JP2011520896A5 - - Google Patents
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- Publication number
- JP2011520896A5 JP2011520896A5 JP2011509628A JP2011509628A JP2011520896A5 JP 2011520896 A5 JP2011520896 A5 JP 2011520896A5 JP 2011509628 A JP2011509628 A JP 2011509628A JP 2011509628 A JP2011509628 A JP 2011509628A JP 2011520896 A5 JP2011520896 A5 JP 2011520896A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- pharmaceutically acceptable
- acceptable salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZYOUZMYPAWIGKT-UHFFFAOYSA-N CCCC(C)C(C)N=C Chemical compound CCCC(C)C(C)N=C ZYOUZMYPAWIGKT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5292608P | 2008-05-13 | 2008-05-13 | |
| US61/052,926 | 2008-05-13 | ||
| PCT/US2009/043691 WO2009140320A1 (en) | 2008-05-13 | 2009-05-13 | Pyrrolopyridines as kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015032474A Division JP2015098482A (ja) | 2008-05-13 | 2015-02-23 | キナーゼ阻害剤としてのピロロピリジン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011520896A JP2011520896A (ja) | 2011-07-21 |
| JP2011520896A5 true JP2011520896A5 (https=) | 2014-07-31 |
| JP5703212B2 JP5703212B2 (ja) | 2015-04-15 |
Family
ID=40810786
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509628A Expired - Fee Related JP5703212B2 (ja) | 2008-05-13 | 2009-05-13 | キナーゼ阻害剤としてのピロロピリジン |
| JP2015032474A Withdrawn JP2015098482A (ja) | 2008-05-13 | 2015-02-23 | キナーゼ阻害剤としてのピロロピリジン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015032474A Withdrawn JP2015098482A (ja) | 2008-05-13 | 2015-02-23 | キナーゼ阻害剤としてのピロロピリジン |
Country Status (30)
| Country | Link |
|---|---|
| US (6) | US8178131B2 (https=) |
| EP (2) | EP2990407B1 (https=) |
| JP (2) | JP5703212B2 (https=) |
| KR (2) | KR101643426B1 (https=) |
| CN (3) | CN109942575A (https=) |
| AR (1) | AR071717A1 (https=) |
| AU (1) | AU2009246402B2 (https=) |
| BR (1) | BRPI0913580B8 (https=) |
| CA (1) | CA2724262C (https=) |
| CL (1) | CL2009001152A1 (https=) |
| CO (1) | CO6321244A2 (https=) |
| CR (1) | CR11803A (https=) |
| CY (1) | CY1116692T1 (https=) |
| DK (1) | DK2307409T3 (https=) |
| ES (1) | ES2552643T3 (https=) |
| HK (1) | HK1219950A1 (https=) |
| HR (1) | HRP20151018T1 (https=) |
| HU (1) | HUE026160T2 (https=) |
| IL (1) | IL209258A (https=) |
| MX (1) | MX2010012449A (https=) |
| NZ (1) | NZ589318A (https=) |
| PH (1) | PH12013501779B1 (https=) |
| PL (1) | PL2307409T3 (https=) |
| PT (1) | PT2307409E (https=) |
| RS (1) | RS54358B1 (https=) |
| RU (1) | RU2517194C2 (https=) |
| SI (1) | SI2307409T1 (https=) |
| TW (2) | TWI458727B (https=) |
| UA (1) | UA111933C2 (https=) |
| WO (1) | WO2009140320A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2711614A1 (en) | 2008-01-08 | 2009-07-16 | Array Biopharma Inc. | Pyrrolopyridines as kinase inhibitors |
| CA2711741A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Pyrazolopyridines as kinase inhibitors |
| JP2009256298A (ja) * | 2008-03-26 | 2009-11-05 | Sumitomo Chemical Co Ltd | ピペリジン−3−イルカーバメート化合物の光学分割方法およびその中間体 |
| CL2009001152A1 (es) * | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. |
| US8481557B2 (en) | 2009-04-11 | 2013-07-09 | Array Biopharma Inc. | Method of treatment using checkpoint kinase 1 inhibitors |
| JP5805071B2 (ja) * | 2009-04-11 | 2015-11-04 | アレイ バイオファーマ、インコーポレイテッド | Dna損傷因子増強のためのチェックポイントキナーゼ1阻害剤 |
| TWI466885B (zh) | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| EP2485589A4 (en) * | 2009-09-04 | 2013-02-06 | Biogen Idec Inc | HETEROARYL-BTK INHIBITORS |
| KR101541086B1 (ko) | 2010-08-20 | 2015-08-03 | 허치슨 메디파르마 리미티드 | 피롤로피리미딘 화합물 및 그 용도 |
| RU2017127088A (ru) * | 2010-11-16 | 2019-02-04 | Эррэй Биофарма Инк. | Комбинация ингибиторов чекпойнт-киназы 1 и ингибиторов киназы wee 1 |
| BR112013021675A2 (pt) | 2011-02-25 | 2016-11-01 | Array Biopharma Inc | compostos de triazolopiridina como inibidores de pim cinase |
| CA2834166A1 (en) | 2011-04-29 | 2012-11-01 | Amgen Inc. | Bicyclic pyridazine compounds as pim inhibitors |
| GB201201566D0 (en) * | 2012-01-30 | 2012-03-14 | Vernalis R&D Ltd | New chemical compounds |
| SG11201406818VA (en) | 2012-04-23 | 2014-11-27 | Genentech Inc | Intermediates and processes for preparing compounds |
| CN112472699A (zh) | 2013-07-26 | 2021-03-12 | 种族肿瘤学公司 | 改善比生群及衍生物的治疗益处的组合方法 |
| WO2015027090A1 (en) * | 2013-08-22 | 2015-02-26 | Genentech, Inc. | Intermediates and processes for preparing compounds |
| CN105705499B (zh) * | 2013-08-22 | 2018-10-12 | 基因泰克公司 | 用于制备化合物的方法 |
| SG11201602265PA (en) * | 2013-09-25 | 2016-04-28 | Vertex Pharma | A selective inhibitor of phosphatidylinositol 3-kinase-gamma |
| SG11201608303QA (en) | 2014-04-04 | 2016-11-29 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| TW201613919A (en) | 2014-07-02 | 2016-04-16 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| MA41599A (fr) | 2015-02-26 | 2018-01-02 | Array Biopharma Inc | Formes cristallines d'un composé pyrrolopyridine |
| WO2017003090A1 (ko) | 2015-06-30 | 2017-01-05 | 서울바이오시스 주식회사 | Uv led가 적용된 포충기 |
| PL3371165T3 (pl) * | 2015-11-04 | 2022-05-02 | Merck Patent Gmbh | Inhibitor btk do zastosowania w terapii rakowej |
| AU2016378579A1 (en) * | 2015-12-22 | 2018-06-14 | Vitae Pharmaceuticals, Inc. | Inhibitors of the menin-MLL interaction |
| WO2017214367A1 (en) | 2016-06-10 | 2017-12-14 | Vitae Pharmaceuticals, Inc. | Inhibitors of the menin-mll interaction |
| EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
| CN112839648B (zh) | 2018-06-07 | 2025-04-04 | 达萨玛治疗公司 | Sarm1抑制剂 |
| CN120004785A (zh) * | 2018-07-03 | 2025-05-16 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| CN109053526A (zh) * | 2018-08-13 | 2018-12-21 | 南通大学 | 一种(3r,4s)-4-甲基吡咯烷-3-基氨基甲酸叔丁酯盐酸盐的化学合成方法 |
| CN108912032A (zh) * | 2018-08-13 | 2018-11-30 | 南通大学 | 一种(3s,4r)-4-甲基吡咯烷-3-基氨基甲醇叔丁酯盐酸盐的化学合成方法 |
| EP3897670A4 (en) | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS |
| TW202043198A (zh) | 2019-01-17 | 2020-12-01 | 美商Ifm Due有限公司 | 用於治療與sting活性相關之病況的化合物及組合物 |
| EP4132932A4 (en) | 2020-04-07 | 2024-04-17 | Syndax Pharmaceuticals, Inc. | COMBINATIONS OF MENIN INHIBITORS AND CYP3A4 INHIBITORS AND METHODS OF USE THEREOF |
| WO2022015975A1 (en) | 2020-07-15 | 2022-01-20 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| EP4274824A1 (en) | 2021-01-08 | 2023-11-15 | IFM Due, Inc. | Heterobicyclic compounds having an urea or analogue and their compositions for treating conditions associated with sting activity |
| IL308476A (en) | 2021-05-14 | 2024-01-01 | Syndax Pharmaceuticals Inc | Inhibitors of the menin-mil interaction |
| IL310724A (en) | 2021-08-10 | 2024-04-01 | Ifm Due Inc | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH STING ACTIVITY |
| CN119798252A (zh) * | 2023-10-09 | 2025-04-11 | 中国石油化工股份有限公司 | 一种制备n邻位-酰基取代的含氮杂环化合物及其缩胺合铁(ii)配合物的方法 |
| WO2025260014A1 (en) * | 2024-06-14 | 2025-12-18 | Tenvie Therapeutics, Inc. | Compounds, compositions, and methods |
| WO2025261366A1 (zh) * | 2024-06-18 | 2025-12-26 | 南京正大天晴制药有限公司 | 一种五元并六元杂环化合物及用途 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0723545B1 (en) * | 1993-10-14 | 2002-05-08 | Abbott Laboratories | Quinolizinone type compounds |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| WO2001058869A2 (en) | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
| MXPA02010222A (es) | 2000-04-18 | 2003-05-23 | Agouron Pharma | Pirazoles para inhibir proteina cinasa. |
| WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| WO2003028724A1 (en) | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
| US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
| TWI329112B (en) | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
| AU2003250539A1 (en) | 2002-08-07 | 2004-02-25 | Mitsubishi Pharma Corporation | Dihydropyrazolopyridine compounds |
| US20050256157A1 (en) | 2002-08-23 | 2005-11-17 | Chiron Corporation | Combination therapy with CHK1 inhibitors |
| US8580782B2 (en) | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| TWI270549B (en) | 2002-12-26 | 2007-01-11 | Taisho Pharmaceutical Co Ltd | Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group |
| EP1613625A1 (en) | 2003-03-14 | 2006-01-11 | AstraZeneca AB | Novel fused triazolones and the uses thereof |
| GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| GB0330042D0 (en) * | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them |
| GB0330043D0 (en) * | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them |
| AR049333A1 (es) * | 2004-04-02 | 2006-07-19 | Vertex Pharma | Azaindoles inhibidores de proteinquinasas rock y otras proteinas quinasas. composiciones farmaceuticas. |
| TWI380816B (zh) * | 2004-04-13 | 2013-01-01 | Synta Pharmaceuticals Corp | 抑制介白素-12(il-12)生成之二鹽抑制劑 |
| GB0409080D0 (en) | 2004-04-23 | 2004-05-26 | Biofocus Discovery Ltd | Compounds which interact with protein kinases |
| JP2007161585A (ja) | 2004-06-25 | 2007-06-28 | Taisho Pharmaceut Co Ltd | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
| UY29177A1 (es) | 2004-10-25 | 2006-05-31 | Astex Therapeutics Ltd | Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos |
| GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| EP1869052A1 (en) | 2005-04-06 | 2007-12-26 | AstraZeneca AB | Substituted heterocycles and their use as chk1, pdk1 and pak inhibitors |
| EP2354140A1 (en) | 2005-05-20 | 2011-08-10 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| CA2621181C (en) * | 2005-08-30 | 2011-04-19 | Asahi Kasei Pharma Corporation | 5-isoquinolinesulfonamide compounds |
| JP5052518B2 (ja) | 2005-10-06 | 2012-10-17 | シェーリング コーポレイション | プロテインキナーゼインヒビターとしてのピラゾロピリミジン |
| BRPI0616985B1 (pt) | 2005-10-06 | 2021-10-26 | Merck Sharp & Dohme Corp. | Composto de pirazolo[1,5-a]pirimidina, e, uso de um composto |
| SG10202003901UA (en) | 2005-12-13 | 2020-05-28 | Incyte Holdings Corp | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
| WO2007084667A2 (en) | 2006-01-19 | 2007-07-26 | Osi Pharmaceutical, Inc. | Fused heterobicyclic kinase inhibitors |
| DE102006005179A1 (de) | 2006-02-06 | 2007-08-09 | Merck Patent Gmbh | Aminoindazolderivate |
| DE102006005180A1 (de) | 2006-02-06 | 2007-08-09 | Merck Patent Gmbh | Indazol-heteroaryl-derivate |
| DK3421471T3 (da) | 2006-04-25 | 2021-06-14 | Astex Therapeutics Ltd | Purin- og deazapurinderivater som farmaceutiske forbindelser |
| EP2037931A2 (en) | 2006-04-25 | 2009-03-25 | Astex Therapeutics Limited | Pharmaceutical combinations of pk inhibitors and other active agents |
| WO2007125315A2 (en) | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Pharmaceutical compounds |
| WO2008012635A2 (en) | 2006-07-26 | 2008-01-31 | Pfizer Products Inc. | Amine derivatives useful as anticancer agents |
| WO2008075007A1 (en) | 2006-12-21 | 2008-06-26 | Cancer Research Technology Limited | Morpholino-substituted bicycloheteroaryl compounds and their use as anti cancer agents |
| CA2679659C (en) | 2007-03-01 | 2016-01-19 | Novartis Ag | Pim kinase inhibitors and methods of their use |
| US8618121B2 (en) * | 2007-07-02 | 2013-12-31 | Cancer Research Technology Limited | 9H-pyrimido[4,5-B]indoles, 9H-pyrido[4',3':4,5]pyrrolo[2,3-D]pyridines, and 9H 1,3,6,9 tetraaza-fluorenes as CHK1 kinase function inhibitors |
| JP2011503084A (ja) | 2007-11-07 | 2011-01-27 | シェーリング コーポレイション | 新規の細胞周期チェックポイント調節剤およびこれらの調節剤とチェックポイント阻害剤との併用 |
| CA2711614A1 (en) * | 2008-01-08 | 2009-07-16 | Array Biopharma Inc. | Pyrrolopyridines as kinase inhibitors |
| CA2711741A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Pyrazolopyridines as kinase inhibitors |
| CL2009001152A1 (es) | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. |
| US8481557B2 (en) * | 2009-04-11 | 2013-07-09 | Array Biopharma Inc. | Method of treatment using checkpoint kinase 1 inhibitors |
| US20140221370A1 (en) | 2010-07-09 | 2014-08-07 | Array Biopharma Inc. | Pyrrolopyridines as kinase inhibitors |
| RU2017127088A (ru) | 2010-11-16 | 2019-02-04 | Эррэй Биофарма Инк. | Комбинация ингибиторов чекпойнт-киназы 1 и ингибиторов киназы wee 1 |
-
2009
- 2009-05-12 CL CL2009001152A patent/CL2009001152A1/es unknown
- 2009-05-12 AR ARP090101708A patent/AR071717A1/es active IP Right Grant
- 2009-05-13 RS RS20150711A patent/RS54358B1/sr unknown
- 2009-05-13 CA CA2724262A patent/CA2724262C/en active Active
- 2009-05-13 JP JP2011509628A patent/JP5703212B2/ja not_active Expired - Fee Related
- 2009-05-13 US US12/992,468 patent/US8178131B2/en active Active
- 2009-05-13 CN CN201910068067.1A patent/CN109942575A/zh active Pending
- 2009-05-13 SI SI200931284T patent/SI2307409T1/sl unknown
- 2009-05-13 ES ES09747404.3T patent/ES2552643T3/es active Active
- 2009-05-13 MX MX2010012449A patent/MX2010012449A/es active IP Right Grant
- 2009-05-13 CN CN200980127299.4A patent/CN102089307B/zh not_active Expired - Fee Related
- 2009-05-13 TW TW098115906A patent/TWI458727B/zh not_active IP Right Cessation
- 2009-05-13 RU RU2010150786/04A patent/RU2517194C2/ru active
- 2009-05-13 CN CN201510289964.7A patent/CN104926810B/zh not_active Expired - Fee Related
- 2009-05-13 WO PCT/US2009/043691 patent/WO2009140320A1/en not_active Ceased
- 2009-05-13 KR KR1020107027941A patent/KR101643426B1/ko not_active Expired - Fee Related
- 2009-05-13 PT PT97474043T patent/PT2307409E/pt unknown
- 2009-05-13 PL PL09747404T patent/PL2307409T3/pl unknown
- 2009-05-13 HU HUE09747404A patent/HUE026160T2/en unknown
- 2009-05-13 HR HRP20151018TT patent/HRP20151018T1/hr unknown
- 2009-05-13 KR KR1020147015705A patent/KR101657856B1/ko not_active Expired - Fee Related
- 2009-05-13 EP EP15175131.0A patent/EP2990407B1/en active Active
- 2009-05-13 BR BRPI0913580A patent/BRPI0913580B8/pt not_active IP Right Cessation
- 2009-05-13 EP EP09747404.3A patent/EP2307409B1/en active Active
- 2009-05-13 AU AU2009246402A patent/AU2009246402B2/en not_active Ceased
- 2009-05-13 UA UAA201015012A patent/UA111933C2/uk unknown
- 2009-05-13 TW TW103133772A patent/TWI554512B/zh not_active IP Right Cessation
- 2009-05-13 DK DK09747404.3T patent/DK2307409T3/en active
- 2009-05-13 NZ NZ589318A patent/NZ589318A/en not_active IP Right Cessation
-
2010
- 2010-11-11 IL IL209258A patent/IL209258A/en active IP Right Grant
- 2010-11-19 CR CR11803A patent/CR11803A/es unknown
- 2010-11-30 CO CO10150963A patent/CO6321244A2/es active IP Right Grant
-
2012
- 2012-03-20 US US13/425,186 patent/US8545897B2/en not_active Expired - Fee Related
-
2013
- 2013-08-23 US US13/974,895 patent/US8758830B2/en active Active
- 2013-08-28 PH PH12013501779A patent/PH12013501779B1/en unknown
-
2014
- 2014-05-06 US US14/271,129 patent/US8981085B2/en active Active
-
2015
- 2015-01-07 US US14/591,691 patent/US9365568B2/en active Active
- 2015-02-23 JP JP2015032474A patent/JP2015098482A/ja not_active Withdrawn
- 2015-09-16 CY CY20151100812T patent/CY1116692T1/el unknown
-
2016
- 2016-01-05 US US14/988,521 patent/US9969727B2/en active Active
- 2016-07-08 HK HK16107983.6A patent/HK1219950A1/en unknown
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