JP2008510691A5 - - Google Patents
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- Publication number
- JP2008510691A5 JP2008510691A5 JP2007526463A JP2007526463A JP2008510691A5 JP 2008510691 A5 JP2008510691 A5 JP 2008510691A5 JP 2007526463 A JP2007526463 A JP 2007526463A JP 2007526463 A JP2007526463 A JP 2007526463A JP 2008510691 A5 JP2008510691 A5 JP 2008510691A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- pseudohalogen
- alkynyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052736 halogen Inorganic materials 0.000 claims 27
- 150000002367 halogens Chemical class 0.000 claims 24
- 125000002577 pseudohalo group Chemical group 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000001072 heteroaryl group Chemical group 0.000 claims 19
- 125000000623 heterocyclic group Chemical group 0.000 claims 19
- 125000001424 substituent group Chemical group 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 7
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- -1 bicyclic aryl compound Chemical class 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 230000001028 anti-proliverative effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04019775.8 | 2004-08-20 | ||
| EP04019775 | 2004-08-20 | ||
| PCT/EP2005/054089 WO2006021544A1 (de) | 2004-08-20 | 2005-08-18 | 2,4-di(amimopheyl) pyrimidine als plk inhibitoren |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008510691A JP2008510691A (ja) | 2008-04-10 |
| JP2008510691A5 true JP2008510691A5 (https=) | 2009-03-05 |
| JP5060294B2 JP5060294B2 (ja) | 2012-10-31 |
Family
ID=34926239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526463A Expired - Fee Related JP5060294B2 (ja) | 2004-08-20 | 2005-08-18 | Ｐｌｋインヒビターとしてのピリミジン化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US7521457B2 (https=) |
| EP (1) | EP1781640B1 (https=) |
| JP (1) | JP5060294B2 (https=) |
| KR (1) | KR101277506B1 (https=) |
| CN (1) | CN101044137A (https=) |
| AR (1) | AR051195A1 (https=) |
| AU (1) | AU2005276500B2 (https=) |
| BR (1) | BRPI0514371A (https=) |
| CA (1) | CA2573371C (https=) |
| DK (1) | DK1781640T3 (https=) |
| ES (1) | ES2532611T3 (https=) |
| HU (1) | HUE025285T2 (https=) |
| IL (1) | IL181421A (https=) |
| MX (1) | MX2007002055A (https=) |
| NZ (1) | NZ553632A (https=) |
| PL (1) | PL1781640T3 (https=) |
| RU (1) | RU2404979C2 (https=) |
| TW (1) | TWI421248B (https=) |
| WO (1) | WO2006021544A1 (https=) |
| ZA (1) | ZA200700084B (https=) |
Families Citing this family (98)
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| US20090306067A1 (en) * | 2006-04-10 | 2009-12-10 | Harald Engelhardt | 2, 4-diaminopyrimidide derivates and their use for the treatment of cancer |
| PE20120006A1 (es) * | 2006-05-15 | 2012-02-02 | Boehringer Ingelheim Int | Compuestos derivados de pirimidina como inhibidores de la quinasa aurora |
| DE102006039003A1 (de) | 2006-08-19 | 2008-02-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Verbindungen |
| SG158147A1 (en) * | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
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| CN101535276B (zh) | 2006-10-23 | 2013-08-28 | 赛福伦公司 | 作为ALK和c-MET抑制剂的2,4-二氨基嘧啶稠合双环衍生物 |
| DE102007010801A1 (de) | 2007-03-02 | 2008-09-04 | Bayer Cropscience Ag | Diaminopyrimidine als Fungizide |
| BRPI0810411B8 (pt) * | 2007-04-18 | 2021-05-25 | Pfizer Prod Inc | derivados de sulfonil amida para o tratamento de crescimento celular anormal, seu sos, bem como composição farmacêutica |
| AU2008254318B2 (en) * | 2007-05-16 | 2012-04-05 | Eli Lilly And Company | Triazolyl aminopyrimidine compounds |
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| US6582439B1 (en) * | 2001-12-28 | 2003-06-24 | Yacmur Llc | Vertebroplasty system |
| AU2003284399A1 (en) * | 2002-11-14 | 2004-06-03 | Kyowa Hakko Kogyo Co., Ltd. | Plk inhibitors |
| ES2325440T3 (es) | 2003-02-20 | 2009-09-04 | Smithkline Beecham Corporation | Compuestos de pirimidina. |
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| NZ585188A (en) * | 2003-08-15 | 2011-09-30 | Novartis Ag | 2,4-Pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders |
| CA2543295A1 (en) * | 2003-10-23 | 2005-05-06 | Trans1 Inc. | Tools and tool kits for performing minimally invasive procedures on the spine |
| US7699852B2 (en) * | 2003-11-19 | 2010-04-20 | Zimmer Spine, Inc. | Fenestrated bone tap and method |
| WO2005052214A2 (de) * | 2003-11-28 | 2005-06-09 | Roiner, Maria | Verfahren und vorrichtung zur herstellung eines oder mehrerer gase |
| EP1598343A1 (de) * | 2004-05-19 | 2005-11-23 | Boehringer Ingelheim International GmbH | 2-Arylaminopyrimidine als PLK Inhibitoren |
| US7521457B2 (en) * | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| US7513901B2 (en) * | 2005-05-19 | 2009-04-07 | Warsaw Orthopedic, Inc. | Graft syringe assembly |
| US20070118144A1 (en) * | 2005-09-01 | 2007-05-24 | Csaba Truckai | Systems for sensing retrograde flows of bone fill material |
| US7901409B2 (en) * | 2006-01-20 | 2011-03-08 | Canaveral Villegas Living Trust | Intramedullar devices and methods to reduce and/or fix damaged bone |
-
2005
- 2005-08-17 US US11/206,703 patent/US7521457B2/en not_active Expired - Fee Related
- 2005-08-18 KR KR1020077004974A patent/KR101277506B1/ko not_active Expired - Fee Related
- 2005-08-18 NZ NZ553632A patent/NZ553632A/en not_active IP Right Cessation
- 2005-08-18 DK DK05777896T patent/DK1781640T3/en active
- 2005-08-18 MX MX2007002055A patent/MX2007002055A/es active IP Right Grant
- 2005-08-18 EP EP05777896.1A patent/EP1781640B1/de not_active Expired - Lifetime
- 2005-08-18 HU HUE05777896A patent/HUE025285T2/en unknown
- 2005-08-18 CN CNA2005800359954A patent/CN101044137A/zh active Pending
- 2005-08-18 JP JP2007526463A patent/JP5060294B2/ja not_active Expired - Fee Related
- 2005-08-18 CA CA2573371A patent/CA2573371C/en not_active Expired - Fee Related
- 2005-08-18 AU AU2005276500A patent/AU2005276500B2/en not_active Ceased
- 2005-08-18 ES ES05777896.1T patent/ES2532611T3/es not_active Expired - Lifetime
- 2005-08-18 PL PL05777896T patent/PL1781640T3/pl unknown
- 2005-08-18 BR BRPI0514371-3A patent/BRPI0514371A/pt active Search and Examination
- 2005-08-18 RU RU2007109870/04A patent/RU2404979C2/ru not_active IP Right Cessation
- 2005-08-18 WO PCT/EP2005/054089 patent/WO2006021544A1/de not_active Ceased
- 2005-08-19 TW TW094128434A patent/TWI421248B/zh not_active IP Right Cessation
- 2005-08-22 AR ARP050103502A patent/AR051195A1/es not_active Application Discontinuation
-
2007
- 2007-01-03 ZA ZA200700084A patent/ZA200700084B/xx unknown
- 2007-02-19 IL IL181421A patent/IL181421A/en active IP Right Grant
-
2009
- 2009-02-05 US US12/366,078 patent/US20090149438A1/en not_active Abandoned
- 2009-02-05 US US12/366,075 patent/US20090163465A1/en not_active Abandoned
-
2010
- 2010-12-20 US US12/972,976 patent/US20110086842A1/en not_active Abandoned
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