JP2016512520A5 - - Google Patents
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- Publication number
- JP2016512520A5 JP2016512520A5 JP2016501185A JP2016501185A JP2016512520A5 JP 2016512520 A5 JP2016512520 A5 JP 2016512520A5 JP 2016501185 A JP2016501185 A JP 2016501185A JP 2016501185 A JP2016501185 A JP 2016501185A JP 2016512520 A5 JP2016512520 A5 JP 2016512520A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- aryl
- pharmaceutically acceptable
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 239000000651 prodrug Substances 0.000 claims 14
- 229940002612 prodrug Drugs 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 11
- 150000002148 esters Chemical class 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical class *C#N 0.000 claims 5
- 125000001188 haloalkyl group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- -1 carbocycle Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361776520P | 2013-03-11 | 2013-03-11 | |
| US61/776,520 | 2013-03-11 | ||
| PCT/US2014/023263 WO2014164704A2 (en) | 2013-03-11 | 2014-03-11 | Compounds and compositions for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512520A JP2016512520A (ja) | 2016-04-28 |
| JP2016512520A5 true JP2016512520A5 (https=) | 2017-04-13 |
| JP6511430B2 JP6511430B2 (ja) | 2019-05-15 |
Family
ID=50729763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501185A Active JP6511430B2 (ja) | 2013-03-11 | 2014-03-11 | がんの治療のための化合物および組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9890127B2 (https=) |
| EP (1) | EP2970145B1 (https=) |
| JP (1) | JP6511430B2 (https=) |
| WO (1) | WO2014164704A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016062279A1 (zh) * | 2014-10-24 | 2016-04-28 | 朗齐生物医学股份有限公司 | 苹果酸丙氯陪拉辛锭用于制备治疗癌症药物的用途 |
| CN104478809B (zh) * | 2014-11-14 | 2016-08-17 | 成都新恒创药业有限公司 | 一种左西孟旦杂质及其制备和检测方法 |
| CN112675178A (zh) | 2014-12-22 | 2021-04-20 | 速达制药有限公司 | 预防和治疗血小板增多的癌症患者中的转移性疾病 |
| LT3319959T (lt) | 2015-07-06 | 2021-12-27 | Alkermes, Inc. | Histono deacetilazės hetero-halogeno inhibitoriai |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| CA2995375C (en) | 2015-08-13 | 2024-06-18 | The Broad Institute, Inc. | Compositions and methods for cancer expressing pde3a or slfn12 |
| CA3013402C (en) * | 2016-02-05 | 2024-05-28 | Bayer Pharma Aktiengesellschaft | Compounds, compositions and methods for cancer patient stratification and cancer treatment |
| EP3414216B1 (en) * | 2016-02-08 | 2020-10-21 | AAA Chemistry ApS | Arylation of aliphatic amines |
| EA036423B1 (ru) * | 2016-03-04 | 2020-11-10 | Оцука Фармасьютикал Ко., Лтд. | Производное 5-метил-6-фенил-4,5-дигидро-2h-пиридазин-3-она |
| US11395820B2 (en) | 2016-03-16 | 2022-07-26 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Small molecules against cereblon to enhance effector t cell function |
| CN105968054B (zh) * | 2016-05-12 | 2018-09-14 | 海门慧聚药业有限公司 | 匹莫苯丹关键中间体的制备 |
| RS62959B1 (sr) | 2017-01-11 | 2022-03-31 | Alkermes Inc | Biciklični inhibitori histon-deacetilaze |
| EP3576742B1 (en) | 2017-02-03 | 2025-07-02 | The Broad Institute, Inc. | 6-[3,5-dihalogeno-4-(morpholin-4-yl)phenyl]-5-methyl-4,5-dihydropyridazin-3(2h)-one, modulators of pde3a or 3b for use in the treatment of cancer |
| CA3071795A1 (en) * | 2017-08-04 | 2019-02-07 | Bayer Aktiengesellschaft | 6-phenyl-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer |
| JOP20200024A1 (ar) * | 2017-08-04 | 2020-02-02 | Bayer Ag | مركبات ثنائي هيدروكساديازينون |
| US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
| JP7104588B2 (ja) * | 2017-09-01 | 2022-07-21 | 大塚製薬株式会社 | ５－メチル－６－フェニル－４，５－ジヒドロ－２ｈ－ピリダジン－３－オン誘導体を含有する悪性腫瘍治療剤 |
| CN110117257B (zh) * | 2018-02-05 | 2022-12-06 | 安徽省新星药物开发有限责任公司 | 一种含胍基的p2y12受体拮抗剂、制备方法及其用途 |
| CN108997349B (zh) * | 2018-06-20 | 2021-03-16 | 合肥华方医药科技有限公司 | 一种依匹斯汀有关物质的制备方法 |
| BR112021000395A2 (pt) | 2018-07-11 | 2021-04-06 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Compostos imunomoduladores diméricos contra mecanismos baseados em cereblon |
| WO2020157201A1 (en) * | 2019-02-01 | 2020-08-06 | Bayer Aktiengesellschaft | Oxadiazinone compounds for the treatment of hyperproliferative diseases |
| WO2020157188A1 (en) * | 2019-02-01 | 2020-08-06 | Bayer Aktiengesellschaft | Dihydrooxadiazinones for the treatment of hyperproliferative diseases |
| WO2020157199A1 (en) * | 2019-02-01 | 2020-08-06 | Bayer Aktiengesellschaft | Annulated dihydropyridazinone compounds as anti-cancer compounds |
| WO2020157194A1 (en) * | 2019-02-01 | 2020-08-06 | Bayer Aktiengesellschaft | 1,2,4-triazin-3(2h)-one compounds for the treatment of hyperproliferative diseases |
| CN113582974B (zh) * | 2020-04-30 | 2022-05-17 | 江西济民可信集团有限公司 | 一类作为蛋白降解剂的化合物及其制备方法和医药用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2624730A (en) * | 1950-08-16 | 1953-01-06 | Sterling Drug Inc | 6-haloaryl-3-pyridazones |
| SE352811B (https=) | 1971-06-04 | 1973-01-15 | Pharmacia Ab | |
| US3960150A (en) | 1971-09-09 | 1976-06-01 | Alza Corporation | Bioerodible ocular device |
| US3867519A (en) | 1972-04-27 | 1975-02-18 | Alza Corp | Bioerodible drug delivery device |
| US3824271A (en) * | 1972-07-20 | 1974-07-16 | American Cyanamid Co | 3-alkyl-3-(benzoyl)propionitriles |
| SE375007B (https=) | 1972-11-30 | 1975-04-07 | Pharmacia Ab | |
| US3963025A (en) | 1974-09-16 | 1976-06-15 | Alza Corporation | Ocular drug delivery device |
| US4052395A (en) | 1975-09-11 | 1977-10-04 | Sankyo Company Limited | Agricultural fungicidal compositions containing 6-(substituted phenyl)-pyridazinones and said pyridazinones |
| US4092311A (en) * | 1976-06-03 | 1978-05-30 | American Cyanamid Company | Hypotensive alkyl-3-[6-(aryl)-3-pyridazinyl]-carbazates |
| US4186184A (en) | 1977-12-27 | 1980-01-29 | Alza Corporation | Selective administration of drug with ocular therapeutic system |
| US4303637A (en) | 1980-04-04 | 1981-12-01 | Alza Corporation | Medication indicated for ocular hypertension |
| DE3263497D1 (en) * | 1981-03-04 | 1985-06-20 | Ciba Geigy Ag | Pyridazinones, method for their preparation, pharmaceutical compositions containing these compounds and their use |
| US4717730A (en) * | 1982-12-03 | 1988-01-05 | Warner-Lambert Company | 4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions containing the compounds as active components |
| JPS6061570A (ja) * | 1983-09-16 | 1985-04-09 | Sankyo Co Ltd | ピリダジノン誘導体及び農業用殺菌剤 |
| JPS6153270A (ja) * | 1984-08-17 | 1986-03-17 | チバ・ガイギー・アクチエンゲゼルシヤフト | 置換ピリダジノン、その製造方法及び該化合物を含む医薬製剤 |
| GB8426804D0 (en) * | 1984-10-23 | 1984-11-28 | Ciba Geigy Ag | Pyridazinones preparations |
| DE3531658A1 (de) | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel |
| DE3804490A1 (de) * | 1988-02-12 | 1989-08-24 | Heumann Pharma Gmbh & Co | Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US5053338A (en) * | 1989-09-01 | 1991-10-01 | Glaxo Inc. | Kinetic resolution of pyridazinones using lipase |
| GB2251615B (en) | 1991-01-03 | 1995-02-08 | Orion Yhtymae Oy | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile |
| JPH05140116A (ja) * | 1991-11-21 | 1993-06-08 | Nippon Soda Co Ltd | 光学活性な化合物 |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| AU3855995A (en) * | 1994-11-11 | 1996-06-06 | Nippon Soda Co., Ltd. | Optically active compound |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6525053B1 (en) * | 1997-08-22 | 2003-02-25 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| UA95644C2 (ru) * | 2006-07-25 | 2011-08-25 | Сефалон, Инк. | Пиридазиноновые производные, фармацевтическая композиция и способ лечения заболеваний |
| JP2010013354A (ja) * | 2006-09-07 | 2010-01-21 | Kyorin Pharmaceut Co Ltd | ２−アルキル−６−（ピラゾロピリジン−４−イル）ピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤 |
| CN101538245B (zh) * | 2008-03-18 | 2011-02-16 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物及其制备方法和制备药物的用途 |
-
2014
- 2014-03-11 JP JP2016501185A patent/JP6511430B2/ja active Active
- 2014-03-11 US US14/775,354 patent/US9890127B2/en active Active
- 2014-03-11 EP EP14724186.3A patent/EP2970145B1/en active Active
- 2014-03-11 WO PCT/US2014/023263 patent/WO2014164704A2/en not_active Ceased
-
2018
- 2018-01-18 US US15/874,500 patent/US20180244629A1/en not_active Abandoned
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