|
JP2004516239A
(ja)
|
2000-07-06 |
2004-06-03 |
ニューロジェン コーポレイション |
メラニン凝集ホルモン受容体リガンド
|
|
US6858619B2
(en)
|
2001-05-04 |
2005-02-22 |
Amgen Inc. |
Fused heterocyclic compounds
|
|
US6809104B2
(en)
|
2001-05-04 |
2004-10-26 |
Tularik Inc. |
Fused heterocyclic compounds
|
|
CA2448080A1
(en)
|
2001-05-22 |
2002-11-28 |
Neurogen Corporation |
Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
|
|
AU2002352878B2
(en)
|
2001-11-27 |
2007-11-22 |
Merck Sharp & Dohme Corp. |
2-Aminoquinoline compounds
|
|
US7160879B2
(en)
*
|
2002-01-10 |
2007-01-09 |
Neurogen Corporation |
Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues
|
|
WO2003059289A2
(en)
|
2002-01-10 |
2003-07-24 |
Neurogen Corporation |
Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
DE10238865A1
(de)
*
|
2002-08-24 |
2004-03-11 |
Boehringer Ingelheim International Gmbh |
Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
|
|
US7351719B2
(en)
|
2002-10-31 |
2008-04-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
|
|
CN101134757A
(zh)
|
2002-11-06 |
2008-03-05 |
安姆根有限公司 |
稠合杂环化合物
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
EP1595867A4
(en)
*
|
2003-02-10 |
2008-05-21 |
Banyu Pharma Co Ltd |
PIPERIDINE DERIVATIVES AS AN ACTIVE ANTAGONIST AT THE RECIPE OF MELANIN CONCENTRATING HORMONE
|
|
US7601868B2
(en)
|
2003-02-12 |
2009-10-13 |
Takeda Pharmaceutical Company Limited |
Amine derivative
|
|
EP1654225A4
(en)
*
|
2003-08-13 |
2007-11-28 |
Amgen Inc |
HORMONE RECEPTOR ANTAGONISTS CONCENTRATING MELANIN
|
|
AU2004266233A1
(en)
*
|
2003-08-13 |
2005-03-03 |
Amgen, Inc. |
Melanin concentrating hormone receptor antagonist
|
|
ATE547404T1
(de)
|
2003-09-22 |
2012-03-15 |
Msd Kk |
Piperidinderivate
|
|
US20060247239A1
(en)
*
|
2003-10-01 |
2006-11-02 |
Hu Xiufeng E |
Melanin concentrating hormone antagonists
|
|
SG146692A1
(en)
*
|
2003-10-01 |
2008-10-30 |
Procter & Gamble |
Melanin concentrating hormone antagonists
|
|
US7592373B2
(en)
|
2003-12-23 |
2009-09-22 |
Boehringer Ingelheim International Gmbh |
Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
|
|
EP1734963A4
(en)
|
2004-04-02 |
2008-06-18 |
Merck & Co Inc |
METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
|
|
WO2005110982A2
(en)
*
|
2004-04-07 |
2005-11-24 |
Neurogen Corporation |
Substituted 1-benzyl-4-substituted piperazine analogues
|
|
WO2005110989A1
(en)
*
|
2004-04-07 |
2005-11-24 |
Neurogen Corporation |
Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
|
|
US7524862B2
(en)
|
2004-04-14 |
2009-04-28 |
Boehringer Ingelheim International Gmbh |
Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
|
|
DE102004017934A1
(de)
|
2004-04-14 |
2005-11-03 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
|
|
TW200609219A
(en)
*
|
2004-06-17 |
2006-03-16 |
Neurogen Corp |
Aryl-substituted piperazine derivatives
|
|
US7063034B2
(en)
*
|
2004-08-10 |
2006-06-20 |
Watermark Paddlesports, Inc. |
Spray skirt for watercraft
|
|
EP1784390A2
(en)
|
2004-08-13 |
2007-05-16 |
Amgen Inc. |
Substituted benzofused heterocycles
|
|
CN101094689B
(zh)
|
2004-11-01 |
2013-06-12 |
安米林药品有限责任公司 |
治疗肥胖以及肥胖相关疾病和病症的方法
|
|
US8394765B2
(en)
|
2004-11-01 |
2013-03-12 |
Amylin Pharmaceuticals Llc |
Methods of treating obesity with two different anti-obesity agents
|
|
WO2007022123A2
(en)
|
2005-08-11 |
2007-02-22 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides with selectable properties
|
|
US7737155B2
(en)
|
2005-05-17 |
2010-06-15 |
Schering Corporation |
Nitrogen-containing heterocyclic compounds and methods of use thereof
|
|
BRPI0610580B8
(pt)
|
2005-05-30 |
2021-05-25 |
Banyu Pharma Co Ltd |
composto derivado de piperidina
|
|
CA2610671A1
(en)
*
|
2005-05-31 |
2006-12-07 |
Astrazeneca Ab |
Novel mchr1 antagonists and their use for the treatment of mchr1 mediated conditions and disorders
|
|
JPWO2007018248A1
(ja)
|
2005-08-10 |
2009-02-19 |
萬有製薬株式会社 |
ピリドン化合物
|
|
EP2330125A3
(en)
|
2005-08-11 |
2012-12-12 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides with selectable properties
|
|
WO2007024004A1
(ja)
|
2005-08-24 |
2007-03-01 |
Banyu Pharmaceutical Co., Ltd. |
フェニルピリドン誘導体
|
|
WO2007029847A1
(ja)
|
2005-09-07 |
2007-03-15 |
Banyu Pharmaceutical Co., Ltd. |
二環性芳香族置換ピリドン誘導体
|
|
EP1940842B1
(en)
|
2005-09-29 |
2012-05-30 |
Merck Sharp & Dohme Corp. |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
|
ATE429428T1
(de)
|
2005-09-30 |
2009-05-15 |
Hoffmann La Roche |
Indanderivate als antagonisten des mch-rezeptors
|
|
JP2009512715A
(ja)
|
2005-10-21 |
2009-03-26 |
ノバルティス アクチエンゲゼルシャフト |
レニン阻害剤と抗異脂肪血症剤および／または抗肥満症剤の組み合わせ
|
|
EP1944301A4
(en)
|
2005-10-27 |
2012-01-04 |
Msd Kk |
NEW BENZOXATHIIN DERIVATIVES
|
|
ES2381205T3
(es)
|
2005-11-10 |
2012-05-24 |
Msd K.K. |
Derivado espiro aza-sustituido
|
|
AU2006336504C9
(en)
*
|
2005-12-28 |
2015-05-14 |
Vertex Pharmaceuticals Incorporated |
1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
|
|
US7671221B2
(en)
*
|
2005-12-28 |
2010-03-02 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
|
US20080027072A1
(en)
*
|
2006-04-20 |
2008-01-31 |
Ampla Pharmaceuticals, Inc. |
Potentiation of MC4 receptor activity
|
|
US8173629B2
(en)
|
2006-09-22 |
2012-05-08 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
|
US20090247560A1
(en)
|
2006-09-28 |
2009-10-01 |
Banyu Pharmaceutical Co., Ltd. |
Diaryl ketimine derivative
|
|
US8012955B2
(en)
*
|
2006-12-28 |
2011-09-06 |
Rigel Pharmaceuticals, Inc. |
N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
|
|
JP5319518B2
(ja)
|
2007-04-02 |
2013-10-16 |
Ｍｓｄ株式会社 |
インドールジオン誘導体
|
|
JP5514716B2
(ja)
*
|
2007-05-11 |
2014-06-04 |
コリア・リサーチ・インスティテュート・オブ・ケミカル・テクノロジー |
アリールピペリジン置換基を有するイミダゾール誘導体、その製造方法及びこれを含む医薬組成物
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
MX354786B
(es)
|
2007-06-04 |
2018-03-21 |
Synergy Pharmaceuticals Inc |
Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
|
|
EP2264026A4
(en)
|
2008-03-06 |
2012-03-28 |
Msd Kk |
ALKYLAMINOPYRIDINDERIVATE
|
|
WO2009119726A1
(ja)
|
2008-03-28 |
2009-10-01 |
萬有製薬株式会社 |
メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体
|
|
ES2522968T3
(es)
|
2008-06-04 |
2014-11-19 |
Synergy Pharmaceuticals Inc. |
Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
|
|
JPWO2009154132A1
(ja)
|
2008-06-19 |
2011-12-01 |
Ｍｓｄ株式会社 |
スピロジアミン−ジアリールケトオキシム誘導体
|
|
AU2009270833B2
(en)
|
2008-07-16 |
2015-02-19 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
|
EP2319841A1
(en)
|
2008-07-30 |
2011-05-11 |
Msd K.K. |
(5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative
|
|
EP2348857B1
(en)
|
2008-10-22 |
2016-02-24 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
MX2011004551A
(es)
|
2008-10-30 |
2011-05-25 |
Merck Sharp & Dohme |
Antagonistas del receptor de orexina de isonicotinamida.
|
|
US8329914B2
(en)
|
2008-10-31 |
2012-12-11 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
EP2379547A1
(en)
|
2008-12-16 |
2011-10-26 |
Schering Corporation |
Pyridopyrimidine derivatives and methods of use thereof
|
|
US20110243940A1
(en)
|
2008-12-16 |
2011-10-06 |
Schering Corporation |
Bicyclic pyranone derivatives and methods of use thereof
|
|
JP2013520502A
(ja)
|
2010-02-25 |
2013-06-06 |
メルク・シャープ・エンド・ドーム・コーポレイション |
有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
SG192941A1
(en)
|
2011-02-25 |
2013-09-30 |
Merck Sharp & Dohme |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
|
|
AR088352A1
(es)
|
2011-10-19 |
2014-05-28 |
Merck Sharp & Dohme |
Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
|
|
RU2015106909A
(ru)
|
2012-08-02 |
2016-09-27 |
Мерк Шарп И Доум Корп. |
Антидиабетические трициклические соединения
|
|
KR20150118158A
(ko)
|
2013-02-22 |
2015-10-21 |
머크 샤프 앤드 돔 코포레이션 |
항당뇨병 비시클릭 화합물
|
|
WO2014139388A1
(en)
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
AU2014235209B2
(en)
|
2013-03-15 |
2018-06-14 |
Bausch Health Ireland Limited |
Guanylate cyclase receptor agonists combined with other drugs
|
|
AU2014235215A1
(en)
|
2013-03-15 |
2015-10-01 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
|
BR112015030326A2
(pt)
|
2013-06-05 |
2017-08-29 |
Synergy Pharmaceuticals Inc |
Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
KR102431436B1
(ko)
|
2014-08-29 |
2022-08-10 |
테스 파마 에스.알.엘. |
α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
|
|
WO2018069532A1
(en)
|
2016-10-14 |
2018-04-19 |
Tes Pharma S.R.L. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
|
US11072602B2
(en)
|
2016-12-06 |
2021-07-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
EP3558298B1
(en)
|
2016-12-20 |
2026-03-11 |
Merck Sharp & Dohme LLC |
Antidiabetic spirochroman compounds
|
|
AR117122A1
(es)
|
2018-11-20 |
2021-07-14 |
Tes Pharma S R L |
INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
|
|
US11098029B2
(en)
|
2019-02-13 |
2021-08-24 |
Merck Sharp & Dohme Corp. |
5-alkyl pyrrolidine orexin receptor agonists
|
|
WO2020167701A1
(en)
|
2019-02-13 |
2020-08-20 |
Merck Sharp & Dohme Corp. |
Pyrrolidine orexin receptor agonists
|
|
WO2021026047A1
(en)
|
2019-08-08 |
2021-02-11 |
Merck Sharp & Dohme Corp. |
Heteroaryl pyrrolidine and piperidine orexin receptor agonists
|
|
BR112023002957A2
(pt)
|
2020-08-18 |
2023-04-04 |
Merck Sharp & Dohme Llc |
Composto, composição farmacêutica, e, métodos para tratar narcolepsia e para tratar hipersonia em um sujeito mamífero
|