MX2021006347A - Metodos de tratamiento de cánceres que sobreexpresan whsc1 mediante la inhibición de setd2. - Google Patents

Metodos de tratamiento de cánceres que sobreexpresan whsc1 mediante la inhibición de setd2.

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Publication number
MX2021006347A
MX2021006347A MX2021006347A MX2021006347A MX2021006347A MX 2021006347 A MX2021006347 A MX 2021006347A MX 2021006347 A MX2021006347 A MX 2021006347A MX 2021006347 A MX2021006347 A MX 2021006347A MX 2021006347 A MX2021006347 A MX 2021006347A
Authority
MX
Mexico
Prior art keywords
whsc1
treating
methods
setd2
overexpressing cancers
Prior art date
Application number
MX2021006347A
Other languages
English (en)
Inventor
Michael Thomenius
Jennifer Anne Totman
Katherine Louise Cosmopoulos
Original Assignee
Epizyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2019/046569 external-priority patent/WO2020037079A1/en
Application filed by Epizyme Inc filed Critical Epizyme Inc
Publication of MX2021006347A publication Critical patent/MX2021006347A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

La presente divulgación proporciona métodos y composiciones farmacéuticas para tratar o ralentizar la progresión de cánceres que sobreexpresan la histona metiltransferasa WHSC1, por ejemplo, mieloma múltiple t(4;14), mediante la administración, a un sujeto que lo necesite, de una cantidad terapéuticamente eficaz de un inhibidor de la histona metiltransferasa, SETD2.
MX2021006347A 2018-11-30 2019-11-26 Metodos de tratamiento de cánceres que sobreexpresan whsc1 mediante la inhibición de setd2. MX2021006347A (es)

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US201862773770P 2018-11-30 2018-11-30
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US201962886880P 2019-08-14 2019-08-14
PCT/US2019/046569 WO2020037079A1 (en) 2018-08-14 2019-08-14 Substituted indoles and methods of use thereof
PCT/US2019/063405 WO2020112872A1 (en) 2018-11-30 2019-11-26 Methods of treating whsc1-overexpressing cancers by inhibiting setd2

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US20230226047A1 (en) * 2019-10-16 2023-07-20 Health Research, Inc. Combination therapy for treatment of cancers
BR112022010561A2 (pt) 2019-12-02 2022-11-16 Storm Therapeutics Ltd Compostos poli-heterocíclicos como inibidores de mettl3
US20230133671A1 (en) * 2020-02-19 2023-05-04 Epizyme, Inc. Setd2 inhibitors and related methods and uses, including combination therapies

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EP2531598A4 (en) * 2010-02-03 2013-05-22 Oncotherapy Science Inc WHSC1 AND WHSC1L1 FOR TARGET GENES TO CANCER THERAPY AND DIAGNOSIS
EP2771343B1 (en) * 2011-10-27 2016-07-13 Memorial Sloan-Kettering Cancer Center Methyltransferase inhibitors for treating cancer
US20190026440A1 (en) * 2015-12-17 2019-01-24 Albert Einstein College Of Medicine, Inc. Nuclear receptor set domain containing protein 2 transition state and uses thereof
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US20230049113A1 (en) 2023-02-16
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EP3886867A1 (en) 2021-10-06
CN113365638A (zh) 2021-09-07
MA54317A (fr) 2022-03-09
AU2019387124A1 (en) 2021-07-22
SG11202105325QA (en) 2021-06-29
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CA3121546A1 (en) 2020-06-04
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