JP2025505200A5 - - Google Patents

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Publication number
JP2025505200A5
JP2025505200A5 JP2024546424A JP2024546424A JP2025505200A5 JP 2025505200 A5 JP2025505200 A5 JP 2025505200A5 JP 2024546424 A JP2024546424 A JP 2024546424A JP 2024546424 A JP2024546424 A JP 2024546424A JP 2025505200 A5 JP2025505200 A5 JP 2025505200A5
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JP
Japan
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groups
optionally substituted
alkyl
independently selected
compound
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2024546424A
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English (en)
Japanese (ja)
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JP2025505200A (ja
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Application filed filed Critical
Priority claimed from PCT/US2023/012579 external-priority patent/WO2023154310A1/en
Publication of JP2025505200A publication Critical patent/JP2025505200A/ja
Publication of JP2025505200A5 publication Critical patent/JP2025505200A5/ja
Pending legal-status Critical Current

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JP2024546424A 2022-02-08 2023-02-08 Ａｐｏｌ１の阻害剤としての２－メチル－４－フェニルピペリジン－４－オール誘導体、及びそれを使用する方法 Pending JP2025505200A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263307933P 2022-02-08 2022-02-08
US63/307,933 2022-02-08
PCT/US2023/012579 WO2023154310A1 (en) 2022-02-08 2023-02-08 2-methyl-4-phenylpiperidin-4-ol derivatives as inhibitors of apol1 and methods of using same

Publications (2)

Publication Number Publication Date
JP2025505200A JP2025505200A (ja) 2025-02-21
JP2025505200A5 true JP2025505200A5 (https=) 2026-02-04

Family

ID=85570218

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024546424A Pending JP2025505200A (ja) 2022-02-08 2023-02-08 Ａｐｏｌ１の阻害剤としての２－メチル－４－フェニルピペリジン－４－オール誘導体、及びそれを使用する方法

Country Status (7)

Country Link
US (1) US20250163021A1 (https=)
EP (1) EP4476199A1 (https=)
JP (1) JP2025505200A (https=)
CN (1) CN118984821A (https=)
AU (1) AU2023219516A1 (https=)
CA (1) CA3251230A1 (https=)
WO (1) WO2023154310A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11618746B2 (en) 2018-12-17 2023-04-04 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
WO2021154997A1 (en) 2020-01-29 2021-08-05 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same
CN115867543A (zh) 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1抑制剂的固体形式及其使用方法
CA3185604A1 (en) 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and use of the same
CN116547287B (zh) 2020-08-26 2025-09-26 弗特克斯药品有限公司 Apol1的抑制剂及其使用方法
US12612379B2 (en) 2021-11-30 2026-04-28 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
MX2024008868A (es) 2022-01-18 2024-09-23 Maze Therapeutics Inc Inhibidores de la apolipoproteína l1 (apol1) y métodos de uso.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4039676A (en) * 1975-06-23 1977-08-02 Ciba-Geigy Corporation 2-piperidinoalkyl-1,4-benzodioxans
US6518423B1 (en) * 1996-08-09 2003-02-11 Eisai Co., Ltd. Benzopiperidine derivatives
AR048523A1 (es) * 2004-04-07 2006-05-03 Kalypsys Inc Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos
JP5406722B2 (ja) * 2006-10-16 2014-02-05 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ブラジキニン１受容体モジュレータとしての置換されたスルホンアミド誘導体
BR102012024778A2 (pt) * 2012-09-28 2014-08-19 Cristalia Prod Quimicos Farm Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica
CN106749330A (zh) * 2016-12-29 2017-05-31 长春海谱润斯科技有限公司 一种杂环衍生物及使用该杂环衍生物的有机发光器件
US20220144838A1 (en) * 2019-03-13 2022-05-12 Nanjing Immunophage Biotech Co., Ltd. Compounds as Inhibitors of Macrophage Migration Inhibitory Factor
IL296423A (en) * 2020-04-22 2022-11-01 Anima Biotech Inc Collagen 1 translation inhibitors and methods of use thereof
CN115867532A (zh) * 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1的抑制剂及其用途

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