JP2021515010A5 - - Google Patents
Info
- Publication number
- JP2021515010A5 JP2021515010A5 JP2020545666A JP2020545666A JP2021515010A5 JP 2021515010 A5 JP2021515010 A5 JP 2021515010A5 JP 2020545666 A JP2020545666 A JP 2020545666A JP 2020545666 A JP2020545666 A JP 2020545666A JP 2021515010 A5 JP2021515010 A5 JP 2021515010A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- alkenyl
- heterocyclyl
- heteroaryl
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862636614P | 2018-02-28 | 2018-02-28 | |
| US62/636,614 | 2018-02-28 | ||
| PCT/US2019/019854 WO2019168999A1 (en) | 2018-02-28 | 2019-02-27 | Compounds with ferroptosis inducing activity and methods of their use |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021515010A JP2021515010A (ja) | 2021-06-17 |
| JP2021515010A5 true JP2021515010A5 (https=) | 2022-06-22 |
| JPWO2019168999A5 JPWO2019168999A5 (https=) | 2022-06-22 |
| JP7348906B2 JP7348906B2 (ja) | 2023-09-21 |
Family
ID=65729467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545666A Active JP7348906B2 (ja) | 2018-02-28 | 2019-02-27 | フェロトーシス誘導活性を有する化合物およびそれらの使用方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11098040B2 (https=) |
| EP (1) | EP3759075B1 (https=) |
| JP (1) | JP7348906B2 (https=) |
| KR (1) | KR20200135961A (https=) |
| CN (1) | CN112041301A (https=) |
| AR (2) | AR114417A1 (https=) |
| AU (1) | AU2019229256A1 (https=) |
| BR (1) | BR112020017561A2 (https=) |
| CA (1) | CA3092143A1 (https=) |
| EA (1) | EA202091846A1 (https=) |
| ES (1) | ES3038012T3 (https=) |
| IL (1) | IL276788A (https=) |
| MX (2) | MX2020008906A (https=) |
| SG (1) | SG11202008230PA (https=) |
| TW (1) | TW202000663A (https=) |
| WO (1) | WO2019168999A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11040964B2 (en) | 2019-02-27 | 2021-06-22 | Ferro Therapeutics, Inc. | Compounds and methods of use |
| MX2021010173A (es) * | 2019-02-27 | 2021-12-10 | Ferro Therapeutics Inc | Compuestos con actividad inductora de ferroptosis y métodos de uso. |
| US20220227765A1 (en) * | 2019-08-28 | 2022-07-21 | Ferro Therapeutics, Inc. | Pyrido-indole analogues as gpx4 inhibitors |
| CN110511253B (zh) * | 2019-09-04 | 2023-10-13 | 上海药明康德新药开发有限公司 | DNA编码化合物库构建中On-DNA四氢-β-咔啉类化合物的合成方法 |
| CN110627786B (zh) * | 2019-10-29 | 2020-11-24 | 株洲千金药业股份有限公司 | 一种他达拉非中间体的制备方法 |
| JP2023509359A (ja) | 2019-12-17 | 2023-03-08 | フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド | 鉄依存性細胞分解の誘導物質との併用抗癌療法 |
| US11998534B2 (en) * | 2020-02-12 | 2024-06-04 | Eubulus Biotherapeutics Inc. | GPX4 inhibitor in combination with anticancer agent for treating proliferative disease |
| CN115243719B (zh) * | 2020-03-06 | 2024-09-13 | 北京先通生物医药技术有限公司 | CTB006与Ponatinib联合应用 |
| TW202227399A (zh) * | 2020-08-26 | 2022-07-16 | 美商費洛醫療公司 | 化合物及使用方法 |
| AU2021391453A1 (en) * | 2020-12-04 | 2023-07-13 | Eubulus Biotherapeutics Inc. | Heteroaryl-acetylenes, pharmaceutical compositions thereof, and their therapeutic applications |
| KR20220139813A (ko) * | 2021-04-08 | 2022-10-17 | 서울대학교산학협력단 | 암 환자의 예후 예측용 바이오마커 및 이의 용도 |
| CN113336748B (zh) * | 2021-04-12 | 2022-03-25 | 北京大学 | 一种gpx4蛋白降解剂及其制备方法和应用、一种抗肿瘤细胞药物 |
| US11541116B1 (en) | 2022-01-07 | 2023-01-03 | Kojin Therapeutics, Inc. | Methods and compositions for inducing ferroptosis in vivo |
| WO2024015637A1 (en) * | 2022-07-15 | 2024-01-18 | Ferro Therapeutics, Inc. | Glutathione peroxidase 4 (gpx4) inhibitors for the treatment of cancer |
| WO2024039860A1 (en) * | 2022-08-19 | 2024-02-22 | Olema Pharmaceuticals, Inc. | 2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole derivatives as estrogen receptor modulators for the treatment of cancer |
| WO2024123412A1 (en) * | 2022-12-09 | 2024-06-13 | The University Of Toledo | Ferroptosis inducers to treat cancer |
| CN118994147B (zh) * | 2024-07-18 | 2026-01-02 | 中国海洋大学 | 一种基于疏水标签的gpx4蛋白降解剂及其制备方法和应用 |
| CN120923499A (zh) * | 2025-08-08 | 2025-11-11 | 兰州大学 | 一种铁死亡激动剂、缺氧响应型纳米共递送系统及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9514465D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| CA2411008C (en) | 2000-06-07 | 2006-04-11 | Lilly Icos Llc | Derivatives of 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione |
| WO2001094347A1 (en) * | 2000-06-08 | 2001-12-13 | Lilly Icos Llc | Tetracyclic diketopiperazine compounds as pdev inhibitors |
| WO2002028858A2 (en) * | 2000-10-02 | 2002-04-11 | Lilly Icos Llc | Hexahydropyrazino `1'2' : 1, 6!- pyrido `3, 4-b! indole-1, 4-dione derivatives for the treatment of cardiovascular disorders and erectile disfunction |
| MXPA03004023A (es) | 2000-11-08 | 2004-02-12 | Lilly Icos Llc | Compuestos quimicos. |
| AU2006275702A1 (en) * | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
| EP1914235A1 (en) * | 2006-10-10 | 2008-04-23 | Universite de Lille 2 Droit et Santé | Chiral tetra-hydro beta-carboline derivatives and applications thereof as antiparasitic compounds |
| WO2008103470A2 (en) * | 2007-02-21 | 2008-08-28 | Trustees Of Columbia University In The City Of New York | Oncogenic-ras-signal dependent lethal compounds |
| FR2916200A1 (fr) * | 2007-05-18 | 2008-11-21 | Fourtillan Snc | Nouveaux derives des 1,2,3,4,6,7,12,12a-octahydro pyrazino[1',2':1,6]pyrido[3,4-b]indoles, leur preparation et leur utilisation en therapeutique |
| WO2011063223A1 (en) | 2009-11-20 | 2011-05-26 | Southern Research Institute | TETRAHYDRO-β-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF |
| WO2014011973A2 (en) | 2012-07-13 | 2014-01-16 | The Trustees Of Columbia University In The City Of New York | Quinazolinone-based oncogenic-ras-selective lethal compounds and their use |
| WO2015051149A1 (en) | 2013-10-04 | 2015-04-09 | The Trustees Of Columbia University In The City Of New York | Sorafenib analogs and uses thereof |
| EP3094332B1 (en) | 2014-01-15 | 2018-09-12 | The Trustees of Columbia University in the City of New York | Carbonyl erastin analogs and their use |
| CN107530303A (zh) | 2014-12-16 | 2018-01-02 | Adt制药有限责任公司 | Ras‑抑制性茚基乙酰胺化合物、组合物和用途 |
| JP6974178B2 (ja) | 2015-05-29 | 2021-12-01 | メモリアル スローン ケタリング キャンサー センター | フェロトーシスを介して栄養欠乏がん細胞の細胞死を誘導するための極小ナノ粒子を使用する処置方法 |
| US10519148B2 (en) | 2015-11-12 | 2019-12-31 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Acrylic acid derivative, preparation method and use in medicine thereof |
| US20190008961A1 (en) * | 2016-01-07 | 2019-01-10 | The Broad Institute, Inc. | Compounds and methods for increasing tumor infiltration by immune cells |
| BR112018013730B1 (pt) | 2016-01-08 | 2022-06-28 | Championx Usa Inc. | Método para intensificar a produção e/ou o transporte de óleo bruto |
| CN109362222B (zh) | 2016-02-05 | 2021-03-19 | 益方生物科技(上海)股份有限公司 | 选择性雌激素受体降解物及其用途 |
| WO2018118711A1 (en) | 2016-12-19 | 2018-06-28 | The Trustees Of Columbia University In The City Of New York | Small molecule ferroptosis inducers |
| WO2018218087A1 (en) | 2017-05-24 | 2018-11-29 | K-Gen, Inc. | Methods of cancer treatment |
| US11530413B2 (en) | 2017-07-21 | 2022-12-20 | Novartis Ag | Compositions and methods to treat cancer |
| WO2019106434A1 (en) | 2017-12-01 | 2019-06-06 | Collaborative Medicinal Development Pty. Ltd. | Heterobicyclic aromatic derivatives for the treatment of ferroptosis-related disorders |
| US20200383943A1 (en) | 2017-12-04 | 2020-12-10 | Memorial Sloan Kettering Cancer Center | Methods of cancer treatment via regulated ferroptosis |
| CN109796424A (zh) | 2019-02-19 | 2019-05-24 | 四川大学 | 一种抑制铁死亡的小分子化合物及其制备方法与应用 |
| MX2021010173A (es) | 2019-02-27 | 2021-12-10 | Ferro Therapeutics Inc | Compuestos con actividad inductora de ferroptosis y métodos de uso. |
-
2019
- 2019-02-27 TW TW108106912A patent/TW202000663A/zh unknown
- 2019-02-27 AU AU2019229256A patent/AU2019229256A1/en not_active Abandoned
- 2019-02-27 US US16/287,805 patent/US11098040B2/en active Active
- 2019-02-27 CN CN201980028824.0A patent/CN112041301A/zh active Pending
- 2019-02-27 WO PCT/US2019/019854 patent/WO2019168999A1/en not_active Ceased
- 2019-02-27 BR BR112020017561-7A patent/BR112020017561A2/pt not_active IP Right Cessation
- 2019-02-27 ES ES19710558T patent/ES3038012T3/es active Active
- 2019-02-27 KR KR1020207027582A patent/KR20200135961A/ko not_active Withdrawn
- 2019-02-27 SG SG11202008230PA patent/SG11202008230PA/en unknown
- 2019-02-27 CA CA3092143A patent/CA3092143A1/en active Pending
- 2019-02-27 EA EA202091846A patent/EA202091846A1/ru unknown
- 2019-02-27 MX MX2020008906A patent/MX2020008906A/es unknown
- 2019-02-27 JP JP2020545666A patent/JP7348906B2/ja active Active
- 2019-02-27 EP EP19710558.8A patent/EP3759075B1/en active Active
- 2019-02-28 AR ARP190100499A patent/AR114417A1/es not_active Application Discontinuation
-
2020
- 2020-02-27 AR ARP200100540A patent/AR118205A1/es not_active Application Discontinuation
- 2020-08-18 IL IL276788A patent/IL276788A/en unknown
- 2020-08-26 MX MX2023001527A patent/MX2023001527A/es unknown
-
2021
- 2021-07-06 US US17/368,708 patent/US20230039846A1/en not_active Abandoned
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