ES2335535T3 - Derivados de n4-fenil-quinazolin-4-amina ycompuestos afines como inhibidores de la tirosina quinasa receptora erbb tipo i para el tratamiento de enfermedades hiperproliferativas. - Google Patents

Derivados de n4-fenil-quinazolin-4-amina ycompuestos afines como inhibidores de la tirosina quinasa receptora erbb tipo i para el tratamiento de enfermedades hiperproliferativas. Download PDF

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Publication number
ES2335535T3
ES2335535T3 ES06837728T ES06837728T ES2335535T3 ES 2335535 T3 ES2335535 T3 ES 2335535T3 ES 06837728 T ES06837728 T ES 06837728T ES 06837728 T ES06837728 T ES 06837728T ES 2335535 T3 ES2335535 T3 ES 2335535T3
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alkyl
saturated
heterocyclyl
partially unsaturated
heteroaryl
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English (en)
Spanish (es)
Inventor
Joseph P. Lyssikatos
Fredrik P. Marmsater
Qian Zhao
Julie Marie Greschuk
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Array Biopharma Inc
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Array Biopharma Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
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ES06837728T 2005-11-15 2006-11-15 Derivados de n4-fenil-quinazolin-4-amina ycompuestos afines como inhibidores de la tirosina quinasa receptora erbb tipo i para el tratamiento de enfermedades hiperproliferativas. Active ES2335535T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73628905P 2005-11-15 2005-11-15
US736289P 2005-11-15
US81701906P 2006-06-28 2006-06-28
US817019P 2006-06-28

Publications (1)

Publication Number Publication Date
ES2335535T3 true ES2335535T3 (es) 2010-03-29

Family

ID=38022019

Family Applications (2)

Application Number Title Priority Date Filing Date
ES06837728T Active ES2335535T3 (es) 2005-11-15 2006-11-15 Derivados de n4-fenil-quinazolin-4-amina ycompuestos afines como inhibidores de la tirosina quinasa receptora erbb tipo i para el tratamiento de enfermedades hiperproliferativas.
ES09157031T Active ES2364901T3 (es) 2005-11-15 2006-11-15 Procesos e intermedios para la preparación de derivados de n4-fenil-quinazolin-4-amina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES09157031T Active ES2364901T3 (es) 2005-11-15 2006-11-15 Procesos e intermedios para la preparación de derivados de n4-fenil-quinazolin-4-amina.

Country Status (29)

Country Link
US (6) US8648087B2 (https=)
EP (2) EP1971601B1 (https=)
JP (2) JP5134548B2 (https=)
KR (1) KR101086967B1 (https=)
CN (2) CN101356171A (https=)
AT (2) ATE446294T1 (https=)
AU (2) AU2006315383B2 (https=)
BE (1) BE2021C531I2 (https=)
BR (2) BRPI0618668B1 (https=)
CA (2) CA2755268C (https=)
CY (3) CY1110583T1 (https=)
DE (2) DE602006021645D1 (https=)
DK (2) DK1971601T3 (https=)
ES (2) ES2335535T3 (https=)
FI (1) FIC20210022I1 (https=)
FR (1) FR21C1031I2 (https=)
HU (1) HUS2100028I1 (https=)
IL (2) IL239149A (https=)
LT (1) LTC1971601I2 (https=)
LU (1) LUC00217I2 (https=)
NL (1) NL301113I2 (https=)
NO (1) NO342413B1 (https=)
PL (2) PL2090575T3 (https=)
PT (2) PT1971601E (https=)
RU (2) RU2592703C9 (https=)
SG (1) SG152230A1 (https=)
SI (2) SI2090575T1 (https=)
WO (1) WO2007059257A2 (https=)
ZA (1) ZA200804498B (https=)

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ATE446294T1 (de) 2005-11-15 2009-11-15 Array Biopharma Inc N4-phenyl-chinazolin-4-aminderivate und verwandte verbindungen als inhibitoren der erbb-typ-i- rezeptortyrosinkinase zur behandlung hyperproliferativer krankheiten
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
AU2007296746B2 (en) * 2006-09-11 2012-07-05 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
WO2008033747A2 (en) * 2006-09-11 2008-03-20 Curis, Inc. Multi-functional small molecules as anti-proliferative agents
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
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SI2203439T1 (sl) 2007-09-14 2011-05-31 Ortho Mcneil Janssen Pharm 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
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