JP2004517087A5 - - Google Patents
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- Publication number
- JP2004517087A5 JP2004517087A5 JP2002547912A JP2002547912A JP2004517087A5 JP 2004517087 A5 JP2004517087 A5 JP 2004517087A5 JP 2002547912 A JP2002547912 A JP 2002547912A JP 2002547912 A JP2002547912 A JP 2002547912A JP 2004517087 A5 JP2004517087 A5 JP 2004517087A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclopentyl
- propionamide
- phenyl
- methanesulfonyl
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000004432 carbon atom Chemical group C* 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- -1 (4-methanesulfonyl-3-trifluoromethyl-phenyl) -N-quinolin-2-yl-propionamide Chemical compound 0.000 claims 5
- 150000001721 carbon Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 150000003457 sulfones Chemical class 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- QQZSSOYUTMZBTM-MRXNPFEDSA-N (2r)-n-(1,3-benzothiazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 QQZSSOYUTMZBTM-MRXNPFEDSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- VXZQZJYMVXNSMK-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 VXZQZJYMVXNSMK-UHFFFAOYSA-N 0.000 claims 2
- 238000005897 peptide coupling reaction Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229940080818 propionamide Drugs 0.000 claims 2
- SOYSPEAIZRNEAT-LJQANCHMSA-N (2r)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-n-quinolin-2-ylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 SOYSPEAIZRNEAT-LJQANCHMSA-N 0.000 claims 1
- OBWANNDHEQDAJQ-OAHLLOKOSA-N (2r)-n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1[C@H](C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 OBWANNDHEQDAJQ-OAHLLOKOSA-N 0.000 claims 1
- KYRDLJWNZRNWSG-GOSISDBHSA-N (2r)-n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonylphenyl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 KYRDLJWNZRNWSG-GOSISDBHSA-N 0.000 claims 1
- AAQDRZIJUPVUDR-MRXNPFEDSA-N (2r)-n-(1,3-benzoxazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 AAQDRZIJUPVUDR-MRXNPFEDSA-N 0.000 claims 1
- ACXDSKDJMZEDQU-OAHLLOKOSA-N (2r)-n-(1,3-benzoxazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1[C@H](C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 ACXDSKDJMZEDQU-OAHLLOKOSA-N 0.000 claims 1
- VXZQZJYMVXNSMK-MRXNPFEDSA-N (2r)-n-(1h-benzimidazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 VXZQZJYMVXNSMK-MRXNPFEDSA-N 0.000 claims 1
- CLTWWLUHQCWZQM-OAHLLOKOSA-N (2r)-n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1[C@H](C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 CLTWWLUHQCWZQM-OAHLLOKOSA-N 0.000 claims 1
- IEDAZVJYMUBPHE-GOSISDBHSA-N (2r)-n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonylphenyl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 IEDAZVJYMUBPHE-GOSISDBHSA-N 0.000 claims 1
- QZZFVLPXDBVTEZ-UHFFFAOYSA-N 2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentyl-n-quinolin-2-ylpropanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 QZZFVLPXDBVTEZ-UHFFFAOYSA-N 0.000 claims 1
- SOYSPEAIZRNEAT-UHFFFAOYSA-N 2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-n-quinolin-2-ylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 SOYSPEAIZRNEAT-UHFFFAOYSA-N 0.000 claims 1
- AWINNBCBCPJDHB-UHFFFAOYSA-N 2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentyl-n-quinolin-2-ylpropanamide Chemical compound C1=C(C#N)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 AWINNBCBCPJDHB-UHFFFAOYSA-N 0.000 claims 1
- DAFGCELMAUAKCZ-UHFFFAOYSA-N 3-cyclopentyl-2-(3,4-dichlorophenyl)-n-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(C(=O)NC=1SC=2CCCCC=2N=1)CC1CCCC1 DAFGCELMAUAKCZ-UHFFFAOYSA-N 0.000 claims 1
- HMOSAIJSNNENRZ-UHFFFAOYSA-N 3-cyclopentyl-2-(3,4-dichlorophenyl)-n-(6-fluoro-1,3-benzothiazol-2-yl)propanamide Chemical compound S1C2=CC(F)=CC=C2N=C1NC(=O)C(C=1C=C(Cl)C(Cl)=CC=1)CC1CCCC1 HMOSAIJSNNENRZ-UHFFFAOYSA-N 0.000 claims 1
- CCEZAKRHOWJHQJ-UHFFFAOYSA-N 3-cyclopentyl-2-(3,4-dichlorophenyl)-n-(6-methylsulfonyl-1,3-benzothiazol-2-yl)propanamide Chemical compound S1C2=CC(S(=O)(=O)C)=CC=C2N=C1NC(=O)C(C=1C=C(Cl)C(Cl)=CC=1)CC1CCCC1 CCEZAKRHOWJHQJ-UHFFFAOYSA-N 0.000 claims 1
- NPIXKNXGHOZWPG-UHFFFAOYSA-N 3-cyclopentyl-2-(3,4-dichlorophenyl)-n-quinolin-2-ylpropanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 NPIXKNXGHOZWPG-UHFFFAOYSA-N 0.000 claims 1
- VDCMBEAIYGSKSX-UHFFFAOYSA-N 3-cyclopentyl-2-(4-methylsulfonyl-3-nitrophenyl)-n-quinolin-2-ylpropanamide Chemical compound C1=C([N+]([O-])=O)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 VDCMBEAIYGSKSX-UHFFFAOYSA-N 0.000 claims 1
- RBFUJKPDVLOKBZ-UHFFFAOYSA-N 3-cyclopentyl-2-(4-methylsulfonylphenyl)-n-quinolin-2-ylpropanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 RBFUJKPDVLOKBZ-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- CDJWHCDZRBGAPD-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 CDJWHCDZRBGAPD-UHFFFAOYSA-N 0.000 claims 1
- QQZSSOYUTMZBTM-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 QQZSSOYUTMZBTM-UHFFFAOYSA-N 0.000 claims 1
- CBSDSSJLVTWRIQ-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(C#N)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 CBSDSSJLVTWRIQ-UHFFFAOYSA-N 0.000 claims 1
- OBWANNDHEQDAJQ-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 OBWANNDHEQDAJQ-UHFFFAOYSA-N 0.000 claims 1
- SKOFSWUZPQBFAM-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonyl-3-nitrophenyl)propanamide Chemical compound C1=C([N+]([O-])=O)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 SKOFSWUZPQBFAM-UHFFFAOYSA-N 0.000 claims 1
- KYRDLJWNZRNWSG-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonylphenyl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 KYRDLJWNZRNWSG-UHFFFAOYSA-N 0.000 claims 1
- RNCVQIUDLLDVEL-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]propanamide Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 RNCVQIUDLLDVEL-UHFFFAOYSA-N 0.000 claims 1
- XGRBXFPWATYYSK-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 XGRBXFPWATYYSK-UHFFFAOYSA-N 0.000 claims 1
- AAQDRZIJUPVUDR-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 AAQDRZIJUPVUDR-UHFFFAOYSA-N 0.000 claims 1
- CXKICAVMPHVLQN-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(C#N)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 CXKICAVMPHVLQN-UHFFFAOYSA-N 0.000 claims 1
- ACXDSKDJMZEDQU-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 ACXDSKDJMZEDQU-UHFFFAOYSA-N 0.000 claims 1
- NDVQEFQAKFEDNT-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonyl-3-nitrophenyl)propanamide Chemical compound C1=C([N+]([O-])=O)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 NDVQEFQAKFEDNT-UHFFFAOYSA-N 0.000 claims 1
- DZCJSSWRHOHJCP-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonylphenyl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 DZCJSSWRHOHJCP-UHFFFAOYSA-N 0.000 claims 1
- MXRIOGBIGBFHTL-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-3-cyclopentyl-2-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]propanamide Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 MXRIOGBIGBFHTL-UHFFFAOYSA-N 0.000 claims 1
- WVGDMEFWIHUPTL-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 WVGDMEFWIHUPTL-UHFFFAOYSA-N 0.000 claims 1
- MXHYIYKLWIIIDN-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(C#N)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 MXHYIYKLWIIIDN-UHFFFAOYSA-N 0.000 claims 1
- CLTWWLUHQCWZQM-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 CLTWWLUHQCWZQM-UHFFFAOYSA-N 0.000 claims 1
- QMQHSWHJSHWERL-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonyl-3-nitrophenyl)propanamide Chemical compound C1=C([N+]([O-])=O)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 QMQHSWHJSHWERL-UHFFFAOYSA-N 0.000 claims 1
- IEDAZVJYMUBPHE-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonylphenyl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 IEDAZVJYMUBPHE-UHFFFAOYSA-N 0.000 claims 1
- AYXGRWBIQWQTFT-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]propanamide Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 AYXGRWBIQWQTFT-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25163700P | 2000-12-06 | 2000-12-06 | |
| PCT/EP2001/013870 WO2002046173A1 (en) | 2000-12-06 | 2001-11-28 | Fused heteroaromatic glucokinase activators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004517087A JP2004517087A (ja) | 2004-06-10 |
| JP2004517087A5 true JP2004517087A5 (https=) | 2005-05-26 |
| JP4109111B2 JP4109111B2 (ja) | 2008-07-02 |
Family
ID=22952803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002547912A Expired - Fee Related JP4109111B2 (ja) | 2000-12-06 | 2001-11-28 | 縮合複素環式芳香族グルコキナーゼアクチベーター |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6441184B1 (https=) |
| EP (1) | EP1341774B1 (https=) |
| JP (1) | JP4109111B2 (https=) |
| KR (1) | KR100545431B1 (https=) |
| CN (1) | CN1226294C (https=) |
| AR (1) | AR031627A1 (https=) |
| AT (1) | ATE316965T1 (https=) |
| AU (2) | AU2002221902B2 (https=) |
| BR (1) | BR0115999A (https=) |
| CA (1) | CA2429642C (https=) |
| DE (1) | DE60117059T2 (https=) |
| DK (1) | DK1341774T3 (https=) |
| ES (1) | ES2256340T3 (https=) |
| GT (1) | GT200100243A (https=) |
| MX (1) | MXPA03005119A (https=) |
| PA (1) | PA8534301A1 (https=) |
| PE (1) | PE20020753A1 (https=) |
| PT (1) | PT1341774E (https=) |
| UY (1) | UY27055A1 (https=) |
| WO (1) | WO2002046173A1 (https=) |
| ZA (1) | ZA200303748B (https=) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| BR0312023A (pt) * | 2002-06-27 | 2005-03-22 | Novo Nordisk As | Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica |
| RU2340605C2 (ru) | 2002-06-27 | 2008-12-10 | Ново Нордиск А/С | Арилкарбонильные производные в качестве терапевтических средств |
| US6775812B2 (en) * | 2002-07-17 | 2004-08-10 | Hewlett-Packard Development Company, L.P. | Layout design process and system for providing bypass capacitance and compliant density in an integrated circuit |
| RU2309956C2 (ru) | 2002-10-03 | 2007-11-10 | Ф.Хоффманн-Ля Рош Аг | Производные индол-3-карбоксамида в качестве активаторов глюкокиназы |
| BR0314864A (pt) * | 2002-10-03 | 2005-08-02 | Novartis Ag | Compostos orgânicos |
| GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| GB0226931D0 (en) * | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| PE20040801A1 (es) | 2002-12-12 | 2004-11-25 | Hoffmann La Roche | Derivados de pirazina y piridina 5-sustituidos como activadores de glucoquinasa |
| PL378117A1 (pl) * | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| WO2004072066A1 (en) * | 2003-02-11 | 2004-08-26 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
| JP2007506654A (ja) * | 2003-06-20 | 2007-03-22 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｂ１受容体逆作動物質としての２−アミノベンゾチアゾール類 |
| JP4834840B2 (ja) | 2004-01-06 | 2011-12-14 | ノヴォ ノルディスク アー／エス | ヘテロアリール尿素およびグルコキナーゼ活性化剤としてのその使用 |
| KR20070007104A (ko) * | 2004-02-18 | 2007-01-12 | 아스트라제네카 아베 | 화합물 |
| DE602005013491D1 (de) * | 2004-02-18 | 2009-05-07 | Astrazeneca Ab | Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel |
| AU2005229415B2 (en) * | 2004-04-02 | 2009-05-14 | Novartis Ag | Thiazolopyridine derivatives, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
| US7750020B2 (en) * | 2004-04-02 | 2010-07-06 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of Type 2 diabetes |
| CA2563192A1 (en) * | 2004-04-21 | 2005-11-03 | Prosidion Limited | Tri(cyclo) substituted amide compounds |
| TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| AU2005271016A1 (en) | 2004-08-12 | 2006-02-16 | Prosidion Limited | Substituted phenylacetamides and their use as glucokinase activators |
| GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| KR20070085371A (ko) | 2004-10-16 | 2007-08-27 | 아스트라제네카 아베 | 페녹시 벤즈아미드 화합물의 제조 방법 |
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| US3840550A (en) * | 1971-05-24 | 1974-10-08 | Ciba Geigy Corp | Certain 6-isothiocyanobenzothiazoles |
| US6320050B1 (en) * | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
| SI1169312T1 (en) * | 1999-03-29 | 2005-02-28 | F. Hoffmann-La Roche Ag | Glucokinase activators |
-
2001
- 2001-11-28 WO PCT/EP2001/013870 patent/WO2002046173A1/en not_active Ceased
- 2001-11-28 JP JP2002547912A patent/JP4109111B2/ja not_active Expired - Fee Related
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- 2001-11-28 CN CNB018194494A patent/CN1226294C/zh not_active Expired - Fee Related
- 2001-11-28 ES ES01999565T patent/ES2256340T3/es not_active Expired - Lifetime
- 2001-11-28 AT AT01999565T patent/ATE316965T1/de not_active IP Right Cessation
- 2001-11-28 DK DK01999565T patent/DK1341774T3/da active
- 2001-11-28 CA CA002429642A patent/CA2429642C/en not_active Expired - Fee Related
- 2001-11-28 EP EP01999565A patent/EP1341774B1/en not_active Expired - Lifetime
- 2001-11-28 KR KR1020037007517A patent/KR100545431B1/ko not_active Expired - Fee Related
- 2001-11-28 AU AU2002221902A patent/AU2002221902B2/en not_active Ceased
- 2001-11-28 DE DE60117059T patent/DE60117059T2/de not_active Expired - Lifetime
- 2001-11-28 PT PT01999565T patent/PT1341774E/pt unknown
- 2001-11-28 AU AU2190202A patent/AU2190202A/xx active Pending
- 2001-12-04 PE PE2001001217A patent/PE20020753A1/es not_active Application Discontinuation
- 2001-12-04 US US10/006,168 patent/US6441184B1/en not_active Expired - Fee Related
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- 2001-12-04 US US10/006,170 patent/US6545155B2/en not_active Expired - Fee Related
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- 2001-12-05 UY UY27055A patent/UY27055A1/es not_active Application Discontinuation
- 2001-12-05 GT GT200100243A patent/GT200100243A/es unknown
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2003
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