JP2020517707A5 - - Google Patents
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- JP2020517707A5 JP2020517707A5 JP2019558443A JP2019558443A JP2020517707A5 JP 2020517707 A5 JP2020517707 A5 JP 2020517707A5 JP 2019558443 A JP2019558443 A JP 2019558443A JP 2019558443 A JP2019558443 A JP 2019558443A JP 2020517707 A5 JP2020517707 A5 JP 2020517707A5
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- 239000000203 mixture Substances 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 10
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 3
- 229940124597 therapeutic agent Drugs 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000011519 second-line treatment Methods 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 239000003981 vehicle Substances 0.000 claims 2
- 238000000034 method Methods 0.000 description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
- 125000005842 heteroatom Chemical group 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 239000001301 oxygen Chemical group 0.000 description 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 229910052717 sulfur Chemical group 0.000 description 6
- 239000011593 sulfur Chemical group 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 229920006395 saturated elastomer Chemical group 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 2
- 229910052796 boron Inorganic materials 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 1
- -1 1H-pyrrolill Chemical group 0.000 description 1
- VZWOXDYRBDIHMA-UHFFFAOYSA-N 2-methyl-1,3-thiazole Chemical compound CC1=NC=CS1 VZWOXDYRBDIHMA-UHFFFAOYSA-N 0.000 description 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 description 1
- 206010003805 Autism Diseases 0.000 description 1
- 208000020706 Autistic disease Diseases 0.000 description 1
- 208000024720 Fabry Disease Diseases 0.000 description 1
- 102000008135 Mechanistic Target of Rapamycin Complex 1 Human genes 0.000 description 1
- 108010035196 Mechanistic Target of Rapamycin Complex 1 Proteins 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 206010072930 Mucolipidosis type IV Diseases 0.000 description 1
- 102100026502 Mucolipin-1 Human genes 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000035269 cancer or benign tumor Diseases 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
- 125000001620 monocyclic carbocycle group Chemical group 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762490280P | 2017-04-26 | 2017-04-26 | |
| US62/490,280 | 2017-04-26 | ||
| PCT/US2018/029288 WO2018200625A1 (en) | 2017-04-26 | 2018-04-25 | Modulators of sestrin-gator2 interaction and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517707A JP2020517707A (ja) | 2020-06-18 |
| JP2020517707A5 true JP2020517707A5 (https=) | 2021-07-29 |
| JP7179015B2 JP7179015B2 (ja) | 2022-11-28 |
Family
ID=63920059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558443A Active JP7179015B2 (ja) | 2017-04-26 | 2018-04-25 | Ｓｅｓｔｒｉｎ－ＧＡＴＯＲ２相互座用のモジュレーターおよびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10912750B2 (https=) |
| EP (2) | EP4556069A3 (https=) |
| JP (1) | JP7179015B2 (https=) |
| CN (2) | CN110809467B (https=) |
| AU (2) | AU2018258355B2 (https=) |
| CA (1) | CA3061611A1 (https=) |
| ES (1) | ES3040534T3 (https=) |
| PL (1) | PL3615019T3 (https=) |
| TW (1) | TWI776886B (https=) |
| WO (1) | WO2018200625A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE061437T2 (hu) | 2015-10-23 | 2023-06-28 | Navitor Pharm Inc | A Sestrin-GATOR2 kölcsönhatás modulátorai és ezek alkalmazásai |
| US10912750B2 (en) | 2017-04-26 | 2021-02-09 | Navitor Pharmaceuticals, Inc. | Modulators of Sestrin-GATOR2 interaction and uses thereof |
| CN113164414A (zh) | 2018-10-24 | 2021-07-23 | 纳维托制药有限公司 | 多晶型化合物和其用途 |
| KR102659859B1 (ko) | 2018-10-30 | 2024-04-25 | 길리애드 사이언시즈, 인코포레이티드 | 알파4β7 인테그린의 억제를 위한 화합물 |
| AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| EP4541422A3 (en) | 2018-10-30 | 2025-06-25 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
| CN112969700B (zh) | 2018-10-30 | 2024-08-20 | 吉利德科学公司 | 作为α4β7整合素抑制剂的咪唑并吡啶衍生物 |
| CN111689993B (zh) * | 2019-03-11 | 2023-04-14 | 凯特立斯（深圳）科技有限公司 | 一种新的含硼类佐米药物关键中间体手性α-氨基硼酸酯的制备方法 |
| KR102908219B1 (ko) | 2019-08-14 | 2026-01-08 | 길리애드 사이언시즈, 인코포레이티드 | 알파 4 베타 7 인테그린의 저해용 화합물 |
| CA3156436A1 (en) * | 2019-11-01 | 2021-05-06 | Steven LEVENTER | Methods of treatment using an mtorc1 modulator |
| CN113876784B (zh) * | 2021-09-27 | 2023-07-21 | 潍坊博创国际生物医药研究院 | 硼代亮氨酸类化合物的新用途 |
| CN115927459A (zh) * | 2022-07-19 | 2023-04-07 | 华南农业大学 | 猪ctns基因在促进动物骨骼肌生长中的应用 |
| EP4612120A1 (en) * | 2022-11-01 | 2025-09-10 | Navitor Pharmaceuticals, Inc. | Modulators of mtorc1 activity and uses thereof |
| CN120993707B (zh) * | 2025-08-18 | 2026-02-10 | 衡水海宏环保设备制造有限公司 | 一种滤饼成型动态压控智能调控方法 |
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| CN113164414A (zh) | 2018-10-24 | 2021-07-23 | 纳维托制药有限公司 | 多晶型化合物和其用途 |
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| CA3156436A1 (en) | 2019-11-01 | 2021-05-06 | Steven LEVENTER | Methods of treatment using an mtorc1 modulator |
| JP6689441B1 (ja) | 2019-11-01 | 2020-04-28 | エヌ・ティ・ティ・コミュニケーションズ株式会社 | 電子マネー管理システムおよび電子マネー管理方法 |
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2018
- 2018-04-25 US US15/962,123 patent/US10912750B2/en active Active
- 2018-04-25 WO PCT/US2018/029288 patent/WO2018200625A1/en not_active Ceased
- 2018-04-25 CA CA3061611A patent/CA3061611A1/en active Pending
- 2018-04-25 CN CN201880039788.3A patent/CN110809467B/zh active Active
- 2018-04-25 EP EP25169183.8A patent/EP4556069A3/en active Pending
- 2018-04-25 EP EP18791427.0A patent/EP3615019B1/en active Active
- 2018-04-25 CN CN202310282338.XA patent/CN116370448B/zh active Active
- 2018-04-25 JP JP2019558443A patent/JP7179015B2/ja active Active
- 2018-04-25 ES ES18791427T patent/ES3040534T3/es active Active
- 2018-04-25 AU AU2018258355A patent/AU2018258355B2/en active Active
- 2018-04-25 TW TW107114086A patent/TWI776886B/zh active
- 2018-04-25 PL PL18791427.0T patent/PL3615019T3/pl unknown
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2020
- 2020-11-30 US US17/106,584 patent/US11679090B2/en active Active
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2023
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2024
- 2024-08-30 AU AU2024216489A patent/AU2024216489A1/en active Pending
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2025
- 2025-08-20 US US19/304,835 patent/US20260034084A1/en active Pending
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