JP2009515988A5 - - Google Patents
Info
- Publication number
- JP2009515988A5 JP2009515988A5 JP2008541330A JP2008541330A JP2009515988A5 JP 2009515988 A5 JP2009515988 A5 JP 2009515988A5 JP 2008541330 A JP2008541330 A JP 2008541330A JP 2008541330 A JP2008541330 A JP 2008541330A JP 2009515988 A5 JP2009515988 A5 JP 2009515988A5
- Authority
- JP
- Japan
- Prior art keywords
- saturated
- partially unsaturated
- alkyl
- heterocyclyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC=NN(*)C(*)=* Chemical compound CC=NN(*)C(*)=* 0.000 description 6
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73628905P | 2005-11-15 | 2005-11-15 | |
| US60/736,289 | 2005-11-15 | ||
| US81701906P | 2006-06-28 | 2006-06-28 | |
| US60/817,019 | 2006-06-28 | ||
| PCT/US2006/044431 WO2007059257A2 (en) | 2005-11-15 | 2006-11-15 | N4-phenyl-quinaz0line-4 -amine derivatives and related compounds as erbb type i receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010198848A Division JP5232841B2 (ja) | 2005-11-15 | 2010-09-06 | N4−フェニルキナゾリン−4−アミン誘導体の製造方法およびその中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009515988A JP2009515988A (ja) | 2009-04-16 |
| JP2009515988A5 true JP2009515988A5 (https=) | 2010-10-21 |
| JP5134548B2 JP5134548B2 (ja) | 2013-01-30 |
Family
ID=38022019
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541330A Active JP5134548B2 (ja) | 2005-11-15 | 2006-11-15 | 過剰増殖性疾患の処置のためのErbBI型受容体チロシンキナーゼ阻害剤としてのN4−フェニルキナゾリン−4−アミン誘導体および関連化合物 |
| JP2010198848A Active JP5232841B2 (ja) | 2005-11-15 | 2010-09-06 | N4−フェニルキナゾリン−4−アミン誘導体の製造方法およびその中間体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010198848A Active JP5232841B2 (ja) | 2005-11-15 | 2010-09-06 | N4−フェニルキナゾリン−4−アミン誘導体の製造方法およびその中間体 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US8648087B2 (https=) |
| EP (2) | EP1971601B1 (https=) |
| JP (2) | JP5134548B2 (https=) |
| KR (1) | KR101086967B1 (https=) |
| CN (2) | CN101356171A (https=) |
| AT (2) | ATE446294T1 (https=) |
| AU (2) | AU2006315383B2 (https=) |
| BE (1) | BE2021C531I2 (https=) |
| BR (2) | BRPI0618668B1 (https=) |
| CA (2) | CA2755268C (https=) |
| CY (3) | CY1110583T1 (https=) |
| DE (2) | DE602006021645D1 (https=) |
| DK (2) | DK1971601T3 (https=) |
| ES (2) | ES2335535T3 (https=) |
| FI (1) | FIC20210022I1 (https=) |
| FR (1) | FR21C1031I2 (https=) |
| HU (1) | HUS2100028I1 (https=) |
| IL (2) | IL239149A (https=) |
| LT (1) | LTC1971601I2 (https=) |
| LU (1) | LUC00217I2 (https=) |
| NL (1) | NL301113I2 (https=) |
| NO (1) | NO342413B1 (https=) |
| PL (2) | PL2090575T3 (https=) |
| PT (2) | PT1971601E (https=) |
| RU (2) | RU2592703C9 (https=) |
| SG (1) | SG152230A1 (https=) |
| SI (2) | SI2090575T1 (https=) |
| WO (1) | WO2007059257A2 (https=) |
| ZA (1) | ZA200804498B (https=) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7501427B2 (en) | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
| DK1660090T3 (da) | 2003-08-14 | 2012-12-17 | Array Biopharma Inc | Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| ATE446294T1 (de) | 2005-11-15 | 2009-11-15 | Array Biopharma Inc | N4-phenyl-chinazolin-4-aminderivate und verwandte verbindungen als inhibitoren der erbb-typ-i- rezeptortyrosinkinase zur behandlung hyperproliferativer krankheiten |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| US7547781B2 (en) | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| AU2007296746B2 (en) * | 2006-09-11 | 2012-07-05 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| WO2008033747A2 (en) * | 2006-09-11 | 2008-03-20 | Curis, Inc. | Multi-functional small molecules as anti-proliferative agents |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| CL2008001626A1 (es) * | 2007-06-05 | 2009-06-05 | Takeda Pharmaceuticals Co | Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer. |
| SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
| PL2200985T3 (pl) | 2007-09-14 | 2011-12-30 | Ortho Mcneil Janssen Pharmaceuticals Inc | 1,3-Dipodstawione-4-(arylo-X-fenylo)-1H-pirydyn-2-ony |
| CN101801930B (zh) | 2007-09-14 | 2013-01-30 | 奥梅-杨森制药有限公司 | 1,3-二取代的-4-苯基-1h-吡啶-2-酮 |
| CN101861316B (zh) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| EP2344470B1 (en) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| ES2599458T3 (es) * | 2008-10-14 | 2017-02-01 | Sunshine Lake Pharma Co., Ltd. | Compuestos y métodos de uso |
| WO2010043396A1 (en) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
| MX2011006219A (es) | 2008-12-11 | 2011-06-28 | Respivert Ltd | Inhibidores de la proteina cinasa activada por el mitogeno p38. |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
| US8586581B2 (en) | 2009-12-17 | 2013-11-19 | Hoffmann-La Roche Inc | Ethynyl compounds useful for treatment of CNS disorders |
| US8343977B2 (en) | 2009-12-30 | 2013-01-01 | Arqule, Inc. | Substituted triazolo-pyrimidine compounds |
| CN102382106A (zh) | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
| US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| CA2822357A1 (en) | 2010-12-22 | 2012-06-28 | Abbvie Inc. | Hepatitis c inhibitors and uses thereof |
| JP2014156400A (ja) * | 2011-05-24 | 2014-08-28 | Astellas Pharma Inc | 腫瘍の画像診断用標識誘導体 |
| AU2012323890A1 (en) * | 2011-10-14 | 2014-05-29 | Array Biopharma Inc. | Polymorphs of arry-380, a selective ErbB2 inhibitor and pharmaceutical compositions containing them |
| WO2013056108A2 (en) * | 2011-10-14 | 2013-04-18 | Array Biopharma Inc. | Solid dispersion |
| EP3400943B1 (en) * | 2012-03-23 | 2020-12-02 | Array Biopharma, Inc. | Compounds for use in the treatment of brain metastases in a patient with erbb2+ breast cancer |
| EP2964638B1 (en) * | 2013-03-06 | 2017-08-09 | Astrazeneca AB | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
| JP6364472B2 (ja) * | 2013-03-15 | 2018-07-25 | デシフェラ ファーマシューティカルズ,エルエルシー | 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| US10124003B2 (en) | 2013-07-18 | 2018-11-13 | Taiho Pharmaceutical Co., Ltd. | Therapeutic agent for FGFR inhibitor-resistant cancer |
| AU2014291161B2 (en) * | 2013-07-18 | 2018-04-26 | Taiho Pharmaceutical Co., Ltd. | Antitumor drug for intermittent administration of FGFR inhibitor |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| ME03518B (me) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena |
| MX386697B (es) | 2014-01-21 | 2025-03-19 | Janssen Pharmaceutica Nv | Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso |
| NZ732511A (en) | 2014-12-15 | 2018-11-30 | Univ Michigan Regents | Small molecule inhibitors of egfr and pi3k |
| PT3279202T (pt) | 2015-03-31 | 2020-08-31 | Taiho Pharmaceutical Co Ltd | Cristal de composto de alquinilo de benzeno 3,5-dissubstituído |
| WO2017148391A1 (zh) | 2016-03-01 | 2017-09-08 | 上海医药集团股份有限公司 | 一种含氮杂环化合物、制备方法、中间体、组合物和应用 |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| EP3424505A4 (en) | 2016-03-04 | 2019-10-16 | Taiho Pharmaceutical Co., Ltd. | PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS |
| CN106117182B (zh) * | 2016-06-20 | 2019-08-30 | 中国药科大学 | 喹唑啉-n-苯乙基四氢异喹啉类化合物及其制备方法和应用 |
| CN107793395B (zh) | 2016-09-01 | 2021-01-05 | 南京药捷安康生物科技有限公司 | 成纤维细胞生长因子受体抑制剂及其用途 |
| EP3516071B1 (en) | 2016-09-22 | 2021-02-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of lung cancer |
| EP3567030B1 (en) * | 2016-12-30 | 2022-02-09 | Medshine Discovery Inc. | Quinazoline compound for egfr inhibition |
| BR112019022280A2 (pt) | 2017-04-28 | 2020-05-19 | Seattle Genetics Inc | tratamento de cânceres de her2 positivo |
| JP7333313B2 (ja) * | 2017-09-01 | 2023-08-24 | シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド | 窒素含有複素環化合物、製造方法、中間体、組成物および使用 |
| JP6918204B2 (ja) | 2018-03-19 | 2021-08-11 | 大鵬薬品工業株式会社 | アルキル硫酸ナトリウムを含む医薬組成物 |
| TWI858848B (zh) * | 2018-05-08 | 2024-10-11 | 大陸商迪哲(江蘇)醫藥股份有限公司 | ErbB受體抑制劑 |
| US20220411422A1 (en) * | 2018-05-08 | 2022-12-29 | Dizal (Jiangsu) Pharmaceutical Co., Ltd. | Erbb receptor inhibitors |
| WO2019214651A1 (zh) | 2018-05-08 | 2019-11-14 | 南京明德新药研发有限公司 | 作为选择性HER2抑制剂的吡咯并[2,1-f][1,2,4]三嗪类衍生物及其应用 |
| EP4523755A3 (en) * | 2018-09-18 | 2025-06-11 | F. Hoffmann-La Roche AG | Quinazoline derivatives as antitumor agents |
| CN109942576B (zh) * | 2019-03-07 | 2020-09-11 | 上海工程技术大学 | Irbinitinib及中间体的制备方法 |
| CN111825604A (zh) * | 2019-04-16 | 2020-10-27 | 宁波药腾医药科技有限公司 | 一种图卡替尼及其中间产物的合成方法 |
| WO2021088987A1 (zh) * | 2019-11-08 | 2021-05-14 | 南京明德新药研发有限公司 | 作为选择性her2抑制剂的盐型、晶型及其应用 |
| JP7626774B2 (ja) * | 2020-02-03 | 2025-02-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | HER2阻害薬としての[1,3]ジアジノ[5,4-d]ピリミジン |
| EP4100409B1 (en) * | 2020-02-03 | 2024-08-28 | Boehringer Ingelheim International GmbH | [1,3]diazino[5,4-d]pyrimidines as her2 inhibitors |
| WO2021179274A1 (en) * | 2020-03-13 | 2021-09-16 | Suzhou Zanrong Pharma Ltd. | ErbB RECEPTOR INHIBITORS AS ANTI-TUMOR AGENTS |
| US11608343B2 (en) | 2020-04-24 | 2023-03-21 | Boehringer Ingelheim International Gmbh | Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors |
| TW202214641A (zh) * | 2020-06-30 | 2022-04-16 | 美商艾瑞生藥股份有限公司 | Her2突變抑制劑 |
| EP4267137A4 (en) * | 2020-12-22 | 2024-11-06 | Enliven Inc. | HETEROARYL-LACTAM-FUSION PYRIMIDINE DERIVATIVES AS ERBB2 INHIBITORS |
| US20240239764A1 (en) | 2020-12-22 | 2024-07-18 | Mekanistic Therapeutics | Substituted aminobenzyl heteroaryl compounds as egfr and/or pi3k inhibitors |
| BR112023018676A2 (pt) | 2021-03-18 | 2023-10-10 | Seagen Inc | Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco |
| TW202309022A (zh) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | 用於治療具egfr突變之癌症之胺基取代雜環 |
| CR20230604A (es) * | 2021-06-26 | 2024-02-19 | Array Biopharma Inc | Inhibidores de mutación de her2 |
| KR102598580B1 (ko) * | 2021-07-16 | 2023-11-06 | 한양대학교 에리카산학협력단 | 니트로알켄 화합물의 신규 제조방법 |
| IL312004A (en) * | 2021-10-20 | 2024-06-01 | Hoffmann La Roche | Crystalline forms of quinazoline derivatives, their preparation, assembly and use |
| WO2023081637A1 (en) | 2021-11-02 | 2023-05-11 | Enliven Therapeutics, Inc. | Fused tetracyclic quinazoline derivatives as inhibitors of erbb2 |
| KR102884401B1 (ko) * | 2022-02-25 | 2025-11-11 | 중앙대학교 산학협력단 | 헤테로아릴 유도체를 유효성분으로 함유하는 her2 억제용 조성물 |
| CN118715216A (zh) * | 2022-03-28 | 2024-09-27 | 江苏恒瑞医药股份有限公司 | 含氮杂环类化合物、其制备方法及其在医药上的应用 |
| CA3267358A1 (en) * | 2022-04-05 | 2025-03-22 | Voronoi Inc. | Heteroaryl derivatives for the treatment of her2-related diseases |
| CN117384162A (zh) * | 2022-05-17 | 2024-01-12 | 浙江文达医药科技有限公司 | 选择性her2抑制剂 |
| WO2024027695A1 (zh) * | 2022-08-04 | 2024-02-08 | 微境生物医药科技(上海)有限公司 | 作为her2抑制剂的化合物 |
| CN115650975B (zh) * | 2022-08-23 | 2024-07-02 | 四川大学华西医院 | 一种靶向降解人表皮生长因子受体2的蛋白降解靶向嵌合体化合物及其应用 |
| AU2024319770A1 (en) | 2023-08-07 | 2026-02-19 | Cogent Biosciences, Inc. | Compounds for fgfr inhibition |
| CN121969632A (zh) | 2023-09-27 | 2026-05-01 | 江苏恒瑞医药股份有限公司 | 一种喹唑啉衍生物的可药用盐、其结晶形式及用途 |
| CN121969633A (zh) | 2023-09-27 | 2026-05-01 | 江苏恒瑞医药股份有限公司 | 一种喹唑啉衍生物的结晶形式及其制备方法 |
| CN118084901A (zh) * | 2023-12-15 | 2024-05-28 | 江苏希迪制药有限公司 | 妥卡替尼的合成方法 |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US4029792A (en) | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| DE2653005A1 (de) * | 1975-12-03 | 1977-06-08 | Sandoz Ag | Neue organische verbindungen, ihre verwendung und herstellung |
| US6743782B1 (en) | 1987-10-28 | 2004-06-01 | Wellstat Therapeutics Corporation | Acyl deoxyribonucleoside derivatives and uses thereof |
| US5204348A (en) | 1988-10-06 | 1993-04-20 | Mitsui Toatsu Chemicals Inc. | Heterocyclic compounds and anticancer-drug potentiaters conaining them as effective components |
| CA1340821C (en) | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
| US5517680A (en) | 1992-01-22 | 1996-05-14 | Ericsson Inc. | Self correction of PST simulcast system timing |
| US5502187A (en) | 1992-04-03 | 1996-03-26 | The Upjohn Company | Pharmaceutically active bicyclic-heterocyclic amines |
| WO1995010506A1 (en) * | 1993-10-12 | 1995-04-20 | The Du Pont Merck Pharmaceutical Company | 1n-alkyl-n-arylpyrimidinamines and derivatives thereof |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| TW321649B (https=) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| GB9424233D0 (en) | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| DE69720965T2 (de) | 1996-02-13 | 2004-02-05 | Astrazeneca Ab | Chinazolinderivate und deren verwendung als vegf hemmer |
| GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| NZ331191A (en) | 1996-03-05 | 2000-03-27 | Zeneca Ltd | 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof |
| EA001595B1 (ru) | 1996-04-12 | 2001-06-25 | Варнер-Ламберт Компани | Необратимые ингибиторы тирозинкиназ |
| AR007857A1 (es) | 1996-07-13 | 1999-11-24 | Glaxo Group Ltd | Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios uso en medicina ycomposiciones farmaceuticas que los contienen. |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| US6225318B1 (en) | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| DE19735682A1 (de) | 1997-08-19 | 1999-02-25 | Basf Ag | Verfahren zur Herstellung von 3-Isopropyl-1H-2,1,3-benzothiadiazin-4(3H)-on-2,2-dioxid |
| EP1028964A1 (en) | 1997-11-11 | 2000-08-23 | Pfizer Products Inc. | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
| JP2002505288A (ja) | 1998-03-02 | 2002-02-19 | コセンシス,インコーポレイテッド | 置換キナゾリンおよびアナログならびにそれらの使用 |
| US6017922A (en) | 1998-05-18 | 2000-01-25 | U.S. Bioscience, Inc. | Thermally stable trimetrexates and processes for producing the same |
| EA003786B1 (ru) | 1998-11-19 | 2003-10-30 | Варнер Ламберт Компани | N-[4-(3-хлор-4-фторфениламино)-7-(3-морфолин-4-илпропокси)хиназолин-6-ил]акриламид - необратимый ингибитор тирозинкиназ |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| IL144214A0 (en) | 1999-01-13 | 2002-05-23 | Warner Lambert Co | Benzoheterocycles and their use as mek inhibitors |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| GB9910577D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| CA2384282A1 (en) | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline compounds and pharmaceutical compositions containing them |
| AU2001258628A1 (en) | 2000-05-31 | 2001-12-11 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| BR0111377A (pt) | 2000-06-06 | 2003-06-03 | Pfizer Prod Inc | Derivados de tiofeno úteis como agentes anticancerìgenos |
| EP1292591B1 (en) | 2000-06-22 | 2005-02-02 | Pfizer Products Inc. | Substituted bicyclic derivatives for the treatment of abnormal cell growth |
| AU2001273071B2 (en) | 2000-06-30 | 2005-09-08 | Glaxo Group Limited | Quinazoline ditosylate salt compounds |
| MXPA02012905A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como agentes de dano vascular.. |
| MXPA02012903A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como inhibidores de angiogenesis. |
| EP1337513A1 (en) | 2000-11-02 | 2003-08-27 | AstraZeneca AB | 4-substituted quinolines as antitumor agents |
| SE0100569D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | New compounds |
| WO2002083622A2 (en) | 2001-04-10 | 2002-10-24 | Leo Pharma A/S | Novel aminophenyl ketone derivatives |
| GB0126433D0 (en) | 2001-11-03 | 2002-01-02 | Astrazeneca Ab | Compounds |
| US20050043336A1 (en) | 2001-11-03 | 2005-02-24 | Hennequin Laurent Francois Andre | Quinazoline derivatives as antitumor agents |
| US6756006B1 (en) | 2002-03-05 | 2004-06-29 | Peter Levijoki | Method of forming sculptured designs onto a substrate |
| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| US7488823B2 (en) | 2003-11-10 | 2009-02-10 | Array Biopharma, Inc. | Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors |
| CA2514479A1 (en) | 2003-01-23 | 2004-08-05 | T.K. Signal Ltd. | Irreversible inhibitors of egf receptor tyrosine kinases and uses thereof |
| PE20040945A1 (es) | 2003-02-05 | 2004-12-14 | Warner Lambert Co | Preparacion de quinazolinas substituidas |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| BRPI0410720A (pt) | 2003-05-27 | 2006-06-20 | Pfizer Prod Inc | quinazolinas e pirido[3,4-d]pirimidinas como inibidores do receptor de tirosina cinase |
| WO2005007083A2 (en) * | 2003-06-18 | 2005-01-27 | Smithkline Beecham Corporation | Chemical compounds |
| US7501427B2 (en) | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
| DK1660090T3 (da) | 2003-08-14 | 2012-12-17 | Array Biopharma Inc | Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer |
| CA2536140A1 (en) | 2003-08-18 | 2005-02-24 | Pfizer Products Inc. | Dosing schedule for erbb2 anticancer agents |
| DE10337942A1 (de) | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Aminobenzimidazolderivate |
| US7399865B2 (en) | 2003-09-15 | 2008-07-15 | Wyeth | Protein tyrosine kinase enzyme inhibitors |
| EP1664028A1 (en) * | 2003-09-16 | 2006-06-07 | AstraZeneca AB | Quinazoline derivatives as tyrosine kinase inhibitors |
| GB0321648D0 (en) * | 2003-09-16 | 2003-10-15 | Astrazeneca Ab | Quinazoline derivatives |
| JP2007510708A (ja) | 2003-11-06 | 2007-04-26 | ファイザー・プロダクツ・インク | 癌の治療における選択的erbB2阻害剤/抗erbB抗体の組合せ |
| KR100735639B1 (ko) | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
| ATE446294T1 (de) * | 2005-11-15 | 2009-11-15 | Array Biopharma Inc | N4-phenyl-chinazolin-4-aminderivate und verwandte verbindungen als inhibitoren der erbb-typ-i- rezeptortyrosinkinase zur behandlung hyperproliferativer krankheiten |
-
2006
- 2006-11-15 AT AT06837728T patent/ATE446294T1/de active
- 2006-11-15 AU AU2006315383A patent/AU2006315383B2/en active Active
- 2006-11-15 CN CNA2006800506892A patent/CN101356171A/zh active Pending
- 2006-11-15 PT PT06837728T patent/PT1971601E/pt unknown
- 2006-11-15 PT PT09157031T patent/PT2090575E/pt unknown
- 2006-11-15 SI SI200631044T patent/SI2090575T1/sl unknown
- 2006-11-15 ES ES06837728T patent/ES2335535T3/es active Active
- 2006-11-15 AT AT09157031T patent/ATE507224T1/de active
- 2006-11-15 CA CA2755268A patent/CA2755268C/en active Active
- 2006-11-15 CN CN201210320423.2A patent/CN102887891B/zh active Active
- 2006-11-15 WO PCT/US2006/044431 patent/WO2007059257A2/en not_active Ceased
- 2006-11-15 KR KR1020087014416A patent/KR101086967B1/ko active Active
- 2006-11-15 ZA ZA200804498A patent/ZA200804498B/xx unknown
- 2006-11-15 JP JP2008541330A patent/JP5134548B2/ja active Active
- 2006-11-15 EP EP06837728A patent/EP1971601B1/en active Active
- 2006-11-15 CA CA2632194A patent/CA2632194C/en active Active
- 2006-11-15 DK DK06837728.2T patent/DK1971601T3/da active
- 2006-11-15 RU RU2011122539/04A patent/RU2592703C9/ru active
- 2006-11-15 EP EP09157031A patent/EP2090575B1/en active Active
- 2006-11-15 PL PL09157031T patent/PL2090575T3/pl unknown
- 2006-11-15 PL PL06837728T patent/PL1971601T3/pl unknown
- 2006-11-15 DE DE602006021645T patent/DE602006021645D1/de active Active
- 2006-11-15 BR BRPI0618668-8A patent/BRPI0618668B1/pt active IP Right Grant
- 2006-11-15 SG SG200902466-2A patent/SG152230A1/en unknown
- 2006-11-15 SI SI200630539T patent/SI1971601T1/sl unknown
- 2006-11-15 BR BR122018075851-1A patent/BR122018075851B1/pt active IP Right Grant
- 2006-11-15 ES ES09157031T patent/ES2364901T3/es active Active
- 2006-11-15 US US12/085,048 patent/US8648087B2/en active Active
- 2006-11-15 DE DE602006009968T patent/DE602006009968D1/de active Active
- 2006-11-15 RU RU2008118417/04A patent/RU2428421C2/ru active
- 2006-11-15 DK DK09157031.7T patent/DK2090575T3/da active
-
2008
- 2008-06-10 NO NO20082598A patent/NO342413B1/no unknown
-
2010
- 2010-01-15 CY CY20101100043T patent/CY1110583T1/el unknown
- 2010-06-04 AU AU2010202330A patent/AU2010202330B2/en active Active
- 2010-09-06 JP JP2010198848A patent/JP5232841B2/ja active Active
-
2011
- 2011-07-15 CY CY20111100696T patent/CY1112754T1/el unknown
-
2013
- 2013-09-23 US US14/034,361 patent/US9693989B2/en active Active
-
2015
- 2015-06-02 IL IL239149A patent/IL239149A/en active IP Right Grant
-
2016
- 2016-11-15 IL IL248993A patent/IL248993B/en active IP Right Grant
-
2017
- 2017-05-19 US US15/599,867 patent/US20170252317A1/en not_active Abandoned
-
2018
- 2018-05-09 US US15/975,323 patent/US10780073B2/en active Active
-
2020
- 2020-07-27 US US16/940,091 patent/US20210008023A1/en not_active Abandoned
-
2021
- 2021-07-06 NL NL301113C patent/NL301113I2/nl unknown
- 2021-07-09 CY CY2021019C patent/CY2021019I2/el unknown
- 2021-07-09 FI FIC20210022C patent/FIC20210022I1/fi unknown
- 2021-07-20 FR FR21C1031C patent/FR21C1031I2/fr active Active
- 2021-07-20 LU LU00217C patent/LUC00217I2/fr unknown
- 2021-07-20 LT LTPA2021516C patent/LTC1971601I2/lt unknown
- 2021-07-29 HU HUS2100028C patent/HUS2100028I1/hu unknown
- 2021-08-04 BE BE2021C531C patent/BE2021C531I2/nl unknown
-
2022
- 2022-09-08 US US17/940,902 patent/US12171739B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009515988A5 (https=) | ||
| JP2010501478A5 (https=) | ||
| JP2005526076A5 (https=) | ||
| JP2011525192A5 (https=) | ||
| JP2016503799A5 (https=) | ||
| JP2010504908A5 (https=) | ||
| JP2016540742A5 (https=) | ||
| JP2019524883A5 (https=) | ||
| JP2008510828A5 (https=) | ||
| JP2012507535A5 (https=) | ||
| JP2006206609A5 (https=) | ||
| JP2018535967A5 (https=) | ||
| JP2007502295A5 (https=) | ||
| JP2010535722A5 (https=) | ||
| JP2006508979A5 (https=) | ||
| CA2632194A1 (en) | N4-phenyl-quinazoline-4-amine derivatives and related compounds as erbb type i receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases | |
| JP2006524225A5 (https=) | ||
| JP2014504646A5 (https=) | ||
| JP2013540712A5 (https=) | ||
| JP2017506666A5 (https=) | ||
| JP2010520214A5 (https=) | ||
| JP2013544854A5 (https=) | ||
| JP2016535769A5 (https=) | ||
| JP2012509265A5 (https=) | ||
| JP2024530956A5 (https=) |