JP2024524766A5 - - Google Patents

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Publication number
JP2024524766A5
JP2024524766A5 JP2024522590A JP2024522590A JP2024524766A5 JP 2024524766 A5 JP2024524766 A5 JP 2024524766A5 JP 2024522590 A JP2024522590 A JP 2024522590A JP 2024522590 A JP2024522590 A JP 2024522590A JP 2024524766 A5 JP2024524766 A5 JP 2024524766A5
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JP
Japan
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alkyl
pharmaceutically acceptable
acceptable form
hydrogen
independently selected
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JP2024522590A
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English (en)
Japanese (ja)
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JP7741981B2 (ja
JP2024524766A (ja
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Priority claimed from CN202110724794.6A external-priority patent/CN115536648B/zh
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JP2024522590A 2021-06-29 2022-06-28 Ｒｎａヘリカーゼｄｈｘ３３を阻害する多環式化合物及びその応用 Active JP7741981B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202110724794.6A CN115536648B (zh) 2021-06-29 2021-06-29 一类抑制rna解旋酶dhx33的多环化合物及其应用
CN202110724794.6 2021-06-29
PCT/CN2022/102010 WO2023274251A1 (zh) 2021-06-29 2022-06-28 一类抑制rna解旋酶dhx33的多环化合物及其应用

Publications (3)

Publication Number Publication Date
JP2024524766A JP2024524766A (ja) 2024-07-05
JP2024524766A5 true JP2024524766A5 (https=) 2025-02-04
JP7741981B2 JP7741981B2 (ja) 2025-09-18

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JP2024522590A Active JP7741981B2 (ja) 2021-06-29 2022-06-28 Ｒｎａヘリカーゼｄｈｘ３３を阻害する多環式化合物及びその応用

Country Status (5)

Country Link
US (1) US20240182454A1 (https=)
EP (1) EP4378940A4 (https=)
JP (1) JP7741981B2 (https=)
CN (1) CN115536648B (https=)
WO (1) WO2023274251A1 (https=)

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WO2023111996A1 (en) 2021-12-17 2023-06-22 Reglagene Holding, Inc. Compositions and methods of making and using small molecules in the treatment of cancer
CN115969980B (zh) * 2022-12-30 2023-10-24 深圳开悦生命科技有限公司 Rna解旋酶dhx33抑制剂在制备用于治疗胃癌的药物中的应用
CN116099004B (zh) * 2022-12-30 2024-01-30 深圳开悦生命科技有限公司 Rna解旋酶dhx33抑制剂在制备用于治疗膀胱癌的药物中的应用
CN116036282B (zh) * 2022-12-30 2023-12-26 深圳开悦生命科技有限公司 Rna解旋酶dhx33抑制剂在制备用于治疗前列腺癌的药物中的应用
CN115944739B (zh) * 2022-12-30 2023-12-19 深圳开悦生命科技有限公司 Rna解旋酶dhx33抑制剂在制备用于治疗黑色素瘤的药物中的应用
US12215102B2 (en) 2023-02-28 2025-02-04 Reglagene, Inc. Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions
CN116478147B (zh) * 2023-04-25 2025-08-29 深圳开悦生命科技有限公司 抑制rna解旋酶dhx33活性的氘代化合物、合成方法、药物组合物及用途
CN118955485A (zh) * 2023-05-15 2024-11-15 深圳开悦生命科技有限公司 一种化合物的晶型、药物组合物及用途
CN118415976A (zh) * 2024-05-09 2024-08-02 深圳开悦生命科技有限公司 多环化合物注射剂及其制备方法
CN118561829A (zh) * 2024-05-23 2024-08-30 深圳开悦生命科技有限公司 一种含吡咯环的化合物的合成方法及其检测方法

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TWI287010B (en) * 2003-06-12 2007-09-21 Euro Celtique Sa Therapeutic agents useful for treating pain
WO2005095386A1 (en) * 2004-03-30 2005-10-13 Chiron Corporation Substituted thiophene derivatives as anti-cancer agents
CN101006052B (zh) * 2004-07-30 2013-11-06 埃克塞利希斯股份有限公司 作为药用制剂的吡咯衍生物
WO2008085302A1 (en) * 2006-12-20 2008-07-17 Merck & Co., Inc. Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
IN2012DN02474A (https=) * 2009-08-28 2015-08-21 Arena Pharm Inc
WO2011099832A2 (en) * 2010-02-12 2011-08-18 Crystalgenomics, Inc. Novel benzimidazole compound, preparation method thereof and pharmaceutical composition comprising the same
US9464064B2 (en) * 2011-09-07 2016-10-11 University Of Kansas HCV helicase inhibitors and methods of use thereof
AU2014283378B2 (en) * 2013-06-18 2018-09-27 4Sc Ag 2,3-dihydrobenzofuran-5-yl compounds as DYRK kinase inhibitors
CN112585119A (zh) * 2018-08-14 2021-03-30 Epizyme股份有限公司 经取代的吲哚及其使用方法
MX2021006347A (es) * 2018-11-30 2021-10-13 Epizyme Inc Metodos de tratamiento de cánceres que sobreexpresan whsc1 mediante la inhibición de setd2.
CN110295233B (zh) * 2019-07-08 2023-04-25 深圳开悦生命科技有限公司 DHX33基因作为Ras驱动的癌症分子靶点的应用
CN112538078B (zh) * 2020-12-23 2024-03-19 成都开悦生命科技有限公司 一类抑制dhx33解旋酶的多环化合物
EP4714456A2 (en) * 2020-12-16 2026-03-25 Shenzhen Keye Life Technologies, Co., Ltd. Polycyclic compounds for inhibiting rna helicase dhx33 and use thereof
CN112898284B (zh) * 2021-03-01 2022-06-21 深圳开悦生命科技有限公司 一类抑制rna解旋酶dhx33的化合物及其应用
CN112661754B (zh) * 2020-12-30 2023-06-16 成都开悦生命科技有限公司 一类抑制rna解旋酶dhx33的多环化合物

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