JP2021534108A5 - - Google Patents
Info
- Publication number
- JP2021534108A5 JP2021534108A5 JP2021506683A JP2021506683A JP2021534108A5 JP 2021534108 A5 JP2021534108 A5 JP 2021534108A5 JP 2021506683 A JP2021506683 A JP 2021506683A JP 2021506683 A JP2021506683 A JP 2021506683A JP 2021534108 A5 JP2021534108 A5 JP 2021534108A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- independently selected
- heterocyclyls
- pharmaceutically acceptable
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862715850P | 2018-08-08 | 2018-08-08 | |
| US62/715,850 | 2018-08-08 | ||
| PCT/US2019/045466 WO2020033520A1 (en) | 2018-08-08 | 2019-08-07 | Indole and azaindole inhibitors of pad enzymes |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021534108A JP2021534108A (ja) | 2021-12-09 |
| JP2021534108A5 true JP2021534108A5 (https=) | 2022-08-16 |
| JPWO2020033520A5 JPWO2020033520A5 (https=) | 2022-08-16 |
| JP7651451B2 JP7651451B2 (ja) | 2025-03-26 |
Family
ID=67766306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021506683A Active JP7651451B2 (ja) | 2018-08-08 | 2019-08-07 | Ｐａｄ酵素のインドールおよびアザインドール阻害剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US11524959B1 (https=) |
| EP (1) | EP3833440A1 (https=) |
| JP (1) | JP7651451B2 (https=) |
| KR (1) | KR102885181B1 (https=) |
| CN (1) | CN112805067B (https=) |
| AR (1) | AR115920A1 (https=) |
| AU (1) | AU2019319835A1 (https=) |
| BR (1) | BR112021002091A2 (https=) |
| CA (1) | CA3108791A1 (https=) |
| CL (1) | CL2021000296A1 (https=) |
| CO (1) | CO2021001217A2 (https=) |
| EA (1) | EA202190462A1 (https=) |
| IL (1) | IL280650A (https=) |
| MX (1) | MX2021001565A (https=) |
| PE (1) | PE20211068A1 (https=) |
| SG (1) | SG11202101174RA (https=) |
| TW (1) | TW202019415A (https=) |
| WO (1) | WO2020033520A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3833671B1 (en) | 2018-08-08 | 2022-08-24 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| EP4100405A1 (en) | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| EP4143189A1 (en) * | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| CN111943947B (zh) * | 2020-07-24 | 2021-04-30 | 重庆文理学院 | 1H-吡咯[2,3-b]吡啶衍生物及其合成方法与应用 |
| CN116075510A (zh) | 2020-08-19 | 2023-05-05 | 百时美施贵宝公司 | 1H-苯并[d]咪唑衍生物作为TLR9抑制剂用于治疗纤维化 |
| WO2022040267A1 (en) | 2020-08-19 | 2022-02-24 | Bristol-Myers Squibb Company | 1h-pyrrolo[3,2-c]pyridine and 1h-pyrrolo[2,3-c]pyridine derivatives as tlr9 inhibitors for the treatment of fibrosis |
| TW202241884A (zh) * | 2020-12-22 | 2022-11-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140428A2 (en) * | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| CN117427074A (zh) * | 2023-11-13 | 2024-01-23 | 山东第一医科大学(山东省医学科学院) | 四氢喹啉醇作为铁死亡抑制剂在制备急性肾损伤药物中的应用 |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS55684B1 (sr) | 2012-07-26 | 2017-07-31 | Glaxo Group Ltd | 2-(azaindol-2-il)benzimidazoli kao pad4 inhibitori |
| US10407407B2 (en) | 2015-05-21 | 2019-09-10 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as PAD4 inhibitors |
| AR107030A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| RU2747431C2 (ru) | 2015-12-22 | 2021-05-05 | Кансера Аб | Бициклические гидроксамовые кислоты, полезные в качестве ингибиторов активности деацетилазы гистонов млекопитающих |
| JP6926126B2 (ja) | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| KR102398941B1 (ko) | 2016-07-27 | 2022-05-17 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 공유결합성 억제제 |
| JP7118951B2 (ja) | 2016-09-12 | 2022-08-16 | パドロック・セラピューティクス・インコーポレイテッド | Ｐａｄ４のヘテロアリール阻害剤 |
| CN110582489B (zh) | 2017-06-30 | 2023-10-27 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| AU2018352142B2 (en) | 2017-10-18 | 2022-08-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| CN112789087B (zh) | 2018-08-08 | 2024-08-13 | 百时美施贵宝公司 | Pad酶的苯并咪唑抑制剂 |
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| WO2020033488A1 (en) | 2018-08-08 | 2020-02-13 | Bristol-Myers Squibb Company | Substituted benzimidazoles as pad4 inhibitors |
| EP3833671B1 (en) | 2018-08-08 | 2022-08-24 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
-
2019
- 2019-08-07 AU AU2019319835A patent/AU2019319835A1/en not_active Abandoned
- 2019-08-07 EA EA202190462A patent/EA202190462A1/ru unknown
- 2019-08-07 SG SG11202101174RA patent/SG11202101174RA/en unknown
- 2019-08-07 US US17/265,842 patent/US11524959B1/en active Active
- 2019-08-07 CA CA3108791A patent/CA3108791A1/en active Pending
- 2019-08-07 PE PE2021000171A patent/PE20211068A1/es unknown
- 2019-08-07 KR KR1020217006477A patent/KR102885181B1/ko active Active
- 2019-08-07 AR ARP190102237A patent/AR115920A1/es not_active Application Discontinuation
- 2019-08-07 TW TW108128155A patent/TW202019415A/zh unknown
- 2019-08-07 EP EP19759141.5A patent/EP3833440A1/en active Pending
- 2019-08-07 MX MX2021001565A patent/MX2021001565A/es unknown
- 2019-08-07 BR BR112021002091-8A patent/BR112021002091A2/pt not_active Application Discontinuation
- 2019-08-07 CN CN201980064963.9A patent/CN112805067B/zh active Active
- 2019-08-07 WO PCT/US2019/045466 patent/WO2020033520A1/en not_active Ceased
- 2019-08-07 JP JP2021506683A patent/JP7651451B2/ja active Active
-
2021
- 2021-02-03 CO CONC2021/0001217A patent/CO2021001217A2/es unknown
- 2021-02-03 CL CL2021000296A patent/CL2021000296A1/es unknown
- 2021-02-04 IL IL280650A patent/IL280650A/en unknown