JP2021534124A5 - - Google Patents
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- Publication number
- JP2021534124A5 JP2021534124A5 JP2021506929A JP2021506929A JP2021534124A5 JP 2021534124 A5 JP2021534124 A5 JP 2021534124A5 JP 2021506929 A JP2021506929 A JP 2021506929A JP 2021506929 A JP2021506929 A JP 2021506929A JP 2021534124 A5 JP2021534124 A5 JP 2021534124A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- independently selected
- halo
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023132960A JP7579402B2 (ja) | 2018-08-10 | 2023-08-17 | 癌治療用ｐｔｐｎ１１（ｓｈｐ２）阻害剤としての６－（４－アミノ－３－メチル－２－オキサ－８－アザスピロ［４．５］デカン－８－イル）－３－（２，３－ジクロロフェニル）－２－メチルピリミジン－４（３ｈ）－オン誘導体及び関連化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862717588P | 2018-08-10 | 2018-08-10 | |
| US62/717,588 | 2018-08-10 | ||
| US201862773921P | 2018-11-30 | 2018-11-30 | |
| US62/773,921 | 2018-11-30 | ||
| PCT/US2019/045903 WO2020033828A1 (en) | 2018-08-10 | 2019-08-09 | 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one derivatives and related compounds as ptpn11 (shp2) inhibitors for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023132960A Division JP7579402B2 (ja) | 2018-08-10 | 2023-08-17 | 癌治療用ｐｔｐｎ１１（ｓｈｐ２）阻害剤としての６－（４－アミノ－３－メチル－２－オキサ－８－アザスピロ［４．５］デカン－８－イル）－３－（２，３－ジクロロフェニル）－２－メチルピリミジン－４（３ｈ）－オン誘導体及び関連化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021534124A JP2021534124A (ja) | 2021-12-09 |
| JP2021534124A5 true JP2021534124A5 (https=) | 2022-08-18 |
Family
ID=67766350
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021506929A Ceased JP2021534124A (ja) | 2018-08-10 | 2019-08-09 | 癌治療用ｐｔｐｎ１１（ｓｈｐ２）阻害剤としての６−（４−アミノ−３−メチル−２−オキサ−８−アザスピロ［４．５］デカン−８−イル）−３−（２，３−ジクロロフェニル）−２−メチルピリミジン−４（３ｈ）−オン誘導体及び関連化合物 |
| JP2023132960A Active JP7579402B2 (ja) | 2018-08-10 | 2023-08-17 | 癌治療用ｐｔｐｎ１１（ｓｈｐ２）阻害剤としての６－（４－アミノ－３－メチル－２－オキサ－８－アザスピロ［４．５］デカン－８－イル）－３－（２，３－ジクロロフェニル）－２－メチルピリミジン－４（３ｈ）－オン誘導体及び関連化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023132960A Active JP7579402B2 (ja) | 2018-08-10 | 2023-08-17 | 癌治療用ｐｔｐｎ１１（ｓｈｐ２）阻害剤としての６－（４－アミノ－３－メチル－２－オキサ－８－アザスピロ［４．５］デカン－８－イル）－３－（２，３－ジクロロフェニル）－２－メチルピリミジン－４（３ｈ）－オン誘導体及び関連化合物 |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US11104675B2 (https=) |
| EP (2) | EP4356973A3 (https=) |
| JP (2) | JP2021534124A (https=) |
| KR (1) | KR102707409B1 (https=) |
| CN (1) | CN112601750B (https=) |
| AU (1) | AU2019319971B2 (https=) |
| BR (1) | BR112021002327A2 (https=) |
| CA (1) | CA3109181A1 (https=) |
| CL (1) | CL2021000355A1 (https=) |
| CO (1) | CO2021003074A2 (https=) |
| CR (1) | CR20210132A (https=) |
| DK (1) | DK3833670T3 (https=) |
| ES (1) | ES2981592T3 (https=) |
| FI (1) | FI3833670T3 (https=) |
| HR (1) | HRP20240861T1 (https=) |
| HU (1) | HUE067297T2 (https=) |
| IL (2) | IL307361B2 (https=) |
| LT (1) | LT3833670T (https=) |
| MX (2) | MX2021001608A (https=) |
| PE (1) | PE20211050A1 (https=) |
| PH (1) | PH12021550268A1 (https=) |
| PL (1) | PL3833670T3 (https=) |
| PT (1) | PT3833670T (https=) |
| RS (1) | RS65728B1 (https=) |
| SA (1) | SA521421205B1 (https=) |
| SG (1) | SG11202100199UA (https=) |
| SI (1) | SI3833670T1 (https=) |
| SM (1) | SMT202400192T1 (https=) |
| TW (1) | TWI827646B (https=) |
| UA (1) | UA128559C2 (https=) |
| WO (1) | WO2020033828A1 (https=) |
| ZA (1) | ZA202101449B (https=) |
Families Citing this family (52)
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| WO2017210134A1 (en) | 2016-05-31 | 2017-12-07 | Board Of Regents, University Of Texas System | Heterocyclic inhibitors of ptpn11 |
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| TW202500565A (zh) | 2016-10-24 | 2025-01-01 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
| EP3630770B1 (en) | 2017-05-26 | 2024-08-28 | Relay Therapeutics, Inc. | Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors |
| EP3687997A1 (en) | 2017-09-29 | 2020-08-05 | Relay Therapeutics, Inc. | Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors |
| US12138263B2 (en) | 2018-03-21 | 2024-11-12 | Relay Therapeutics, Inc. | Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors and methods of use thereof |
| AU2019240299B2 (en) | 2018-03-21 | 2023-06-22 | D.E. Shaw Research, Llc | SHP2 phosphatase inhibitors and methods of use thereof |
| MX2020011528A (es) | 2018-05-02 | 2021-02-09 | Navire Pharma Inc | Inhibidores heterociclicos sustituidos de ptpn11. |
| CN112601750B (zh) | 2018-08-10 | 2023-10-31 | 纳维尔制药有限公司 | Ptpn11（shp2）抑制剂 |
| CR20210175A (es) | 2018-09-18 | 2021-06-01 | Nikang Therapeutics Inc | Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2 (shp2) |
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| JP7335882B2 (ja) | 2018-02-13 | 2023-08-30 | ブルーレイ セラピューティクス （シャンハイ） カンパニー，リミティド | ピリミジン縮合環式化合物及びその製造方法、並びに使用 |
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| IL276232B2 (en) | 2018-03-02 | 2024-04-01 | Otsuka Pharma Co Ltd | Pyrazine derivatives, pharmaceutical compositions comprising them and their use for treating diseases |
| US12138263B2 (en) | 2018-03-21 | 2024-11-12 | Relay Therapeutics, Inc. | Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors and methods of use thereof |
| AU2019240299B2 (en) | 2018-03-21 | 2023-06-22 | D.E. Shaw Research, Llc | SHP2 phosphatase inhibitors and methods of use thereof |
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2019
- 2019-08-09 CN CN201980046071.6A patent/CN112601750B/zh active Active
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2021
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2023
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