TW202019415A - Pad酶之吲哚及氮雜吲哚抑制劑 - Google Patents

Info

Publication number

TW202019415A

TW202019415A TW108128155A TW108128155A TW202019415A TW 202019415 A TW202019415 A TW 202019415A TW 108128155 A TW108128155 A TW 108128155A TW 108128155 A TW108128155 A TW 108128155A TW 202019415 A TW202019415 A TW 202019415A

Authority

TW

Taiwan

Prior art keywords

substituted

alkyl

occurrence

independently selected

substituents

Prior art date

2018-08-08

Links

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• 239000003112 inhibitor Substances 0.000 title abstract description 22
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• 108090000790 Enzymes Proteins 0.000 title description 4
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• RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 188
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• 125000000217 alkyl group Chemical group 0.000 claims description 412
• -1 -NR a C(=O)OR b Chemical group 0.000 claims description 174
• 125000001424 substituent group Chemical group 0.000 claims description 171
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• 229910052739 hydrogen Inorganic materials 0.000 claims description 125
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• 150000003839 salts Chemical class 0.000 claims description 98
• 125000000623 heterocyclic group Chemical group 0.000 claims description 90
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 80
• 125000002837 carbocyclic group Chemical group 0.000 claims description 69
• 229910052799 carbon Inorganic materials 0.000 claims description 68
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 67
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 60
• 229910052757 nitrogen Inorganic materials 0.000 claims description 53
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 42
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