JP2016535769A5 - - Google Patents
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- Publication number
- JP2016535769A5 JP2016535769A5 JP2016551037A JP2016551037A JP2016535769A5 JP 2016535769 A5 JP2016535769 A5 JP 2016535769A5 JP 2016551037 A JP2016551037 A JP 2016551037A JP 2016551037 A JP2016551037 A JP 2016551037A JP 2016535769 A5 JP2016535769 A5 JP 2016535769A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- represents hydrogen
- here
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CC(C1)=CC=C/C=C/[C@](C2)C1=CC=C2*=C Chemical compound CC(C1)=CC=C/C=C/[C@](C2)C1=CC=C2*=C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13192183 | 2013-11-08 | ||
| EP13192183.5 | 2013-11-08 | ||
| PCT/EP2014/073800 WO2015067651A1 (de) | 2013-11-08 | 2014-11-05 | Substituierte uracile als chymase inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016535769A JP2016535769A (ja) | 2016-11-17 |
| JP2016535769A5 true JP2016535769A5 (https=) | 2017-12-14 |
Family
ID=49582563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016551037A Ceased JP2016535769A (ja) | 2013-11-08 | 2014-11-05 | キマーゼ阻害薬としての置換されているウラシル類 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9695131B2 (https=) |
| EP (1) | EP3066096A1 (https=) |
| JP (1) | JP2016535769A (https=) |
| CN (1) | CN105873919A (https=) |
| CA (1) | CA2929763A1 (https=) |
| HK (1) | HK1224288A1 (https=) |
| WO (1) | WO2015067651A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105658647B (zh) * | 2013-11-08 | 2019-09-06 | 拜耳医药股份有限公司 | 化合物的盐 |
| EP3338780A1 (de) | 2016-12-20 | 2018-06-27 | Bayer Pharma Aktiengesellschaft | Verwendung von chymaseinhibitoren zur behandlung von endometriose, post-operativer fibrose und erkrankungen die durch fibrosebildung gekennzeichnet sind |
| WO2018197333A1 (en) * | 2017-04-27 | 2018-11-01 | Bayer Aktiengesellschaft | Selective adrenoreceptor alpha2c receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (pad) |
| CN113811530B (zh) * | 2019-07-03 | 2022-07-19 | 南京明德新药研发有限公司 | 作为糜酶抑制剂的嘧啶酮类化合物及其应用 |
| GB201918414D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency |
| US12569481B2 (en) | 2020-06-12 | 2026-03-10 | Vanderbilt University | Methods of treatment for gastrointestinal motility disorders |
| CN114685472B (zh) * | 2020-12-25 | 2024-04-26 | 广东东阳光药业股份有限公司 | 多取代的尿嘧啶衍生物及其用途 |
| CN114671878B (zh) * | 2020-12-25 | 2023-08-04 | 广东东阳光药业有限公司 | 取代的含氮双环化合物及其用途 |
| CN114671856B (zh) * | 2020-12-25 | 2023-10-20 | 广东东阳光药业股份有限公司 | 多取代的尿嘧啶衍生物及其用途 |
| WO2023194222A1 (en) | 2022-04-05 | 2023-10-12 | Socpra Sciences Santé Humaines S.E.C. | Inhibitors of chymase for use in the selective resolution of thrombi in thrombotic or thromboembolic disorders |
| CN118994100A (zh) * | 2023-05-22 | 2024-11-22 | 苏州大学 | 一种二酮类化合物及其制备方法与应用 |
| CN119019341B (zh) * | 2023-05-23 | 2025-11-18 | 苏州大学 | 一种腈类化合物及其制备方法与应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0721944B1 (en) * | 1994-07-29 | 2001-01-17 | Suntory Limited | Imidazolidine derivative and use thereof |
| US5948785A (en) | 1995-04-27 | 1999-09-07 | The Green Cross Corporation | Heterocyclic amide compounds and pharmaceutical use of the same |
| BR9712000A (pt) * | 1996-09-06 | 1999-08-24 | Nippon Kayaku Kk | Derivados de acetamida sais dos mesmos composi-Æo farmac-utica inibidores de protease de quimase de desgranula-Æo de mastÄcitos ou de libera-Æo de histamina de mastÄcitos e de ativa-Æo de eosinÄfilo ou de libera-Æo de oxig-nio ativo de eosinÄfilo e processo para produzir os dervados de acetamida |
| JPH10195063A (ja) | 1996-10-21 | 1998-07-28 | Dai Ichi Seiyaku Co Ltd | エチニルチアゾール誘導体 |
| EP0940400A4 (en) * | 1996-10-25 | 2002-10-02 | Mitsubishi Pharma Corp | HETEROCYCLIC AMID COMPOUNDS AND THEIR MEDICAL APPLICATION |
| AU744739B2 (en) * | 1998-02-17 | 2002-02-28 | Nippon Kayaku Kabushiki Kaisha | Novel acetamide derivative and use thereof |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| EP1192950B1 (en) * | 2000-02-22 | 2006-07-26 | Daiichi Asubio Pharma Co., Ltd. | Therapeutic drugs for dermatitis exhibiting a biphasic skin reaction containing chymase inhibitors as the active ingredient |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| JP2009520038A (ja) | 2005-12-19 | 2009-05-21 | ジェネンテック・インコーポレーテッド | ピリミジンキナーゼインヒビター |
| WO2007122634A2 (en) * | 2006-04-24 | 2007-11-01 | Jubilant Biosys Limited | Pyrimidinediones as tyrosine kinase inhibitors |
| JO2934B1 (en) | 2006-06-23 | 2015-09-15 | سميث كلاين بيتشام كوربوريشن | Prolyl hydroxylase inhibitors |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| GB0622472D0 (en) | 2006-11-10 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel heterocyclic derivatives |
| AU2008219166B2 (en) | 2007-02-16 | 2013-05-16 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-Met inhibitors |
| WO2009049112A1 (en) | 2007-10-10 | 2009-04-16 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
| DE102008030091B4 (de) | 2008-06-25 | 2011-03-03 | Resprotect Gmbh | Uracilderivate und deren Verwendung |
| WO2010019910A1 (en) | 2008-08-15 | 2010-02-18 | N30 Pharmaceuticals, Llc | Novel pyrrole inhibitors of s-nitrosoglutathione reductase as therapeutic agents |
| EP2780338B1 (en) | 2011-11-14 | 2016-11-09 | Ignyta, Inc. | Uracil derivatives as axl and c-met kinase inhibitors |
| UA112897C2 (uk) * | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
-
2014
- 2014-11-05 HK HK16112522.4A patent/HK1224288A1/zh unknown
- 2014-11-05 CN CN201480071681.9A patent/CN105873919A/zh active Pending
- 2014-11-05 JP JP2016551037A patent/JP2016535769A/ja not_active Ceased
- 2014-11-05 US US15/034,995 patent/US9695131B2/en active Active
- 2014-11-05 EP EP14799368.7A patent/EP3066096A1/de not_active Withdrawn
- 2014-11-05 WO PCT/EP2014/073800 patent/WO2015067651A1/de not_active Ceased
- 2014-11-05 CA CA2929763A patent/CA2929763A1/en not_active Abandoned
-
2017
- 2017-06-01 US US15/611,467 patent/US20170267648A1/en not_active Abandoned
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