JP2011525192A5 - - Google Patents
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- JP2011525192A5 JP2011525192A5 JP2011514859A JP2011514859A JP2011525192A5 JP 2011525192 A5 JP2011525192 A5 JP 2011525192A5 JP 2011514859 A JP2011514859 A JP 2011514859A JP 2011514859 A JP2011514859 A JP 2011514859A JP 2011525192 A5 JP2011525192 A5 JP 2011525192A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heterocyclyl
- heteroaryl
- halo
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000005843 halogen group Chemical group 0.000 claims description 46
- 150000001875 compounds Chemical class 0.000 claims description 44
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 36
- 125000001072 heteroaryl group Chemical group 0.000 claims description 35
- 125000001424 substituent group Chemical group 0.000 claims description 31
- 125000000623 heterocyclic group Chemical group 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 28
- 125000003118 aryl group Chemical group 0.000 claims description 27
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 22
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 8
- 125000000304 alkynyl group Chemical group 0.000 claims description 8
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
- 125000004429 atom Chemical group 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 125000005741 alkyl alkenyl group Chemical group 0.000 claims description 2
- 125000004043 oxo group Chemical group O=* 0.000 claims description 2
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims description 2
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 13
- 125000003386 piperidinyl group Chemical group 0.000 claims 11
- 125000004076 pyridyl group Chemical group 0.000 claims 9
- -1 imidazolpyridinyl Chemical group 0.000 claims 6
- 125000002757 morpholinyl group Chemical group 0.000 claims 5
- 125000001425 triazolyl group Chemical group 0.000 claims 4
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims 2
- 125000003838 furazanyl group Chemical group 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 2
- 125000001786 isothiazolyl group Chemical group 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 2
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 claims 2
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000004306 triazinyl group Chemical group 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 125000004601 benzofurazanyl group Chemical group N1=C2C(=NO1)C(=CC=C2)* 0.000 claims 1
- 125000004612 furopyridinyl group Chemical group O1C(=CC2=C1C=CC=N2)* 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 claims 1
- 125000005458 thianyl group Chemical group 0.000 claims 1
- 0 *c1c(*)c(*)c(*)[n]2nc(N*)nc12 Chemical compound *c1c(*)c(*)c(*)[n]2nc(N*)nc12 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7450608P | 2008-06-20 | 2008-06-20 | |
| US61/074,506 | 2008-06-20 | ||
| PCT/US2009/048017 WO2009155551A1 (en) | 2008-06-20 | 2009-06-19 | Triazolopyridine jak inhibitor compounds and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011525192A JP2011525192A (ja) | 2011-09-15 |
| JP2011525192A5 true JP2011525192A5 (https=) | 2014-04-10 |
| JP5512665B2 JP5512665B2 (ja) | 2014-06-04 |
Family
ID=41434469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514859A Expired - Fee Related JP5512665B2 (ja) | 2008-06-20 | 2009-06-19 | トリアゾロピリジンｊａｋ阻害剤化合物と方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20100048557A1 (https=) |
| EP (1) | EP2288260A4 (https=) |
| JP (1) | JP5512665B2 (https=) |
| KR (1) | KR20110033223A (https=) |
| CN (1) | CN102131389A (https=) |
| AU (1) | AU2009259853A1 (https=) |
| BR (1) | BRPI0910021A2 (https=) |
| CA (1) | CA2727036C (https=) |
| IL (1) | IL209763A0 (https=) |
| MX (1) | MX2010014005A (https=) |
| PE (1) | PE20110545A1 (https=) |
| RU (1) | RU2560153C2 (https=) |
| SG (1) | SG178812A1 (https=) |
| WO (1) | WO2009155551A1 (https=) |
| ZA (1) | ZA201008957B (https=) |
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| JP5328816B2 (ja) | 2008-02-22 | 2013-10-30 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドβの調節薬 |
| WO2009155565A1 (en) * | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine jak inhibitor compounds and methods |
| CN102131389A (zh) * | 2008-06-20 | 2011-07-20 | 健泰科生物技术公司 | 三唑并吡啶jak抑制剂化合物和方法 |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| WO2010040661A1 (en) | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| AU2009312856A1 (en) | 2008-11-10 | 2010-05-14 | F. Hoffmann-La Roche Ag | Heterocyclic gamma secretase modulators |
| SG173610A1 (en) * | 2009-02-13 | 2011-09-29 | Fovea Pharmaceuticals Sa | [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors |
| AU2011211410B2 (en) * | 2009-02-13 | 2013-01-31 | Fovea Pharmaceuticals Sa | [1,2,4] triazolo [1,5-A] pyridines as kinase inhibitors |
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-
2009
- 2009-06-19 CN CN2009801324950A patent/CN102131389A/zh active Pending
- 2009-06-19 WO PCT/US2009/048017 patent/WO2009155551A1/en not_active Ceased
- 2009-06-19 JP JP2011514859A patent/JP5512665B2/ja not_active Expired - Fee Related
- 2009-06-19 MX MX2010014005A patent/MX2010014005A/es active IP Right Grant
- 2009-06-19 PE PE2010001173A patent/PE20110545A1/es not_active Application Discontinuation
- 2009-06-19 AU AU2009259853A patent/AU2009259853A1/en not_active Abandoned
- 2009-06-19 KR KR1020117001425A patent/KR20110033223A/ko not_active Ceased
- 2009-06-19 RU RU2011101898/04A patent/RU2560153C2/ru not_active IP Right Cessation
- 2009-06-19 US US12/488,312 patent/US20100048557A1/en not_active Abandoned
- 2009-06-19 EP EP09767860.1A patent/EP2288260A4/en not_active Withdrawn
- 2009-06-19 BR BRPI0910021-0A patent/BRPI0910021A2/pt not_active IP Right Cessation
- 2009-06-19 SG SG2012012241A patent/SG178812A1/en unknown
- 2009-06-19 CA CA2727036A patent/CA2727036C/en not_active Expired - Fee Related
-
2010
- 2010-12-05 IL IL209763A patent/IL209763A0/en unknown
- 2010-12-13 ZA ZA2010/08957A patent/ZA201008957B/en unknown
-
2012
- 2012-05-14 US US13/471,269 patent/US8609687B2/en not_active Expired - Fee Related
-
2013
- 2013-10-09 US US14/049,458 patent/US9434732B2/en not_active Expired - Fee Related
-
2016
- 2016-07-26 US US15/220,087 patent/US20160333011A1/en not_active Abandoned
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