JP2021527126A5 - - Google Patents
Info
- Publication number
- JP2021527126A5 JP2021527126A5 JP2021518047A JP2021518047A JP2021527126A5 JP 2021527126 A5 JP2021527126 A5 JP 2021527126A5 JP 2021518047 A JP2021518047 A JP 2021518047A JP 2021518047 A JP2021518047 A JP 2021518047A JP 2021527126 A5 JP2021527126 A5 JP 2021527126A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- pharmaceutical composition
- partially unsaturated
- independently selected
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862682054P | 2018-06-07 | 2018-06-07 | |
| US62/682,054 | 2018-06-07 | ||
| PCT/US2019/035846 WO2019236890A1 (en) | 2018-06-07 | 2019-06-06 | Inhibitors of sarm1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021527126A JP2021527126A (ja) | 2021-10-11 |
| JP2021527126A5 true JP2021527126A5 (https=) | 2023-02-10 |
| JP7481329B2 JP7481329B2 (ja) | 2024-05-10 |
Family
ID=68770700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021518047A Active JP7481329B2 (ja) | 2018-06-07 | 2019-06-06 | Ｓａｒｍ１阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210261537A1 (https=) |
| EP (1) | EP3801503A4 (https=) |
| JP (1) | JP7481329B2 (https=) |
| CN (2) | CN120398784A (https=) |
| CA (1) | CA3108669A1 (https=) |
| MA (1) | MA52812A (https=) |
| WO (1) | WO2019236890A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112839647B (zh) | 2018-06-07 | 2025-09-23 | 达萨玛治疗公司 | Sarm1抑制剂 |
| CN112839648B (zh) | 2018-06-07 | 2025-04-04 | 达萨玛治疗公司 | Sarm1抑制剂 |
| WO2020081923A1 (en) * | 2018-10-19 | 2020-04-23 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with nad+ or a nad+ precursor |
| EP3897670A4 (en) | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS |
| JP7289375B2 (ja) * | 2019-06-06 | 2023-06-09 | ディスアーム セラピューティクス， インコーポレイテッド | Ｓａｒｍ１の阻害剤 |
| US12595252B2 (en) | 2019-06-14 | 2026-04-07 | Disarm Therapeutics, Inc. | Inhibitors of SARM1 |
| CA3150878A1 (en) | 2019-09-12 | 2021-03-18 | Jonathan Bentley | Inhibitors of sarm1 |
| JP7528212B2 (ja) * | 2019-11-26 | 2024-08-05 | ディスアーム セラピューティクス， インコーポレイテッド | 神経保護のための方法および組成物 |
| EP4083037A4 (en) * | 2019-12-26 | 2024-01-24 | Yonsei University, University-Industry Foundation(UIF). | Pyrrolidine derivative, and pharmaceutical composition for preventing or treating beta-amyloid or tau protein-associated diseases containing same |
| WO2021142006A1 (en) * | 2020-01-07 | 2021-07-15 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 |
| US12435084B2 (en) | 2020-04-09 | 2025-10-07 | Eli Lilly And Company | Indazole derivatives as inhibitors of SARM1 |
| US12606558B2 (en) | 2020-04-09 | 2026-04-21 | Disarm Therapeutics, Inc. | Condensed pyrazole derivatives as inhibitors of SARM1 |
| US12404265B2 (en) | 2020-08-04 | 2025-09-02 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
| TWI904906B (zh) * | 2020-08-24 | 2025-11-11 | 美商達薩瑪治療公司 | Sarm1之抑制劑 |
| CN116438171A (zh) * | 2020-09-16 | 2023-07-14 | 努拉生物公司 | 作为sarm1抑制剂的取代的吡啶衍生物 |
| CN117797146A (zh) * | 2020-11-12 | 2024-04-02 | 科辉智药生物科技（无锡）有限公司 | Sarm1酶活性抑制剂及其在神经退行性疾病中的应用 |
| JP7746384B2 (ja) * | 2020-12-08 | 2025-09-30 | ディスアーム セラピューティクス， インコーポレイテッド | Ｓａｒｍ１のベンゾピラゾール阻害剤 |
| EP4376840A4 (en) | 2021-07-28 | 2025-05-21 | Nura Bio, Inc. | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS |
| WO2023193809A1 (zh) * | 2022-04-08 | 2023-10-12 | 深圳众格生物科技有限公司 | Sarm1抑制剂化合物、包含其的药物组合物及其制备方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7109208B2 (en) * | 2001-04-11 | 2006-09-19 | Senju Pharmaceutical Co., Ltd. | Visual function disorder improving agents |
| US6989451B2 (en) * | 2002-06-04 | 2006-01-24 | Valeant Research & Development | Heterocyclic compounds and uses thereof |
| US6727241B2 (en) * | 2002-06-12 | 2004-04-27 | Chemocentryx | Anti-inflammatory compositions and methods of use |
| US20060217390A1 (en) * | 2005-02-24 | 2006-09-28 | Esmir Gunic | Cycloalkl, aryl and heteroaryl amino isothiazoles for the treatment of Hepatitis C virus |
| WO2006133417A1 (en) * | 2005-06-07 | 2006-12-14 | Valeant Pharmaceuticals International | Phenylamino isothiazole carboxamidines as mek inhibitors |
| TWI433677B (zh) * | 2007-06-04 | 2014-04-11 | Avila Therapeutics Inc | 雜環化合物及其用途 |
| IL251949A0 (en) * | 2017-04-26 | 2017-07-31 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | Small organic molecules for use in the treatment of neuro-inflammatory diseases |
| EP3897670A4 (en) * | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS |
-
2019
- 2019-06-06 CA CA3108669A patent/CA3108669A1/en active Pending
- 2019-06-06 JP JP2021518047A patent/JP7481329B2/ja active Active
- 2019-06-06 CN CN202510537996.8A patent/CN120398784A/zh active Pending
- 2019-06-06 US US16/972,670 patent/US20210261537A1/en active Pending
- 2019-06-06 MA MA052812A patent/MA52812A/fr unknown
- 2019-06-06 WO PCT/US2019/035846 patent/WO2019236890A1/en not_active Ceased
- 2019-06-06 CN CN201980052440.2A patent/CN112867489A/zh active Pending
- 2019-06-06 EP EP19815890.9A patent/EP3801503A4/en active Pending
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