SG11201402004YA - Uracil derivatives as axl and c-met kinase inhibitors - Google Patents

Uracil derivatives as axl and c-met kinase inhibitors

Info

Publication number
SG11201402004YA
SG11201402004YA SG11201402004YA SG11201402004YA SG11201402004YA SG 11201402004Y A SG11201402004Y A SG 11201402004YA SG 11201402004Y A SG11201402004Y A SG 11201402004YA SG 11201402004Y A SG11201402004Y A SG 11201402004YA SG 11201402004Y A SG11201402004Y A SG 11201402004YA
Authority
SG
Singapore
Prior art keywords
axl
kinase inhibitors
met kinase
uracil derivatives
uracil
Prior art date
Application number
SG11201402004YA
Inventor
Reddeppareddy Dandu
Robert L Hudkins
Kurt A Josef
Catherine P Prouty
Rabindranath Tripathy
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Publication of SG11201402004YA publication Critical patent/SG11201402004YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
SG11201402004YA 2011-11-14 2012-11-14 Uracil derivatives as axl and c-met kinase inhibitors SG11201402004YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161559312P 2011-11-14 2011-11-14
PCT/US2012/065019 WO2013074633A1 (en) 2011-11-14 2012-11-14 Uracil derivatives as axl and c-met kinase inhibitors

Publications (1)

Publication Number Publication Date
SG11201402004YA true SG11201402004YA (en) 2014-05-29

Family

ID=47297443

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201510307WA SG10201510307WA (en) 2011-11-14 2012-11-14 Uracil derivatives as axl and c-met kinase inhibitors
SG11201402004YA SG11201402004YA (en) 2011-11-14 2012-11-14 Uracil derivatives as axl and c-met kinase inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201510307WA SG10201510307WA (en) 2011-11-14 2012-11-14 Uracil derivatives as axl and c-met kinase inhibitors

Country Status (26)

Country Link
US (5) US9029538B2 (en)
EP (2) EP2780338B1 (en)
JP (2) JP6051434B2 (en)
KR (1) KR20140090678A (en)
CN (2) CN108047201A (en)
AR (1) AR088872A1 (en)
AU (2) AU2012339640B2 (en)
BR (1) BR112014011548A2 (en)
CA (1) CA2852697A1 (en)
DK (1) DK2780338T3 (en)
EA (1) EA023521B1 (en)
ES (1) ES2614824T3 (en)
HK (1) HK1202528A1 (en)
HU (1) HUE033032T2 (en)
IL (3) IL232405A (en)
MX (1) MX342241B (en)
PH (1) PH12016501535A1 (en)
PL (1) PL2780338T3 (en)
PT (1) PT2780338T (en)
SG (2) SG10201510307WA (en)
SI (1) SI2780338T1 (en)
TW (1) TWI562989B (en)
UA (1) UA114900C2 (en)
UY (1) UY34451A (en)
WO (1) WO2013074633A1 (en)
ZA (1) ZA201402940B (en)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108047201A (en) 2011-11-14 2018-05-18 亚尼塔公司 Uracil derivative as AXL and c-MET kinase inhibitors
CN102643268B (en) * 2011-12-30 2014-05-21 沈阳药科大学 Quinoline and cinnoline compound and application thereof
BR102013027577A2 (en) * 2012-10-25 2016-03-29 Memorialsloan Kettering Cancer Ct method of detecting an increased axl or gas6 level and method of identifying an egfr inhibitor resistant cancer patient
ES2728531T3 (en) 2013-07-08 2019-10-25 Bayer Cropscience Ag Six-membered arylsulfide and C-N-linked arylsulfoxide derivatives as agents to fight parasites
TWI649308B (en) * 2013-07-24 2019-02-01 小野藥品工業股份有限公司 Quinoline derivative
EP3027623A4 (en) * 2013-08-02 2017-03-01 Ignyta, Inc. METHODS OF TREATING VARIOUS CANCERS USING AN AXL/cMET INHIBITOR ALONE OR IN COMBINATION WITH OTHER AGENTS
CN105873919A (en) 2013-11-08 2016-08-17 拜耳医药股份有限公司 Substituted uracils as chymase inhibitors
CN105980381A (en) * 2013-11-08 2016-09-28 拜耳医药股份有限公司 Substituted uracils and use thereof
US9771333B2 (en) 2013-11-20 2017-09-26 Signalchem Lifesciences Corp. Quinazoline derivatives as TAM family kinase inhibitors
JP6496731B2 (en) 2013-11-27 2019-04-03 シグナルケム・ライフサイエンシーズ・コーポレイションＳｉｇｎａｌｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ Aminopyridine derivatives as TAM family kinase inhibitors
PL3087070T3 (en) * 2013-12-26 2018-03-30 Ignyta, Inc. Pyrazolo[1,5-a]pyridine derivatives and methods of their use
JP6708130B2 (en) * 2014-12-25 2020-06-10 小野薬品工業株式会社 Quinoline derivative
JP6617155B6 (en) * 2015-04-07 2020-01-22 グアンドン・レイノーヴェント・バイオテック・カンパニー・リミテッド Tyrosine kinase inhibitor and pharmaceutical composition containing the same
AU2016249860B2 (en) * 2015-04-14 2019-10-10 Lead Discovery Center Gmbh Quinoline derivatives as TAM RTK inhibitors
WO2016183071A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Hetero-tricyclic compounds and their use for the treatment of cancer
WO2017027717A1 (en) 2015-08-12 2017-02-16 Incyte Corporation Bicyclic fused pyrimidine compounds as tam inhibitors
CN106467541B (en) * 2015-08-18 2019-04-05 暨南大学 Substituted quinolone analog derivative or its pharmaceutically acceptable salt or stereoisomer and its Pharmaceutical composition and application
WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
WO2017062500A2 (en) 2015-10-05 2017-04-13 The Trustees Of Columbia University In The City Of New York Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
JP6885390B2 (en) 2016-02-26 2021-06-16 小野薬品工業株式会社 A drug for the treatment of cancer, which comprises administering a combination of an Axl inhibitor and an immune checkpoint inhibitor.
RS65129B1 (en) 2016-03-28 2024-02-29 Incyte Corp Pyrrolotriazine compounds as tam inhibitors
CN109689056A (en) * 2016-08-01 2019-04-26 亚尼塔公司 Combination for treating cancer
WO2018026877A1 (en) 2016-08-05 2018-02-08 Calitor Sciences, Llc Process for preparing substituted quinolin-4-ol compounds
EP3503887A4 (en) * 2016-08-24 2020-05-06 Ignyta, Inc. Combinations for the treatment of cancer
CN106543145B (en) * 2016-10-28 2019-07-19 山西医科大学 C-Met kinases presses down agent 3- (4- fluorophenyl) pyrimidone -5- benzoic acid amides derivative, preparation method and application
CN108250200A (en) * 2016-12-28 2018-07-06 中国科学院上海药物研究所 A kind of compound and its preparation and application with Axl inhibitory activity
ES2872923T3 (en) 2017-01-26 2021-11-03 Ono Pharmaceutical Co N- {5 - [(6,7-dimethoxy-4-quinolinyl) oxy] -2-pyridinyl} -2,5-dioxo-1-phenyl-1,2,5,6,7,8- ethanesulfonate salt hexahydro-3-quinolinecarboxamide
CN108623568B (en) * 2017-03-21 2022-04-19 南京汇诚制药有限公司 Salt form of 9,10 dihydrophenanthrene hepatitis C virus inhibitor and preparation thereof
US20200197385A1 (en) 2017-08-23 2020-06-25 Ono Pharmaceutical Co., Ltd. Therapeutic agent for cancer containing axl inhibitor as active ingredient
WO2019067594A1 (en) 2017-09-27 2019-04-04 Incyte Corporation Salts of pyrrolotriazine derivatives useful as tam inhibitors
JP7223998B2 (en) 2017-10-13 2023-02-17 小野薬品工業株式会社 Solid cancer therapeutic agent containing an Axl inhibitor as an active ingredient
CN107573340B (en) * 2017-10-23 2020-11-24 江西科技师范大学 Preparation and application of 2-carbamoyl-4-aryl hetero pyridine compound
US11623923B2 (en) 2017-11-24 2023-04-11 Medshine Discovery, Inc. Uracil compound as c-MET/AXL inhibitor
WO2019141202A1 (en) * 2018-01-17 2019-07-25 南京药捷安康生物科技有限公司 Tam family kinase /and csf1r kinase inhibitor and use thereof
WO2019213340A1 (en) * 2018-05-03 2019-11-07 Bristol-Myers Squibb Company Uracil derivatives as mer-axl inhibitors
CN110511218A (en) * 2018-05-21 2019-11-29 中国科学院上海药物研究所 A kind of and ring pyrazolone Carbox amide and preparation method thereof, pharmaceutical composition and purposes
CA3101983A1 (en) * 2018-06-01 2019-12-05 Rigel Pharmaceuticals, Inc. Quinoline derivatives useful as tyrosine kinase inhibitors
PE20211805A1 (en) 2018-06-29 2021-09-14 Incyte Corp FORMULATIONS OF AN AXL / MER INHIBITOR
EP3842425A4 (en) * 2018-08-24 2022-05-18 Nanjing Transthera Biosciences Co., Ltd. Novel quinoline derivative inhibitor
WO2020042618A1 (en) 2018-08-27 2020-03-05 北京越之康泰生物医药科技有限公司 Multi-substituted pyridone derivatives and medical use thereof
UY38349A (en) 2018-08-30 2020-03-31 Array Biopharma Inc PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES
TW202027748A (en) * 2018-10-12 2020-08-01 美商拓臻股份有限公司 Thyroid hormone receptor beta agonist compounds
CN111196814B (en) * 2018-11-19 2022-12-06 北京赛特明强医药科技有限公司 Aromatic ring-linked dioxane quinazoline or quinoline compound, composition and application thereof
CN111320609A (en) 2018-12-13 2020-06-23 拓臻股份有限公司 THR β receptor agonist compound and preparation method and application thereof
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
CN111848580B (en) * 2019-04-30 2021-09-14 武汉盛云生物医药科技有限责任公司 Crystal form of quinoline compound containing 1,2, 4-triazine-3, 5-diketone as well as preparation method and application thereof
US20220235029A1 (en) * 2019-05-24 2022-07-28 Medshine Discovery Inc. Crystal form of c-met/axl inhibitor
WO2020238802A1 (en) * 2019-05-24 2020-12-03 南京明德新药研发有限公司 Crystal form of c-met/axl inhibitor
AU2020342108B2 (en) * 2019-09-06 2024-03-07 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Compound having Axl and c-Met kinase inhibitory activity, preparation thereof and application thereof
CN112625026B (en) * 2019-09-24 2022-09-09 药捷安康(南京)科技股份有限公司 Quinoline derivatives of TAM family kinase inhibitors
JP2022551422A (en) * 2019-09-26 2022-12-09 エグゼリクシス， インコーポレイテッド Pyridone compounds and methods of use in modulating protein kinases
CN114555080A (en) 2019-10-16 2022-05-27 凯莫森特里克斯股份有限公司 Heteroaryl biphenylamines useful for the treatment of PD-L1 disease
JP2022551973A (en) 2019-10-16 2022-12-14 ケモセントリックス，インコーポレイティド Heteroaryl-biphenylamides for the treatment of PD-L1 disease
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
GB202004960D0 (en) * 2020-04-03 2020-05-20 Kinsenus Ltd Inhibitor compounds
CN113620873B (en) * 2020-05-07 2023-12-08 沈阳药科大学 Preparation method and application of zinc-containing binding group and quinoline skeleton compound
AU2021297216A1 (en) * 2020-06-23 2023-02-02 Chemocentryx, Inc. Methods of treating cancer using heteroaryl-biphenyl amide derivatives
JP2023541011A (en) * 2020-09-08 2023-09-27 イデアヤ、バイオサイエンシズ、インコーポレイテッド Pharmaceutical combinations and tumor treatment
CN112675170B (en) * 2021-02-03 2022-02-01 南华大学附属第一医院 Application of V027-0576 in preparation of antitumor drugs
EP4294804A1 (en) * 2021-02-19 2023-12-27 Exelixis, Inc. Pyridone compounds and methods of use
WO2022220227A1 (en) * 2021-04-14 2022-10-20 エーザイ・アール・アンド・ディー・マネジメント株式会社 Tetrahydropyridopyrimidine compound
WO2022237843A1 (en) * 2021-05-12 2022-11-17 微境生物医药科技(上海)有限公司 Axl inhibitor
JPWO2023286719A1 (en) * 2021-07-13 2023-01-19
IT202100022682A1 (en) * 2021-09-01 2023-03-01 Luigi Frati PYRIMIDINES DERIVATIVES AND THEIR USE IN THE TREATMENT OF TUMORS
CN116693452A (en) * 2023-05-24 2023-09-05 中山大学 Quinoline derivative and preparation method and application thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017329A1 (en) 1995-11-07 1997-05-15 Kirin Beer Kabushiki Kaisha Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same
AU733551B2 (en) 1996-09-25 2001-05-17 Astrazeneca Ab Qinoline derivatives inhibiting the effect of growth factors such as VEGF
HU230789B1 (en) 1999-01-22 2018-05-02 Kyowa Hakko Kirin Co Quinoline derivatives and quinazoline derivatives, pharmaceutical compositions containing them and their use
WO2007033196A1 (en) * 2005-09-14 2007-03-22 Bristol-Myers Squibb Company Met kinase inhibitors
US20080004273A1 (en) 2006-05-30 2008-01-03 Stephane Raeppel Inhibitors of protein tyrosine kinase activity
US20110053931A1 (en) 2006-06-08 2011-03-03 John Gaudino Quinoline compounds and methods of use
EP2139869A2 (en) * 2007-04-13 2010-01-06 SuperGen, Inc. Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders
HUE032873T2 (en) 2008-03-17 2017-11-28 Ambit Biosciences Corp 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea as raf kinase modulator in the treatment of cancer diseases
MX2010011224A (en) * 2008-04-16 2011-02-25 Max Planck Ges Zur Fa Rderung Der Wissenschaften E V Quinoline derivatives as axl kinase inhibitors.
UY31800A (en) * 2008-05-05 2009-11-10 Smithkline Beckman Corp CANCER TREATMENT METHOD USING A CMET AND AXL INHIBITOR AND AN ERBB INHIBITOR
EP2311809A1 (en) 2009-10-16 2011-04-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Quinolinyloxyphenylsulfonamides
EP2423208A1 (en) * 2010-08-28 2012-02-29 Lead Discovery Center GmbH Pharmaceutically active compounds as Axl inhibitors
ME03523B (en) 2011-04-01 2020-04-20 Curis Inc Phosphoinositide 3-kinase inhibitor with a zinc binding moiety
CN108047201A (en) 2011-11-14 2018-05-18 亚尼塔公司 Uracil derivative as AXL and c-MET kinase inhibitors

Also Published As

Publication number Publication date
EP3045453A1 (en) 2016-07-20
US20150209358A1 (en) 2015-07-30
US10017496B2 (en) 2018-07-10
PL2780338T3 (en) 2017-04-28
AU2012339640A1 (en) 2014-06-05
CN108047201A (en) 2018-05-18
IL232405A0 (en) 2014-07-01
US20140275077A1 (en) 2014-09-18
US20170050949A1 (en) 2017-02-23
JP6051434B2 (en) 2016-12-27
ZA201402940B (en) 2017-08-30
CN103958497A (en) 2014-07-30
CN103958497B (en) 2017-09-01
CA2852697A1 (en) 2013-05-23
AU2012339640B2 (en) 2017-01-05
IL232405A (en) 2017-02-28
TWI562989B (en) 2016-12-21
JP2017071612A (en) 2017-04-13
US9745283B2 (en) 2017-08-29
AU2017201042A1 (en) 2017-03-09
EP2780338B1 (en) 2016-11-09
PH12016501535A1 (en) 2017-05-22
HK1202528A1 (en) 2015-10-02
US9522902B2 (en) 2016-12-20
US20170320853A1 (en) 2017-11-09
IL245658A (en) 2017-06-29
NZ712194A (en) 2016-05-27
MX342241B (en) 2016-09-21
EA201490971A1 (en) 2014-09-30
EA023521B1 (en) 2016-06-30
ES2614824T3 (en) 2017-06-02
AR088872A1 (en) 2014-07-16
BR112014011548A2 (en) 2017-05-09
PT2780338T (en) 2017-02-17
IL245658A0 (en) 2016-06-30
SG10201510307WA (en) 2016-01-28
DK2780338T3 (en) 2016-12-19
US20150210670A1 (en) 2015-07-30
NZ624945A (en) 2015-09-25
EP2780338A1 (en) 2014-09-24
WO2013074633A1 (en) 2013-05-23
UY34451A (en) 2013-05-31
JP2014533287A (en) 2014-12-11
MX2014005766A (en) 2014-05-30
JP6404299B2 (en) 2018-10-10
US9120778B2 (en) 2015-09-01
UA114900C2 (en) 2017-08-28
SI2780338T1 (en) 2017-04-26
HUE033032T2 (en) 2017-11-28
TW201332992A (en) 2013-08-16
US9029538B2 (en) 2015-05-12
IL252517A0 (en) 2017-07-31
KR20140090678A (en) 2014-07-17

Similar Documents

Publication Publication Date Title
IL252517A0 (en) Uracil derivatives as axl and c-met kinase inhibitors
HRP20181429T8 (en) Novel benzimidazole derivatives as kinase inhibitors
HK1210775A1 (en) Imidazotriazinecarbonitriles useful as kinase inhibitors
SG11201600062RA (en) Pyrimidine derivatives as kinase inhibitors
ZA201406078B (en) Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhibitors
HK1199880A1 (en) Benzonitrile derivatives as kinase inhibitors
HK1211027A1 (en) Pyrrolotriazinone derivatives as pi3k inhibitors pi3k
HK1210777A1 (en) Quinazolinone derivatives as parp inhibitors parp
IL232234A0 (en) Aminopyrimidine kinase inhibitors
IL228928A0 (en) Aminopyrimidine kinase inhibitors
SG11201500973WA (en) Amino-quinolines as kinase inhibitors