JP2021523200A5 - - Google Patents
Info
- Publication number
- JP2021523200A5 JP2021523200A5 JP2020564158A JP2020564158A JP2021523200A5 JP 2021523200 A5 JP2021523200 A5 JP 2021523200A5 JP 2020564158 A JP2020564158 A JP 2020564158A JP 2020564158 A JP2020564158 A JP 2020564158A JP 2021523200 A5 JP2021523200 A5 JP 2021523200A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- solvate
- acceptable salt
- compound according
- alkyl
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862671985P | 2018-05-15 | 2018-05-15 | |
| US62/671,985 | 2018-05-15 | ||
| PCT/US2019/032289 WO2019222266A1 (en) | 2018-05-15 | 2019-05-14 | Magl inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021523200A JP2021523200A (ja) | 2021-09-02 |
| JPWO2019222266A5 JPWO2019222266A5 (https=) | 2022-06-01 |
| JP2021523200A5 true JP2021523200A5 (https=) | 2022-06-01 |
Family
ID=68534223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564158A Ceased JP2021523200A (ja) | 2018-05-15 | 2019-05-14 | Ｍａｇｌ阻害剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US11332453B2 (https=) |
| EP (1) | EP3793547A4 (https=) |
| JP (1) | JP2021523200A (https=) |
| KR (1) | KR20210010475A (https=) |
| CN (1) | CN112088001A (https=) |
| AR (1) | AR115092A1 (https=) |
| AU (1) | AU2019271123A1 (https=) |
| BR (1) | BR112020000863A2 (https=) |
| CA (1) | CA3097063A1 (https=) |
| CL (1) | CL2020002927A1 (https=) |
| CO (1) | CO2020013550A2 (https=) |
| CR (1) | CR20200545A (https=) |
| DO (1) | DOP2020000207A (https=) |
| EA (1) | EA202092586A1 (https=) |
| GE (2) | GEP20227443B (https=) |
| JO (1) | JOP20200276A1 (https=) |
| MA (1) | MA52635A (https=) |
| MX (1) | MX2020012158A (https=) |
| NI (1) | NI202000080A (https=) |
| PE (1) | PE20211385A1 (https=) |
| PH (1) | PH12020551934A1 (https=) |
| SG (1) | SG11202011228TA (https=) |
| TW (1) | TW201946906A (https=) |
| WO (1) | WO2019222266A1 (https=) |
| ZA (1) | ZA202006327B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20141702A1 (es) | 2012-01-06 | 2014-11-19 | Abide Therapeutics Inc | Compuestos de carbamato y preparacion y uso de los mismos |
| US10899737B2 (en) | 2016-09-19 | 2021-01-26 | Lundbeck La Jolla Research Center, Inc. | Piperazine carbamates and methods of making and using same |
| EP3793565B1 (en) | 2018-05-14 | 2022-01-05 | Gilead Sciences, Inc. | Mcl-1 inhibitors |
| GEP20227443B (en) | 2018-05-15 | 2022-11-25 | H Lundbeck As | Magl inhibitors |
| PE20210368A1 (es) | 2018-06-27 | 2021-02-26 | Eth Zuerich | Nuevos compuestos de piridina y pirazina como inhibidores del receptor cannabinoide 2 |
| JP7456948B2 (ja) | 2018-06-27 | 2024-03-27 | エフ． ホフマン－ラ ロシュ アーゲー | 放射性標識カンナビノイド受容体２リガンド |
| CN112119068A (zh) | 2018-06-27 | 2020-12-22 | 豪夫迈·罗氏有限公司 | 作为大麻素受体2的抑制剂的新型氮杂环丁烷-取代的吡啶和吡嗪化合物 |
| CA3125636A1 (en) * | 2019-01-25 | 2020-07-30 | H. Lundbeck A/S | Methods of treating disease with magl inhibitors |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| KR20220101095A (ko) * | 2019-11-15 | 2022-07-19 | 하. 룬드벡 아크티에셀스카브 | Magl 억제제의 결정형 |
| CN114787139B (zh) | 2019-11-26 | 2025-03-11 | 吉利德科学公司 | 用于制备mcl1抑制剂的方法和中间体 |
| WO2021214550A1 (en) | 2020-04-21 | 2021-10-28 | H. Lundbeck A/S | Synthesis of a monoacylglycerol lipase inhibitor |
| EP4247783A1 (en) | 2020-11-19 | 2023-09-27 | Gilead Sciences, Inc. | Processes and intermediates for preparing macrocyclic mcl1 inhibitors |
| EP4198023A1 (en) | 2021-12-16 | 2023-06-21 | Basf Se | Pesticidally active thiosemicarbazone compounds |
| CA3242372A1 (en) | 2021-12-29 | 2023-07-06 | Psy Therapeutics, Inc. | Inhibiting monoacylglycerol lipase (magl) |
| US20250197358A1 (en) | 2022-02-17 | 2025-06-19 | Basf Se | Pesticidally active thiosemicarbazone compounds |
| EP4665718A1 (en) | 2023-02-13 | 2025-12-24 | Apogee Pharmaceuticals, Inc. | Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1593586A (https=) | 1967-10-17 | 1970-06-01 | ||
| JPS6183073A (ja) | 1984-10-01 | 1986-04-26 | Oki Electric Ind Co Ltd | 印字装置の用紙送り方法 |
| WO1989011794A1 (fr) | 1988-06-07 | 1989-12-14 | Rikagaku Kenkyusho | Inhibiteur de la croissance de plantes |
| EP0619804B1 (en) | 1991-11-27 | 1996-05-22 | E.I. Du Pont De Nemours And Company | Herbicidal acylated amino-(phenyl- or pyridinyl- or thienyl-)-phenyl derivatives |
| DE69408873T2 (de) | 1993-12-22 | 1998-07-09 | Shell Int Research | Verfahren zur herstellung von carbamaten |
| WO1997018196A1 (en) | 1995-11-15 | 1997-05-22 | Zeneca Limited | Herbicidal substituted pyrazole compounds |
| AU3440597A (en) | 1996-07-02 | 1998-01-21 | Novartis Ag | N-phenylimino heterocyclic derivatives and their use as herbicides |
| RU2167150C2 (ru) | 1998-03-25 | 2001-05-20 | Фокин Александр Васильевич | Полифторалкил-n-арилкарбаматы, обладающие антимикробной активностью |
| AU7855900A (en) | 1999-10-04 | 2001-05-10 | University Of Medicine And Dentistry Of New Jersey | Methods for identifying rna binding compounds |
| EP1201298A1 (en) | 2000-10-24 | 2002-05-02 | Urea Casale S.A. | Carbamate condensation unit |
| DE10348022A1 (de) | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| FR2864080B1 (fr) | 2003-12-23 | 2006-02-03 | Sanofi Synthelabo | Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique |
| WO2005063698A1 (en) | 2003-12-31 | 2005-07-14 | Council Of Scientific & Industrial Research | Process for preparing carbamates |
| BRPI0507499A (pt) | 2004-02-18 | 2007-07-24 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitável ou hidrato dos mesmos, composição farmacêutica, uso do composto, e, métodos para tratar distúrbios mediados por mglur 5 e para inibir a ativação de receptores de mglur 5 |
| US7786113B2 (en) | 2004-12-23 | 2010-08-31 | Hoffman-La Roche Inc. | Heterocyclic carbamate derivatives, their manufacture and use as pharmaceutical agents |
| AR055831A1 (es) | 2004-12-30 | 2007-09-12 | Janssen Pharmaceutica Nv | Pepirazinilureas y piperidinilureas como moduladores de hidrolasa de amida de acidos grasos |
| WO2007052023A2 (en) | 2005-11-05 | 2007-05-10 | Astrazeneca Ab | Novel compounds |
| JP2009523729A (ja) | 2006-01-13 | 2009-06-25 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｃ型肝炎の治療方法 |
| WO2008078091A1 (en) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
| US7795457B2 (en) | 2007-02-26 | 2010-09-14 | Kosan Biosciences Incorporated | Carbamate compounds |
| US8188098B2 (en) | 2008-05-19 | 2012-05-29 | Hoffmann-La Roche Inc. | GPR119 receptor agonists |
| JP2011528368A (ja) | 2008-07-16 | 2011-11-17 | シェーリング コーポレイション | 二環式ヘテロ環誘導体およびｇｐｃｒモジュレーターとしてのその使用 |
| WO2010056309A2 (en) | 2008-11-14 | 2010-05-20 | The Scripps Research Institute | Methods and compositions related to targeting monoacylglycerol lipase |
| WO2010111050A1 (en) | 2009-03-23 | 2010-09-30 | Banyu Pharmaceutical Co., Ltd. | Novel aminopyridine derivatives having aurora a selective inhibitory action |
| US8455476B2 (en) | 2009-04-22 | 2013-06-04 | Janssen Pharmaceutica, Nv | Azetidinyl diamides as monoacylglycerol lipase inhibitors |
| UA107791C2 (en) | 2009-05-05 | 2015-02-25 | Dow Agrosciences Llc | Pesticidal compositions |
| ES2433235T3 (es) | 2009-11-03 | 2013-12-10 | Bayer Intellectual Property Gmbh | Fluorouretanos como aditivos en una formulación de fotopolímero |
| FR2960875B1 (fr) | 2010-06-04 | 2012-12-28 | Sanofi Aventis | Derives de carbamates d'hexafluoroisopropyle, leur preparation et leur application en therapeutique |
| NZ627096A (en) | 2012-01-06 | 2017-02-24 | Agios Pharmaceuticals Inc | Triazinyl compounds and their methods of use |
| PE20141702A1 (es) | 2012-01-06 | 2014-11-19 | Abide Therapeutics Inc | Compuestos de carbamato y preparacion y uso de los mismos |
| CA2866302A1 (en) | 2012-03-19 | 2013-09-26 | Abide Therapeutics, Inc. | Carbamate compounds and of making and using same |
| JP2014005245A (ja) | 2012-06-26 | 2014-01-16 | Dainippon Sumitomo Pharma Co Ltd | 二環性ピリミジン誘導体を含有する医薬組成物 |
| US9551036B2 (en) | 2013-02-25 | 2017-01-24 | Whitehead Institute For Biomedical Research | Metabolic gene mesenchymal signatures and uses thereof |
| JP6647592B2 (ja) | 2013-07-03 | 2020-02-14 | ルンドベック ラ ホーヤ リサーチ センター，インク． | ピロロピロールカルバメート、および関連する有機化合物、医薬組成物、ならびにその医学的使用 |
| US10570146B2 (en) | 2014-07-25 | 2020-02-25 | Northeastern University | Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof |
| JP2018513119A (ja) | 2015-03-18 | 2018-05-24 | アビデ セラピューティクス，インク． | ピペラジンカルバメート、およびピペラジンカルバメートを製造ならびに使用する方法 |
| US10899737B2 (en) | 2016-09-19 | 2021-01-26 | Lundbeck La Jolla Research Center, Inc. | Piperazine carbamates and methods of making and using same |
| MA46866B1 (fr) | 2016-11-16 | 2021-11-30 | H Lundbeck As | Une forme cristalline d'un inhibiteur de magl |
| JOP20190105A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| JOP20190106A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| CN111032034B (zh) * | 2017-08-29 | 2023-05-02 | H.隆德贝克有限公司 | 螺环化合物及其制造和使用方法 |
| GEP20227443B (en) | 2018-05-15 | 2022-11-25 | H Lundbeck As | Magl inhibitors |
| CA3125636A1 (en) | 2019-01-25 | 2020-07-30 | H. Lundbeck A/S | Methods of treating disease with magl inhibitors |
-
2019
- 2019-05-14 GE GEAP201915479A patent/GEP20227443B/en unknown
- 2019-05-14 BR BR112020000863-0A patent/BR112020000863A2/pt not_active Application Discontinuation
- 2019-05-14 JO JOP/2020/0276A patent/JOP20200276A1/ar unknown
- 2019-05-14 EP EP19803143.7A patent/EP3793547A4/en not_active Withdrawn
- 2019-05-14 CA CA3097063A patent/CA3097063A1/en active Pending
- 2019-05-14 US US17/055,079 patent/US11332453B2/en active Active
- 2019-05-14 MX MX2020012158A patent/MX2020012158A/es unknown
- 2019-05-14 MA MA052635A patent/MA52635A/fr unknown
- 2019-05-14 CR CR20200545A patent/CR20200545A/es unknown
- 2019-05-14 SG SG11202011228TA patent/SG11202011228TA/en unknown
- 2019-05-14 JP JP2020564158A patent/JP2021523200A/ja not_active Ceased
- 2019-05-14 AU AU2019271123A patent/AU2019271123A1/en not_active Abandoned
- 2019-05-14 CN CN201980031137.4A patent/CN112088001A/zh active Pending
- 2019-05-14 AR ARP190101283A patent/AR115092A1/es not_active Application Discontinuation
- 2019-05-14 EA EA202092586A patent/EA202092586A1/ru unknown
- 2019-05-14 GE GEAP202215479A patent/GEAP202215479A/en unknown
- 2019-05-14 KR KR1020207033709A patent/KR20210010475A/ko not_active Ceased
- 2019-05-14 WO PCT/US2019/032289 patent/WO2019222266A1/en not_active Ceased
- 2019-05-14 PE PE2020001853A patent/PE20211385A1/es unknown
- 2019-05-14 TW TW108116518A patent/TW201946906A/zh unknown
- 2019-05-14 US US16/412,212 patent/US10570106B2/en not_active Expired - Fee Related
-
2020
- 2020-01-10 US US16/739,642 patent/US11214557B2/en not_active Expired - Fee Related
- 2020-10-12 ZA ZA2020/06327A patent/ZA202006327B/en unknown
- 2020-10-28 CO CONC2020/0013550A patent/CO2020013550A2/es unknown
- 2020-11-10 DO DO2020000207A patent/DOP2020000207A/es unknown
- 2020-11-11 CL CL2020002927A patent/CL2020002927A1/es unknown
- 2020-11-13 PH PH12020551934A patent/PH12020551934A1/en unknown
- 2020-11-13 NI NI202000080A patent/NI202000080A/es unknown
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