JP2007527919A5 - - Google Patents
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- Publication number
- JP2007527919A5 JP2007527919A5 JP2007502996A JP2007502996A JP2007527919A5 JP 2007527919 A5 JP2007527919 A5 JP 2007527919A5 JP 2007502996 A JP2007502996 A JP 2007502996A JP 2007502996 A JP2007502996 A JP 2007502996A JP 2007527919 A5 JP2007527919 A5 JP 2007527919A5
- Authority
- JP
- Japan
- Prior art keywords
- substituents
- optionally substituted
- cycloalkyl
- independently
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001424 substituent group Chemical group 0.000 claims 33
- 125000003118 aryl group Chemical group 0.000 claims 22
- 125000001072 heteroaryl group Chemical group 0.000 claims 22
- 125000000753 cycloalkyl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000000623 heterocyclic group Chemical group 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 8
- 108090000312 Calcium Channels Proteins 0.000 claims 7
- 102000003922 Calcium Channels Human genes 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- -1 1,2-methylenedioxy Chemical group 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 208000024891 symptom Diseases 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 101150047856 Cav2 gene Proteins 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 229920001774 Perfluoroether Polymers 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 206010046543 Urinary incontinence Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 230000006793 arrhythmia Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 230000001537 neural effect Effects 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000036407 pain Effects 0.000 claims 2
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- 125000006479 2-pyridyl methyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 101000935123 Homo sapiens Voltage-dependent N-type calcium channel subunit alpha-1B Proteins 0.000 claims 1
- 102100025342 Voltage-dependent N-type calcium channel subunit alpha-1B Human genes 0.000 claims 1
- DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55160604P | 2004-03-08 | 2004-03-08 | |
| US57919304P | 2004-06-10 | 2004-06-10 | |
| PCT/US2005/007920 WO2005087750A1 (en) | 2004-03-08 | 2005-03-07 | Ion channel modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007527919A JP2007527919A (ja) | 2007-10-04 |
| JP2007527919A5 true JP2007527919A5 (https=) | 2008-04-24 |
Family
ID=34975510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007502996A Pending JP2007527919A (ja) | 2004-03-08 | 2005-03-07 | イオンチャンネルモジュレーター |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070203194A1 (https=) |
| EP (1) | EP1723123A4 (https=) |
| JP (1) | JP2007527919A (https=) |
| AU (1) | AU2005222402A1 (https=) |
| BR (1) | BRPI0508537A (https=) |
| CA (1) | CA2558224A1 (https=) |
| WO (1) | WO2005087750A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005097758A1 (en) * | 2004-03-26 | 2005-10-20 | Amphora Discovery Corporation | Certain triazole-based compounds, compositions, and uses thereof |
| WO2006055760A1 (en) * | 2004-11-18 | 2006-05-26 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| EP1888575A2 (en) * | 2005-05-09 | 2008-02-20 | Hydra Biosciences, Inc. | Compounds for modulating trpv3 function |
| AU2007267843B2 (en) | 2006-05-25 | 2011-10-13 | Synta Pharmaceuticals Corp. | Method for treating proliferative disorders associated with protooncogene products |
| US8183384B2 (en) | 2006-05-25 | 2012-05-22 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate HSP90 activity |
| WO2007139960A2 (en) * | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Compounds that modulate hsp90 activity and methods for identifying same |
| JP5099794B2 (ja) | 2007-11-27 | 2012-12-19 | アルデア バイオサイエンシーズ インク． | 新規化合物、組成物、及び使用方法 |
| US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| CN102395567A (zh) * | 2009-02-12 | 2012-03-28 | 埃克塞利希斯股份有限公司 | 在治疗糖尿病和肥胖症中用作的tgr5激动剂的三唑和咪唑衍生物 |
| CA2761335A1 (en) * | 2009-05-20 | 2010-11-25 | Ardea Biosciences, Inc. | Compounds, compositions and methods for modulating uric acid levels |
| EP2432468A2 (en) | 2009-05-20 | 2012-03-28 | Ardea Biosciences, Inc. | Methods of modulating uric acid levels |
| EP2435407B1 (en) * | 2009-05-29 | 2019-12-25 | RaQualia Pharma Inc. | Aryl substituted carboxamide derivatives as calcium or sodium channel blockers |
| CN102781922A (zh) | 2009-12-11 | 2012-11-14 | 埃克塞利希斯股份有限公司 | Tgr5激动剂 |
| US9205086B2 (en) | 2010-04-19 | 2015-12-08 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor |
| CN103402988B (zh) | 2010-10-25 | 2015-11-25 | 范德比尔特大学 | 用于抑制昆虫宿主感觉的组合物 |
| JP2013544874A (ja) | 2010-12-08 | 2013-12-19 | オスロ ユニヴァーシティー ホスピタル エイチエフ | Ｗｎｔシグナル伝達経路阻害薬としてのトリアゾール誘導体 |
| EP3653054A1 (en) | 2011-05-06 | 2020-05-20 | Vanderbilt University | Composition for inhibition of insect sensing |
| EP2773345A1 (en) | 2011-11-02 | 2014-09-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
| AU2012332424A1 (en) | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with platinum-containing agents |
| WO2013074594A1 (en) | 2011-11-14 | 2013-05-23 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
| EP2828249B1 (en) | 2012-03-23 | 2018-10-10 | The Regents of The University of California | Premature-termination-codons readthrough compounds |
| ITMI20120786A1 (it) * | 2012-05-09 | 2013-11-10 | Fond Italiana Sclerosi M Ultipla Fism Onlu | Modulatori del recettore gpr17 |
| CA2882127A1 (en) * | 2012-08-16 | 2014-02-20 | Janssen Pharmaceutica Nv | Pyrrolopyrazoles as n-type calcium channel blockers |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| US10323016B2 (en) | 2014-06-12 | 2019-06-18 | Universite De Lille 2 Droit Et Sante | Imidazol- or 1,2,4-triazol-derivatives and their use |
| US10791739B2 (en) | 2015-03-25 | 2020-10-06 | Vanderbilt University | Binary compositions as disruptors of orco-mediated odorant sensing |
| US11932610B1 (en) * | 2023-10-17 | 2024-03-19 | King Faisal University | 4-(5-(3-fluorophenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)butanoic acid as an antimicrobial compound |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2805756A1 (de) * | 1978-02-10 | 1979-08-16 | Bayer Ag | N-azolylalkyl-aniline sowie verfahren zu ihrer herstellung |
| US4243408A (en) * | 1978-05-11 | 1981-01-06 | Chevron Research Company | Herbicidal N-triazolylmethyl-substituted alpha-haloacetanilide |
| DE2930452A1 (de) * | 1979-07-26 | 1981-02-26 | Bayer Ag | N,n'-bis-(halogenacyl)-diaza-cycloalkane zum schutz von kulturpflanzen vor schaedigungen durch herbizide |
| US5260450A (en) * | 1987-01-27 | 1993-11-09 | Merrell Dow Pharmaceuticals Inc. | 3-aryl-5-alkylthio-4H-1,2,4-triazoles |
| EP1293503A4 (en) * | 2000-05-19 | 2008-04-02 | Astellas Pharma Inc | Triazole derivatives |
| MXPA05002070A (es) * | 2002-08-23 | 2005-07-05 | Ribapharm Inc | Inhibidores no nucleosidicos de la transcriptasa inversa. |
| WO2004089367A1 (en) * | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Pharmaceutical use of substituted 1,2,4-triazoles |
| US20060094699A1 (en) * | 2003-04-11 | 2006-05-04 | Kampen Gita Camilla T | Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy |
| WO2005060956A1 (en) * | 2003-12-12 | 2005-07-07 | University Of Maryland, Baltimore | IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE pY+3 BINDING SITE OF TYROSENE KINASE p56 LCK SH2 DOMAIN |
| JP2007527917A (ja) * | 2004-03-08 | 2007-10-04 | ワイス | イオンチャンネルモジュレーター |
| WO2005086892A2 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| US20070208064A1 (en) * | 2004-03-08 | 2007-09-06 | Wyeth | Ion channel modulators |
| CA2558214A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| CA2557672A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| BRPI0508522A (pt) * | 2004-03-08 | 2007-08-14 | Wyeth Corp | moduladores de canal de ìon |
| US7368467B2 (en) * | 2004-03-08 | 2008-05-06 | Wyeth | Ion channel modulators |
| EP1723120A4 (en) * | 2004-03-08 | 2007-09-26 | Wyeth Corp | MODULATORS OF THE ION CHANNEL FUNCTION |
| EP1723117A4 (en) * | 2004-03-08 | 2009-12-02 | Wyeth Corp | ION CHANNEL MODULATORS |
-
2005
- 2005-03-07 JP JP2007502996A patent/JP2007527919A/ja active Pending
- 2005-03-07 US US10/592,270 patent/US20070203194A1/en not_active Abandoned
- 2005-03-07 BR BRPI0508537-3A patent/BRPI0508537A/pt not_active IP Right Cessation
- 2005-03-07 AU AU2005222402A patent/AU2005222402A1/en not_active Abandoned
- 2005-03-07 EP EP05725226A patent/EP1723123A4/en not_active Withdrawn
- 2005-03-07 WO PCT/US2005/007920 patent/WO2005087750A1/en not_active Ceased
- 2005-03-07 CA CA002558224A patent/CA2558224A1/en not_active Abandoned
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