JP2021534104A5 - - Google Patents
Info
- Publication number
- JP2021534104A5 JP2021534104A5 JP2021506660A JP2021506660A JP2021534104A5 JP 2021534104 A5 JP2021534104 A5 JP 2021534104A5 JP 2021506660 A JP2021506660 A JP 2021506660A JP 2021506660 A JP2021506660 A JP 2021506660A JP 2021534104 A5 JP2021534104 A5 JP 2021534104A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- independently selected
- cycloalkyl
- aryl
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862715845P | 2018-08-08 | 2018-08-08 | |
| US62/715,845 | 2018-08-08 | ||
| PCT/US2019/045459 WO2020033514A1 (en) | 2018-08-08 | 2019-08-07 | Benzimidazole inhibitors of pad enzymes |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021534104A JP2021534104A (ja) | 2021-12-09 |
| JP2021534104A5 true JP2021534104A5 (https=) | 2022-08-16 |
| JPWO2020033514A5 JPWO2020033514A5 (https=) | 2022-08-16 |
| JP7434281B2 JP7434281B2 (ja) | 2024-02-20 |
Family
ID=67766305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021506660A Active JP7434281B2 (ja) | 2018-08-08 | 2019-08-07 | Ｐａｄ酵素のベンズイミダゾール阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220348562A1 (https=) |
| EP (1) | EP3833439B1 (https=) |
| JP (1) | JP7434281B2 (https=) |
| KR (1) | KR20210042933A (https=) |
| CN (1) | CN112789087B (https=) |
| ES (1) | ES2956090T3 (https=) |
| WO (1) | WO2020033514A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3833671B1 (en) | 2018-08-08 | 2022-08-24 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| EP4100405A1 (en) | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| EP4143189A1 (en) * | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| TW202241884A (zh) | 2020-12-22 | 2022-11-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140428A2 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001021634A1 (en) | 1999-09-21 | 2001-03-29 | Lion Bioscience Ag | Benzimidazole derivatives and combinatorial libraries thereof |
| EP2358202B1 (en) * | 2008-11-03 | 2016-06-15 | Merck Sharp & Dohme Corp. | Benzimidazole and aza-benzimidazole carboxamides |
| RS55684B1 (sr) * | 2012-07-26 | 2017-07-31 | Glaxo Group Ltd | 2-(azaindol-2-il)benzimidazoli kao pad4 inhibitori |
| US10407407B2 (en) | 2015-05-21 | 2019-09-10 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as PAD4 inhibitors |
| AR107032A1 (es) * | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| AR107030A1 (es) * | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| JP6926126B2 (ja) * | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| KR102398941B1 (ko) * | 2016-07-27 | 2022-05-17 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 공유결합성 억제제 |
| CN107311933B (zh) | 2017-06-28 | 2020-12-22 | 中国人民解放军军事医学科学院毒物药物研究所 | 一类苯并咪唑衍生物，及其制备方法和用途 |
-
2019
- 2019-08-07 CN CN201980064964.3A patent/CN112789087B/zh active Active
- 2019-08-07 US US17/265,840 patent/US20220348562A1/en active Pending
- 2019-08-07 ES ES19759140T patent/ES2956090T3/es active Active
- 2019-08-07 JP JP2021506660A patent/JP7434281B2/ja active Active
- 2019-08-07 WO PCT/US2019/045459 patent/WO2020033514A1/en not_active Ceased
- 2019-08-07 EP EP19759140.7A patent/EP3833439B1/en active Active
- 2019-08-07 KR KR1020217006470A patent/KR20210042933A/ko active Pending
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