JP2022544714A5 - - Google Patents

Info

Publication number
JP2022544714A5
JP2022544714A5 JP2022512349A JP2022512349A JP2022544714A5 JP 2022544714 A5 JP2022544714 A5 JP 2022544714A5 JP 2022512349 A JP2022512349 A JP 2022512349A JP 2022512349 A JP2022512349 A JP 2022512349A JP 2022544714 A5 JP2022544714 A5 JP 2022544714A5
Authority
JP
Japan
Application number
JP2022512349A
Other languages
Japanese (ja)
Other versions
JP7646632B2 (ja
JPWO2021041237A5 (https=
JP2022544714A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/047467 external-priority patent/WO2021041237A1/en
Publication of JP2022544714A publication Critical patent/JP2022544714A/ja
Publication of JP2022544714A5 publication Critical patent/JP2022544714A5/ja
Publication of JPWO2021041237A5 publication Critical patent/JPWO2021041237A5/ja
Priority to JP2025034294A priority Critical patent/JP2025106242A/ja
Application granted granted Critical
Publication of JP7646632B2 publication Critical patent/JP7646632B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022512349A 2019-08-23 2020-08-21 甲状腺ホルモン受容体ベータアゴニスト化合物 Active JP7646632B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025034294A JP2025106242A (ja) 2019-08-23 2025-03-05 甲状腺ホルモン受容体ベータアゴニスト化合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962891078P 2019-08-23 2019-08-23
US62/891,078 2019-08-23
US202062967943P 2020-01-30 2020-01-30
US62/967,943 2020-01-30
PCT/US2020/047467 WO2021041237A1 (en) 2019-08-23 2020-08-21 Thyroid hormone receptor beta agonist compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025034294A Division JP2025106242A (ja) 2019-08-23 2025-03-05 甲状腺ホルモン受容体ベータアゴニスト化合物

Publications (4)

Publication Number Publication Date
JP2022544714A JP2022544714A (ja) 2022-10-20
JP2022544714A5 true JP2022544714A5 (https=) 2023-08-28
JPWO2021041237A5 JPWO2021041237A5 (https=) 2023-08-28
JP7646632B2 JP7646632B2 (ja) 2025-03-17

Family

ID=74684314

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022512349A Active JP7646632B2 (ja) 2019-08-23 2020-08-21 甲状腺ホルモン受容体ベータアゴニスト化合物
JP2025034294A Pending JP2025106242A (ja) 2019-08-23 2025-03-05 甲状腺ホルモン受容体ベータアゴニスト化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025034294A Pending JP2025106242A (ja) 2019-08-23 2025-03-05 甲状腺ホルモン受容体ベータアゴニスト化合物

Country Status (7)

Country Link
US (1) US12528791B2 (https=)
EP (1) EP4017875A4 (https=)
JP (2) JP7646632B2 (https=)
CN (1) CN114430743A (https=)
AU (1) AU2020336272A1 (https=)
CA (1) CA3154488A1 (https=)
WO (1) WO2021041237A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111320609A (zh) 2018-12-13 2020-06-23 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
GEP20247637B (en) 2019-05-08 2024-06-25 Aligos Therapeutics Inc Modulators of thr-b and methods of use thereof
AU2020336272A1 (en) 2019-08-23 2022-04-14 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
CN114375193B (zh) 2019-09-12 2024-05-14 拓臻制药公司 甲状腺激素受体β激动剂化合物
AU2021306314A1 (en) 2020-07-10 2023-02-09 Aligos Therapeutics, Inc. Modulators of THR-β and methods of use thereof
CN114075173A (zh) * 2020-08-19 2022-02-22 成都凡诺西生物医药科技有限公司 腈代三嗪类衍生物及其制备方法和应用
CA3212130A1 (en) * 2021-03-03 2022-09-09 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
WO2022194278A1 (zh) * 2021-03-19 2022-09-22 南京明德新药研发有限公司 双环苯酚类化合物及其应用
WO2022242743A1 (zh) * 2021-05-21 2022-11-24 深圳微芯生物科技股份有限公司 一种杂环化合物及其应用
CN113979963B (zh) * 2021-12-24 2022-03-11 凯思凯旭(上海)医药科技有限公司 一种作为甲状腺激素β受体激动剂的化合物及其用途
TWI910297B (zh) * 2021-12-24 2026-01-01 大陸商廣東東陽光藥業股份有限公司 一種作為甲狀腺激素β受體激動劑的化合物及其用途
CN116354934A (zh) * 2021-12-28 2023-06-30 中国科学院上海药物研究所 一类喹啉类化合物及其制备方法、药物组合物和用途
US20240398794A1 (en) 2023-04-07 2024-12-05 Terns Pharmaceuticals, Inc. COMBINATIONS OF GLP-1R AND THRß AGONISTS AND METHODS OF USE THEREOF
CN120923503A (zh) * 2025-10-10 2025-11-11 吉斯凯(苏州)制药有限公司 具有杂环结构的化合物、THRβ受体激动剂及用途

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197307A (en) 1977-04-12 1980-04-08 Ciba-Geigy Corporation 2-Alkylthio-, 2-alkylsulphinyl- and 2-alkylsulfonyl-6-phenylbenzimidazoles as anthelmintic agents
EP0377903A3 (de) 1989-01-09 1991-07-17 Bayer Ag Substituierte Hexahydro-1,2,4-triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
EP1088819B1 (en) 1999-09-30 2005-06-15 Pfizer Products Inc. 6-azauracil derivatives as thyroid receptor ligands
US6787652B1 (en) * 1999-09-30 2004-09-07 Pfizer, Inc. 6-Azauracil derivatives as thyroid receptor ligands
GB0015205D0 (en) 2000-06-21 2000-08-09 Karobio Ab Bioisosteric thyroid receptor ligands and method
WO2002051805A1 (de) 2000-12-27 2002-07-04 Bayer Aktiengesellschaft Indol-derivate
US7230031B2 (en) 2002-01-30 2007-06-12 Kissei Pharmaceutical Co., Ltd. Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof
WO2003094845A2 (en) 2002-05-08 2003-11-20 Bristol-Myers Squibb Company Pyridine-based thyroid receptor ligands
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
GB0327319D0 (en) 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
FR2882750B1 (fr) 2005-03-03 2007-05-11 Pierre Fabre Medicament Sa Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine
GB0513692D0 (en) * 2005-07-04 2005-08-10 Karobio Ab Novel pharmaceutical compositions
PL1919878T3 (pl) 2005-07-21 2011-03-31 Hoffmann La Roche Pochodne pirydazynonu jako agoniści receptora hormonu tarczycy
GB0608724D0 (en) * 2006-05-03 2006-06-14 Karobio Ab Novel Pharmaceutical Compositions
WO2007132475A1 (en) 2006-05-15 2007-11-22 Cadila Healthcare Limited Selective tr-beta 1 agonist
GB0610322D0 (en) * 2006-05-24 2006-07-05 Karobio Ab Novel pharmaceutical compositions
US8394811B2 (en) 2007-04-18 2013-03-12 Molsoft Llc Hydrazide compounds as thyroid hormone receptor modulators and uses thereof
WO2009001359A2 (en) 2007-06-27 2008-12-31 Quark Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of pro-apoptotic genes
TW200906823A (en) 2007-07-16 2009-02-16 Lilly Co Eli Compounds and methods for modulating FXR
US8076334B2 (en) * 2007-09-20 2011-12-13 Hoffmann-La Roche Inc. Prodrugs of thyroid hormone analogs
FR2933979B1 (fr) 2008-07-15 2012-08-24 Pf Medicament Derives de triazines et uraciles, leur preparation et leur application en therapeutique humaine
TWI534144B (zh) 2009-04-20 2016-05-21 田邊三菱製藥股份有限公司 甲狀腺荷爾蒙β受體作動藥
WO2011038207A1 (en) 2009-09-25 2011-03-31 Metabasis Therapeutics, Inc. Phosphorus-containing thyroid hormone receptor agonists and methods of use
EP2780338B1 (en) 2011-11-14 2016-11-09 Ignyta, Inc. Uracil derivatives as axl and c-met kinase inhibitors
CN103130723B (zh) 2011-11-30 2015-01-14 成都地奥制药集团有限公司 一种多聚(adp-核糖)聚合酶抑制剂
CN102898377B (zh) 2012-02-14 2016-01-20 南京圣和药业股份有限公司 一类酞嗪酮衍生物及其用途
LT4406594T (lt) 2012-09-17 2025-12-29 Madrigal Pharmaceuticals, Inc. Skydliaukės hormono analogai
BR112016023269A8 (pt) 2014-04-11 2021-06-29 Cymabay Therapeutics Inc uso de ácido (r)-2-(4-((2-etóxi-3-(4-(trifluormetil)fenóxi)propil)-tio)-2-metilfenóxi)-acético ou sal do mesmo na fabricação de um medicamento para tratar doença hepática gordurosa não alcoólica ou esteato-hepatite não alcoólica
EP3189046B1 (en) 2014-09-05 2020-08-26 Genentech, Inc. Therapeutic compounds and uses thereof
CN105477636B (zh) 2015-10-16 2019-09-17 厦门大学 使用阿维菌素及其衍生物治疗代谢疾病的方法
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ROR-γ調節劑
JPWO2017170434A1 (ja) 2016-03-28 2019-01-31 インターセプト ファーマシューティカルズ, インコーポレイテッド Fxrアゴニストとarbの組み合わせ医薬
HRP20250776T1 (hr) 2016-03-31 2025-08-29 Genfit Elafibranor za uporabu u liječenju primarnog bilijarnog kolangitisa
BR112018073460A2 (pt) 2016-05-25 2019-07-09 Akarna Therapeutics Ltd terapias combinadas usando moduladores do receptor farnesoide x (fxr)
WO2018027892A1 (en) 2016-08-12 2018-02-15 Eli Lilly And Company Amino pyrimidine ssao inhibitors
IL266054B2 (en) * 2016-10-18 2023-10-01 Madrigal Pharmaceuticals Inc Methods for treating liver disorders or lipid disorders using a THR-BETA agonist
BR112019005930A2 (pt) 2016-10-19 2019-06-11 Boehringer Ingelheim Int combinações compreendendo um inibidor de ssao/vap-1 e um inibidor de sglt2, e usos das mesmas
WO2018103624A1 (zh) 2016-12-06 2018-06-14 江苏恒瑞医药股份有限公司 一种κ阿片受体激动剂在制备治疗法尼醇X受体激动剂引起的瘙痒的药物中的用途
KR20190117632A (ko) 2017-02-21 2019-10-16 장피트 Ppar 효현제와 fxr 효현제의 병용
KR20190122806A (ko) 2017-03-13 2019-10-30 장피트 조합 치료요법용 약학 조성물
US20200131129A1 (en) 2017-03-15 2020-04-30 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
CN110536682B (zh) 2017-04-18 2023-01-06 基恩菲特公司 依拉非诺或其衍生物与抗nash、抗纤维化或抗胆汁淤积药剂的组合
WO2018208707A1 (en) 2017-05-08 2018-11-15 Neurovia, Inc. Methods and compositions for treating demyelinating diseases
US20210121493A1 (en) 2017-07-25 2021-04-29 Cedars-Sinai Medical Center Methods for treating liver diseases
JP2020531023A (ja) 2017-08-25 2020-11-05 ジェンフィットGenfit 非アルコール性脂肪性肝疾患、非アルコール性脂肪性肝炎、及び/又は肝線維症の非侵襲的診断
WO2019053235A1 (en) 2017-09-15 2019-03-21 Genfit NON-INVASIVE DIAGNOSIS OF NON ALCOHOLIC LIVER DISEASES, NON ALCOHOLIC STHEATHEPATITIS AND / OR HEPATIC FIBROSIS
EA202090715A1 (ru) 2017-09-18 2020-07-15 Женфит Неинвазивная диагностика неалкогольных жировых дистрофий печени, неалкогольного стеатогепатита и/или фиброза печени
CN111511731B (zh) 2017-11-01 2023-05-23 百时美施贵宝公司 作为法尼醇x受体调节剂的烯烃化合物
ES2986647T3 (es) 2017-11-13 2024-11-12 Gilead Sciences Inc Método de estadificación de la fibrosis hepática en pacientes con EHNA
CN109574995B (zh) * 2018-01-23 2020-07-24 深圳市塔吉瑞生物医药有限公司 取代的哒嗪酮化合物
CA3101274A1 (en) 2018-04-24 2019-10-31 Ph Pharma Co., Ltd. Use of neutrophil elastase inhibitors in liver disease
CN111801324B (zh) 2018-06-12 2021-10-22 四川海思科制药有限公司 甲状腺激素受体激动剂及其用途
CA3110520A1 (en) 2018-08-24 2020-02-27 Terns, Inc. Thyroid hormone receptor beta agonist compounds
SG11202101863YA (en) 2018-08-30 2021-03-30 Terns Pharmaceuticals Inc Treating liver disorders
IL281427B2 (en) 2018-09-18 2026-01-01 Terns Inc Compounds that inhibit tyrosine kinase activity for use in the treatment of leukemia
EA202190661A1 (ru) 2018-09-18 2021-08-13 Метакрайн, Инк. Агонисты фарнезоидного х-рецептора для лечения заболевания
TWI840423B (zh) 2018-10-12 2024-05-01 美商拓臻股份有限公司 甲狀腺素受體β促效劑化合物
US12391677B2 (en) 2018-10-12 2025-08-19 InventisBio Co., Ltd. Thyroid hormone receptor agonists
CN111320609A (zh) 2018-12-13 2020-06-23 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
WO2020131578A2 (en) 2018-12-17 2020-06-25 Mitopower Llc Nicotinyl riboside compounds and their uses
CN111484481A (zh) 2019-01-26 2020-08-04 察略盛医药科技(上海)有限公司 哒嗪酮类衍生物、其制备方法及其在医药上的用途
US12338206B2 (en) 2019-02-21 2025-06-24 Nanjing Ruijie Pharma Co., Ltd. Compounds and their uses as thyroid hormone receptor agonists
GEP20247637B (en) 2019-05-08 2024-06-25 Aligos Therapeutics Inc Modulators of thr-b and methods of use thereof
WO2020228577A1 (zh) 2019-05-10 2020-11-19 深圳微芯生物科技股份有限公司 一种哒嗪酮衍生物及其应用
CN114174282A (zh) 2019-05-29 2022-03-11 南京明德新药研发有限公司 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用
KR20220038368A (ko) 2019-07-23 2022-03-28 노파르티스 아게 Fxr 작용제를 이용하는 간 질환의 병용 치료
CN112409340B (zh) 2019-08-21 2022-03-18 海创药业股份有限公司 卤素取代的苯醚类化合物及其用途
AU2020336272A1 (en) 2019-08-23 2022-04-14 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
CN114375193B (zh) 2019-09-12 2024-05-14 拓臻制药公司 甲状腺激素受体β激动剂化合物
WO2021121210A1 (zh) 2019-12-16 2021-06-24 江苏恒瑞医药股份有限公司 并环类衍生物、其制备方法及其在医药上的应用
US20210379040A1 (en) 2020-05-13 2021-12-09 Terns Pharmaceuticals, Inc. Combination treatment of liver disorders
IL298144A (en) 2020-05-13 2023-01-01 Terns Pharmaceuticals Inc Combination treatment of liver disorders
IL302099A (en) 2020-10-15 2023-06-01 Lilly Co Eli Polymorphs of an fxr agonist
CN114437034A (zh) 2020-11-06 2022-05-06 深圳微芯生物科技股份有限公司 一种酞嗪类化合物的可药用盐、晶型及其制备方法
JP2024502673A (ja) 2021-01-14 2024-01-22 ウエヌイグレックオ・ファーマ Hbv感染の処置のためのfxrアゴニストとifnの相乗効果
CA3212130A1 (en) 2021-03-03 2022-09-09 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
WO2022194278A1 (zh) 2021-03-19 2022-09-22 南京明德新药研发有限公司 双环苯酚类化合物及其应用
JP2024544538A (ja) 2021-11-11 2024-12-03 ターンズ・ファーマシューティカルズ・インコーポレイテッド THR-βアゴニストによる肝障害の治療
TW202327589A (zh) 2021-11-11 2023-07-16 美商拓臻製藥公司 肝病之組合療法
CA3238102A1 (en) 2021-11-11 2023-05-19 Terns Pharmaceuticals, Inc. Treating liver disorders with an ssao inhibitor
WO2023220404A1 (en) 2022-05-13 2023-11-16 Terns Pharmaceuticals, Inc. Treatment of non-alcoholic steatohepatitis
US20240398794A1 (en) 2023-04-07 2024-12-05 Terns Pharmaceuticals, Inc. COMBINATIONS OF GLP-1R AND THRß AGONISTS AND METHODS OF USE THEREOF

Similar Documents

Publication Publication Date Title
BR112023005462A2 (https=)
BR112023012656A2 (https=)
BR112021014123A2 (https=)
BR112023009656A2 (https=)
BR112022009896A2 (https=)
BR112021017747A2 (https=)
BR112022024743A2 (https=)
BR112022026905A2 (https=)
BR112023011738A2 (https=)
BR112023004146A2 (https=)
BR112023006729A2 (https=)
BR102021018859A2 (https=)
BR102021015500A2 (https=)
BR102021007058A2 (https=)
BR102020022030A2 (https=)
BR112023016292A2 (https=)
BR112023011539A2 (https=)
BR112023011610A2 (https=)
BR112023008976A2 (https=)
BR102021020147A2 (https=)
BR102021018926A2 (https=)
BR102021018167A2 (https=)
BR102021017576A2 (https=)
BR102021016837A2 (https=)
BR102021016551A2 (https=)