JP2021534106A5 - - Google Patents
Info
- Publication number
- JP2021534106A5 JP2021534106A5 JP2021506663A JP2021506663A JP2021534106A5 JP 2021534106 A5 JP2021534106 A5 JP 2021534106A5 JP 2021506663 A JP2021506663 A JP 2021506663A JP 2021506663 A JP2021506663 A JP 2021506663A JP 2021534106 A5 JP2021534106 A5 JP 2021534106A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- independently selected
- pharmaceutically acceptable
- cycloalkyl
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862715834P | 2018-08-08 | 2018-08-08 | |
| US62/715,834 | 2018-08-08 | ||
| PCT/US2019/045426 WO2020033490A1 (en) | 2018-08-08 | 2019-08-07 | Substituted thienopyrroles as pad4 inhibitors |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021534106A JP2021534106A (ja) | 2021-12-09 |
| JPWO2020033490A5 JPWO2020033490A5 (https=) | 2022-08-16 |
| JP2021534106A5 true JP2021534106A5 (https=) | 2022-08-16 |
| JP7447080B2 JP7447080B2 (ja) | 2024-03-11 |
Family
ID=67766300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021506663A Active JP7447080B2 (ja) | 2018-08-08 | 2019-08-07 | Ｐａｄ４阻害剤としての置換チエノピロール |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11981680B2 (https=) |
| EP (1) | EP3833671B1 (https=) |
| JP (1) | JP7447080B2 (https=) |
| KR (1) | KR102851932B1 (https=) |
| CN (1) | CN112566916B (https=) |
| ES (1) | ES2929200T3 (https=) |
| WO (1) | WO2020033490A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| EP3833671B1 (en) | 2018-08-08 | 2022-08-24 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
| TW202115083A (zh) * | 2019-09-27 | 2021-04-16 | 大陸商南京藥捷安康生物科技有限公司 | 肽醯精胺酸脫亞胺酶抑制劑及其用途 |
| EP4100405A1 (en) | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| EP4143189A1 (en) | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| CN116940578A (zh) * | 2020-07-02 | 2023-10-24 | 雷密克斯医疗公司 | 5-[5-(哌啶-4-基)噻吩并[3,2-c]吡唑-2-基]吲唑衍生物和相关化合物作为调节剂用于剪接核酸和治疗增殖性疾病 |
| MX2023000167A (es) * | 2020-07-02 | 2023-05-03 | Remix Therapeutics Inc | Derivados de 5-[5-(piperidin-4-il)tieno[3,2-c]pirazol-2-il]indazol y compuestos relacionados como moduladores para el corte y empalme de ácidos nucleicos y para el tratamiento de enfermedades proliferativas. |
| TW202241884A (zh) | 2020-12-22 | 2022-11-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140428A2 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| WO2023133229A2 (en) * | 2022-01-05 | 2023-07-13 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2024109945A1 (en) * | 2022-11-24 | 2024-05-30 | Helios Huaming Biopharma Co., Ltd. | Selenium containing heterocycle compounds and use thereof |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS55684B1 (sr) | 2012-07-26 | 2017-07-31 | Glaxo Group Ltd | 2-(azaindol-2-il)benzimidazoli kao pad4 inhibitori |
| US10407407B2 (en) | 2015-05-21 | 2019-09-10 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as PAD4 inhibitors |
| AR107030A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| RU2747431C2 (ru) | 2015-12-22 | 2021-05-05 | Кансера Аб | Бициклические гидроксамовые кислоты, полезные в качестве ингибиторов активности деацетилазы гистонов млекопитающих |
| JP6926126B2 (ja) | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| KR102398941B1 (ko) | 2016-07-27 | 2022-05-17 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 공유결합성 억제제 |
| JP7118951B2 (ja) | 2016-09-12 | 2022-08-16 | パドロック・セラピューティクス・インコーポレイテッド | Ｐａｄ４のヘテロアリール阻害剤 |
| CN110582489B (zh) | 2017-06-30 | 2023-10-27 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| AU2018352142B2 (en) | 2017-10-18 | 2022-08-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| EP3760628A4 (en) | 2018-02-26 | 2021-10-13 | Nanjing Transthera Biosciences Co., Ltd. | PEPTIDYLARGININE DEIMINASE INHIBITOR AND ITS USES |
| CN112789087B (zh) | 2018-08-08 | 2024-08-13 | 百时美施贵宝公司 | Pad酶的苯并咪唑抑制剂 |
| WO2020033488A1 (en) * | 2018-08-08 | 2020-02-13 | Bristol-Myers Squibb Company | Substituted benzimidazoles as pad4 inhibitors |
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| EP3833671B1 (en) | 2018-08-08 | 2022-08-24 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
-
2019
- 2019-08-07 EP EP19759134.0A patent/EP3833671B1/en active Active
- 2019-08-07 JP JP2021506663A patent/JP7447080B2/ja active Active
- 2019-08-07 WO PCT/US2019/045426 patent/WO2020033490A1/en not_active Ceased
- 2019-08-07 KR KR1020217006481A patent/KR102851932B1/ko active Active
- 2019-08-07 US US17/265,833 patent/US11981680B2/en active Active
- 2019-08-07 CN CN201980053221.6A patent/CN112566916B/zh active Active
- 2019-08-07 ES ES19759134T patent/ES2929200T3/es active Active
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