JP2019501125A5 - - Google Patents

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Publication number
JP2019501125A5
JP2019501125A5 JP2018525654A JP2018525654A JP2019501125A5 JP 2019501125 A5 JP2019501125 A5 JP 2019501125A5 JP 2018525654 A JP2018525654 A JP 2018525654A JP 2018525654 A JP2018525654 A JP 2018525654A JP 2019501125 A5 JP2019501125 A5 JP 2019501125A5
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JP
Japan
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alkyl
halo
heteroaryl
substituted
bicyclic
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JP2018525654A
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English (en)
Japanese (ja)
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JP6843135B2 (ja
JP2019501125A (ja
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Priority claimed from PCT/US2016/062396 external-priority patent/WO2017087590A1/en
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Publication of JP2019501125A5 publication Critical patent/JP2019501125A5/ja
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JP2018525654A 2015-11-18 2016-11-17 IL−12、IL−23および/またはIFNα応答のモジュレーターとして有用なイミダゾピリダジン化合物 Active JP6843135B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562256784P 2015-11-18 2015-11-18
US62/256,784 2015-11-18
US201662404827P 2016-10-06 2016-10-06
US62/404,827 2016-10-06
PCT/US2016/062396 WO2017087590A1 (en) 2015-11-18 2016-11-17 Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses

Publications (3)

Publication Number Publication Date
JP2019501125A JP2019501125A (ja) 2019-01-17
JP2019501125A5 true JP2019501125A5 (https=) 2019-12-26
JP6843135B2 JP6843135B2 (ja) 2021-03-17

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ID=57472068

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018525654A Active JP6843135B2 (ja) 2015-11-18 2016-11-17 IL−12、IL−23および/またはIFNα応答のモジュレーターとして有用なイミダゾピリダジン化合物

Country Status (7)

Country Link
US (1) US10479793B2 (https=)
EP (1) EP3377496B1 (https=)
JP (1) JP6843135B2 (https=)
KR (1) KR102782807B1 (https=)
CN (1) CN108473500B (https=)
ES (1) ES2828733T3 (https=)
WO (1) WO2017087590A1 (https=)

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US20170333435A1 (en) 2014-11-06 2017-11-23 Lysosomal Therapeutics Inc. Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
US20180185368A1 (en) 2014-11-06 2018-07-05 Lysosomal Therapeutics Inc. Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
EP4406616A3 (en) 2014-11-06 2024-11-06 Bial-R&D Investments, S.A. Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders
CA3020305A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
EP3440081A4 (en) 2016-04-06 2019-09-18 Lysosomal Therapeutics Inc. PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER
AU2017246455B2 (en) 2016-04-06 2021-09-30 Bial - R&D Investments, S.A. Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
KR102530515B1 (ko) 2016-05-05 2023-05-09 비알 - 알&디 인베스트먼츠, 에스.에이. 치환된 이미다조[1,2-b]피리다진, 치환된 이미다조[1,5-b]피리다진, 관련 화합물, 및 의학적 장애의 치료에서의 그의 용도
ES2902995T3 (es) * 2016-10-07 2022-03-30 Bristol Myers Squibb Co Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa
EP3541817B1 (en) * 2016-11-17 2020-12-23 Bristol-Myers Squibb Company Imidazopyridazine modulators of il-12, il-23 and/or ifn-alpha
SI3658557T1 (sl) * 2017-07-28 2024-10-30 Takeda Pharmaceutical Company Limited Zaviralci TYK2 in njihova uporaba
AR117398A1 (es) 2018-03-12 2021-08-04 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa 2
JP7179161B2 (ja) * 2018-09-10 2022-11-28 イーライ リリー アンド カンパニー 乾癬および全身性エリテマトーデスの処置に有用なピラゾロ[1,5-a]ピリミジン-3-カルボキサミド誘導体
JP7631193B2 (ja) 2018-10-22 2025-02-18 アルミス インコーポレイテッド Tyk2阻害剤およびその使用
AR117177A1 (es) 2018-12-10 2021-07-14 Lilly Co Eli DERIVADOS DE 7-(METILAMINO)PIRAZOLO[1,5-A]PIRIMIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE IL-23 E INFa
TWI752400B (zh) * 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
CN113348021B (zh) * 2019-01-23 2025-07-11 武田药品工业株式会社 Tyk2抑制剂和其用途
JP2022519696A (ja) * 2019-02-07 2022-03-24 ベンティックス バイオサイエンシーズ,インク. Tyk2偽キナーゼリガンド
US12473290B2 (en) 2019-03-05 2025-11-18 Bristol Myers-Squibb Company Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
CA3132632A1 (en) * 2019-03-11 2020-09-17 Esker Therapeutics, Inc. Tyk2 inhibitors and uses thereof
TWI810520B (zh) 2020-02-12 2023-08-01 美商美國禮來大藥廠 7-(甲基胺基)吡唑并[1,5-a]嘧啶-3-甲醯胺化合物
CN115052660B (zh) 2020-02-12 2024-01-09 伊莱利利公司 取代的7-(甲氨基)吡唑并[1,5-a]嘧啶-3-甲酰胺衍生物
CN115867348B (zh) * 2020-04-30 2025-05-06 詹森药业有限公司 作为il-17调节剂的咪唑并嘧啶
PE20230469A1 (es) * 2020-04-30 2023-03-14 Janssen Pharmaceutica Nv Imidazopiridazinas como moduladores de il-17
EP3944859A1 (en) 2020-07-30 2022-02-02 Assistance Publique Hôpitaux de Paris Method for treating immune toxicities induced by immune checkpoint inhibitors
CN115916207A (zh) * 2020-08-20 2023-04-04 轶诺(浙江)药业有限公司 一类五元并六元杂环化合物及其作为蛋白受体激酶抑制剂的用途
EP4214215A1 (en) * 2020-09-16 2023-07-26 Alumis Inc. Tyk2 inhibitors and uses thereof
WO2022156657A1 (en) * 2021-01-19 2022-07-28 Anrui Biomedical Technology (Guangzhou) Co., Ltd. Imidazolopyridazine or pyrazolopyrimidine compounds and compositions
CA3213816A1 (en) 2021-03-16 2022-09-22 Anrui Biomedical Technology (Guangzhou) Co., Ltd. Amino heteroaryl compounds and compositions
EP4423086A1 (en) 2021-10-25 2024-09-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
CN118580191A (zh) * 2022-01-28 2024-09-03 和记黄埔医药(上海)有限公司 用于制备咪唑并[1,2-b]哒嗪类化合物的中间体
WO2025168035A1 (zh) * 2024-02-07 2025-08-14 合肥羿科医药有限公司 杂环类化合物、其药物组合物及其应用

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CN101730699A (zh) 2007-03-21 2010-06-09 百时美施贵宝公司 可用于治疗增殖性、变应性、自身免疫性和炎症性疾病的稠合杂环化合物
EP2217601A1 (en) * 2007-11-08 2010-08-18 Centro Nacional de Investigaciones Oncológicas (CNIO) Imidazopyridazines for use as protein kinase inhibitors
WO2009100375A1 (en) 2008-02-06 2009-08-13 Bristol-Myers Squibb Company Substituted imidazopyridazines useful as kinase inhibitors
TWI491610B (zh) 2008-10-09 2015-07-11 必治妥美雅史谷比公司 作為激酶抑制劑之咪唑并嗒腈
JP6073343B2 (ja) * 2011-10-20 2017-02-01 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ
WO2013134219A1 (en) * 2012-03-09 2013-09-12 Lexicon Pharmaceuticals, Inc. Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof
ES2702126T3 (es) * 2013-12-10 2019-02-27 Bristol Myers Squibb Co Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa

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