JP2006505543A5 - - Google Patents
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- Publication number
- JP2006505543A5 JP2006505543A5 JP2004541500A JP2004541500A JP2006505543A5 JP 2006505543 A5 JP2006505543 A5 JP 2006505543A5 JP 2004541500 A JP2004541500 A JP 2004541500A JP 2004541500 A JP2004541500 A JP 2004541500A JP 2006505543 A5 JP2006505543 A5 JP 2006505543A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- halogen
- disubstituted
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 8
- -1 monosubstituted phenyl Chemical group 0.000 claims 8
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 claims 7
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000002252 acyl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000001624 naphthyl group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 150000003248 quinolines Chemical class 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000005257 alkyl acyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 150000000178 1,2,4-triazoles Chemical class 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 150000002460 imidazoles Chemical class 0.000 claims 1
- AWJUIBRHMBBTKR-UHFFFAOYSA-N iso-quinoline Natural products C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US0226816 | 2002-08-23 | ||
| PCT/US2003/027433 WO2004030611A2 (en) | 2002-08-23 | 2003-08-22 | Non-nucleoside reverse transcriptase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006505543A JP2006505543A (ja) | 2006-02-16 |
| JP2006505543A5 true JP2006505543A5 (https=) | 2006-04-06 |
| JP4413781B2 JP4413781B2 (ja) | 2010-02-10 |
Family
ID=32067653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004541500A Expired - Fee Related JP4413781B2 (ja) | 2002-08-23 | 2003-08-22 | 非ヌクレオシド逆転写酵素インヒビター |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20060135556A1 (https=) |
| EP (2) | EP2353593B1 (https=) |
| JP (1) | JP4413781B2 (https=) |
| CN (1) | CN1697650B (https=) |
| AT (1) | ATE504294T1 (https=) |
| AU (2) | AU2003295324B2 (https=) |
| BR (1) | BR0313747A (https=) |
| CA (1) | CA2496565C (https=) |
| DE (1) | DE60336664D1 (https=) |
| EA (1) | EA009478B1 (https=) |
| MX (1) | MXPA05002070A (https=) |
| WO (1) | WO2004030611A2 (https=) |
| ZA (1) | ZA200502384B (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004030611A2 (en) * | 2002-08-23 | 2004-04-15 | Ribapharm Inc. | Non-nucleoside reverse transcriptase inhibitors |
| US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| GB0315111D0 (en) * | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| EP1723123A4 (en) * | 2004-03-08 | 2009-12-02 | Wyeth Corp | ION CHANNEL MODULATORS |
| WO2005090320A2 (en) * | 2004-03-12 | 2005-09-29 | Wyeth | Triazole derivatives and method of using the same to treat hiv infections |
| WO2005115147A2 (en) * | 2004-05-18 | 2005-12-08 | Merck & Co., Inc. | Hiv reverse transcriptase inhibitors |
| US7517998B2 (en) * | 2004-06-01 | 2009-04-14 | Boehringer Ingelheim International Gmbh | Non nucleoside reverse transcriptase inhibitors |
| WO2007050087A1 (en) * | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| DK2135608T3 (da) * | 2004-08-25 | 2012-01-23 | Ardea Biosciences Inc | S-triazolyl-alfa-mercaptoacetanilider som inhibitorer for HIV-revers transkriptase |
| KR20110089463A (ko) * | 2006-07-24 | 2011-08-08 | 한국화학연구원 | 신규 ｈｉｖ 역전사 효소 억제제 |
| WO2009030996A1 (en) * | 2007-09-05 | 2009-03-12 | Coley Pharmaceutical Group, Inc. | Triazole compounds as toll-like receptor (tlr) agonists |
| ME01294B (me) | 2007-11-27 | 2013-06-20 | Ardea Biosciences Inc | Nova jedinjenja i kompozicije i metode upotrebe |
| US8173690B2 (en) | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| CA2736117C (en) * | 2008-09-04 | 2013-11-19 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| EP2432468A2 (en) | 2009-05-20 | 2012-03-28 | Ardea Biosciences, Inc. | Methods of modulating uric acid levels |
| AU2010307262A1 (en) | 2009-07-10 | 2012-03-01 | Microbiotix, Inc. | Inhibitors of filovirus entry into host cells |
| MX2012015097A (es) * | 2010-07-02 | 2013-05-28 | Gilead Sciences Inc | Derivados de acido naft-2-ilacetico para tratar sida. |
| CN101899013B (zh) * | 2010-07-12 | 2012-07-25 | 山东大学 | 2-(2-取代芳基-2h-1,2,4-三唑-3-巯基)乙酰胺衍生物及其制备方法与应用 |
| CN105394046B (zh) | 2010-10-25 | 2019-03-01 | 范德比尔特大学 | 用于抑制昆虫宿主感觉的组合物 |
| US9578881B2 (en) | 2011-05-06 | 2017-02-28 | Vanderbilt University | Compositions for inhibition of insect sensing |
| ITMI20120786A1 (it) * | 2012-05-09 | 2013-11-10 | Fond Italiana Sclerosi M Ultipla Fism Onlu | Modulatori del recettore gpr17 |
| AR091651A1 (es) | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
| RU2626003C2 (ru) * | 2014-04-28 | 2017-07-21 | Общество с ограниченной ответственностью "Квантум Фармасьютикалс" | Амид 1,2,4-триазол-3-илтиогликолевой кислоты, обладающий противовирусной активностью, или его фармацевтически приемлемые соли, фармацевтические композиции и их применение для лечения и профилактики гриппа |
| EP3273779A4 (en) | 2015-03-25 | 2018-09-05 | Vanderbilt University | Binary compositions as disruptors of orco-mediated odorant sensing |
| HUE050317T2 (hu) | 2015-05-20 | 2020-11-30 | Amgen Inc | APJ receptor triazol agonistái |
| US9988369B2 (en) | 2016-05-03 | 2018-06-05 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the APJ receptor |
| WO2018093576A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the apj receptor |
| US10736883B2 (en) | 2016-11-16 | 2020-08-11 | Amgen Inc. | Triazole furan compounds as agonists of the APJ receptor |
| WO2018093577A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| WO2018093579A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
| EP3541803B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
| MA50509A (fr) | 2017-11-03 | 2021-06-02 | Amgen Inc | Agonistes de triazole fusionnés du récepteur apj |
| US11807624B2 (en) | 2018-05-01 | 2023-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the APJ receptor |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0759563B2 (ja) * | 1987-01-28 | 1995-06-28 | 大塚化学株式会社 | ピラゾ−ル誘導体、その製造方法及び該誘導体を有効成分とする除草剤 |
| EP0303301A3 (en) * | 1987-08-14 | 1989-05-17 | Fuji Photo Film Co., Ltd. | Silver halide photographic material |
| US6832996B2 (en) * | 1995-06-07 | 2004-12-21 | Arthrocare Corporation | Electrosurgical systems and methods for treating tissue |
| US6245817B1 (en) * | 1997-02-14 | 2001-06-12 | Bayer Corporation | NPY5 receptor antagonists and methods for using same |
| WO1998035957A1 (en) | 1997-02-14 | 1998-08-20 | Bayer Corporation | Amide derivatives as selective neuropeptide y receptor antagonists |
| KR100643419B1 (ko) * | 1998-03-27 | 2006-11-10 | 얀센 파마슈티카 엔.브이. | Ｈｉｖ를 억제하는 피리미딘 유도체 |
| WO2000037471A1 (en) * | 1998-12-23 | 2000-06-29 | Neurogen Corporation | 2-amino-9-alkylpurines: gaba brain receptor ligands |
| US6593077B2 (en) * | 1999-03-22 | 2003-07-15 | Special Materials Research And Technology, Inc. | Method of making thin films dielectrics using a process for room temperature wet chemical growth of SiO based oxides on a substrate |
| AU2002254056C1 (en) | 2001-03-02 | 2006-04-13 | Smithkline Beecham Corporation | Benzophenones as inhibitors of reverse transcriptase |
| WO2004030611A2 (en) * | 2002-08-23 | 2004-04-15 | Ribapharm Inc. | Non-nucleoside reverse transcriptase inhibitors |
| US7642277B2 (en) * | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| US20060205026A1 (en) * | 2002-12-19 | 2006-09-14 | Valeant Research & Development | Parallel inducible cell-based kinase screen |
| WO2007050087A1 (en) * | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
| US7842836B2 (en) * | 2006-04-11 | 2010-11-30 | Ardea Biosciences | N-aryl-N'alkyl sulfamides as MEK inhibitors |
| JP5269762B2 (ja) * | 2006-04-18 | 2013-08-21 | アーディア・バイオサイエンシーズ・インコーポレイテッド | Ｍｅｋ阻害剤としてのピリドンスルホンアミドおよびピリドンスルファミド |
| EP2132211A4 (en) * | 2006-11-09 | 2011-12-07 | Ardea Biosciences Inc | 4-CYANPHENYLAMINO-SUBSTITUTED BICYCLIC AND HETEROCYCLIC COMPOUNDS AS AN HIV HEMMER |
-
2003
- 2003-08-22 WO PCT/US2003/027433 patent/WO2004030611A2/en not_active Ceased
- 2003-08-22 JP JP2004541500A patent/JP4413781B2/ja not_active Expired - Fee Related
- 2003-08-22 CA CA2496565A patent/CA2496565C/en not_active Expired - Fee Related
- 2003-08-22 CN CN038243377A patent/CN1697650B/zh not_active Expired - Fee Related
- 2003-08-22 AT AT03786506T patent/ATE504294T1/de not_active IP Right Cessation
- 2003-08-22 AU AU2003295324A patent/AU2003295324B2/en not_active Ceased
- 2003-08-22 BR BR0313747-3A patent/BR0313747A/pt not_active Application Discontinuation
- 2003-08-22 US US10/526,249 patent/US20060135556A1/en not_active Abandoned
- 2003-08-22 MX MXPA05002070A patent/MXPA05002070A/es active IP Right Grant
- 2003-08-22 EP EP11160994A patent/EP2353593B1/en not_active Expired - Lifetime
- 2003-08-22 EA EA200500399A patent/EA009478B1/ru not_active IP Right Cessation
- 2003-08-22 DE DE60336664T patent/DE60336664D1/de not_active Expired - Lifetime
- 2003-08-22 EP EP03786506A patent/EP1545483B1/en not_active Expired - Lifetime
-
2005
- 2005-03-22 ZA ZA200502384A patent/ZA200502384B/en unknown
-
2008
- 2008-05-02 US US12/114,467 patent/US20080249131A1/en not_active Abandoned
- 2008-11-19 AU AU2008246249A patent/AU2008246249B2/en not_active Ceased