JP2014531434A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014531434A5 JP2014531434A5 JP2014529919A JP2014529919A JP2014531434A5 JP 2014531434 A5 JP2014531434 A5 JP 2014531434A5 JP 2014529919 A JP2014529919 A JP 2014529919A JP 2014529919 A JP2014529919 A JP 2014529919A JP 2014531434 A5 JP2014531434 A5 JP 2014531434A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- substituted
- contrast component
- contrast
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001072 heteroaryl group Chemical group 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 150000002431 hydrogen Chemical group 0.000 claims 24
- 125000004122 cyclic group Chemical group 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 20
- 125000004452 carbocyclyl group Chemical group 0.000 claims 15
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 15
- 125000000547 substituted alkyl group Chemical group 0.000 claims 15
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 15
- 125000003107 substituted aryl group Chemical group 0.000 claims 15
- 101000651021 Homo sapiens Splicing factor, arginine/serine-rich 19 Proteins 0.000 claims 14
- 102100027779 Splicing factor, arginine/serine-rich 19 Human genes 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 12
- 239000002872 contrast media Substances 0.000 claims 12
- 238000003384 imaging method Methods 0.000 claims 12
- 125000002950 monocyclic group Chemical group 0.000 claims 10
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 150000003839 salts Chemical group 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 230000030214 innervation Effects 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 230000010412 perfusion Effects 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000002015 acyclic group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 239000002738 chelating agent Substances 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 208000010125 myocardial infarction Diseases 0.000 claims 3
- 125000001845 4 membered carbocyclic group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 230000000747 cardiac effect Effects 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004011 3 membered carbocyclic group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000002638 denervation Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017131851A JP6964450B2 (ja) | 2011-09-09 | 2017-07-05 | 造影剤の合成および使用のための組成物、方法およびシステム |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161533133P | 2011-09-09 | 2011-09-09 | |
| US61/533,133 | 2011-09-09 | ||
| US201261656489P | 2012-06-06 | 2012-06-06 | |
| US201261656492P | 2012-06-06 | 2012-06-06 | |
| US61/656,489 | 2012-06-06 | ||
| US61/656,492 | 2012-06-06 | ||
| PCT/US2012/054309 WO2013036869A2 (en) | 2011-09-09 | 2012-09-07 | Compositions, methods, and systems for the synthesis and use of imaging agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017131851A Division JP6964450B2 (ja) | 2011-09-09 | 2017-07-05 | 造影剤の合成および使用のための組成物、方法およびシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531434A JP2014531434A (ja) | 2014-11-27 |
| JP2014531434A5 true JP2014531434A5 (https=) | 2015-11-05 |
| JP6174026B2 JP6174026B2 (ja) | 2017-08-02 |
Family
ID=47832802
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529919A Active JP6174026B2 (ja) | 2011-09-09 | 2012-09-07 | 造影剤の合成および使用のための組成物、方法およびシステム |
| JP2017131851A Expired - Fee Related JP6964450B2 (ja) | 2011-09-09 | 2017-07-05 | 造影剤の合成および使用のための組成物、方法およびシステム |
| JP2019147621A Withdrawn JP2019218371A (ja) | 2011-09-09 | 2019-08-09 | 造影剤の合成および使用のための組成物、方法およびシステム |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017131851A Expired - Fee Related JP6964450B2 (ja) | 2011-09-09 | 2017-07-05 | 造影剤の合成および使用のための組成物、方法およびシステム |
| JP2019147621A Withdrawn JP2019218371A (ja) | 2011-09-09 | 2019-08-09 | 造影剤の合成および使用のための組成物、方法およびシステム |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9550000B2 (https=) |
| EP (2) | EP2753605B1 (https=) |
| JP (3) | JP6174026B2 (https=) |
| KR (4) | KR102527562B1 (https=) |
| CN (2) | CN108484449A (https=) |
| AU (3) | AU2012304359B2 (https=) |
| BR (2) | BR112014005286B1 (https=) |
| CA (2) | CA2848147C (https=) |
| DK (1) | DK2753605T3 (https=) |
| ES (1) | ES2731471T3 (https=) |
| IL (2) | IL231414B (https=) |
| SG (2) | SG2014013767A (https=) |
| TW (2) | TWI700268B (https=) |
| WO (1) | WO2013036869A2 (https=) |
| ZA (2) | ZA201401940B (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| ES2405655T3 (es) | 2006-12-26 | 2013-05-31 | Lantheus Medical Imaging, Inc. | N-[3-bromo-4-(3-[18F]fluoropropoxi)-bencil]-guanidina para la formación de imágenes de la inervación cardíaca |
| WO2009108376A2 (en) | 2008-02-29 | 2009-09-03 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including perfusion imaging |
| KR20160030589A (ko) | 2009-04-15 | 2016-03-18 | 랜티우스 메디컬 이메징, 인크. | 아스코르브산을 사용한 방사성 약제 조성물의 안정화 |
| DK3323810T3 (da) | 2010-02-08 | 2022-03-28 | Lantheus Medical Imaging Inc | Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| ES2608474T3 (es) | 2010-04-22 | 2017-04-11 | Vertex Pharmaceuticals Incorporated | Proceso de producción de compuestos indol cycloalkylcarboxamido |
| ES2763815T3 (es) | 2010-05-11 | 2020-06-01 | Lantheus Medical Imaging Inc | Composiciones, métodos y sistemas para la síntesis y uso de agentes de formación de imágenes |
| CA2852395C (en) * | 2011-10-21 | 2020-04-28 | Lantheus Medical Imaging, Inc. | Compositions comprising ascorbic acid and pyridaben and pyridaben analogs attached to an imaging moiety and related methods |
| PT2836241T (pt) | 2012-04-10 | 2019-05-30 | Lantheus Medical Imaging Inc | Métodos de síntese de radiofármacos |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| US10939822B2 (en) | 2013-01-24 | 2021-03-09 | Tylerton International Holdings Inc. | Body structure imaging |
| WO2015033317A2 (en) * | 2013-09-08 | 2015-03-12 | Shlomo Ben-Haim | Detection of reduced-control cardiac zones |
| WO2015054662A1 (en) | 2013-10-10 | 2015-04-16 | Eastern Virginia Medical School | 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as 12-lipoxygenase inhibitors |
| CN106102583B (zh) | 2014-01-10 | 2024-08-09 | 泰勒顿国际控股公司 | 瘢痕和纤维心脏区的检测 |
| ES2885181T3 (es) | 2014-04-15 | 2021-12-13 | Vertex Pharma | Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística |
| US10918742B2 (en) | 2016-03-25 | 2021-02-16 | Nanoprobes, Inc. | Iodine-based particles |
| JP6060302B1 (ja) * | 2016-06-10 | 2017-01-11 | 日本メジフィジックス株式会社 | 心筋核医学画像データの解析方法及び解析装置 |
| MX388518B (es) | 2016-07-20 | 2025-03-19 | Novartis Ag | Derivados de aminopiridina y su uso como inhibidores selectivos de alk-2. |
| EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE |
| WO2020030954A1 (en) | 2018-08-09 | 2020-02-13 | Integrative Medicine Clinic, Sia | Theranostics-like protein sanps conjugated to integrin and pmsa targeting peptides and therapy of prostate cancer |
| CR20210175A (es) | 2018-09-18 | 2021-06-01 | Nikang Therapeutics Inc | Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2 (shp2) |
| EP3682906A1 (en) | 2019-01-17 | 2020-07-22 | Julius-Maximilians-Universität Würzburg | Compound targeting norepinephrine transporter |
| GB201915206D0 (en) | 2019-10-21 | 2019-12-04 | Ge Healthcare Ltd | Use of cyclodextrins as a radiostabilizer |
| JP7717065B2 (ja) | 2019-11-22 | 2025-08-01 | インサイト コーポレーション | Ａｌｋ２阻害剤及びｊａｋ２阻害剤を含む併用療法 |
| US12441707B2 (en) | 2019-12-30 | 2025-10-14 | Tyra Biosciences, Inc. | Indazole compounds |
| WO2021257532A1 (en) | 2020-06-16 | 2021-12-23 | Incyte Corporation | Alk2 inhibitors for the treatment of anemia |
| KR20230152654A (ko) | 2020-12-30 | 2023-11-03 | 타이라 바이오사이언시스, 인크. | 키나아제 억제제로서의 인다졸 화합물 |
| AU2022229037A1 (en) * | 2021-03-02 | 2023-09-28 | Mindset Pharma Inc. | Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto |
| CN113292405B (zh) * | 2021-06-01 | 2024-07-26 | 湖南华腾制药有限公司 | 一种2-溴-4氯苯甲醛的制备方法 |
| CN113418940B (zh) * | 2021-06-24 | 2023-03-14 | 电子科技大学 | 一种基于x射线示踪颗粒的检测方法及检测装置 |
| CN113461567B (zh) * | 2021-07-30 | 2023-08-22 | 长沙创新药物工业技术研究院有限公司 | 一种2-溴-4腈基苯甲醛的制备方法 |
| US20240247001A1 (en) | 2022-12-16 | 2024-07-25 | Astrazeneca Ab | 2,6,9-trisubstituted purines |
| CN119978393B (zh) * | 2025-04-14 | 2025-07-04 | 西南石油大学 | 一种具有氨基侧链交联的形状记忆聚芳醚腈复合材料及其制备方法和应用 |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1125126A (en) * | 1913-01-06 | 1915-01-19 | Reinhold Krumming | Temporary binder or loose-sheet holder. |
| FR1010218A (fr) | 1949-02-10 | 1952-06-09 | American Cyanamid Co | Perfectionnements aux sels de guanidine |
| GB1215255A (en) | 1968-03-13 | 1970-12-09 | Pfizer & Co C | Halophenylalkylguanidine compounds |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| JPS61260018A (ja) | 1985-05-14 | 1986-11-18 | Nissan Chem Ind Ltd | 抗アレルギ−剤 |
| CA1283827C (en) | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| US5417959A (en) | 1993-10-04 | 1995-05-23 | Mallinckrodt Medical, Inc. | Functionalized aza-crytand ligands for diagnostic imaging applications |
| US5493026A (en) | 1993-10-25 | 1996-02-20 | Organix, Inc. | Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders |
| JPH07252236A (ja) | 1994-01-28 | 1995-10-03 | Takeda Chem Ind Ltd | 抗癌剤 |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| WO2000009115A1 (en) * | 1998-08-14 | 2000-02-24 | Smithkline Beecham Corporation | Grp receptor ligands |
| EP1140204A2 (en) | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | Vitronectin receptor antagonist pharmaceuticals |
| GB0019357D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| DE10114561A1 (de) | 2001-03-24 | 2002-09-26 | Wella Ag | Verwendung von Mitteln enthaltend Kreatin, Kreatin und/oder deren Derivaten zur Verstärkung und Strukturverbesserung von keratinischen Fasern |
| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| WO2004037166A2 (en) | 2002-09-17 | 2004-05-06 | Isis Pharmaceuticals, Inc. | Therapeutic guanidines |
| AU2004294989B2 (en) | 2003-12-01 | 2009-03-19 | Ignasi Carrio | Novel differential imaging method |
| EP2388017B1 (en) | 2004-02-24 | 2014-12-24 | The General Hospital Corporation | Catalytic radiofluorination |
| WO2005095345A2 (en) | 2004-03-23 | 2005-10-13 | Achillion Pharmaceuticals, Inc. | Heteroaryl guanidines as inhibitors of viral replication |
| US7485283B2 (en) | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
| EP1749815B1 (en) | 2004-05-28 | 2017-06-21 | Hamamatsu Photonics K.K. | Radioactive tyrosine derivative, method for producing same, labeling agent for positron imaging and medical agent for assessing grade of malignancy of tumor respectively composed of radioactive tyrosine derivative, and method for detecting tumor |
| US20070292354A1 (en) | 2004-09-23 | 2007-12-20 | Guerbet | Contrast Agents Encapsulating Systems for Cest Imaging |
| US7534418B2 (en) | 2004-12-10 | 2009-05-19 | The Regents Of The University Of Michigan | Imaging agents |
| GB0512770D0 (en) | 2005-06-23 | 2005-07-27 | Hammersmith Imanet Ltd | Imaging compounds |
| US7824659B2 (en) | 2005-08-10 | 2010-11-02 | Lantheus Medical Imaging, Inc. | Methods of making radiolabeled tracers and precursors thereof |
| JP2007112725A (ja) | 2005-10-18 | 2007-05-10 | Inst Nuclear Energy Research Rocaec | 無支持体の１８Ｆで標識したアミノ酸Ｏ−（２−［１８Ｆ］ｆｌｕｏｒｏｅｔｈｙｌ）−Ｌ−Ｔｙｒｏｓｉｎｅの製造方法。 |
| WO2008118122A2 (en) | 2006-05-08 | 2008-10-02 | Molecular Neuroimaging, Llc | Compounds and amyloid probes thereof for therapeutic and imaging uses |
| KR20090047542A (ko) | 2006-08-25 | 2009-05-12 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｍｃｈ 길항 활성을 갖는 신규한 피리돈 유도체 및 당해 화합물을 포함하는 의약 |
| US7823227B2 (en) * | 2006-10-10 | 2010-11-02 | Joseph Damianoe | Bathroom odor removal apparatus and system |
| GB0625523D0 (en) | 2006-12-21 | 2007-01-31 | Ge Healthcare Ltd | In vivo imaging agents |
| ES2405655T3 (es) * | 2006-12-26 | 2013-05-31 | Lantheus Medical Imaging, Inc. | N-[3-bromo-4-(3-[18F]fluoropropoxi)-bencil]-guanidina para la formación de imágenes de la inervación cardíaca |
| WO2008115593A1 (en) | 2007-03-21 | 2008-09-25 | The University Of Montana | 1-[(2'-substituted)-piperazin-1'-yl]-isoquinolines as norepinephrine transporter inhibitor therapeutics and positron emission tomography imaging agents |
| CA2683433C (en) | 2007-04-05 | 2016-10-11 | Siemens Medical Solutions Usa, Inc. | Nitro-imidazole hypoxia imaging agents |
| KR101068835B1 (ko) | 2007-10-26 | 2011-09-30 | 한국과학기술연구원 | 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를가지는 이소인돌론 화합물 및 이의 제조 방법 |
| WO2009103478A1 (en) | 2008-02-19 | 2009-08-27 | Boehringer Ingelheim International Gmbh | Pyridone and pyridazinone derivatives as mch antagonists |
| WO2010011367A2 (en) | 2008-02-22 | 2010-01-28 | Illinois Institute Of Technology | Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using |
| WO2009108376A2 (en) | 2008-02-29 | 2009-09-03 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including perfusion imaging |
| CN101585816B (zh) | 2008-05-20 | 2011-04-20 | 中国科学院上海应用物理研究所 | 一种苯磺酰胺类羟基衍生物及其中间体及制备方法和应用 |
| WO2010015340A1 (en) | 2008-08-06 | 2010-02-11 | Bayer Schering Pharma Aktiengesellschaft | Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment |
| EP2406233B1 (en) | 2009-03-09 | 2013-11-13 | Bristol-Myers Squibb Company | Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| GB0906274D0 (en) | 2009-04-09 | 2009-05-20 | Ge Healthcare Ltd | Imaging the central nervous system |
| KR20160030589A (ko) | 2009-04-15 | 2016-03-18 | 랜티우스 메디컬 이메징, 인크. | 아스코르브산을 사용한 방사성 약제 조성물의 안정화 |
| CN101555232B (zh) | 2009-05-21 | 2011-01-05 | 北京师范大学 | 氟-18标记哒嗪酮类化合物及制备方法和应用 |
| WO2011005322A2 (en) | 2009-07-08 | 2011-01-13 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| DK3323810T3 (da) | 2010-02-08 | 2022-03-28 | Lantheus Medical Imaging Inc | Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler |
| ES2763815T3 (es) | 2010-05-11 | 2020-06-01 | Lantheus Medical Imaging Inc | Composiciones, métodos y sistemas para la síntesis y uso de agentes de formación de imágenes |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| JP2017131851A (ja) * | 2016-01-29 | 2017-08-03 | 日本特殊陶業株式会社 | マイクロ波加熱用触媒材料、マイクロ波加熱用触媒体、及び、その製造方法 |
-
2012
- 2012-09-07 CN CN201810174512.8A patent/CN108484449A/zh active Pending
- 2012-09-07 SG SG2014013767A patent/SG2014013767A/en unknown
- 2012-09-07 KR KR1020227010193A patent/KR102527562B1/ko active Active
- 2012-09-07 DK DK12829763.7T patent/DK2753605T3/da active
- 2012-09-07 ES ES12829763T patent/ES2731471T3/es active Active
- 2012-09-07 AU AU2012304359A patent/AU2012304359B2/en active Active
- 2012-09-07 EP EP12829763.7A patent/EP2753605B1/en active Active
- 2012-09-07 WO PCT/US2012/054309 patent/WO2013036869A2/en not_active Ceased
- 2012-09-07 TW TW105133321A patent/TWI700268B/zh not_active IP Right Cessation
- 2012-09-07 BR BR112014005286-7A patent/BR112014005286B1/pt active IP Right Grant
- 2012-09-07 KR KR1020217008298A patent/KR20210033558A/ko not_active Ceased
- 2012-09-07 EP EP19165299.9A patent/EP3567029A1/en not_active Withdrawn
- 2012-09-07 JP JP2014529919A patent/JP6174026B2/ja active Active
- 2012-09-07 SG SG10201607437QA patent/SG10201607437QA/en unknown
- 2012-09-07 CN CN201280055406.9A patent/CN104159890B/zh active Active
- 2012-09-07 US US14/343,627 patent/US9550000B2/en active Active
- 2012-09-07 BR BR122019017259-5A patent/BR122019017259B1/pt active IP Right Grant
- 2012-09-07 KR KR1020197002898A patent/KR20190015765A/ko not_active Ceased
- 2012-09-07 CA CA2848147A patent/CA2848147C/en active Active
- 2012-09-07 KR KR1020147009311A patent/KR101946089B1/ko active Active
- 2012-09-07 TW TW101132942A patent/TWI568714B/zh active
- 2012-09-07 CA CA3123737A patent/CA3123737A1/en active Pending
-
2014
- 2014-03-09 IL IL231414A patent/IL231414B/en active IP Right Grant
- 2014-03-17 ZA ZA201401940A patent/ZA201401940B/en unknown
-
2016
- 2016-11-30 US US15/364,678 patent/US20170266326A1/en not_active Abandoned
-
2017
- 2017-02-10 AU AU2017200934A patent/AU2017200934A1/en not_active Abandoned
- 2017-07-05 JP JP2017131851A patent/JP6964450B2/ja not_active Expired - Fee Related
-
2018
- 2018-09-20 IL IL261876A patent/IL261876A/en active IP Right Grant
- 2018-12-14 AU AU2018279007A patent/AU2018279007B2/en not_active Ceased
-
2019
- 2019-05-21 ZA ZA2019/03184A patent/ZA201903184B/en unknown
- 2019-08-09 JP JP2019147621A patent/JP2019218371A/ja not_active Withdrawn
-
2020
- 2020-03-24 US US16/828,119 patent/US20200397927A1/en not_active Abandoned
-
2022
- 2022-04-20 US US17/724,713 patent/US20220339303A1/en active Pending
-
2025
- 2025-01-17 US US19/029,057 patent/US20250170282A1/en active Pending