KR101643426B1 - 키나아제 억제제로서의 피롤로피리딘 - Google Patents

키나아제 억제제로서의 피롤로피리딘 Download PDF

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Publication number
KR101643426B1
KR101643426B1 KR1020107027941A KR20107027941A KR101643426B1 KR 101643426 B1 KR101643426 B1 KR 101643426B1 KR 1020107027941 A KR1020107027941 A KR 1020107027941A KR 20107027941 A KR20107027941 A KR 20107027941A KR 101643426 B1 KR101643426 B1 KR 101643426B1
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pyrrolo
pyridin
alkyl
hydrogen
phenyl
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Expired - Fee Related
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English (en)
Korean (ko)
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KR20110008102A (ko
Inventor
이반 르 위에루
제임스 에프. 블레이크
인드라니 더블유. 군워다나
피터 제이. 모어
엘리 엠. 월래스
빈 왕
마크 시카렐리
마이클 라이온
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어레이 바이오파마 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020107027941A 2008-05-13 2009-05-13 키나아제 억제제로서의 피롤로피리딘 Expired - Fee Related KR101643426B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5292608P 2008-05-13 2008-05-13
US61/052,926 2008-05-13

Related Child Applications (1)

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KR1020147015705A Division KR101657856B1 (ko) 2008-05-13 2009-05-13 키나아제 억제제로서의 피롤로피리딘

Publications (2)

Publication Number Publication Date
KR20110008102A KR20110008102A (ko) 2011-01-25
KR101643426B1 true KR101643426B1 (ko) 2016-07-27

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KR1020107027941A Expired - Fee Related KR101643426B1 (ko) 2008-05-13 2009-05-13 키나아제 억제제로서의 피롤로피리딘
KR1020147015705A Expired - Fee Related KR101657856B1 (ko) 2008-05-13 2009-05-13 키나아제 억제제로서의 피롤로피리딘

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Country Status (30)

Country Link
US (6) US8178131B2 (https=)
EP (2) EP2990407B1 (https=)
JP (2) JP5703212B2 (https=)
KR (2) KR101643426B1 (https=)
CN (3) CN109942575A (https=)
AR (1) AR071717A1 (https=)
AU (1) AU2009246402B2 (https=)
BR (1) BRPI0913580B8 (https=)
CA (1) CA2724262C (https=)
CL (1) CL2009001152A1 (https=)
CO (1) CO6321244A2 (https=)
CR (1) CR11803A (https=)
CY (1) CY1116692T1 (https=)
DK (1) DK2307409T3 (https=)
ES (1) ES2552643T3 (https=)
HK (1) HK1219950A1 (https=)
HR (1) HRP20151018T1 (https=)
HU (1) HUE026160T2 (https=)
IL (1) IL209258A (https=)
MX (1) MX2010012449A (https=)
NZ (1) NZ589318A (https=)
PH (1) PH12013501779B1 (https=)
PL (1) PL2307409T3 (https=)
PT (1) PT2307409E (https=)
RS (1) RS54358B1 (https=)
RU (1) RU2517194C2 (https=)
SI (1) SI2307409T1 (https=)
TW (2) TWI458727B (https=)
UA (1) UA111933C2 (https=)
WO (1) WO2009140320A1 (https=)

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TWI458727B (zh) 2014-11-01
CY1116692T1 (el) 2017-03-15
US20140243520A1 (en) 2014-08-28
HK1152035A1 (en) 2012-02-17
RS54358B1 (sr) 2016-04-28
US20160368916A1 (en) 2016-12-22
CO6321244A2 (es) 2011-09-20
AR071717A1 (es) 2010-07-07
KR101657856B1 (ko) 2016-09-19
CR11803A (es) 2011-02-11
CN102089307A (zh) 2011-06-08
MX2010012449A (es) 2011-05-25
RU2517194C2 (ru) 2014-05-27
DK2307409T3 (en) 2015-09-21
EP2307409A1 (en) 2011-04-13
AU2009246402A1 (en) 2009-11-19
US20110070317A1 (en) 2011-03-24
JP2015098482A (ja) 2015-05-28
EP2990407A1 (en) 2016-03-02
TW201529573A (zh) 2015-08-01
WO2009140320A1 (en) 2009-11-19
US9365568B2 (en) 2016-06-14
JP2011520896A (ja) 2011-07-21
CN102089307B (zh) 2015-07-01
CA2724262C (en) 2017-08-15
US8178131B2 (en) 2012-05-15
US20150322061A1 (en) 2015-11-12
CL2009001152A1 (es) 2009-10-16
BRPI0913580A2 (pt) 2015-10-20
US20140100369A1 (en) 2014-04-10
US8758830B2 (en) 2014-06-24
IL209258A (en) 2017-01-31
CN109942575A (zh) 2019-06-28
KR20140093266A (ko) 2014-07-25
PT2307409E (pt) 2015-11-04
HRP20151018T1 (hr) 2015-10-23
PH12013501779B1 (en) 2019-02-13
RU2010150786A (ru) 2012-06-20
CA2724262A1 (en) 2009-11-19
ES2552643T3 (es) 2015-12-01
US8981085B2 (en) 2015-03-17
TW201002707A (en) 2010-01-16
JP5703212B2 (ja) 2015-04-15
US8545897B2 (en) 2013-10-01
KR20110008102A (ko) 2011-01-25
BRPI0913580B1 (pt) 2020-03-10
EP2990407B1 (en) 2019-10-16
PH12013501779A1 (en) 2014-08-27
CN104926810B (zh) 2019-02-19
AU2009246402B2 (en) 2013-05-23
UA111933C2 (uk) 2016-07-11
SI2307409T1 (sl) 2015-11-30
HUE026160T2 (en) 2016-05-30
US9969727B2 (en) 2018-05-15
PL2307409T3 (pl) 2016-01-29
EP2307409B1 (en) 2015-08-12
TWI554512B (zh) 2016-10-21
HK1219950A1 (en) 2017-04-21
NZ589318A (en) 2011-06-30
IL209258A0 (en) 2011-01-31
US20130045286A1 (en) 2013-02-21
BRPI0913580B8 (pt) 2021-05-25
CN104926810A (zh) 2015-09-23

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