CN115536648B - 一类抑制rna解旋酶dhx33的多环化合物及其应用 - Google Patents

一类抑制rna解旋酶dhx33的多环化合物及其应用 Download PDF

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CN115536648B
CN115536648B CN202110724794.6A CN202110724794A CN115536648B CN 115536648 B CN115536648 B CN 115536648B CN 202110724794 A CN202110724794 A CN 202110724794A CN 115536648 B CN115536648 B CN 115536648B
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compound
formula
pharmaceutically acceptable
alkyl
dhx33
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CN115536648A (zh
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张严冬
李相鲁
聂光丽
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Shenzhen Keye Health Co ltd
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Shenzhen Keye Health Co ltd
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Priority to CN202110724794.6A priority Critical patent/CN115536648B/zh
Application filed by Shenzhen Keye Health Co ltd filed Critical Shenzhen Keye Health Co ltd
Priority to EP25227757.9A priority patent/EP4714456A2/en
Priority to PCT/CN2021/115973 priority patent/WO2022127199A1/zh
Priority to EP21905132.3A priority patent/EP4089089A4/en
Priority to US17/907,952 priority patent/US20230146233A1/en
Priority to JP2023515620A priority patent/JP7530510B2/ja
Priority to EP25227729.8A priority patent/EP4736860A2/en
Priority to EP25227708.2A priority patent/EP4714455A2/en
Priority to EP25227694.4A priority patent/EP4725493A2/en
Priority to JP2024522590A priority patent/JP7741981B2/ja
Priority to US18/278,234 priority patent/US20240182454A1/en
Priority to EP22832064.4A priority patent/EP4378940A4/en
Priority to PCT/CN2022/102010 priority patent/WO2023274251A1/zh
Publication of CN115536648A publication Critical patent/CN115536648A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202110724794.6A 2020-12-16 2021-06-29 一类抑制rna解旋酶dhx33的多环化合物及其应用 Active CN115536648B (zh)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CN202110724794.6A CN115536648B (zh) 2021-06-29 2021-06-29 一类抑制rna解旋酶dhx33的多环化合物及其应用
EP25227708.2A EP4714455A2 (en) 2020-12-16 2021-09-01 Polycyclic compounds for inhibiting rna helicase dhx33 and use thereof
EP21905132.3A EP4089089A4 (en) 2020-12-16 2021-09-01 POLYCYCLIC COMPOUNDS FOR INHIBITING THE RNA HELICASE DHX33 AND THEIR USE
US17/907,952 US20230146233A1 (en) 2020-12-16 2021-09-01 A class of polycyclic compounds inhibiting rna helicase dhx33 and the application thereof
JP2023515620A JP7530510B2 (ja) 2020-12-16 2021-09-01 Ｒｎａヘリカーゼｄｈｘ３３を阻害する多環式化合物及びその応用
EP25227729.8A EP4736860A2 (en) 2020-12-16 2021-09-01 Polycyclic compounds for inhibiting rna helicase dhx33 and use thereof
EP25227757.9A EP4714456A2 (en) 2020-12-16 2021-09-01 Polycyclic compounds for inhibiting rna helicase dhx33 and use thereof
EP25227694.4A EP4725493A2 (en) 2020-12-16 2021-09-01 Polycyclic compounds for inhibiting rna helicase dhx33 and use thereof
PCT/CN2021/115973 WO2022127199A1 (zh) 2020-12-16 2021-09-01 一类抑制rna解旋酶dhx33的多环化合物及其应用
JP2024522590A JP7741981B2 (ja) 2021-06-29 2022-06-28 Ｒｎａヘリカーゼｄｈｘ３３を阻害する多環式化合物及びその応用
US18/278,234 US20240182454A1 (en) 2021-06-29 2022-06-28 Polycyclic Compound for Inhibiting RNA Helicase DHX33, and Application of Compound
EP22832064.4A EP4378940A4 (en) 2021-06-29 2022-06-28 POLYCYCLIC COMPOUND FOR INHIBITING RNA HELICASE DHX33 AND APPLICATION OF THE COMPOUND
PCT/CN2022/102010 WO2023274251A1 (zh) 2021-06-29 2022-06-28 一类抑制rna解旋酶dhx33的多环化合物及其应用

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CN116099004B (zh) * 2022-12-30 2024-01-30 深圳开悦生命科技有限公司 Rna解旋酶dhx33抑制剂在制备用于治疗膀胱癌的药物中的应用
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JP2024524766A (ja) 2024-07-05
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WO2023274251A1 (zh) 2023-01-05
EP4378940A1 (en) 2024-06-05
CN115536648A (zh) 2022-12-30
US20240182454A1 (en) 2024-06-06

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