JP2002534523A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002534523A5 JP2002534523A5 JP2000593608A JP2000593608A JP2002534523A5 JP 2002534523 A5 JP2002534523 A5 JP 2002534523A5 JP 2000593608 A JP2000593608 A JP 2000593608A JP 2000593608 A JP2000593608 A JP 2000593608A JP 2002534523 A5 JP2002534523 A5 JP 2002534523A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- embedded image
- acceptable salt
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 description 18
- 125000003118 aryl group Chemical group 0.000 description 16
- 239000002207 metabolite Substances 0.000 description 16
- 239000000651 prodrug Substances 0.000 description 16
- 229940002612 prodrug Drugs 0.000 description 16
- 239000012453 solvate Substances 0.000 description 16
- 125000003342 alkenyl group Chemical group 0.000 description 15
- 125000000217 alkyl group Chemical group 0.000 description 15
- 125000000304 alkynyl group Chemical group 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 15
- 102000004190 Enzymes Human genes 0.000 description 14
- 108090000790 Enzymes Proteins 0.000 description 14
- 125000000753 cycloalkyl group Chemical group 0.000 description 14
- 125000001072 heteroaryl group Chemical group 0.000 description 14
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 14
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 description 13
- 229910052736 halogen Inorganic materials 0.000 description 13
- 150000002367 halogens Chemical class 0.000 description 13
- 125000000547 substituted alkyl group Chemical group 0.000 description 12
- 101710179684 Poly [ADP-ribose] polymerase Proteins 0.000 description 11
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 description 11
- 230000002401 inhibitory effect Effects 0.000 description 8
- 0 *Cc(cc1)ccc1-c([n]c1ccc2)c(CN3)c1c2C3=O Chemical compound *Cc(cc1)ccc1-c([n]c1ccc2)c(CN3)c1c2C3=O 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000012661 PARP inhibitor Substances 0.000 description 4
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 230000003013 cytotoxicity Effects 0.000 description 4
- 231100000135 cytotoxicity Toxicity 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 102100037664 Poly [ADP-ribose] polymerase tankyrase-1 Human genes 0.000 description 2
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 description 2
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 description 2
- 108010017601 Tankyrases Proteins 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- -1 nitro, amino Chemical group 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- PKVZFELFJSNJPB-UHFFFAOYSA-N C#CCNC(c([nH]c1ccc2)c(CCN3)c1c2C3=O)=O Chemical compound C#CCNC(c([nH]c1ccc2)c(CCN3)c1c2C3=O)=O PKVZFELFJSNJPB-UHFFFAOYSA-N 0.000 description 1
- PELPWRMBLNFENG-NSCUHMNNSA-N C/C=C/c1cc([nH]c(Br)c2CCNC3=O)c2c3c1 Chemical compound C/C=C/c1cc([nH]c(Br)c2CCNC3=O)c2c3c1 PELPWRMBLNFENG-NSCUHMNNSA-N 0.000 description 1
- NWDFKLBRQRPNMY-UHFFFAOYSA-N C=C(CCCc1c(C(Nc2cc3ccccc3cc2)=O)[nH]2)c3c1c2ccc3 Chemical compound C=C(CCCc1c(C(Nc2cc3ccccc3cc2)=O)[nH]2)c3c1c2ccc3 NWDFKLBRQRPNMY-UHFFFAOYSA-N 0.000 description 1
- GTARMXPKNIBDGR-UHFFFAOYSA-N CC(C)NC(c([nH]c1ccc2)c(CCN3)c1c2C3=O)=O Chemical compound CC(C)NC(c([nH]c1ccc2)c(CCN3)c1c2C3=O)=O GTARMXPKNIBDGR-UHFFFAOYSA-N 0.000 description 1
- LHVVSOGORITFFH-UHFFFAOYSA-N CCCc1c(-c(cc2)ccc2S(C)=O)[nH]c2c1c(C(CC)=O)ccc2 Chemical compound CCCc1c(-c(cc2)ccc2S(C)=O)[nH]c2c1c(C(CC)=O)ccc2 LHVVSOGORITFFH-UHFFFAOYSA-N 0.000 description 1
- LYIUAHZNJYYRLK-UHFFFAOYSA-N CCCc1c(-c2ccc(CN3CCCC3)cc2)[nH]c2c1c(C(C=N)=O)cc(F)c2 Chemical compound CCCc1c(-c2ccc(CN3CCCC3)cc2)[nH]c2c1c(C(C=N)=O)cc(F)c2 LYIUAHZNJYYRLK-UHFFFAOYSA-N 0.000 description 1
- CVNBRRDKEKIBCA-UHFFFAOYSA-N CCCc1c(C(C(c2ccccc2)=N)=O)[nH]c2cccc(C(C)=O)c12 Chemical compound CCCc1c(C(C(c2ccccc2)=N)=O)[nH]c2cccc(C(C)=O)c12 CVNBRRDKEKIBCA-UHFFFAOYSA-N 0.000 description 1
- VBWVXWCLBKEBCB-UHFFFAOYSA-N CCCc1c(C(Nc(cc2)ccc2Cl)=O)[nH]c2cccc(C=O)c12 Chemical compound CCCc1c(C(Nc(cc2)ccc2Cl)=O)[nH]c2cccc(C=O)c12 VBWVXWCLBKEBCB-UHFFFAOYSA-N 0.000 description 1
- OZSBLJFTXFBONL-UHFFFAOYSA-N CNC(c1c(CCNC(C2CC=C3)=O)c2c3[nH]1)=O Chemical compound CNC(c1c(CCNC(C2CC=C3)=O)c2c3[nH]1)=O OZSBLJFTXFBONL-UHFFFAOYSA-N 0.000 description 1
- KKWMDDGYIRVOMY-UHFFFAOYSA-N CNCc1cccc(-c2c(CCNC(c3cc(F)c4)=O)c3c4[nH]2)c1 Chemical compound CNCc1cccc(-c2c(CCNC(c3cc(F)c4)=O)c3c4[nH]2)c1 KKWMDDGYIRVOMY-UHFFFAOYSA-N 0.000 description 1
- TVTOPSASQLZYEB-UHFFFAOYSA-N COc(ccc(Cl)c1)c1-c1c(CCNC(c2ccc3)=O)c2c3[nH]1 Chemical compound COc(ccc(Cl)c1)c1-c1c(CCNC(c2ccc3)=O)c2c3[nH]1 TVTOPSASQLZYEB-UHFFFAOYSA-N 0.000 description 1
- QMCBHIPGPJWTMX-UHFFFAOYSA-N CS(c(cc1)ccc1-c1c(CCNC(c2ccc3)=O)c2c3[nH]1)(=O)=O Chemical compound CS(c(cc1)ccc1-c1c(CCNC(c2ccc3)=O)c2c3[nH]1)(=O)=O QMCBHIPGPJWTMX-UHFFFAOYSA-N 0.000 description 1
- MRDWIBPBWIAABA-UHFFFAOYSA-N CSc(cc1)ccc1-c1c(CCNC(c2ccc3)=O)c2c3[nH]1 Chemical compound CSc(cc1)ccc1-c1c(CCNC(c2ccc3)=O)c2c3[nH]1 MRDWIBPBWIAABA-UHFFFAOYSA-N 0.000 description 1
- SYGXSZZARIQGNS-UHFFFAOYSA-N C[n](cc1CN(C)C2=O)c3c1c2ccc3 Chemical compound C[n](cc1CN(C)C2=O)c3c1c2ccc3 SYGXSZZARIQGNS-UHFFFAOYSA-N 0.000 description 1
- VXHGKYBDQFTADR-UHFFFAOYSA-N C[n](cc1CNC2=O)c3c1c2ccc3 Chemical compound C[n](cc1CNC2=O)c3c1c2ccc3 VXHGKYBDQFTADR-UHFFFAOYSA-N 0.000 description 1
- UGQGSXIPHIMFTJ-UHFFFAOYSA-N Cc1cc(C(CCCc2c(-c3ccc(CNC)cc3)[nH]3)=O)c2c3c1 Chemical compound Cc1cc(C(CCCc2c(-c3ccc(CNC)cc3)[nH]3)=O)c2c3c1 UGQGSXIPHIMFTJ-UHFFFAOYSA-N 0.000 description 1
- VNUZUFYYLSIZFY-UHFFFAOYSA-N N=C(CC(c([nH]c1ccc2)c(CCN3)c1c2C3=O)=O)C1CC1 Chemical compound N=C(CC(c([nH]c1ccc2)c(CCN3)c1c2C3=O)=O)C1CC1 VNUZUFYYLSIZFY-UHFFFAOYSA-N 0.000 description 1
- SMQBDMFORQBOIM-UHFFFAOYSA-N O=C(c1cccc([nH]2)c11)NCc1c2Br Chemical compound O=C(c1cccc([nH]2)c11)NCc1c2Br SMQBDMFORQBOIM-UHFFFAOYSA-N 0.000 description 1
- IHJPJQJALQHPFF-UHFFFAOYSA-N O=C1NCCc2c(-c3c(CCNC(c4ccc5)=O)c4c5[nH]3)[nH]c3c2c1ccc3 Chemical compound O=C1NCCc2c(-c3c(CCNC(c4ccc5)=O)c4c5[nH]3)[nH]c3c2c1ccc3 IHJPJQJALQHPFF-UHFFFAOYSA-N 0.000 description 1
- OADDPRZHUAMSOC-UHFFFAOYSA-N O=C1NCCc2c(-c3ccc(CCN4CCCC4)cc3)[nH]c3cccc1c23 Chemical compound O=C1NCCc2c(-c3ccc(CCN4CCCC4)cc3)[nH]c3cccc1c23 OADDPRZHUAMSOC-UHFFFAOYSA-N 0.000 description 1
- AMXUETXVQWSXKX-UHFFFAOYSA-N O=C1NCCc2c(-c3cccc(-c4ccccc4)c3)[nH]c3c2C1CC=C3 Chemical compound O=C1NCCc2c(-c3cccc(-c4ccccc4)c3)[nH]c3c2C1CC=C3 AMXUETXVQWSXKX-UHFFFAOYSA-N 0.000 description 1
- IYQQQOPMPOKHBL-UHFFFAOYSA-N O=C1NCc2c(-c3ccccc3)[nH]c3cccc1c23 Chemical compound O=C1NCc2c(-c3ccccc3)[nH]c3cccc1c23 IYQQQOPMPOKHBL-UHFFFAOYSA-N 0.000 description 1
- QXBNJYBFEBEQQQ-UHFFFAOYSA-N O=Cc(cc1)ccc1-c([nH]c1ccc2)c(CN3)c1c2C3=O Chemical compound O=Cc(cc1)ccc1-c([nH]c1ccc2)c(CN3)c1c2C3=O QXBNJYBFEBEQQQ-UHFFFAOYSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11543199P | 1999-01-11 | 1999-01-11 | |
| US60/115,431 | 1999-01-11 | ||
| PCT/US2000/000411 WO2000042040A1 (en) | 1999-01-11 | 2000-01-10 | Tricyclic inhibitors of poly(adp-ribose) polymerases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002534523A JP2002534523A (ja) | 2002-10-15 |
| JP2002534523A5 true JP2002534523A5 (https=) | 2006-09-21 |
| JP4093448B2 JP4093448B2 (ja) | 2008-06-04 |
Family
ID=22361361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000593608A Expired - Lifetime JP4093448B2 (ja) | 1999-01-11 | 2000-01-10 | ポリ（ａｄｐ−リボース）ポリメラーゼの三環系阻害剤 |
Country Status (39)
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291425B1 (en) | 1999-09-01 | 2001-09-18 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage |
| KR20010087401A (ko) * | 1999-09-28 | 2001-09-15 | 스타르크, 카르크 | 아제피노인돌 유도체, 그의 제법 및 용도 |
| US6589725B1 (en) | 1999-10-25 | 2003-07-08 | Rigel Pharmaceuticals, Inc. | Tankyrase H, compositions involved in the cell cycle and methods of use |
| US6476048B1 (en) | 1999-12-07 | 2002-11-05 | Inotek Pharamaceuticals Corporation | Substituted phenanthridinones and methods of use thereof |
| US6531464B1 (en) | 1999-12-07 | 2003-03-11 | Inotek Pharmaceutical Corporation | Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives |
| NZ521792A (en) * | 2000-03-20 | 2004-06-25 | N Gene Res Lab Inc | Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and use in treating conditions connected with oxygen deficiency |
| US6534651B2 (en) | 2000-04-06 | 2003-03-18 | Inotek Pharmaceuticals Corp. | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof |
| MXPA03004832A (es) * | 2000-12-01 | 2004-05-04 | Guilford Pharm Inc | Compuestos y sus usos. |
| DE60218458T2 (de) | 2001-05-08 | 2007-11-15 | Kudos Pharmaceuticals Ltd. | Isochinolinon derivate als parp inhibitoren |
| KR100955015B1 (ko) | 2001-08-15 | 2010-04-28 | 이코스 코포레이션 | 2ｈ-프탈라진-1-온 및 이것의 사용 방법 |
| US6956035B2 (en) | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| US20030096833A1 (en) | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| WO2003051879A1 (en) * | 2001-12-14 | 2003-06-26 | Altana Pharma Ag | Known and novel 4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-ones useful as poly(adp-ribose)polymerase inhibitors |
| DE60335359D1 (de) | 2002-04-30 | 2011-01-27 | Kudos Pharm Ltd | Phthalazinonderivate |
| CA2512683C (en) * | 2003-01-09 | 2010-03-16 | Pfizer Inc. | Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy |
| JP2007501857A (ja) | 2003-02-28 | 2007-02-01 | イノテック ファーマシューティカルズ コーポレーション | 四環系ベンズアミド誘導体およびその使用方法 |
| US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
| MXPA05010563A (es) * | 2003-03-31 | 2005-11-23 | Pfizer | Sales de los inhibidores triciclicos de las poli(adp-ribosa) polimerasas. |
| WO2004105700A2 (en) * | 2003-05-28 | 2004-12-09 | Guildford Pharmaceuticals, Inc. | Compounds, methods and pharmaceutical compositions for inhibiting parp |
| GB0317466D0 (en) * | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
| SI1660095T1 (sl) * | 2003-07-25 | 2010-05-31 | Cancer Rec Tech Ltd | Triciklični parp inhibitorji |
| KR20060123403A (ko) | 2003-12-01 | 2006-12-01 | 쿠도스 파마슈티칼스 리미티드 | 암 치료를 위한 ｄｎａ 손상 수복 억제제 |
| EA200601558A1 (ru) | 2004-02-26 | 2007-08-31 | Инотек Фармасьютикалз Корпорейшн | Производные изохинолинов и способы их использования |
| GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| DK1794163T3 (da) * | 2004-09-22 | 2010-04-12 | Pfizer | Fremgangsmåde til fremstilling af poly(ADP-ribose)polymeraseinhibitorer |
| EP1799685B1 (en) * | 2004-09-22 | 2012-03-28 | Pfizer Inc. | Polymorphic forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one |
| CN101133061B (zh) * | 2004-09-22 | 2011-09-07 | 辉瑞有限公司 | 8-氟-2-{4-[（甲基氨基）甲基]苯基}-1,3,4,5-四氢-6H-氮杂卓并[5,4,3-cd]吲哚-6-酮的磷酸盐的多晶型物和非晶物 |
| EP1793830A2 (en) * | 2004-09-22 | 2007-06-13 | Pfizer, Inc. | Therapeutic combinations comprising poly(adp-ribose) polymerases inhibitor |
| WO2006078711A2 (en) | 2005-01-19 | 2006-07-27 | Mgi Gp, Inc. | Diazabenzo[de]anthracen-3-one compounds and methods for inhibiting parp |
| RU2007135362A (ru) | 2005-02-25 | 2009-03-27 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические амино- и карбоксамидосоединения и способ их применения |
| US7297700B2 (en) | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| DE102005022111A1 (de) * | 2005-05-12 | 2006-11-16 | Siemens Ag | Verfahren zum Datenaustausch |
| US20090226412A1 (en) | 2005-06-24 | 2009-09-10 | Ono Pharmaceutical Co., Ltd., | Agent for reduction of bleeding in cerebrovascular disorder |
| ATE478863T1 (de) | 2005-07-14 | 2010-09-15 | Irm Llc | Heterotetracyclische verbindungen als tpo- mimetica |
| CA2615374A1 (en) | 2005-07-18 | 2007-01-25 | Ernest Kun Kun | Treatment of cancer |
| CN101316592A (zh) | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
| ME02121B (me) * | 2006-01-17 | 2014-06-30 | Abbvie Ireland Unlimited Co | Kombinovana terapija sa parp inhibitorima |
| TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途 |
| US20080262062A1 (en) * | 2006-11-20 | 2008-10-23 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
| CA2662337A1 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
| JP2010502730A (ja) | 2006-09-05 | 2010-01-28 | バイパー サイエンシズ，インコーポレイティド | 癌の治療法 |
| MX2009009183A (es) | 2007-02-28 | 2009-09-07 | Inotek Pharmaceuticals Corp | Analogos de indenoisoquinolinona y metodos de utilizacion de los mismos. |
| WO2008154129A1 (en) * | 2007-06-08 | 2008-12-18 | Bausch & Lomb Incorporated | Pharmaceutical compositions and method for treating, reducing, ameliorating, alleviating, or preventing dry eye |
| MX2010002749A (es) | 2007-09-14 | 2010-06-25 | Astrazeneca Ab | Derivados de ftalazinona. |
| DK2209375T3 (da) | 2007-10-03 | 2014-10-06 | Eisai Inc | Parp-inhibitorforbindelser, præparater og fremgangsmåder til anvendelse deraf |
| CN103169973A (zh) | 2007-11-12 | 2013-06-26 | 彼帕科学公司 | 使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌 |
| AR070221A1 (es) | 2008-01-23 | 2010-03-25 | Astrazeneca Ab | Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas. |
| GB0804755D0 (en) | 2008-03-14 | 2008-04-16 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| ES2598178T5 (es) | 2008-10-07 | 2023-12-26 | Kudos Pharm Ltd | Formulación farmacéutica 514 |
| WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
| KR100986820B1 (ko) * | 2010-01-27 | 2010-10-12 | (주)에코베이스 | 막힘방지형 고효율 산기장치 및 이를 이용한 수질정화장치 |
| EP2534153B2 (en) | 2010-02-12 | 2024-05-22 | Pfizer Inc. | Salts and polymorphs of 8-fluoro-2-{4-[(methylamino}methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one |
| KR101528688B1 (ko) | 2010-12-02 | 2015-06-12 | 상하이 드 노보 파마테크 컴퍼니 리미티드 | 헤테로사이클릭 유도체, 이의 제조 방법 및 이의 의학적 용도 |
| IN2014DN06169A (https=) | 2011-12-31 | 2015-08-21 | Beigene Ltd | |
| MX2014008071A (es) | 2011-12-31 | 2015-07-06 | Beigene Ltd | Tetra o penta-piridoftalazinonas ciclicas fusionadas como inhibidores de poli(adenosin-difosfato-ribosa)polimerasas. |
| WO2014073447A1 (ja) | 2012-11-08 | 2014-05-15 | 日本化薬株式会社 | カンプトテシン類と抗癌効果増強剤の結合した高分子化合物及びその用途 |
| CA2935857C (en) | 2014-01-05 | 2020-12-15 | Washington University | Radiolabeled tracers for poly (adp-ribose) polymerase-1 (parp-1), methods and uses therefor |
| CN103772395B (zh) * | 2014-01-23 | 2016-05-11 | 中国药科大学 | 一类具有parp抑制活性的化合物、其制备方法及用途 |
| LT3157566T (lt) | 2014-06-17 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Vėžio gydymo būdas, panaudojant chk1 ir atr inhibitorių derinį |
| KR102803917B1 (ko) | 2014-08-22 | 2025-05-07 | 파르마＆ 슈바이츠 게엠베하 | 루카파립의 고 용량 강도 정제 |
| CN105607772B (zh) * | 2014-11-13 | 2020-11-03 | 现代自动车株式会社 | 触摸输入装置以及包括该装置的车辆 |
| TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
| JP6871169B2 (ja) | 2015-03-02 | 2021-05-12 | シナイ ヘルス システム | 相同組換え因子 |
| JP6457696B2 (ja) | 2015-07-23 | 2019-01-23 | アンスティテュ・キュリＩｎｓｔｉｔｕｔ Ｃｕｒｉｅ | 癌を処置するためのＤｂａｉｔ分子とＰＡＲＰインヒビターとの組合せの使用 |
| EP3341375B1 (en) | 2015-08-25 | 2022-04-13 | BeiGene, Ltd. | Process for preparing parp inhibitor, crystalline forms, and uses thereof |
| HK1258570A1 (zh) | 2015-09-30 | 2019-11-15 | Vertex Pharmaceuticals Inc. | 使用dna损伤剂及atr抑制剂的组合治疗癌症的方法 |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| CN107286166B (zh) * | 2016-04-11 | 2020-03-31 | 上海勋和医药科技有限公司 | 取代1，3，4，5-四氢-6h-吡咯并[4，3，2-ef][2]苯并氮杂-6-酮衍生物 |
| US10874641B2 (en) | 2016-07-28 | 2020-12-29 | Mitobridge, Inc. | Methods of treating acute kidney injury |
| CN110087730B (zh) | 2016-09-27 | 2023-03-28 | 百济神州(苏州)生物科技有限公司 | 使用包含parp抑制剂的组合产品治疗癌症 |
| JP6541635B2 (ja) * | 2016-10-28 | 2019-07-10 | ベイジーン リミテッド | Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン |
| AU2017355402A1 (en) | 2016-11-02 | 2019-05-30 | Health Research, Inc. | Combination treatment with antibody-drug conjugates and PARP inhibitors |
| CN106854172B (zh) * | 2016-12-11 | 2019-04-19 | 山东轩德医药科技有限公司 | 一种6-氟-1h-吲哚-4-甲酸甲酯的制备方法 |
| WO2018122168A1 (en) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinations of bub1 kinase and parp inhibitors |
| US10875870B2 (en) | 2017-01-24 | 2020-12-29 | Assia Chemical Industries Ltd. | Solid state forms of rucaparib and of rucaparib salts |
| CN106748958B (zh) * | 2017-01-25 | 2018-12-18 | 伦俊杰 | 一种Rucaparib中间体的制备方法 |
| TW201840564A (zh) | 2017-02-28 | 2018-11-16 | 英屬開曼群島商百濟神州有限公司 | 稠合的四環或五環二氫二氮呯幷哢唑酮的鹽的結晶形式及其用途 |
| WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
| US11161865B2 (en) | 2017-05-24 | 2021-11-02 | The Trustees Of The University Of Pennsylvania | Radiolabeled and fluorescent PARP inhibitors for imaging and radiotherapy |
| IT201700085789A1 (it) | 2017-07-26 | 2019-01-26 | Olon Spa | Metodo per la preparazione di rucaparib ad elevata purezza |
| EP3659307A4 (en) * | 2017-07-28 | 2021-09-22 | Yale University | ANTI-CANCER PRODUCTS AND METHOD FOR MANUFACTURING AND USING THEREOF |
| CN109651376B (zh) * | 2017-10-12 | 2022-06-03 | 江苏创诺制药有限公司 | 一种氮杂卓并[5,4,3-cd]吲哚-6-酮化合物的合成方法 |
| CN109651377B (zh) * | 2017-10-12 | 2020-10-20 | 成都海创药业有限公司 | 一种治疗癌症的化合物及其用途 |
| JP2021501771A (ja) * | 2017-11-03 | 2021-01-21 | サンド・アクチエンゲゼルシヤフト | 三環系ポリ（ａｄｐ−リボース）ポリメラーゼ阻害剤の結晶性塩 |
| WO2019115000A1 (en) | 2017-12-15 | 2019-06-20 | Advitech Advisory And Technologies Sa | Process for the preparation of rucaparib and novel synthesis intermediates |
| WO2019130229A1 (en) | 2017-12-28 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing rucaparib |
| KR20200121800A (ko) | 2018-01-05 | 2020-10-26 | 싸이브렉사 1, 인크. | 산성 또는 저산소성 질환에 걸린 조직에 관련된 질환의 치료를 위한 화합물, 조성물 및 방법 |
| US10442813B2 (en) | 2018-01-30 | 2019-10-15 | RK Pharma Solutions LLC | Polymorphs of rucaparib camsylate and methods of making same |
| CN110229162B (zh) * | 2018-03-05 | 2020-08-11 | 新发药业有限公司 | 一种瑞卡帕布的简便制备方法 |
| KR20200130856A (ko) | 2018-03-13 | 2020-11-20 | 옹쎄오 | 암 치료에서 획득한 내성에 대한 디베이트 분자 |
| CN110272419A (zh) * | 2018-03-14 | 2019-09-24 | 上海艾力斯医药科技有限公司 | 二氢吡啶并酞嗪酮衍生物、其制备方法及应用 |
| WO2019207596A1 (en) | 2018-04-25 | 2019-10-31 | Mylan Laboratories Limited | Novel crystalline forms of rucaparib (s)-camsylate salt and rucaparib free base |
| CN108743557A (zh) * | 2018-06-27 | 2018-11-06 | 李莉 | 一种磷酸瑞卡帕布软胶囊及其制备方法 |
| CN108976236B (zh) * | 2018-08-16 | 2020-11-10 | 湖南华腾制药有限公司 | 一种氘代parp抑制剂、其盐、其制备方法及用途 |
| CR20210281A (es) | 2018-10-30 | 2021-10-25 | Repare Therapeutics Inc | Compuestos, composiciones farmacéuticas y métodos de preparación de compuestos y de uso como inhibidores de la cinasa atr |
| CN111217818A (zh) * | 2018-11-27 | 2020-06-02 | 台耀化学股份有限公司 | 芦卡帕尼樟脑磺酸盐的结晶、及制备三环化合物、芦卡帕尼及其樟脑磺酸盐结晶的方法 |
| SG11202108399PA (en) * | 2019-02-02 | 2021-09-29 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Indolo heptamyl oxime analogue as parp inhibitor |
| JP7370032B2 (ja) | 2019-05-14 | 2023-10-27 | スーヂョウ フォー ヘルス ファーマスーティカルズ カンパニー リミテッド | Ｐａｒｒ阻害剤としてのキナゾリン―２．４―ジオン誘導体 |
| CN110256468B (zh) * | 2019-05-14 | 2020-09-01 | 山东省分析测试中心 | 双吲哚生物碱化合物或其药学上可接受的盐及其制备方法和应用 |
| CN114341162B (zh) | 2019-07-10 | 2025-10-17 | 赛博克萨2公司 | 作为治疗剂的细胞毒素的肽缀合物 |
| TW202116356A (zh) | 2019-07-10 | 2021-05-01 | 美商斯布雷克薩三號公司 | 作為治療劑之微管靶向藥劑之肽結合物 |
| WO2021018298A1 (zh) * | 2019-08-01 | 2021-02-04 | 南京明德新药研发有限公司 | 作为parp抑制剂吲哚并七元酰肟化合物 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2021156140A1 (en) | 2020-02-03 | 2021-08-12 | Sandoz Ag | Polymorph of rucaparib mesylate |
| JP2023514794A (ja) * | 2020-02-24 | 2023-04-10 | フーカン（シャンハイ） ヘルス テクノロジー カンパニー、 リミテッド | ポリａｄｐリボースポリメラーゼ阻害剤の抗コロナウイルス応用 |
| EP4143182B1 (en) | 2020-04-28 | 2024-12-11 | Rhizen Pharmaceuticals AG | Novel compounds useful as poly(adp-ribose) polymerase (parp) inhibitors |
| CN111646990B (zh) * | 2020-05-22 | 2023-01-10 | 同济大学 | 一种3,4-桥环吲哚类化合物的制备方法及Rucaparib的合成方法 |
| CN111662299B (zh) * | 2020-07-10 | 2022-07-26 | 中山大学 | 一种取代吲哚并氮杂酮类化合物及其制备方法和应用 |
| EP4182318B1 (en) | 2020-07-14 | 2025-08-27 | Assia Chemical Industries Ltd. | Solid state forms of rucaparib salts |
| CN115698019B (zh) * | 2020-07-31 | 2024-12-06 | 正大天晴药业集团股份有限公司 | 用作parp抑制剂的吲哚并七元酰肟类似物的结晶及其制备方法 |
| CN111961047A (zh) * | 2020-08-19 | 2020-11-20 | 南通大学 | 一种6-乙氧基-3,4-二氢-2,7-萘啶-1（2h）-酮及其合成方法 |
| WO2022090938A1 (en) | 2020-10-31 | 2022-05-05 | Rhizen Pharmaceuticals Ag | Phthalazinone derivatives useful as parp inhibitors |
| US20240093250A1 (en) | 2021-01-08 | 2024-03-21 | Cybrexa 2, Inc. | Process for preparing a conjugate linking moiety |
| WO2022155172A1 (en) | 2021-01-13 | 2022-07-21 | Cybrexa 3, Inc. | Peptide conjugates of therapeutics |
| IL307339A (en) | 2021-04-08 | 2023-11-01 | Rhizen Pharmaceuticals Ag | Poly(ADP-ribose) polymerase inhibitors |
| US20240246933A1 (en) * | 2021-05-18 | 2024-07-25 | Onconic Therapeutics Inc. | Crystalline form of tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same |
| WO2023137060A1 (en) | 2022-01-11 | 2023-07-20 | Assia Chemical Industries Ltd. | Solid state forms of rucaparib tosylate |
| WO2023201338A1 (en) | 2022-04-15 | 2023-10-19 | Ideaya Biosciences, Inc. | Combination therapy comprising a mat2a inhibitor and a parp inhibitor |
| CA3257870A1 (en) | 2022-06-01 | 2023-12-07 | Ideaya Biosciences, Inc. | THIADIAZOLYL DERIVATIVES USED AS DNA POLYMERASE THETA INHIBITORS AND THEIR USES |
| KR20260030809A (ko) | 2023-06-21 | 2026-03-06 | 테트라곤 바이오사이언시스 엘티디 | Hr 능숙형 암을 치료하는 방법에 사용하기 위한 데옥시시티딘 유도체 및 parp 억제제를 포함하는 조합 |
| CN121843950A (zh) * | 2023-06-21 | 2026-04-10 | 瓦罗健康有限公司 | X高酞嗪酮吲哚parp抑制剂及使用方法 |
| US12383633B1 (en) * | 2024-10-01 | 2025-08-12 | Zymeron Corporation | Injectable formulations of PARP inhibitors and uses thereof |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3642820A (en) | 1969-11-03 | 1972-02-15 | Upjohn Co | 4 5-dihydropyrrolo(3 2 1-jk)(1 4)bezodiazepines |
| US3883590A (en) | 1971-06-01 | 1975-05-13 | Universal Oil Prod Co | Preparation of n-alkylarylcarboxamides |
| DE2322434A1 (de) | 1973-05-04 | 1974-11-21 | Bayer Ag | 2-trifluormethylimino-1,3-dithioloeckige klammer auf 4,5-b eckige klammer zu -chinoxaline, verfahren zu ihrer herstellung, sowie ihre verwendung als insektizide, akarizide und fungizide |
| US4033960A (en) | 1973-07-31 | 1977-07-05 | Bayer Aktiengesellschaft | 2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation |
| US3978066A (en) | 1973-11-06 | 1976-08-31 | Ayerst, Mckenna And Harrison Ltd. | Certain 4,6-dihydropyrrolotriazoline-quinoline derivatives |
| US3950343A (en) | 1973-11-06 | 1976-04-13 | Ayerst, Mckenna And Harrison Ltd. | Pyrroloisoquinoline derivatives |
| US3900477A (en) * | 1973-11-06 | 1975-08-19 | Ayerst Mckenna & Harrison | 5-amino-and 5-hydrazinodihydropyrroloisoquinoline derivatives |
| US3959343A (en) * | 1974-10-25 | 1976-05-25 | Wako Pure Chemical Industries, Ltd. | Process for producing hydrazonitriles |
| DE2913728A1 (de) | 1979-04-05 | 1980-10-16 | Bayer Ag | 2-sulfonyl-chinoxaline, verfahren zu ihrer herstellung sowie ihre verwendung als mikrobizide |
| DE3103137A1 (de) | 1981-01-30 | 1982-08-26 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung aliphatischer cyclischer kohlensaeureester |
| JPS57144286A (en) | 1981-03-02 | 1982-09-06 | Takeda Chem Ind Ltd | Azepinoindole derivative and its preparation |
| US5215738A (en) | 1985-05-03 | 1993-06-01 | Sri International | Benzamide and nicotinamide radiosensitizers |
| US4910193A (en) | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
| JPS6434988A (en) * | 1987-07-30 | 1989-02-06 | Kissei Pharmaceutical | Azepinoindole derivative |
| DE4125292A1 (de) | 1991-07-31 | 1993-02-04 | Kali Chemie Pharma Gmbh | 6-oxo-azepinoindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB9117987D0 (en) | 1991-08-20 | 1991-10-09 | Ici Plc | Heterocyclic compounds |
| US5342946A (en) | 1992-12-02 | 1994-08-30 | Guilford Pharmaceuticals Inc. | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors |
| WO1995009159A1 (en) | 1993-09-28 | 1995-04-06 | Otsuka Pharmaceutical Company, Limited | Quinoxaline derivative as antidiabetic agent |
| US5587384A (en) | 1994-02-04 | 1996-12-24 | The Johns Hopkins University | Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity |
| GB9404485D0 (en) | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
| US5561161A (en) | 1994-03-25 | 1996-10-01 | Oxigene, Inc. | Methods of administering and pharmaceutical formulations containing n-substituted benzamides and/or acid addition salts thereof |
| US5589483A (en) | 1994-12-21 | 1996-12-31 | Geron Corporation | Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence |
| ES2105959B1 (es) | 1995-01-17 | 1998-07-01 | Zeneca Pharma Sa | Derivados de 1,4-dioxido de quinoxalina, procedimiento de preparacion y de utilizacion. |
| US5659082A (en) | 1995-04-03 | 1997-08-19 | Centaur Pharmaceuticals, Inc. | Nitro- and aminobenzamide compounds for neurodegenerative disorders |
| US5756548A (en) | 1995-04-03 | 1998-05-26 | Centaur Pharmaceuticals, Inc. | Acetamidobenzamide compounds for neurodegenerative disorders |
| IL123147A (en) * | 1995-08-02 | 2004-02-19 | Univ Newcastle Ventures Ltd | Benzamide imidazole - 4 carboxamide and their use |
| HUT76302A (en) | 1995-11-30 | 1997-07-28 | Chinoin Gyogyszer Es Vegyeszet | Quinoxaline derivatives, pharmaceutical compositions containing them and process for producing them |
| US6028111A (en) | 1996-03-08 | 2000-02-22 | Oxigene, Inc. | Compositions and use of benzamides and nicotinamides as anti-inflammatory agents |
| GB9702701D0 (en) | 1997-02-01 | 1997-04-02 | Univ Newcastle Ventures Ltd | Quinazolinone compounds |
| AU745790B2 (en) | 1997-05-13 | 2002-03-28 | Octamer, Inc. | Methods for treating inflammation and inflammatory diseases using pADPRT inhibitors |
| WO1999011644A1 (en) | 1997-09-03 | 1999-03-11 | Guilford Pharmaceuticals Inc. | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity |
| US6197785B1 (en) | 1997-09-03 | 2001-03-06 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity |
| WO1999011622A1 (en) | 1997-09-03 | 1999-03-11 | Guilford Pharmaceuticals Inc. | Amino-substituted compounds, methods, and compositions for inhibiting parp activity |
| US20020022636A1 (en) | 1997-09-03 | 2002-02-21 | Jia-He Li | Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity |
| US20020028813A1 (en) | 1997-09-03 | 2002-03-07 | Paul F. Jackson | Thioalkyl compounds, methods, and compositions for inhibiting parp activity |
| US6514983B1 (en) | 1997-09-03 | 2003-02-04 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage |
| US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
| JP2002515488A (ja) | 1998-05-15 | 2002-05-28 | ギルフォード ファーマシューティカルズ インコーポレイテッド | カルボキサミド化合物、組成物、及びｐａｒｐ活性の抑制方法 |
| CA2332239A1 (en) * | 1998-05-15 | 1999-11-25 | Guilford Pharmaceuticals Inc. | Fused tricyclic compounds which inhibit parp activity |
| KR20010087401A (ko) | 1999-09-28 | 2001-09-15 | 스타르크, 카르크 | 아제피노인돌 유도체, 그의 제법 및 용도 |
| DE19946289A1 (de) | 1999-09-28 | 2001-03-29 | Basf Ag | Benzodiazepin-Derivate, deren Herstellung und Anwendung |
-
2000
- 2000-01-10 OA OA1200100183A patent/OA11749A/en unknown
- 2000-01-10 ES ES00902358T patent/ES2218110T3/es not_active Expired - Lifetime
- 2000-01-10 AT AT00902358T patent/ATE261963T1/de active
- 2000-01-10 SI SI200020013A patent/SI20691B/sl active Search and Examination
- 2000-01-10 EA EA200100764A patent/EA004989B1/ru not_active IP Right Cessation
- 2000-01-10 CA CA2360003A patent/CA2360003C/en not_active Expired - Lifetime
- 2000-01-10 US US09/479,896 patent/US6495541B1/en not_active Expired - Lifetime
- 2000-01-10 JP JP2000593608A patent/JP4093448B2/ja not_active Expired - Lifetime
- 2000-01-10 EE EEP200100364A patent/EE05006B1/xx unknown
- 2000-01-10 SK SK966-2001A patent/SK287338B6/sk not_active IP Right Cessation
- 2000-01-10 PL PL357049A patent/PL210415B1/pl unknown
- 2000-01-10 DE DE60009033T patent/DE60009033T2/de not_active Expired - Lifetime
- 2000-01-10 KR KR1020017008709A patent/KR100632079B1/ko not_active Expired - Lifetime
- 2000-01-10 EP EP00902358A patent/EP1140936B1/en not_active Expired - Lifetime
- 2000-01-10 MX MXPA01007001A patent/MXPA01007001A/es active IP Right Grant
- 2000-01-10 PT PT00902358T patent/PT1140936E/pt unknown
- 2000-01-10 TR TR2001/02005T patent/TR200102005T2/xx unknown
- 2000-01-10 WO PCT/US2000/000411 patent/WO2000042040A1/en not_active Ceased
- 2000-01-10 RS YUP-490/01A patent/RS50031B/sr unknown
- 2000-01-10 HR HR20010573A patent/HRP20010573B1/xx not_active IP Right Cessation
- 2000-01-10 CZ CZ20012443A patent/CZ302941B6/cs not_active IP Right Cessation
- 2000-01-10 AU AU24088/00A patent/AU781711B2/en not_active Expired
- 2000-01-10 BR BRPI0008614A patent/BRPI0008614B8/pt not_active IP Right Cessation
- 2000-01-10 HU HU0105414A patent/HU229875B1/hu unknown
- 2000-01-10 DK DK00902358T patent/DK1140936T3/da active
- 2000-01-10 RO ROA200100795A patent/RO121778B1/ro unknown
- 2000-01-10 GE GEAP20006045A patent/GEP20033055B/en unknown
- 2000-01-10 AP APAP/P/2001/002211A patent/AP1538A/en active
- 2000-01-10 IL IL14411200A patent/IL144112A0/xx active IP Right Grant
- 2000-01-10 NZ NZ512731A patent/NZ512731A/xx not_active IP Right Cessation
- 2000-01-10 CN CNB008045895A patent/CN100418967C/zh not_active Expired - Lifetime
- 2000-01-19 ID IDW00200101726A patent/ID30138A/id unknown
- 2000-10-01 UA UA2001074881A patent/UA75034C2/uk unknown
-
2001
- 2001-06-29 ZA ZA200105399A patent/ZA200105399B/en unknown
- 2001-07-02 IL IL144112A patent/IL144112A/en not_active IP Right Cessation
- 2001-07-04 NO NO20013313A patent/NO320343B1/no not_active IP Right Cessation
- 2001-07-10 IS IS5995A patent/IS5995A/is unknown
- 2001-08-01 LV LV010115A patent/LV12770B/xx unknown
- 2001-08-10 LT LT2001083A patent/LT4936B/lt not_active IP Right Cessation
- 2001-08-10 BG BG105811A patent/BG65210B1/bg unknown
-
2002
- 2002-08-28 OA OA1200200262A patent/OA12185A/en unknown
- 2002-10-02 US US10/264,018 patent/US20030078254A1/en not_active Abandoned
-
2004
- 2004-12-03 US US11/004,261 patent/US6977298B2/en not_active Expired - Lifetime
-
2005
- 2005-09-06 US US11/221,245 patent/US7429578B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002534523A5 (https=) | ||
| JP2003513015A5 (https=) | ||
| CA2360003A1 (en) | Tricyclic inhibitors of poly(adp-ribose) polymerases | |
| JP2007515405A5 (https=) | ||
| JP2007535491A5 (https=) | ||
| JP2007534636A5 (https=) | ||
| JP2005531488A5 (https=) | ||
| JP2004531544A5 (https=) | ||
| JP2002539128A5 (https=) | ||
| JP2001526218A5 (https=) | ||
| JP2006505543A5 (https=) | ||
| CA2495060A1 (en) | Derivatives of pyrrolo-pyrazines having a kinase inhibitory activity and their biological applications | |
| JP2003523927A5 (https=) | ||
| JP2004538251A5 (https=) | ||
| JP2004518723A5 (https=) | ||
| JP2003519676A5 (https=) | ||
| JP2006502137A5 (https=) | ||
| WO2000057861A3 (en) | Use of cytidine derivatives for the treatment of leukaemia | |
| JP2010513447A5 (https=) | ||
| JP2011507878A5 (https=) | ||
| JP2005526144A5 (https=) | ||
| JP2003509349A5 (https=) | ||
| JP2011520906A5 (https=) | ||
| JP2010501478A5 (https=) | ||
| JP2002527414A5 (https=) |