JP2010513322A5 - - Google Patents
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- Publication number
- JP2010513322A5 JP2010513322A5 JP2009541695A JP2009541695A JP2010513322A5 JP 2010513322 A5 JP2010513322 A5 JP 2010513322A5 JP 2009541695 A JP2009541695 A JP 2009541695A JP 2009541695 A JP2009541695 A JP 2009541695A JP 2010513322 A5 JP2010513322 A5 JP 2010513322A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylaryl
- group
- compound according
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 125000002877 alkyl aryl group Chemical group 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- -1 NR 3 R 4 Chemical group 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000006287 difluorobenzyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
- 0 *CB/C(/N=C(\CCCCC1)/C(CC2)CC1(*)I)=C(/*)\C2=* Chemical compound *CB/C(/N=C(\CCCCC1)/C(CC2)CC1(*)I)=C(/*)\C2=* 0.000 description 5
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2006907283 | 2006-12-22 | ||
| AU2006907283A AU2006907283A0 (en) | 2006-12-22 | Bicyclic pyrimidinones and uses thereof | |
| AU2007902479A AU2007902479A0 (en) | 2007-05-09 | Bicyclic pyrimidinones and uses thereof (2) | |
| AU2007902479 | 2007-05-09 | ||
| AU2007903401 | 2007-06-25 | ||
| AU2007903401A AU2007903401A0 (en) | 2007-06-25 | Bicyclic pyrimidinodes and uses thereof (3) | |
| AU2007904114A AU2007904114A0 (en) | 2007-07-31 | Bicyclic pyrimidinones and uses thereof (4) | |
| AU2007904114 | 2007-07-31 | ||
| PCT/AU2007/001980 WO2008077188A1 (en) | 2006-12-22 | 2007-12-21 | Bicyclic pyrimidinones and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010129801A Division JP2010222370A (ja) | 2006-12-22 | 2010-06-07 | 二環式ピリミジノンおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513322A JP2010513322A (ja) | 2010-04-30 |
| JP2010513322A5 true JP2010513322A5 (https=) | 2010-06-24 |
| JP5208962B2 JP5208962B2 (ja) | 2013-06-12 |
Family
ID=39562030
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541695A Expired - Fee Related JP5208962B2 (ja) | 2006-12-22 | 2007-12-21 | 二環式ピリミジノンおよびその使用 |
| JP2010129801A Withdrawn JP2010222370A (ja) | 2006-12-22 | 2010-06-07 | 二環式ピリミジノンおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010129801A Withdrawn JP2010222370A (ja) | 2006-12-22 | 2010-06-07 | 二環式ピリミジノンおよびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8143268B2 (https=) |
| EP (2) | EP2114903B1 (https=) |
| JP (2) | JP5208962B2 (https=) |
| KR (2) | KR20090097194A (https=) |
| CN (1) | CN101880280B (https=) |
| AR (2) | AR064517A1 (https=) |
| AT (1) | ATE496898T1 (https=) |
| AU (2) | AU2007336703B9 (https=) |
| BR (2) | BRPI0722411A2 (https=) |
| CA (1) | CA2673183C (https=) |
| DE (1) | DE602007012308D1 (https=) |
| DK (1) | DK2114903T3 (https=) |
| MX (1) | MX2009006764A (https=) |
| NZ (1) | NZ577491A (https=) |
| WO (1) | WO2008077188A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102143962B (zh) * | 2008-07-02 | 2015-03-11 | 爱维艾珂瑟有限公司 | 具有抗病毒特性的化合物 |
| EP2291377B1 (en) * | 2008-07-02 | 2015-02-18 | Avexa Limited | Imidazopyrimidinones and uses thereof |
| JP5539978B2 (ja) * | 2008-07-02 | 2014-07-02 | アベキサ・リミテッド | チアゾピリミジノンおよびその使用 |
| CN102336751A (zh) * | 2010-07-16 | 2012-02-01 | 爱维艾珂瑟有限公司 | 新型抗病毒剂 |
| WO2015038655A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| US10195202B2 (en) | 2013-12-19 | 2019-02-05 | Ptc Therapeutics, Inc. | Methods for modulating the amount of RNA transcripts |
| WO2016145103A1 (en) | 2015-03-11 | 2016-09-15 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| US10668171B2 (en) | 2015-05-30 | 2020-06-02 | Ptc Therapeutics, Inc. | Methods for modulating RNA splicing |
| EA201800367A1 (ru) | 2015-12-10 | 2019-02-28 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения болезни хантингтона |
| JP2019535789A (ja) | 2016-11-28 | 2019-12-12 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを調節する方法 |
| EP3634953B1 (en) | 2017-06-05 | 2024-01-03 | PTC Therapeutics, Inc. | Compounds for treating huntington's disease |
| JP2020523365A (ja) | 2017-06-14 | 2020-08-06 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを改変する方法 |
| MX2019015580A (es) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
| CN111182898B (zh) | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| EA202092001A1 (ru) | 2018-03-27 | 2021-01-29 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Соединения для лечения болезни гентингтона |
| WO2020005877A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| EP3814360B8 (en) | 2018-06-27 | 2024-11-06 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| HRP20240935T1 (hr) | 2018-06-27 | 2024-11-22 | Ptc Therapeutics, Inc. | Heterociklični i heteroaril spojevi za liječenje huntingtonove bolesti |
| JP7649257B2 (ja) | 2019-05-13 | 2025-03-19 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| IL293340A (en) | 2019-12-02 | 2022-07-01 | Storm Therapeutics Ltd | Polyheterocyclic compounds as mettl3 inhibitors |
| US12070445B2 (en) * | 2021-08-27 | 2024-08-27 | Wisconsin Alumni Research Foundation | System and assay for monitoring production/release of membrane-lytic toxins in bacteria and compounds for modulating same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE283853T1 (de) | 2000-09-20 | 2004-12-15 | Schering Corp | Substituierte imidazole als duale histamine h1 und h3 agonisten oder antagonisten |
| EP2161258A3 (en) | 2002-11-20 | 2010-04-07 | Japan Tabacco Inc. | 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| EP1697343B1 (en) | 2003-12-18 | 2009-07-01 | Tibotec Pharmaceuticals Ltd. | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| EP1802591B1 (en) | 2004-10-12 | 2012-01-11 | AstraZeneca AB | Quinazoline derivatives |
| CN101146811B (zh) | 2005-03-31 | 2012-01-11 | P.安杰莱蒂分子生物学研究所 | Hiv整合酶抑制剂 |
| CA2622639C (en) * | 2005-10-04 | 2012-01-03 | Istituto Di Recerche Di Biologia Molecolare P. Angeletti S.P.A. | Hiv integrase inhibitors |
-
2007
- 2007-12-21 KR KR1020097014886A patent/KR20090097194A/ko not_active Ceased
- 2007-12-21 KR KR1020107008711A patent/KR20100049698A/ko not_active Ceased
- 2007-12-21 EP EP07855368A patent/EP2114903B1/en active Active
- 2007-12-21 CN CN201010148170.6A patent/CN101880280B/zh not_active Expired - Fee Related
- 2007-12-21 NZ NZ577491A patent/NZ577491A/en not_active IP Right Cessation
- 2007-12-21 US US12/519,273 patent/US8143268B2/en not_active Expired - Fee Related
- 2007-12-21 CA CA2673183A patent/CA2673183C/en not_active Expired - Fee Related
- 2007-12-21 EP EP10164218A patent/EP2269992A1/en not_active Withdrawn
- 2007-12-21 MX MX2009006764A patent/MX2009006764A/es active IP Right Grant
- 2007-12-21 BR BRPI0722411-7A patent/BRPI0722411A2/pt active Search and Examination
- 2007-12-21 AT AT07855368T patent/ATE496898T1/de not_active IP Right Cessation
- 2007-12-21 DK DK07855368.2T patent/DK2114903T3/da active
- 2007-12-21 DE DE602007012308T patent/DE602007012308D1/de active Active
- 2007-12-21 AR ARP070105884A patent/AR064517A1/es not_active Application Discontinuation
- 2007-12-21 BR BRPI0720564-3A patent/BRPI0720564A2/pt not_active IP Right Cessation
- 2007-12-21 WO PCT/AU2007/001980 patent/WO2008077188A1/en not_active Ceased
- 2007-12-21 JP JP2009541695A patent/JP5208962B2/ja not_active Expired - Fee Related
- 2007-12-21 AU AU2007336703A patent/AU2007336703B9/en not_active Ceased
-
2010
- 2010-03-24 AU AU2010201160A patent/AU2010201160A1/en not_active Abandoned
- 2010-04-23 US US12/766,510 patent/US8207334B2/en not_active Expired - Fee Related
- 2010-06-07 JP JP2010129801A patent/JP2010222370A/ja not_active Withdrawn
- 2010-06-09 AR ARP100102037A patent/AR077043A2/es unknown
-
2012
- 2012-02-27 US US13/405,511 patent/US8859563B2/en not_active Expired - Fee Related
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