JP2020521766A5 - - Google Patents
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- Publication number
- JP2020521766A5 JP2020521766A5 JP2019565384A JP2019565384A JP2020521766A5 JP 2020521766 A5 JP2020521766 A5 JP 2020521766A5 JP 2019565384 A JP2019565384 A JP 2019565384A JP 2019565384 A JP2019565384 A JP 2019565384A JP 2020521766 A5 JP2020521766 A5 JP 2020521766A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- solvate
- acceptable salt
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 25
- 150000003839 salts Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 239000012453 solvate Substances 0.000 claims 20
- 150000001204 N-oxides Chemical class 0.000 claims 12
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 150000004677 hydrates Chemical class 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 208000002193 Pain Diseases 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- -1 -C (O) NR 8 R 9 Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 0 C*C1(C*(C)(C)C(C)N(*(C)C)C(C)*(C)C1)*(C)* Chemical compound C*C1(C*(C)(C)C(C)N(*(C)C)C(C)*(C)C1)*(C)* 0.000 description 5
- XSEAVFBAYIZDPC-UHFFFAOYSA-N CNc1cc(N)cc(CO)c1 Chemical compound CNc1cc(N)cc(CO)c1 XSEAVFBAYIZDPC-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022113928A JP7320652B2 (ja) | 2017-05-23 | 2022-07-15 | ピラゾールｍａｇｌ阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762510213P | 2017-05-23 | 2017-05-23 | |
| US62/510,213 | 2017-05-23 | ||
| PCT/US2018/033959 WO2018217805A1 (en) | 2017-05-23 | 2018-05-22 | Pyrazole magl inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022113928A Division JP7320652B2 (ja) | 2017-05-23 | 2022-07-15 | ピラゾールｍａｇｌ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020521766A JP2020521766A (ja) | 2020-07-27 |
| JP2020521766A5 true JP2020521766A5 (https=) | 2021-07-26 |
| JP7157771B2 JP7157771B2 (ja) | 2022-10-20 |
Family
ID=64397020
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565384A Active JP7157771B2 (ja) | 2017-05-23 | 2018-05-22 | ピラゾールｍａｇｌ阻害剤 |
| JP2022113928A Active JP7320652B2 (ja) | 2017-05-23 | 2022-07-15 | ピラゾールｍａｇｌ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022113928A Active JP7320652B2 (ja) | 2017-05-23 | 2022-07-15 | ピラゾールｍａｇｌ阻害剤 |
Country Status (41)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017096315A1 (en) | 2015-12-02 | 2017-06-08 | The Scripps Research Institute | TRIAZOLE DAGL(α) INHIBITORS |
| JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| US10927105B1 (en) | 2017-05-23 | 2021-02-23 | Lundbeck La Jolla Research Center, Inc. | Pyrazole MAGL inhibitors |
| EA201992409A1 (ru) | 2017-05-23 | 2020-03-23 | Лундбекк Ла-Хойя Рисерч Сентер, Инк. | Ингибиторы magl на основе пиразола |
| JOP20190267A1 (ar) | 2017-05-23 | 2019-11-18 | Lundbeck La Jolla Research Center Inc | مثبطات بيرازول magl |
| AU2019389017B2 (en) * | 2018-11-28 | 2025-01-09 | H. Lundbeck A/S | Methods of treating disease with MAGL inhibitors |
| BR112023015210A2 (pt) | 2021-01-29 | 2023-11-07 | Cedilla Therapeutics Inc | Inibidores de cdk2 e métodos de uso dos mesmos |
| CA3225439A1 (en) | 2021-06-26 | 2022-12-29 | Cedilla Therapeutics, Inc. | Cdk2 inhibitors and methods of using the same |
| CN118139863A (zh) | 2021-11-02 | 2024-06-04 | H.隆德贝克有限公司 | 单酰基甘油脂肪酶抑制剂的结晶形式 |
| CA3242372A1 (en) | 2021-12-29 | 2023-07-06 | Psy Therapeutics, Inc. | Inhibiting monoacylglycerol lipase (magl) |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3308130A (en) | 1962-04-26 | 1967-03-07 | Du Pont | N-disubstituted carbamyl pyrazoles |
| EP1309591B1 (en) * | 2000-08-14 | 2007-01-24 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
| CA2439415C (en) * | 2001-03-02 | 2011-09-20 | Merck Frosst Canada & Co. | Cathepsin cysteine protease inhibitors |
| US6727364B2 (en) | 2001-04-30 | 2004-04-27 | The Procter & Gamble Company | Triazole compounds useful in treating diseases associated with unwanted cytokine activity |
| HRP20040767A2 (en) | 2002-02-19 | 2004-12-31 | Teva Pharma | Desolvating solvates of atorvastatin hemi-calcium |
| WO2004080999A1 (en) * | 2003-03-14 | 2004-09-23 | Biolipox Ab | Pyrazole compounds useful in the treatment of inflammation |
| SE0300705D0 (sv) * | 2003-03-14 | 2003-03-14 | Biolipox Ab | New compounds |
| US20110172230A1 (en) | 2006-08-23 | 2011-07-14 | Takahiro Ishii | Urea compound or salt thereof |
| WO2010056309A2 (en) | 2008-11-14 | 2010-05-20 | The Scripps Research Institute | Methods and compositions related to targeting monoacylglycerol lipase |
| MX342128B (es) | 2008-12-24 | 2016-09-14 | Bial - Portela & C A S A | Compuestos farmaceuticos. |
| JP2012524800A (ja) | 2009-04-22 | 2012-10-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | モノアシルグリセロールリパーゼ阻害剤としてのアゼチジニルジアミド |
| CA2830958A1 (en) | 2011-04-06 | 2012-10-11 | The Scripps Research Institute | N1- and n2-carbamoyl-1,2,3-triazole serine hydrolase inhibitors and methods |
| CN103130723B (zh) | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
| US9487495B2 (en) | 2012-01-06 | 2016-11-08 | The Scripts Research Institute | Carbamate compounds and of making and using same |
| EP3087067B1 (en) * | 2013-12-26 | 2018-10-24 | Takeda Pharmaceutical Company Limited | 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (magl) inhibitors |
| WO2015179559A2 (en) * | 2014-05-21 | 2015-11-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| WO2016014975A2 (en) | 2014-07-25 | 2016-01-28 | Northeastern University | Urea/carbamates faah magl or dual faah/magl inhibitors and uses thereof |
| UA121775C2 (uk) | 2015-07-31 | 2020-07-27 | Пфайзер Інк. | 1,1,1-трифтор-3-гідроксипропан-2-ілкарбаматні похідні та 1,1,1-трифтор-4-гідроксибутан-2-ілкарбаматні похідні як інгібітори magl |
| WO2017087858A1 (en) * | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| WO2017087863A1 (en) | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| US10519134B2 (en) | 2015-11-20 | 2019-12-31 | Lundbeck La Jolla Research Center, Inc. | Pyrazole compounds and methods of making and using same |
| WO2017096315A1 (en) | 2015-12-02 | 2017-06-08 | The Scripps Research Institute | TRIAZOLE DAGL(α) INHIBITORS |
| JOP20190106A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| DK3541807T3 (da) | 2016-11-16 | 2021-12-06 | H Lundbeck As | Krystallinsk form af en magl-inhibitor |
| KR20190085046A (ko) | 2016-11-16 | 2019-07-17 | 어바이드 테라퓨틱스, 인크. | 약학 제제 |
| JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| EA201992409A1 (ru) | 2017-05-23 | 2020-03-23 | Лундбекк Ла-Хойя Рисерч Сентер, Инк. | Ингибиторы magl на основе пиразола |
| JOP20190267A1 (ar) | 2017-05-23 | 2019-11-18 | Lundbeck La Jolla Research Center Inc | مثبطات بيرازول magl |
| US10927105B1 (en) | 2017-05-23 | 2021-02-23 | Lundbeck La Jolla Research Center, Inc. | Pyrazole MAGL inhibitors |
| AU2019389017B2 (en) | 2018-11-28 | 2025-01-09 | H. Lundbeck A/S | Methods of treating disease with MAGL inhibitors |
| CN113167617B (zh) | 2018-11-30 | 2024-09-24 | 贝克休斯控股有限责任公司 | 原位超声流量计验证 |
-
2018
- 2018-05-22 EA EA201992409A patent/EA201992409A1/ru unknown
- 2018-05-22 AU AU2018271876A patent/AU2018271876B2/en not_active Ceased
- 2018-05-22 KR KR1020247006820A patent/KR102679766B1/ko active Active
- 2018-05-22 DK DK18806431.5T patent/DK3630744T3/da active
- 2018-05-22 KR KR1020197037042A patent/KR102643778B1/ko active Active
- 2018-05-22 EP EP23151106.4A patent/EP4198024A1/en active Pending
- 2018-05-22 UA UAA201911547A patent/UA124990C2/uk unknown
- 2018-05-22 MY MYPI2019006597A patent/MY200738A/en unknown
- 2018-05-22 SM SM20230071T patent/SMT202300071T1/it unknown
- 2018-05-22 JO JOP/2019/0262A patent/JOP20190262B1/ar active
- 2018-05-22 AR ARP180101355A patent/AR112907A1/es unknown
- 2018-05-22 PT PT188064315T patent/PT3630744T/pt unknown
- 2018-05-22 EP EP18806431.5A patent/EP3630744B1/en active Active
- 2018-05-22 CR CR20190536A patent/CR20190536A/es unknown
- 2018-05-22 US US16/615,747 patent/US11655217B2/en active Active
- 2018-05-22 CN CN201880033044.0A patent/CN110678456B/zh active Active
- 2018-05-22 CA CA3063993A patent/CA3063993A1/en active Pending
- 2018-05-22 MA MA50406A patent/MA50406B1/fr unknown
- 2018-05-22 SI SI201830852T patent/SI3630744T1/sl unknown
- 2018-05-22 PE PE2019002378A patent/PE20200445A1/es unknown
- 2018-05-22 GE GEAP202115219A patent/GEAP202115219A/en unknown
- 2018-05-22 JP JP2019565384A patent/JP7157771B2/ja active Active
- 2018-05-22 BR BR112019024566A patent/BR112019024566A2/pt not_active Application Discontinuation
- 2018-05-22 PL PL18806431.5T patent/PL3630744T3/pl unknown
- 2018-05-22 GE GEAP201815219A patent/GEP20217318B/en unknown
- 2018-05-22 LT LTEPPCT/US2018/033959T patent/LT3630744T/lt unknown
- 2018-05-22 WO PCT/US2018/033959 patent/WO2018217805A1/en not_active Ceased
- 2018-05-22 ES ES18806431T patent/ES2940111T3/es active Active
- 2018-05-22 HU HUE18806431A patent/HUE061614T2/hu unknown
- 2018-05-22 FI FIEP18806431.5T patent/FI3630744T3/fi active
- 2018-05-22 CN CN202310407761.8A patent/CN116473965B/zh active Active
- 2018-05-22 MX MX2019014042A patent/MX394318B/es unknown
- 2018-05-22 US US15/986,747 patent/US10266497B2/en active Active
- 2018-05-22 HR HRP20230233TT patent/HRP20230233T1/hr unknown
- 2018-05-22 RS RS20230152A patent/RS64006B1/sr unknown
- 2018-05-23 TW TW107117623A patent/TWI786117B/zh active
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2019
- 2019-11-06 IL IL270473A patent/IL270473B/en unknown
- 2019-11-08 DO DO2019000283A patent/DOP2019000283A/es unknown
- 2019-11-11 NI NI201900115A patent/NI201900115A/es unknown
- 2019-11-14 PH PH12019502548A patent/PH12019502548A1/en unknown
- 2019-11-18 SA SA519410589A patent/SA519410589B1/ar unknown
- 2019-11-21 CO CONC2019/0013013A patent/CO2019013013A2/es unknown
- 2019-11-21 CL CL2019003397A patent/CL2019003397A1/es unknown
- 2019-11-26 EC ECSENADI201984085A patent/ECSP19084085A/es unknown
- 2019-12-04 ZA ZA2019/08070A patent/ZA201908070B/en unknown
-
2022
- 2022-07-15 JP JP2022113928A patent/JP7320652B2/ja active Active
-
2023
- 2023-03-13 CY CY20231100135T patent/CY1125882T1/el unknown
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