JP2003519102A5 - - Google Patents
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- JP2003519102A5 JP2003519102A5 JP2001541509A JP2001541509A JP2003519102A5 JP 2003519102 A5 JP2003519102 A5 JP 2003519102A5 JP 2001541509 A JP2001541509 A JP 2001541509A JP 2001541509 A JP2001541509 A JP 2001541509A JP 2003519102 A5 JP2003519102 A5 JP 2003519102A5
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- YEGQZWNGCOHAGA-KRWDZBQOSA-N O[C@@H](CC1)CN1c1c(cc(-c2ccccc2)[nH]2)c2nc(-c2ccccc2)n1 Chemical compound O[C@@H](CC1)CN1c1c(cc(-c2ccccc2)[nH]2)c2nc(-c2ccccc2)n1 YEGQZWNGCOHAGA-KRWDZBQOSA-N 0.000 description 1
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
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- RIWRFSMVIUAEBX-UHFFFAOYSA-N n-methyl-1-phenylmethanamine Chemical compound CNCC1=CC=CC=C1 RIWRFSMVIUAEBX-UHFFFAOYSA-N 0.000 description 1
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- 208000012113 pregnancy disease Diseases 0.000 description 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45425499A | 1999-12-02 | 1999-12-02 | |
| US09/454,074 US6878716B1 (en) | 1998-06-02 | 1999-12-02 | Compounds specific to adenosine A1 receptor and uses thereof |
| US09/454,074 | 1999-12-02 | ||
| US09/454,254 | 1999-12-02 | ||
| US09/454,075 | 1999-12-02 | ||
| US09/454,075 US6686366B1 (en) | 1998-06-02 | 1999-12-02 | Compounds specific to adenosine A3 receptor and uses thereof |
| PCT/US2000/032702 WO2001039777A1 (en) | 1999-12-02 | 2000-12-01 | Compounds specific to adenosine a1 a2a, and a3 receptors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519102A JP2003519102A (ja) | 2003-06-17 |
| JP2003519102A5 true JP2003519102A5 (https=) | 2009-04-09 |
Family
ID=27412585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541509A Pending JP2003519102A (ja) | 1999-12-02 | 2000-12-01 | アデノシンａ▲下１▼、ａ▲下２ａ▼およびａ▲下３▼受容体に対して特異的な化合物並びにその使用 |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP1246623B1 (https=) |
| JP (1) | JP2003519102A (https=) |
| KR (1) | KR100840727B1 (https=) |
| AT (1) | ATE335489T1 (https=) |
| AU (1) | AU784878B2 (https=) |
| CA (1) | CA2393179A1 (https=) |
| CY (1) | CY1107653T1 (https=) |
| DE (1) | DE60030002T2 (https=) |
| DK (1) | DK1246623T3 (https=) |
| ES (1) | ES2269217T3 (https=) |
| HK (1) | HK1050319B (https=) |
| IL (2) | IL149935A0 (https=) |
| MX (1) | MXPA02005357A (https=) |
| PT (1) | PT1246623E (https=) |
| WO (1) | WO2001039777A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU76100A (sh) | 1998-06-02 | 2003-12-31 | Osi Pharmaceuticals Inc. | Pirolo(2,3-d) pirimidin preparati i njihova primena |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| EP1317450B1 (en) * | 2000-09-15 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| KR100897430B1 (ko) * | 2000-12-01 | 2009-05-14 | 오에스아이 파마슈티컬스, 인코포레이티드 | 아데노신 ａ₁, ａ₂ａ 및 ａ₃ 수용체에 특이적인 화합물및 그의 용도 |
| US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| AP1893A (en) * | 2000-12-01 | 2008-09-23 | Osi Pharm Inc | Compounds specific to adenosine A1, A2A and A3 receptor and uses thereof |
| NZ526472A (en) | 2000-12-21 | 2004-04-30 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
| UA80258C2 (en) * | 2001-09-06 | 2007-09-10 | Biogen Inc | Methods of treating pulmonary disease |
| DE10148883A1 (de) * | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | Pyrimidinderivate |
| AU2002360436A1 (en) | 2001-11-30 | 2003-06-17 | Osi Pharmaceuticals, Inc. | 2-aryl pyrrologpyrimidines for a1 and a3 receptors |
| EP1465634B1 (en) | 2001-12-12 | 2014-10-22 | The Government of the United States of America, as represented by the Secretary Department of Health and Human Services | Methods for using adenosine receptor inhibitors to enhance immune response and inflammation |
| KR100960827B1 (ko) * | 2001-12-20 | 2010-06-08 | 오에스아이 파마슈티컬스, 인코포레이티드 | 피롤로피리미딘 Ａ₂ｂ 선택성 길항 화합물, 그의 합성방법 및 용도 |
| CN101973998A (zh) | 2001-12-20 | 2011-02-16 | Osi药物公司 | 吡咯并嘧啶A2b选择性拮抗剂化合物 |
| CN1620294A (zh) | 2001-12-20 | 2005-05-25 | Osi药物公司 | 嘧啶a2b选择性拮抗剂化合物,它们的合成及用途 |
| DK1483247T3 (da) | 2002-03-13 | 2009-08-17 | Euro Celtique Sa | Arylsubstituerede pyrimidiner og anvendelsen deraf |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| DK1532145T3 (da) | 2002-08-02 | 2007-01-15 | Vertex Pharma | Pyrazolpræparater der er anvendelige som inhibitorer af GSK-3 |
| EP1610774A4 (en) * | 2003-04-09 | 2008-07-16 | Exelixis Inc | TIE-2 MODULATORS AND METHODS OF USE |
| AR043880A1 (es) * | 2003-04-22 | 2005-08-17 | Solvay Pharm Gmbh | Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas |
| WO2005004875A1 (ja) * | 2003-07-14 | 2005-01-20 | Sankyo Company, Limited | 経肺投与用医薬組成物 |
| EP1954277B1 (en) | 2005-11-03 | 2017-01-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| DE602007013730D1 (de) | 2006-03-27 | 2011-05-19 | Otsuka Chemical Co Ltd | Trehaloseverbindung und arzneimittel mit der verbindung |
| CA2647543A1 (en) * | 2006-03-29 | 2007-11-08 | Foldrx Pharmaceuticals, Inc. | Inhibition of alpha-synuclein toxicity |
| TW200808819A (en) * | 2006-06-19 | 2008-02-16 | Solvay Pharm Gmbh | Use of adenosine A1 antagonists in radiocontrast media induced nephrophaty |
| RU2470635C2 (ru) * | 2007-05-11 | 2012-12-27 | Сантен Фармасьютикал Ко., Лтд. | Профилактическое или терапевтическое средство, применяемое при заболеваниях заднего отдела глаза |
| US8101371B2 (en) | 2007-10-18 | 2012-01-24 | Musc Foundation For Research Development | Methods for the diagnosis of genitourinary cancer |
| AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
| EP2651417B1 (en) | 2010-12-16 | 2016-11-30 | Calchan Limited | Ask1 inhibiting pyrrolopyrimidine derivatives |
| WO2013182580A1 (en) * | 2012-06-07 | 2013-12-12 | F. Hoffmann-La Roche Ag | Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase |
| GB201711234D0 (en) | 2017-07-12 | 2017-08-23 | Galapagos Nv | Pyrrolopyrimidine and pyrrolopyridine derivatives |
| KR20240018000A (ko) * | 2022-08-01 | 2024-02-13 | 주식회사 넥스트젠바이오사이언스 | A3 아데노신 수용체 작용제로서의 신규한 퓨린 유도체 화합물 |
| WO2024233605A1 (en) * | 2023-05-08 | 2024-11-14 | Tango Therapeutics, Inc. | Compounds and their use against cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3910913A (en) * | 1969-11-04 | 1975-10-07 | American Home Prod | 4,5-Diamino-7H-pyrrolo{8 2,3-d{9 pyrimidine derivatives |
| US5516894A (en) | 1992-03-11 | 1996-05-14 | The General Hospital Corporation | A2b -adenosine receptors |
| FI944602A0 (fi) * | 1992-04-03 | 1994-10-03 | Upjohn Co | Farmaseuttisesti aktiiviset bisyklis-heterosykliset amiinit |
| WO1995011681A1 (en) | 1993-10-29 | 1995-05-04 | Merck & Co., Inc. | Human adenosine receptor antagonists |
| IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| US5780450A (en) | 1995-11-21 | 1998-07-14 | Alcon Laboratories, Inc. | Use of adenosine uptake inhibitors for treating retinal or optic nerve head damage |
| WO1997033879A1 (en) | 1996-03-15 | 1997-09-18 | Merck & Co., Inc. | Compounds and methods for selectively inhibiting activation of the human a3 adenosine receptor |
| JPH09291089A (ja) | 1996-04-26 | 1997-11-11 | Yamanouchi Pharmaceut Co Ltd | 新規な５−チアゾリルウラシル誘導体又はその塩 |
| US5786360A (en) | 1996-11-19 | 1998-07-28 | Link Technology Incorporated | A1 adenosine receptor antagonists |
| AU8764398A (en) | 1997-07-29 | 1999-02-22 | Medco Research, Inc. | N6-substituted-adenosine-5'-uronamides as adenosine receptor modulators |
| YU76100A (sh) * | 1998-06-02 | 2003-12-31 | Osi Pharmaceuticals Inc. | Pirolo(2,3-d) pirimidin preparati i njihova primena |
| US9816053B2 (en) | 2015-03-26 | 2017-11-14 | Melynda S DelCotto | Candle having a wooden wick with figured grain |
-
2000
- 2000-12-01 KR KR1020027007039A patent/KR100840727B1/ko not_active Expired - Fee Related
- 2000-12-01 MX MXPA02005357A patent/MXPA02005357A/es active IP Right Grant
- 2000-12-01 AU AU24270/01A patent/AU784878B2/en not_active Ceased
- 2000-12-01 EP EP00988011A patent/EP1246623B1/en not_active Expired - Lifetime
- 2000-12-01 IL IL14993500A patent/IL149935A0/xx unknown
- 2000-12-01 EP EP06016543A patent/EP1731520A1/en not_active Withdrawn
- 2000-12-01 PT PT00988011T patent/PT1246623E/pt unknown
- 2000-12-01 JP JP2001541509A patent/JP2003519102A/ja active Pending
- 2000-12-01 DE DE60030002T patent/DE60030002T2/de not_active Expired - Lifetime
- 2000-12-01 DK DK00988011T patent/DK1246623T3/da active
- 2000-12-01 AT AT00988011T patent/ATE335489T1/de active
- 2000-12-01 CA CA002393179A patent/CA2393179A1/en not_active Abandoned
- 2000-12-01 ES ES00988011T patent/ES2269217T3/es not_active Expired - Lifetime
- 2000-12-01 WO PCT/US2000/032702 patent/WO2001039777A1/en not_active Ceased
- 2000-12-01 HK HK03102257.1A patent/HK1050319B/en not_active IP Right Cessation
-
2006
- 2006-09-04 CY CY20061101246T patent/CY1107653T1/el unknown
-
2009
- 2009-07-15 IL IL199869A patent/IL199869A0/en unknown
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