JP2020521767A5 - - Google Patents
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- Publication number
- JP2020521767A5 JP2020521767A5 JP2019565399A JP2019565399A JP2020521767A5 JP 2020521767 A5 JP2020521767 A5 JP 2020521767A5 JP 2019565399 A JP2019565399 A JP 2019565399A JP 2019565399 A JP2019565399 A JP 2019565399A JP 2020521767 A5 JP2020521767 A5 JP 2020521767A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- solvate
- acceptable salt
- tautomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762510223P | 2017-05-23 | 2017-05-23 | |
| US62/510,223 | 2017-05-23 | ||
| PCT/US2018/033964 WO2018217809A1 (en) | 2017-05-23 | 2018-05-22 | Pyrazole magl inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020521767A JP2020521767A (ja) | 2020-07-27 |
| JP2020521767A5 true JP2020521767A5 (https=) | 2022-07-26 |
| JP7162622B2 JP7162622B2 (ja) | 2022-10-28 |
Family
ID=64397012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565399A Active JP7162622B2 (ja) | 2017-05-23 | 2018-05-22 | ピラゾールｍａｇｌ阻害剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US11149037B2 (https=) |
| EP (1) | EP3634404B1 (https=) |
| JP (1) | JP7162622B2 (https=) |
| KR (1) | KR20200010366A (https=) |
| CN (1) | CN110678177B (https=) |
| AU (1) | AU2018273888A1 (https=) |
| BR (1) | BR112019024488A2 (https=) |
| CA (1) | CA3065898A1 (https=) |
| CL (1) | CL2019003398A1 (https=) |
| CO (1) | CO2019013016A2 (https=) |
| CR (1) | CR20190537A (https=) |
| DO (1) | DOP2019000295A (https=) |
| EA (1) | EA201992504A1 (https=) |
| EC (1) | ECSP19083923A (https=) |
| ES (1) | ES3005265T3 (https=) |
| JO (1) | JOP20190267A1 (https=) |
| MA (1) | MA50405A (https=) |
| MX (1) | MX2019014041A (https=) |
| NI (1) | NI201900120A (https=) |
| PE (1) | PE20200293A1 (https=) |
| PH (1) | PH12019502646A1 (https=) |
| RU (1) | RU2019137094A (https=) |
| WO (1) | WO2018217809A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9487495B2 (en) | 2012-01-06 | 2016-11-08 | The Scripts Research Institute | Carbamate compounds and of making and using same |
| WO2017096315A1 (en) | 2015-12-02 | 2017-06-08 | The Scripps Research Institute | TRIAZOLE DAGL(α) INHIBITORS |
| JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| JOP20190105A1 (ar) * | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| US10927105B1 (en) | 2017-05-23 | 2021-02-23 | Lundbeck La Jolla Research Center, Inc. | Pyrazole MAGL inhibitors |
| EA201992409A1 (ru) | 2017-05-23 | 2020-03-23 | Лундбекк Ла-Хойя Рисерч Сентер, Инк. | Ингибиторы magl на основе пиразола |
| JOP20190267A1 (ar) | 2017-05-23 | 2019-11-18 | Lundbeck La Jolla Research Center Inc | مثبطات بيرازول magl |
| WO2019134985A1 (en) | 2018-01-08 | 2019-07-11 | F. Hoffmann-La Roche Ag | Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors |
| CN114096545A (zh) * | 2019-07-09 | 2022-02-25 | 豪夫迈·罗氏有限公司 | 新杂环化合物 |
| US20240101552A1 (en) * | 2020-09-18 | 2024-03-28 | Shanghai Pharmaceuticals Holding Co., Ltd. | Carbonyl heterocyclic compound and application thereof |
| BR112023015210A2 (pt) | 2021-01-29 | 2023-11-07 | Cedilla Therapeutics Inc | Inibidores de cdk2 e métodos de uso dos mesmos |
| CA3225439A1 (en) | 2021-06-26 | 2022-12-29 | Cedilla Therapeutics, Inc. | Cdk2 inhibitors and methods of using the same |
| CA3242372A1 (en) | 2021-12-29 | 2023-07-06 | Psy Therapeutics, Inc. | Inhibiting monoacylglycerol lipase (magl) |
| EP4665718A1 (en) | 2023-02-13 | 2025-12-24 | Apogee Pharmaceuticals, Inc. | Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof |
| WO2025221154A1 (en) | 2024-04-17 | 2025-10-23 | Captor Therapeutics S.A. | Klhdc2 (kelch domain-containing protein 2) ligase ligands |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3308130A (en) | 1962-04-26 | 1967-03-07 | Du Pont | N-disubstituted carbamyl pyrazoles |
| EP1309591B1 (en) | 2000-08-14 | 2007-01-24 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
| US6727364B2 (en) | 2001-04-30 | 2004-04-27 | The Procter & Gamble Company | Triazole compounds useful in treating diseases associated with unwanted cytokine activity |
| HRP20040767A2 (en) * | 2002-02-19 | 2004-12-31 | Teva Pharma | Desolvating solvates of atorvastatin hemi-calcium |
| SE0300705D0 (sv) | 2003-03-14 | 2003-03-14 | Biolipox Ab | New compounds |
| US20110172230A1 (en) * | 2006-08-23 | 2011-07-14 | Takahiro Ishii | Urea compound or salt thereof |
| MX342128B (es) | 2008-12-24 | 2016-09-14 | Bial - Portela & C A S A | Compuestos farmaceuticos. |
| CA2830958A1 (en) | 2011-04-06 | 2012-10-11 | The Scripps Research Institute | N1- and n2-carbamoyl-1,2,3-triazole serine hydrolase inhibitors and methods |
| CN103130723B (zh) | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
| EP3087067B1 (en) | 2013-12-26 | 2018-10-24 | Takeda Pharmaceutical Company Limited | 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (magl) inhibitors |
| WO2015179559A2 (en) | 2014-05-21 | 2015-11-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| WO2016014795A1 (en) * | 2014-07-23 | 2016-01-28 | Baker Hughes Incorporated | System and method for downhole organic scale monitoring and intervention in a production well |
| WO2016014975A2 (en) | 2014-07-25 | 2016-01-28 | Northeastern University | Urea/carbamates faah magl or dual faah/magl inhibitors and uses thereof |
| UA121775C2 (uk) | 2015-07-31 | 2020-07-27 | Пфайзер Інк. | 1,1,1-трифтор-3-гідроксипропан-2-ілкарбаматні похідні та 1,1,1-трифтор-4-гідроксибутан-2-ілкарбаматні похідні як інгібітори magl |
| WO2017087863A1 (en) | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| US10519134B2 (en) | 2015-11-20 | 2019-12-31 | Lundbeck La Jolla Research Center, Inc. | Pyrazole compounds and methods of making and using same |
| WO2017087858A1 (en) | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| WO2017096315A1 (en) | 2015-12-02 | 2017-06-08 | The Scripps Research Institute | TRIAZOLE DAGL(α) INHIBITORS |
| EA201992409A1 (ru) | 2017-05-23 | 2020-03-23 | Лундбекк Ла-Хойя Рисерч Сентер, Инк. | Ингибиторы magl на основе пиразола |
| JOP20190267A1 (ar) | 2017-05-23 | 2019-11-18 | Lundbeck La Jolla Research Center Inc | مثبطات بيرازول magl |
| US10927105B1 (en) | 2017-05-23 | 2021-02-23 | Lundbeck La Jolla Research Center, Inc. | Pyrazole MAGL inhibitors |
-
2017
- 2017-06-16 JO JOP/2019/0267A patent/JOP20190267A1/ar unknown
-
2018
- 2018-05-22 EA EA201992504A patent/EA201992504A1/ru unknown
- 2018-05-22 EP EP18805515.6A patent/EP3634404B1/en active Active
- 2018-05-22 CR CR20190537A patent/CR20190537A/es unknown
- 2018-05-22 PE PE2019002453A patent/PE20200293A1/es unknown
- 2018-05-22 WO PCT/US2018/033964 patent/WO2018217809A1/en not_active Ceased
- 2018-05-22 RU RU2019137094A patent/RU2019137094A/ru not_active Application Discontinuation
- 2018-05-22 BR BR112019024488-3A patent/BR112019024488A2/pt not_active Application Discontinuation
- 2018-05-22 CA CA3065898A patent/CA3065898A1/en not_active Abandoned
- 2018-05-22 MX MX2019014041A patent/MX2019014041A/es unknown
- 2018-05-22 JP JP2019565399A patent/JP7162622B2/ja active Active
- 2018-05-22 KR KR1020197037406A patent/KR20200010366A/ko not_active Withdrawn
- 2018-05-22 US US16/615,746 patent/US11149037B2/en active Active
- 2018-05-22 MA MA050405A patent/MA50405A/fr unknown
- 2018-05-22 AU AU2018273888A patent/AU2018273888A1/en not_active Abandoned
- 2018-05-22 ES ES18805515T patent/ES3005265T3/es active Active
- 2018-05-22 CN CN201880033866.9A patent/CN110678177B/zh active Active
-
2019
- 2019-11-20 DO DO2019000295A patent/DOP2019000295A/es unknown
- 2019-11-21 CO CONC2019/0013016A patent/CO2019013016A2/es unknown
- 2019-11-21 CL CL2019003398A patent/CL2019003398A1/es unknown
- 2019-11-22 PH PH12019502646A patent/PH12019502646A1/en unknown
- 2019-11-22 NI NI201900120A patent/NI201900120A/es unknown
- 2019-11-25 EC ECSENADI201983923A patent/ECSP19083923A/es unknown
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