de) | 2004-10-21 |
EP1027050B1 (de) | 2004-01-14 |
WO1999021555A2 (en) | 1999-05-06 |
EP1027050A2 (de) | 2000-08-16 |
US6620825B1 (en) | 2003-09-16 |
CA2302417A1 (en) | 1999-05-06 |
JPH11193281A (ja) | 1999-07-21 |
US6436966B1 (en) | 2002-08-20 |
WO1999021555A3 (en) | 1999-07-22 |
ATE257703T1 (de) | 2004-01-15 |
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